Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 361

1.

Chromosomal instability drives metastasis through a cytosolic DNA response.

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC.

Nature. 2018 Jan 25;553(7689):467-472. doi: 10.1038/nature25432. Epub 2018 Jan 17.

PMID:
29342134
2.

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation.

Cheng W, Wang S, Mestre AA, Fu C, Makarem A, Xian F, Hayes LR, Lopez-Gonzalez R, Drenner K, Jiang J, Cleveland DW, Sun S.

Nat Commun. 2018 Jan 4;9(1):51. doi: 10.1038/s41467-017-02495-z.

3.

Rethinking Unconventional Translation in Neurodegeneration.

Gao FB, Richter JD, Cleveland DW.

Cell. 2017 Nov 16;171(5):994-1000. doi: 10.1016/j.cell.2017.10.042.

PMID:
29149615
4.

Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis.

Ly P, Cleveland DW.

Trends Cell Biol. 2017 Dec;27(12):917-930. doi: 10.1016/j.tcb.2017.08.005. Epub 2017 Sep 9. Review.

PMID:
28899600
5.

The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.

Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A, Cleveland DW, Corbett KD.

EMBO J. 2017 Aug 15;36(16):2419-2434. doi: 10.15252/embj.201797291. Epub 2017 Jun 28.

PMID:
28659378
6.

Interrogating cell division errors using random and chromosome-specific missegregation approaches.

Ly P, Cleveland DW.

Cell Cycle. 2017 Jul 3;16(13):1252-1258. doi: 10.1080/15384101.2017.1325047. Epub 2017 Jun 26.

PMID:
28650219
7.

Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition.

Guo LY, Allu PK, Zandarashvili L, McKinley KL, Sekulic N, Dawicki-McKenna JM, Fachinetti D, Logsdon GA, Jamiolkowski RM, Cleveland DW, Cheeseman IM, Black BE.

Nat Commun. 2017 Jun 9;8:15775. doi: 10.1038/ncomms15775.

8.

Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.

Gasset-Rosa F, Chillon-Marinas C, Goginashvili A, Atwal RS, Artates JW, Tabet R, Wheeler VC, Bang AG, Cleveland DW, Lagier-Tourenne C.

Neuron. 2017 Apr 5;94(1):48-57.e4. doi: 10.1016/j.neuron.2017.03.027.

PMID:
28384474
9.

Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.

Ditsworth D, Maldonado M, McAlonis-Downes M, Sun S, Seelman A, Drenner K, Arnold E, Ling SC, Pizzo D, Ravits J, Cleveland DW, Da Cruz S.

Acta Neuropathol. 2017 Jun;133(6):907-922. doi: 10.1007/s00401-017-1698-6. Epub 2017 Mar 29.

10.

Misfolded SOD1 is not a primary component of sporadic ALS.

Da Cruz S, Bui A, Saberi S, Lee SK, Stauffer J, McAlonis-Downes M, Schulte D, Pizzo DP, Parone PA, Cleveland DW, Ravits J.

Acta Neuropathol. 2017 Jul;134(1):97-111. doi: 10.1007/s00401-017-1688-8. Epub 2017 Feb 28.

PMID:
28247063
11.

Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points.

Nechemia-Arbely Y, Fachinetti D, Miga KH, Sekulic N, Soni GV, Kim DH, Wong AK, Lee AY, Nguyen K, Dekker C, Ren B, Black BE, Cleveland DW.

J Cell Biol. 2017 Mar 6;216(3):607-621. doi: 10.1083/jcb.201608083. Epub 2017 Feb 24.

12.

Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.

Levine MS, Bakker B, Boeckx B, Moyett J, Lu J, Vitre B, Spierings DC, Lansdorp PM, Cleveland DW, Lambrechts D, Foijer F, Holland AJ.

Dev Cell. 2017 Feb 6;40(3):313-322.e5. doi: 10.1016/j.devcel.2016.12.022. Epub 2017 Jan 26.

13.

CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres.

Fachinetti D, Logsdon GA, Abdullah A, Selzer EB, Cleveland DW, Black BE.

Dev Cell. 2017 Jan 9;40(1):104-113. doi: 10.1016/j.devcel.2016.12.014.

14.

Biological Spectrum of Amyotrophic Lateral Sclerosis Prions.

Polymenidou M, Cleveland DW.

Cold Spring Harb Perspect Med. 2017 Nov 1;7(11). pii: a024133. doi: 10.1101/cshperspect.a024133. Review.

PMID:
28062558
15.

Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72.

Jiang J, Cleveland DW.

Neuron. 2016 Dec 21;92(6):1160-1163. doi: 10.1016/j.neuron.2016.12.008.

16.

Gene therapy: Gene-editing therapy for neurological disease.

McMahon MA, Cleveland DW.

Nat Rev Neurol. 2017 Jan;13(1):7-9. doi: 10.1038/nrneurol.2016.190. Epub 2016 Dec 16. No abstract available.

PMID:
27982043
17.

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining.

Ly P, Teitz LS, Kim DH, Shoshani O, Skaletsky H, Fachinetti D, Page DC, Cleveland DW.

Nat Cell Biol. 2017 Jan;19(1):68-75. doi: 10.1038/ncb3450. Epub 2016 Dec 5.

18.

CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly.

Hoffmann S, Dumont M, Barra V, Ly P, Nechemia-Arbely Y, McMahon MA, Hervé S, Cleveland DW, Fachinetti D.

Cell Rep. 2016 Nov 22;17(9):2394-2404. doi: 10.1016/j.celrep.2016.10.084.

19.

Decoding ALS: from genes to mechanism.

Taylor JP, Brown RH Jr, Cleveland DW.

Nature. 2016 Nov 10;539(7628):197-206. doi: 10.1038/nature20413. Review.

20.

Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis.

Seredenina T, Nayernia Z, Sorce S, Maghzal GJ, Filippova A, Ling SC, Basset O, Plastre O, Daali Y, Rushing EJ, Giordana MT, Cleveland DW, Aguzzi A, Stocker R, Krause KH, Jaquet V.

Free Radic Biol Med. 2016 Aug;97:95-108. doi: 10.1016/j.freeradbiomed.2016.05.016. Epub 2016 May 19.

21.

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs.

Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C.

Neuron. 2016 May 4;90(3):535-50. doi: 10.1016/j.neuron.2016.04.006. Epub 2016 Apr 21.

22.

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.

Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, Perkerson EA, Yue M, Chew J, Castanedes-Casey M, Kurti A, Wang ZS, Liesinger AM, Baker JD, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Rademakers R, Boylan KB, Bu G, Link CD, Dickey CA, Rothstein JD, Dickson DW, Fryer JD, Petrucelli L.

Nat Neurosci. 2016 May;19(5):668-677. doi: 10.1038/nn.4272. Epub 2016 Mar 21.

23.

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

Quaegebeur A, Segura I, Schmieder R, Verdegem D, Decimo I, Bifari F, Dresselaers T, Eelen G, Ghosh D, Davidson SM, Schoors S, Broekaert D, Cruys B, Govaerts K, De Legher C, Bouché A, Schoonjans L, Ramer MS, Hung G, Bossaert G, Cleveland DW, Himmelreich U, Voets T, Lemmens R, Bennett CF, Robberecht W, De Bock K, Dewerchin M, Ghesquière B, Fendt SM, Carmeliet P.

Cell Metab. 2016 Feb 9;23(2):280-91. doi: 10.1016/j.cmet.2015.12.007. Epub 2016 Jan 7.

24.

CELL BIOLOGY. Disrupted nuclear import-export in neurodegeneration.

Da Cruz S, Cleveland DW.

Science. 2016 Jan 8;351(6269):125-6. doi: 10.1126/science.aad9872. No abstract available.

25.

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.

Sun S, Sun Y, Ling SC, Ferraiuolo L, McAlonis-Downes M, Zou Y, Drenner K, Wang Y, Ditsworth D, Tokunaga S, Kopelevich A, Kaspar BK, Lagier-Tourenne C, Cleveland DW.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6993-7002. doi: 10.1073/pnas.1520639112. Epub 2015 Nov 30.

26.

Synthetic CRISPR RNA-Cas9-guided genome editing in human cells.

Rahdar M, McMahon MA, Prakash TP, Swayze EE, Bennett CF, Cleveland DW.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7110-7. doi: 10.1073/pnas.1520883112. Epub 2015 Nov 16.

27.

Chronic centrosome amplification without tumorigenesis.

Vitre B, Holland AJ, Kulukian A, Shoshani O, Hirai M, Wang Y, Maldonado M, Cho T, Boubaker J, Swing DA, Tessarollo L, Evans SM, Fuchs E, Cleveland DW.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6321-30. doi: 10.1073/pnas.1519388112. Epub 2015 Nov 2.

28.

Epidermal development, growth control, and homeostasis in the face of centrosome amplification.

Kulukian A, Holland AJ, Vitre B, Naik S, Cleveland DW, Fuchs E.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6311-20. doi: 10.1073/pnas.1518376112. Epub 2015 Nov 2.

29.

Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72.

van Blitterswijk M, Gendron TF, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Daughrity LM, Murray ME, Heckman MG, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Petrucelli L, Boeve BF, Graff-Radford NR, Boylan KB, Dickson DW, Rademakers R.

Acta Neuropathol. 2015 Dec;130(6):863-76. doi: 10.1007/s00401-015-1480-6. Epub 2015 Oct 5.

30.

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers.

Gendron TF, van Blitterswijk M, Bieniek KF, Daughrity LM, Jiang J, Rush BK, Pedraza O, Lucas JA, Murray ME, Desaro P, Robertson A, Overstreet K, Thomas CS, Crook JE, Castanedes-Casey M, Rousseau L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Graff-Radford NR, Rademakers R, Lagier-Tourenne C, Edbauer D, Cleveland DW, Dickson DW, Petrucelli L, Boylan KB.

Acta Neuropathol. 2015 Oct;130(4):559-73. doi: 10.1007/s00401-015-1474-4. Epub 2015 Sep 8.

31.

MYC Is a Major Determinant of Mitotic Cell Fate.

Topham C, Tighe A, Ly P, Bennett A, Sloss O, Nelson L, Ridgway RA, Huels D, Littler S, Schandl C, Sun Y, Bechi B, Procter DJ, Sansom OJ, Cleveland DW, Taylor SS.

Cancer Cell. 2015 Jul 13;28(1):129-40. doi: 10.1016/j.ccell.2015.06.001.

32.

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.

Mitchell JC, Constable R, So E, Vance C, Scotter E, Glover L, Hortobagyi T, Arnold ES, Ling SC, McAlonis M, Da Cruz S, Polymenidou M, Tessarolo L, Cleveland DW, Shaw CE.

Acta Neuropathol Commun. 2015 Jun 25;3:36. doi: 10.1186/s40478-015-0212-4.

33.

DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function.

Fachinetti D, Han JS, McMahon MA, Ly P, Abdullah A, Wong AJ, Cleveland DW.

Dev Cell. 2015 May 4;33(3):314-27. doi: 10.1016/j.devcel.2015.03.020.

34.

The curious incident of the translational dog that didn't bark.

Bertuzzi S, Cleveland DW.

Trends Cell Biol. 2015 Apr;25(4):187-9. doi: 10.1016/j.tcb.2015.02.003.

35.

Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.

Holland AJ, Reis RM, Niessen S, Pereira C, Andres DA, Spielmann HP, Cleveland DW, Desai A, Gassmann R.

Mol Biol Cell. 2015 May 15;26(10):1845-56. doi: 10.1091/mbc.E14-11-1560. Epub 2015 Mar 25.

36.

Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.

Israelson A, Ditsworth D, Sun S, Song S, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, Maldonado M, Bui A, Navarro M, Zhou H, Marsala M, Kaspar BK, Da Cruz S, Cleveland DW.

Neuron. 2015 Apr 8;86(1):218-32. doi: 10.1016/j.neuron.2015.02.034. Epub 2015 Mar 19.

37.

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.

Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW.

Nat Commun. 2015 Jan 27;6:6171. doi: 10.1038/ncomms7171.

38.

Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.

Han JS, Vitre B, Fachinetti D, Cleveland DW.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4185-93. doi: 10.1073/pnas.1416277111. Epub 2014 Sep 22.

39.

Special Issue on amyotrophic lateral sclerosis.

Traynor BJ, Cleveland DW.

Exp Neurol. 2014 Dec;262 Pt B:73-4. doi: 10.1016/j.expneurol.2014.08.020. Epub 2014 Aug 23. No abstract available.

40.

Polo-like kinase 4 inhibition: a strategy for cancer therapy?

Holland AJ, Cleveland DW.

Cancer Cell. 2014 Aug 11;26(2):151-3. doi: 10.1016/j.ccr.2014.07.017.

41.

The quantitative architecture of centromeric chromatin.

Bodor DL, Mata JF, Sergeev M, David AF, Salimian KJ, Panchenko T, Cleveland DW, Black BE, Shah JV, Jansen LE.

Elife. 2014 Jul 15;3:e02137. doi: 10.7554/eLife.02137.

42.

Kinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E.

Vitre B, Gudimchuk N, Borda R, Kim Y, Heuser JE, Cleveland DW, Grishchuk EL.

Mol Biol Cell. 2014 Aug 1;25(15):2272-81. doi: 10.1091/mbc.E14-01-0698. Epub 2014 Jun 11.

43.

Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism.

Mirzaa GM, Vitre B, Carpenter G, Abramowicz I, Gleeson JG, Paciorkowski AR, Cleveland DW, Dobyns WB, O'Driscoll M.

Hum Genet. 2014 Aug;133(8):1023-39. doi: 10.1007/s00439-014-1443-3. Epub 2014 Apr 20.

44.

Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy.

Cortes CJ, Ling SC, Guo LT, Hung G, Tsunemi T, Ly L, Tokunaga S, Lopez E, Sopher BL, Bennett CF, Shelton GD, Cleveland DW, La Spada AR.

Neuron. 2014 Apr 16;82(2):295-307. doi: 10.1016/j.neuron.2014.03.001.

45.

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice.

Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E1035-42. doi: 10.1073/pnas.1401595111. Epub 2014 Mar 3.

46.

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors.

Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage FH, Cleveland DW, Glass CK.

Nat Neurosci. 2014 Apr;17(4):513-21. doi: 10.1038/nn.3668. Epub 2014 Mar 2.

47.

Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice.

Lobsiger CS, Cleveland DW.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E5. No abstract available.

48.

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS.

Meyer K, Ferraiuolo L, Miranda CJ, Likhite S, McElroy S, Renusch S, Ditsworth D, Lagier-Tourenne C, Smith RA, Ravits J, Burghes AH, Shaw PJ, Cleveland DW, Kolb SJ, Kaspar BK.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):829-32. doi: 10.1073/pnas.1314085111. Epub 2013 Dec 30.

49.

Mitochondrial Isolation and Purification from Mouse Spinal Cord.

Parone PA, Da Cruz S, Cleveland DW.

Bio Protoc. 2013 Nov 5;3(21). pii: e961.

50.

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.

Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland DW, Ravits J.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4530-9. doi: 10.1073/pnas.1318835110. Epub 2013 Oct 29.

Supplemental Content

Loading ...
Support Center