Sort by
Items per page

Send to

Choose Destination

Search results

Items: 45


An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target.

Mahil SK, Catapano M, Di Meglio P, Dand N, Ahlfors H, Carr IM, Smith CH, Trembath RC, Peakman M, Wright J, Ciccarelli FD, Barker JN, Capon F.

Sci Transl Med. 2017 Oct 11;9(411). pii: eaan2514. doi: 10.1126/scitranslmed.aan2514. Erratum in: Sci Transl Med. 2017 Dec 13;9(420):.


Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1.

Benedetti L, Cereda M, Monteverde L, Desai N, Ciccarelli FD.

Oncotarget. 2017 Jun 6;8(23):37619-37632. doi: 10.18632/oncotarget.16838.


MEGA-V: detection of variant gene sets in patient cohorts.

Gambardella G, Cereda M, Benedetti L, Ciccarelli FD.

Bioinformatics. 2017 Apr 15;33(8):1248-1249. doi: 10.1093/bioinformatics/btw809.


Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes.

Cereda M, Gambardella G, Benedetti L, Iannelli F, Patel D, Basso G, Guerra RF, Mourikis TP, Puccio I, Sinha S, Laghi L, Spencer J, Rodriguez-Justo M, Ciccarelli FD.

Nat Commun. 2016 Jul 5;7:12072. doi: 10.1038/ncomms12072.


Genetic Redundancy, Functional Compensation, and Cancer Vulnerability.

Cereda M, Mourikis TP, Ciccarelli FD.

Trends Cancer. 2016 Apr;2(4):160-162. doi: 10.1016/j.trecan.2016.03.003. Epub 2016 Mar 28.


NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings.

An O, Dall'Olio GM, Mourikis TP, Ciccarelli FD.

Nucleic Acids Res. 2016 Jan 4;44(D1):D992-9. doi: 10.1093/nar/gkv1123. Epub 2015 Oct 29.


Corrigendum: Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency.

Iannelli F, Collino A, Sinha S, Radaelli E, Nicoli P, D'Antiga L, Sonzogni A, Faivre J, Buendia MA, Sturm E, Thompson RJ, Knisely AS, Natoli G, Ghisletti S, Ciccarelli FD.

Nat Commun. 2015 Jul 2;6:7456. doi: 10.1038/ncomms8456. No abstract available.


Deep sequencing of the X chromosome reveals the proliferation history of colorectal adenomas.

De Grassi A, Iannelli F, Cereda M, Volorio S, Melocchi V, Viel A, Basso G, Laghi L, Caselle M, Ciccarelli FD.

Genome Biol. 2014 Aug 30;15(8):437. doi: 10.1186/s13059-014-0437-8.


Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency.

Iannelli F, Collino A, Sinha S, Radaelli E, Nicoli P, D'Antiga L, Sonzogni A, Faivre J, Buendia MA, Sturm E, Thompson RJ, Knisely AS, Natoli G, Ghisletti S, Ciccarelli FD.

Nat Commun. 2014 May 13;5:3850. doi: 10.1038/ncomms4850. Erratum in: Nat Commun. 2015;6:7456.


NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes.

An O, Pendino V, D'Antonio M, Ratti E, Gentilini M, Ciccarelli FD.

Database (Oxford). 2014 Mar 7;2014:bau015. doi: 10.1093/database/bau015. Print 2014.


Recessive cancer genes engage in negative genetic interactions with their functional paralogs.

D'Antonio M, Guerra RF, Cereda M, Marchesi S, Montani F, Nicassio F, Di Fiore PP, Ciccarelli FD.

Cell Rep. 2013 Dec 26;5(6):1519-26. doi: 10.1016/j.celrep.2013.11.033. Epub 2013 Dec 19.


Integrated analysis of recurrent properties of cancer genes to identify novel drivers.

D'Antonio M, Ciccarelli FD.

Genome Biol. 2013 May 29;14(5):R52. doi: 10.1186/gb-2013-14-5-r52.


Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma.

Shukla R, Upton KR, Muñoz-Lopez M, Gerhardt DJ, Fisher ME, Nguyen T, Brennan PM, Baillie JK, Collino A, Ghisletti S, Sinha S, Iannelli F, Radaelli E, Dos Santos A, Rapoud D, Guettier C, Samuel D, Natoli G, Carninci P, Ciccarelli FD, Garcia-Perez JL, Faivre J, Faulkner GJ.

Cell. 2013 Mar 28;153(1):101-11. doi: 10.1016/j.cell.2013.02.032.


Network of Cancer Genes (NCG 3.0): integration and analysis of genetic and network properties of cancer genes.

D'Antonio M, Pendino V, Sinha S, Ciccarelli FD.

Nucleic Acids Res. 2012 Jan;40(Database issue):D978-83. doi: 10.1093/nar/gkr952. Epub 2011 Nov 12.


Modification of gene duplicability during the evolution of protein interaction network.

D'Antonio M, Ciccarelli FD.

PLoS Comput Biol. 2011 Apr;7(4):e1002029. doi: 10.1371/journal.pcbi.1002029. Epub 2011 Apr 7.


Preface. The seventh RECOMB-CG Workshop, September 27–29, 2009, Alfréd Rényi Institute of Mathematics, Budapest, Hungary.

Miklos I, Ciccarelli FD.

J Comput Biol. 2010 Sep;17(9):1095-6. doi: 10.1089/cmb.2010.004p. No abstract available.


The (r)evolution of cancer genetics.

Ciccarelli FD.

BMC Biol. 2010 Jun 11;8:74. doi: 10.1186/1741-7007-8-74.


Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.

Civril F, Wehenkel A, Giorgi FM, Santaguida S, Di Fonzo A, Grigorean G, Ciccarelli FD, Musacchio A.

Structure. 2010 May 12;18(5):616-26. doi: 10.1016/j.str.2010.02.014.


Ultradeep sequencing of a human ultraconserved region reveals somatic and constitutional genomic instability.

De Grassi A, Segala C, Iannelli F, Volorio S, Bertario L, Radice P, Bernard L, Ciccarelli FD.

PLoS Biol. 2010 Jan;8(1):e1000275. doi: 10.1371/journal.pbio.1000275. Epub 2010 Jan 5.


Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation.

Anelli V, Santoriello C, Distel M, Köster RW, Ciccarelli FD, Mione M.

Zebrafish. 2009 Dec;6(4):417-24. doi: 10.1089/zeb.2009.0612.


Tandem repeats modify the structure of human genes hosted in segmental duplications.

De Grassi A, Ciccarelli FD.

Genome Biol. 2009;10(12):R137. doi: 10.1186/gb-2009-10-12-r137. Epub 2009 Dec 2.


Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes.

Syed AS, D'Antonio M, Ciccarelli FD.

Nucleic Acids Res. 2010 Jan;38(Database issue):D670-5. doi: 10.1093/nar/gkp957. Epub 2009 Nov 11.


FancyGene: dynamic visualization of gene structures and protein domain architectures on genomic loci.

Rambaldi D, Ciccarelli FD.

Bioinformatics. 2009 Sep 1;25(17):2281-2. doi: 10.1093/bioinformatics/btp381. Epub 2009 Jun 19.


Low duplicability and network fragility of cancer genes.

Rambaldi D, Giorgi FM, Capuani F, Ciliberto A, Ciccarelli FD.

Trends Genet. 2008 Sep;24(9):427-30. doi: 10.1016/j.tig.2008.06.003. Epub 2008 Jul 31. Review.


Non-random retention of protein-coding overlapping genes in Metazoa.

Soldà G, Suyama M, Pelucchi P, Boi S, Guffanti A, Rizzi E, Bork P, Tenchini ML, Ciccarelli FD.

BMC Genomics. 2008 Apr 16;9:174. doi: 10.1186/1471-2164-9-174.


Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates.

Fumasoni I, Meani N, Rambaldi D, Scafetta G, Alcalay M, Ciccarelli FD.

BMC Evol Biol. 2007 Oct 4;7:187.


Toward automatic reconstruction of a highly resolved tree of life.

Ciccarelli FD, Doerks T, von Mering C, Creevey CJ, Snel B, Bork P.

Science. 2006 Mar 3;311(5765):1283-7. Erratum in: Science. 2006 May 5;312(5774):697.


Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases.

Mees A, Rock R, Ciccarelli FD, Leberfinger CB, Borawski JM, Bork P, Wiese S, Gessler M, Kerkhoff E.

Gene Expr Patterns. 2005 Dec;6(1):79-85. Epub 2005 Aug 15.


Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK.

Nature. 2005 Apr 7;434(7034):724-31.


Complex genomic rearrangements lead to novel primate gene function.

Ciccarelli FD, von Mering C, Suyama M, Harrington ED, Izaurralde E, Bork P.

Genome Res. 2005 Mar;15(3):343-51. Epub 2005 Feb 14.


The WHy domain mediates the response to desiccation in plants and bacteria.

Ciccarelli FD, Bork P.

Bioinformatics. 2005 Apr 15;21(8):1304-7. Epub 2004 Dec 14.


A protocol for the update of references to scientific literature in biological databases.

Perez-Iratxeta C, Astola N, Ciccarelli FD, Sha PK, Bork P, Andrade MA.

Appl Bioinformatics. 2003;2(3):189-91.


RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export.

Forler D, Rabut G, Ciccarelli FD, Herold A, Köcher T, Niggeweg R, Bork P, Ellenberg J, Izaurralde E.

Mol Cell Biol. 2004 Feb;24(3):1155-67.


The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold.

Ciccarelli FD, Izaurralde E, Bork P.

BMC Bioinformatics. 2003 Dec 19;4:64.


SMART 4.0: towards genomic data integration.

Letunic I, Copley RR, Schmidt S, Ciccarelli FD, Doerks T, Schultz J, Ponting CP, Bork P.

Nucleic Acids Res. 2004 Jan 1;32(Database issue):D142-4.


Genome evolution reveals biochemical networks and functional modules.

von Mering C, Zdobnov EM, Tsoka S, Ciccarelli FD, Pereira-Leal JB, Ouzounis CA, Bork P.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15428-33. Epub 2003 Dec 12.


Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways.

Gatfield D, Unterholzner L, Ciccarelli FD, Bork P, Izaurralde E.

EMBO J. 2003 Aug 1;22(15):3960-70.


The KIND module: a putative signalling domain evolved from the C lobe of the protein kinase fold.

Ciccarelli FD, Bork P, Kerkhoff E.

Trends Biochem Sci. 2003 Jul;28(7):349-52. No abstract available.


The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia.

Ciccarelli FD, Proukakis C, Patel H, Cross H, Azam S, Patton MA, Bork P, Crosby AH.

Genomics. 2003 Apr;81(4):437-41.


NEAT: a domain duplicated in genes near the components of a putative Fe3+ siderophore transporter from Gram-positive pathogenic bacteria.

Andrade MA, Ciccarelli FD, Perez-Iratxeta C, Bork P.

Genome Biol. 2002 Aug 15;3(9):RESEARCH0047. Epub 2002 Aug 15.


SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia.

Patel H, Cross H, Proukakis C, Hershberger R, Bork P, Ciccarelli FD, Patton MA, McKusick VA, Crosby AH.

Nat Genet. 2002 Aug;31(4):347-8. Epub 2002 Jul 22.


A complex prediction: three-dimensional model of the yeast exosome.

Aloy P, Ciccarelli FD, Leutwein C, Gavin AC, Superti-Furga G, Bork P, Bottcher B, Russell RB.

EMBO Rep. 2002 Jul;3(7):628-35.


AMOP, a protein module alternatively spliced in cancer cells.

Ciccarelli FD, Doerks T, Bork P.

Trends Biochem Sci. 2002 Mar;27(3):113-5.


CASH--a beta-helix domain widespread among carbohydrate-binding proteins.

Ciccarelli FD, Copley RR, Doerks T, Russell RB, Bork P.

Trends Biochem Sci. 2002 Feb;27(2):59-62.


Large and diverse numbers of human diseases with HIKE mutations.

Ciccarelli FD, Acciarito A, Alberti S.

Hum Mol Genet. 2000 Apr 12;9(6):1001-7. Review.


Supplemental Content

Loading ...
Support Center