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Breaking Symmetry in Viral Icosahedral Capsids as Seen through the Lenses of X-ray Crystallography and Cryo-Electron Microscopy.

Parent KN, Schrad JR, Cingolani G.

Viruses. 2018 Feb 7;10(2). pii: E67. doi: 10.3390/v10020067. Review.


Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1.

Sankhala RS, Lokareddy RK, Begum S, Pumroy RA, Gillilan RE, Cingolani G.

Nat Commun. 2017 Oct 17;8(1):979. doi: 10.1038/s41467-017-01057-7.


Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms.

Wu W, Sankhala RS, Florio TJ, Zhou L, Nguyen NLT, Lokareddy RK, Cingolani G, Panté N.

Sci Rep. 2017 Sep 12;7(1):11381. doi: 10.1038/s41598-017-11018-1.


A viral scaffolding protein triggers portal ring oligomerization and incorporation during procapsid assembly.

Motwani T, Lokareddy RK, Dunbar CA, Cortines JR, Jarrold MF, Cingolani G, Teschke CM.

Sci Adv. 2017 Jul 26;3(7):e1700423. doi: 10.1126/sciadv.1700423. eCollection 2017 Jul.


Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).

Cingolani G, Panella A, Perrone MG, Vitale P, Di Mauro G, Fortuna CG, Armen RS, Ferorelli S, Smith WL, Scilimati A.

Eur J Med Chem. 2017 Sep 29;138:661-668. doi: 10.1016/j.ejmech.2017.06.045. Epub 2017 Jun 24.


Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation.

Lokareddy RK, Sankhala RS, Roy A, Afonine PV, Motwani T, Teschke CM, Parent KN, Cingolani G.

Nat Commun. 2017 Jan 30;8:14310. doi: 10.1038/ncomms14310.


Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.

Rogers C, Fernandes-Alnemri T, Mayes L, Alnemri D, Cingolani G, Alnemri ES.

Nat Commun. 2017 Jan 3;8:14128. doi: 10.1038/ncomms14128.


Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits.

Sankhala RS, Lokareddy RK, Cingolani G.

J Biol Chem. 2016 May 20;291(21):11420-33. doi: 10.1074/jbc.M116.724393. Epub 2016 Mar 31.


PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage.

Riccio AA, Cingolani G, Pascal JM.

Nucleic Acids Res. 2016 Feb 29;44(4):1691-702. doi: 10.1093/nar/gkv1376. Epub 2015 Dec 23.


Structural Plasticity of the Protein Plug That Traps Newly Packaged Genomes in Podoviridae Virions.

Bhardwaj A, Sankhala RS, Olia AS, Brooke D, Casjens SR, Taylor DJ, Prevelige PE Jr, Cingolani G.

J Biol Chem. 2016 Jan 1;291(1):215-26. doi: 10.1074/jbc.M115.696260. Epub 2015 Nov 16.


A Greasy Aid to Capsid Assembly: Lessons from a Salty Virus.

Sankhala RS, Lokareddy RK, Cingolani G.

Structure. 2015 Oct 6;23(10):1777-9. doi: 10.1016/j.str.2015.09.002.


Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22.

McNulty R, Lokareddy RK, Roy A, Yang Y, Lander G, Heck AJ, Johnson JE, Cingolani G.

J Mol Biol. 2015 Oct 9;427(20):3285-3299. doi: 10.1016/j.jmb.2015.08.013. Epub 2015 Aug 21.


The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD.

Sun J, Siroy A, Lokareddy RK, Speer A, Doornbos KS, Cingolani G, Niederweis M.

Nat Struct Mol Biol. 2015 Sep;22(9):672-8. doi: 10.1038/nsmb.3064. Epub 2015 Aug 3.


Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins.

Kralt A, Jagalur NB, van den Boom V, Lokareddy RK, Steen A, Cingolani G, Fornerod M, Veenhoff LM.

Mol Biol Cell. 2015 Sep 15;26(18):3301-12. doi: 10.1091/mbc.E15-03-0184. Epub 2015 Jul 15.


IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation.

Hwang B, McCool K, Wan J, Wuerzberger-Davis SM, Young EW, Choi EY, Cingolani G, Weaver BA, Miyamoto S.

J Biol Chem. 2015 Jul 17;290(29):17967-84. doi: 10.1074/jbc.M115.645960. Epub 2015 Jun 9.


Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.

Lokareddy RK, Hapsari RA, van Rheenen M, Pumroy RA, Bhardwaj A, Steen A, Veenhoff LM, Cingolani G.

Structure. 2015 Jul 7;23(7):1305-1316. doi: 10.1016/j.str.2015.04.017. Epub 2015 Jun 4.


Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia.

Liao Z, Gu L, Vergalli J, Mariani SA, De Dominici M, Lokareddy RK, Dagvadorj A, Purushottamachar P, McCue PA, Trabulsi E, Lallas CD, Gupta S, Ellsworth E, Blackmon S, Ertel A, Fortina P, Leiby B, Xia G, Rui H, Hoang DT, Gomella LG, Cingolani G, Njar V, Pattabiraman N, Calabretta B, Nevalainen MT.

Mol Cancer Ther. 2015 Aug;14(8):1777-93. doi: 10.1158/1535-7163.MCT-14-0883. Epub 2015 May 29.


Diversification of importin-α isoforms in cellular trafficking and disease states.

Pumroy RA, Cingolani G.

Biochem J. 2015 Feb 15;466(1):13-28. doi: 10.1042/BJ20141186. Review.


Molecular determinants for nuclear import of influenza A PB2 by importin α isoforms 3 and 7.

Pumroy RA, Ke S, Hart DJ, Zachariae U, Cingolani G.

Structure. 2015 Feb 3;23(2):374-84. doi: 10.1016/j.str.2014.11.015. Epub 2015 Jan 15.


Dimeric quaternary structure of human laforin.

Sankhala RS, Koksal AC, Ho L, Nitschke F, Minassian BA, Cingolani G.

J Biol Chem. 2015 Feb 20;290(8):4552-9. doi: 10.1074/jbc.M114.627406. Epub 2014 Dec 23.


Coordination of the filament stabilizing versus destabilizing activities of cofilin through its secondary binding site on actin.

Aggeli D, Kish-Trier E, Lin MC, Haarer B, Cingolani G, Cooper JA, Wilkens S, Amberg DC.

Cytoskeleton (Hoboken). 2014 Jun;71(6):361-79. doi: 10.1002/cm.21178. Epub 2014 Jun 23.


Architecture of viral genome-delivery molecular machines.

Bhardwaj A, Olia AS, Cingolani G.

Curr Opin Struct Biol. 2014 Apr;25:1-8. doi: 10.1016/ Epub 2013 Nov 15. Review.


The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain.

Lieu KG, Shim EH, Wang J, Lokareddy RK, Tao T, Cingolani G, Zambetti GP, Jans DA.

J Cell Biol. 2014 May 12;205(3):301-12. doi: 10.1083/jcb.201304055.


Exploring the atomic structure and conformational flexibility of a 320 Å long engineered viral fiber using X-ray crystallography.

Bhardwaj A, Casjens SR, Cingolani G.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):342-53. doi: 10.1107/S1399004713027685. Epub 2014 Jan 29.


Structure of human PIR1, an atypical dual-specificity phosphatase.

Sankhala RS, Lokareddy RK, Cingolani G.

Biochemistry. 2014 Feb 11;53(5):862-71. doi: 10.1021/bi401240x. Epub 2014 Jan 31.


Endogenous endothelin 1 mediates angiotensin II-induced hypertrophy in electrically paced cardiac myocytes through EGFR transactivation, reactive oxygen species and NHE-1.

Correa MV, Nolly MB, Caldiz CI, de Cingolani GE, Cingolani HE, Ennis IL.

Pflugers Arch. 2014 Sep;466(9):1819-30. doi: 10.1007/s00424-013-1413-y. Epub 2013 Dec 11.


Jamming up the "β-staple": regulation of SIRT1 activity by its C-terminal regulatory segment (CTR).

Pumroy RA, Cingolani G.

J Mol Biol. 2014 Feb 6;426(3):507-9. doi: 10.1016/j.jmb.2013.11.013. Epub 2013 Nov 19. No abstract available.


Structural basis of allosteric interactions among Ca2+-binding sites in a K+ channel RCK domain.

Smith FJ, Pau VP, Cingolani G, Rothberg BS.

Nat Commun. 2013;4:2621. doi: 10.1038/ncomms3621.


The tip of the tail needle affects the rate of DNA delivery by bacteriophage P22.

Leavitt JC, Gogokhia L, Gilcrease EB, Bhardwaj A, Cingolani G, Casjens SR.

PLoS One. 2013 Aug 12;8(8):e70936. doi: 10.1371/journal.pone.0070936. eCollection 2013.


Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase.

Lokareddy RK, Bhardwaj A, Cingolani G.

Biochemistry. 2013 Feb 5;52(5):938-48. doi: 10.1021/bi301476m. Epub 2013 Jan 18.


Crystal structure of a Ba(2+)-bound gating ring reveals elementary steps in RCK domain activation.

Smith FJ, Pau VP, Cingolani G, Rothberg BS.

Structure. 2012 Dec 5;20(12):2038-47. doi: 10.1016/j.str.2012.09.014. Epub 2012 Oct 18.


Improved crystallization of Escherichia coli ATP synthase catalytic complex (F1) by introducing a phosphomimetic mutation in subunit ε.

Roy A, Hutcheon ML, Duncan TM, Cingolani G.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1229-33. doi: 10.1107/S1744309112036718. Epub 2012 Sep 28.


Small terminase couples viral DNA binding to genome-packaging ATPase activity.

Roy A, Bhardwaj A, Datta P, Lander GC, Cingolani G.

Structure. 2012 Aug 8;20(8):1403-13. doi: 10.1016/j.str.2012.05.014. Epub 2012 Jul 5.


Structure of p22 headful packaging nuclease.

Roy A, Cingolani G.

J Biol Chem. 2012 Aug 10;287(33):28196-205. doi: 10.1074/jbc.M112.349894. Epub 2012 Jun 19.


Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin α5.

Pumroy RA, Nardozzi JD, Hart DJ, Root MJ, Cingolani G.

J Biol Chem. 2012 Jan 13;287(3):2022-31. doi: 10.1074/jbc.M111.315838. Epub 2011 Nov 30.


Atomic structure of bacteriophage Sf6 tail needle knob.

Bhardwaj A, Molineux IJ, Casjens SR, Cingolani G.

J Biol Chem. 2011 Sep 2;286(35):30867-77. doi: 10.1074/jbc.M111.260877. Epub 2011 Jun 25.


A minimal nuclear localization signal (NLS) in human phospholipid scramblase 4 that binds only the minor NLS-binding site of importin alpha1.

Lott K, Bhardwaj A, Sims PJ, Cingolani G.

J Biol Chem. 2011 Aug 12;286(32):28160-9. doi: 10.1074/jbc.M111.228007. Epub 2011 Jun 20.


Structure of the ATP synthase catalytic complex (F(1)) from Escherichia coli in an autoinhibited conformation.

Cingolani G, Duncan TM.

Nat Struct Mol Biol. 2011 Jun;18(6):701-7. doi: 10.1038/nsmb.2058. Epub 2011 May 22.


Antibodies against the cardiac sodium/bicarbonate co-transporter (NBCe1) as pharmacological tools.

De Giusti VC, Orlowski A, Villa-Abrille MC, de Cingolani GE, Casey JR, Alvarez BV, Aiello EA.

Br J Pharmacol. 2011 Dec;164(8):1976-89. doi: 10.1111/j.1476-5381.2011.01496.x.


Three-dimensional structure of a viral genome-delivery portal vertex.

Olia AS, Prevelige PE Jr, Johnson JE, Cingolani G.

Nat Struct Mol Biol. 2011 May;18(5):597-603. doi: 10.1038/nsmb.2023. Epub 2011 Apr 17.


Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22.

Tang J, Lander GC, Olia AS, Li R, Casjens S, Prevelige P Jr, Cingolani G, Baker TS, Johnson JE.

Structure. 2011 Apr 13;19(4):496-502. doi: 10.1016/j.str.2011.02.010. Erratum in: Structure. 2011 May 11;19(5):748. Olia, Adam [corrected to Olia, Adam S].


Dimerization of Vaccinia virus VH1 is essential for dephosphorylation of STAT1 at tyrosine 701.

Koksal AC, Cingolani G.

J Biol Chem. 2011 Apr 22;286(16):14373-82. doi: 10.1074/jbc.M111.226357. Epub 2011 Mar 1.


Crystallization of the nonameric small terminase subunit of bacteriophage P22.

Roy A, Bhardwaj A, Cingolani G.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1;67(Pt 1):104-10. doi: 10.1107/S174430911004697X. Epub 2010 Dec 23.


Phosphorylation meets nuclear import: a review.

Nardozzi JD, Lott K, Cingolani G.

Cell Commun Signal. 2010 Dec 23;8:32. doi: 10.1186/1478-811X-8-32.


The importin β binding domain as a master regulator of nucleocytoplasmic transport.

Lott K, Cingolani G.

Biochim Biophys Acta. 2011 Sep;1813(9):1578-92. doi: 10.1016/j.bbamcr.2010.10.012. Epub 2010 Oct 26. Review.


Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5.

Nardozzi J, Wenta N, Yasuhara N, Vinkemeier U, Cingolani G.

J Mol Biol. 2010 Sep 10;402(1):83-100. doi: 10.1016/j.jmb.2010.07.013. Epub 2010 Jul 17.


Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta.

Bhardwaj A, Cingolani G.

Biochemistry. 2010 Jun 22;49(24):5042-7. doi: 10.1021/bi100292y.


The importin beta binding domain modulates the avidity of importin beta for the nuclear pore complex.

Lott K, Bhardwaj A, Mitrousis G, Pante N, Cingolani G.

J Biol Chem. 2010 Apr 30;285(18):13769-80. doi: 10.1074/jbc.M109.095760. Epub 2010 Mar 1.


An evolutionarily conserved family of virion tail needles related to bacteriophage P22 gp26: correlation between structural stability and length of the alpha-helical trimeric coiled coil.

Bhardwaj A, Walker-Kopp N, Casjens SR, Cingolani G.

J Mol Biol. 2009 Aug 7;391(1):227-45. doi: 10.1016/j.jmb.2009.05.069. Epub 2009 May 29.


Structural and thermodynamic analysis of a conformationally strained circular permutant of barnase.

Butler JS, Mitrea DM, Mitrousis G, Cingolani G, Loh SN.

Biochemistry. 2009 Apr 21;48(15):3497-507. doi: 10.1021/bi900039e.

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