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Items: 1 to 50 of 103


Cell mass-dependent expression of an anticancer protein drug by tumor-targeted Salmonella.

Kim K, Min SY, Lim HD, You SH, Lim D, Jeong JH, Kim HJ, Rhee JH, Park K, Shin M, Kim GJ, Min JJ, Choy HE.

Oncotarget. 2018 Jan 5;9(9):8548-8559. doi: 10.18632/oncotarget.24013. eCollection 2018 Feb 2.


Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model.

Lee SH, Nam TS, Kim KH, Kim JH, Yoon W, Heo SH, Kim MJ, Shin BA, Perng MD, Choy HE, Jo J, Kim MK, Choi SY.

BMC Neurol. 2017 Sep 7;17(1):175. doi: 10.1186/s12883-017-0938-7.


Functional validation of novel MKS3/TMEM67 mutations in COACH syndrome.

Lee SH, Nam TS, Li W, Kim JH, Yoon W, Choi YD, Kim KH, Cai H, Kim MJ, Kim C, Choy HE, Kim N, Chay KO, Kim MK, Choi SY.

Sci Rep. 2017 Aug 31;7(1):10222. doi: 10.1038/s41598-017-10652-z.


Anti-tumor activity of an immunotoxin (TGFα-PE38) delivered by attenuated Salmonella typhimurium.

Lim D, Kim KS, Kim H, Ko KC, Song JJ, Choi JH, Shin M, Min JJ, Jeong JH, Choy HE.

Oncotarget. 2017 Jun 6;8(23):37550-37560. doi: 10.18632/oncotarget.17197.


Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin.

Zheng JH, Nguyen VH, Jiang SN, Park SH, Tan W, Hong SH, Shin MG, Chung IJ, Hong Y, Bom HS, Choy HE, Lee SE, Rhee JH, Min JJ.

Sci Transl Med. 2017 Feb 8;9(376). pii: eaak9537. doi: 10.1126/scitranslmed.aak9537.


Microvasculature remodeling in the mouse lower gut during inflammaging.

Jeong JH, Kim K, Lim D, Kim KH, Kim HS, Lee S, Song JH, Moon BG, Choy HE, Park SC.

Sci Rep. 2017 Jan 3;7:39848. doi: 10.1038/srep39848.


Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression.

Kim DK, Kim YH, Jung YS, Kim KS, Jeong JH, Lee YS, Yuk JM, Oh BC, Choy HE, Dooley S, Muckenthaler MU, Lee CH, Choi HS.

Sci Rep. 2016 Sep 30;6:34630. doi: 10.1038/srep34630.


Amino acid residues in the Ler protein critical for derepression of the LEE5 promoter in enteropathogenic E. coli.

Choi SM, Jeong JH, Choy HE, Shin M.

J Microbiol. 2016 Aug;54(8):559-64. doi: 10.1007/s12275-016-6027-6. Epub 2016 Aug 2.


RGD Peptide Cell-Surface Display Enhances the Targeting and Therapeutic Efficacy of Attenuated Salmonella-mediated Cancer Therapy.

Park SH, Zheng JH, Nguyen VH, Jiang SN, Kim DY, Szardenings M, Min JH, Hong Y, Choy HE, Min JJ.

Theranostics. 2016 Jun 20;6(10):1672-82. doi: 10.7150/thno.16135. eCollection 2016.


LAMP-3 (Lysosome-Associated Membrane Protein 3) Promotes the Intracellular Proliferation of Salmonella typhimurium.

Lee EJ, Park KS, Jeon IS, Choi JW, Lee SJ, Choy HE, Song KD, Lee HK, Choi JK.

Mol Cells. 2016 Jul;39(7):566-72. doi: 10.14348/molcells.2016.0112. Epub 2016 Jun 21.


Salmonella typhimurium Suppresses Tumor Growth via the Pro-Inflammatory Cytokine Interleukin-1β.

Kim JE, Phan TX, Nguyen VH, Dinh-Vu HV, Zheng JH, Yun M, Park SG, Hong Y, Choy HE, Szardenings M, Hwang W, Park JA, Park S, Im SH, Min JJ.

Theranostics. 2015 Oct 6;5(12):1328-42. doi: 10.7150/thno.11432. eCollection 2015.


Activation of inflammasome by attenuated Salmonella typhimurium in bacteria-mediated cancer therapy.

Phan TX, Nguyen VH, Duong MT, Hong Y, Choy HE, Min JJ.

Microbiol Immunol. 2015 Nov;59(11):664-75. doi: 10.1111/1348-0421.12333.


Branched-chain amino acid supplementation promotes aerobic growth of Salmonella Typhimurium under nitrosative stress conditions.

Park YM, Lee HJ, Jeong JH, Kook JK, Choy HE, Hahn TW, Bang IS.

Arch Microbiol. 2015 Dec;197(10):1117-27. doi: 10.1007/s00203-015-1151-y. Epub 2015 Sep 15.


Isolation and Characterization of a Monobody with a Fibronectin Domain III Scaffold That Specifically Binds EphA2.

Park SH, Park S, Kim DY, Pyo A, Kimura RH, Sathirachinda A, Choy HE, Min JJ, Gambhir SS, Hong Y.

PLoS One. 2015 Jul 15;10(7):e0132976. doi: 10.1371/journal.pone.0132976. eCollection 2015.


Effect of promoter-upstream sequence on σ38-dependent stationary phase gene transcription.

Lim HJ, Kim K, Shin M, Jeong JH, Ryu PY, Choy HE.

J Microbiol. 2015 Apr;53(4):250-5. doi: 10.1007/s12275-015-4681-8. Epub 2015 Apr 8.


L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors.

Kim K, Jeong JH, Lim D, Hong Y, Lim HJ, Kim GJ, Shin SR, Lee JJ, Yun M, Harris RA, Min JJ, Choy HE.

Mol Ther Oncolytics. 2015 Jun 10;2:15007. doi: 10.1038/mto.2015.7. eCollection 2015.


Targeted deletion of the ara operon of Salmonella typhimurium enhances L-arabinose accumulation and drives PBAD-promoted expression of anti-cancer toxins and imaging agents.

Hong H, Lim D, Kim GJ, Park SH, Sik Kim H, Hong Y, Choy HE, Min JJ.

Cell Cycle. 2014;13(19):3112-20. doi: 10.4161/15384101.2014.949527.


Generation of Minicells from an Endotoxin-Free Gram-Positive Strain Corynebacterium glutamicum.

Lee JY, Choy HE, Lee JH, Kim GJ.

J Microbiol Biotechnol. 2015 Apr;25(4):554-8.


In vivo efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus sepsis.

Jang HC, Choi SM, Kim HK, Kim SE, Kang SJ, Park KH, Ryu PY, Lee TH, Kim YR, Rhee JH, Jung SI, Choy HE.

PLoS One. 2014 Jun 30;9(6):e101118. doi: 10.1371/journal.pone.0101118. eCollection 2014.


DNA looping-dependent autorepression of LEE1 P1 promoters by Ler in enteropathogenic Escherichia coli (EPEC).

Bhat A, Shin M, Jeong JH, Kim HJ, Lim HJ, Rhee JH, Paik SY, Takeyasu K, Tobe T, Yen H, Lee G, Choy HE.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2586-95. doi: 10.1073/pnas.1322033111. Epub 2014 Jun 11.


Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis.

Kim DK, Jeong JH, Lee JM, Kim KS, Park SH, Kim YD, Koh M, Shin M, Jung YS, Kim HS, Lee TH, Oh BC, Kim JI, Park HT, Jeong WI, Lee CH, Park SB, Min JJ, Jung SI, Choi SY, Choy HE, Choi HS.

Nat Med. 2014 Apr;20(4):419-24. doi: 10.1038/nm.3483. Epub 2014 Mar 23.


Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization.

Lim JS, Shin M, Kim HJ, Kim KS, Choy HE, Cho KA.

J Infect Dis. 2014 Sep 1;210(5):793-802. doi: 10.1093/infdis/jiu152. Epub 2014 Mar 12.


Identification of high-specificity H-NS binding site in LEE5 promoter of enteropathogenic Esherichia coli (EPEC).

Bhat AP, Shin M, Choy HE.

J Microbiol. 2014 Jul;52(7):626-9. doi: 10.1007/s12275-014-3562-x. Epub 2014 Mar 7.


hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7.

Cho S, Moon H, Loh TJ, Oh HK, Cho S, Choy HE, Song WK, Chun JS, Zheng X, Shen H.

Biochim Biophys Acta. 2014;1839(4):306-15. doi: 10.1016/j.bbagrm.2014.02.006. Epub 2014 Feb 15.


Rhodobacter sphaeroides, a novel tumor-targeting bacteria that emits natural near-infrared fluorescence.

Kwon SY, Jiang SN, Zheng JH, Choy HE, Min JJ.

Microbiol Immunol. 2014 Mar;58(3):172-9. doi: 10.1111/1348-0421.12134.


Anti-tumoral effect of the mitochondrial target domain of Noxa delivered by an engineered Salmonella typhimurium.

Jeong JH, Kim K, Lim D, Jeong K, Hong Y, Nguyen VH, Kim TH, Ryu S, Lim JA, Kim JI, Kim GJ, Kim SC, Min JJ, Choy HE.

PLoS One. 2014 Jan 8;9(1):e80050. doi: 10.1371/journal.pone.0080050. eCollection 2014.


Bioengineered bacterial outer membrane vesicles as cell-specific drug-delivery vehicles for cancer therapy.

Gujrati V, Kim S, Kim SH, Min JJ, Choy HE, Kim SC, Jon S.

ACS Nano. 2014 Feb 25;8(2):1525-37. doi: 10.1021/nn405724x. Epub 2014 Jan 15.


New paradigm for tumor theranostic methodology using bacteria-based microrobot.

Park SJ, Park SH, Cho S, Kim DM, Lee Y, Ko SY, Hong Y, Choy HE, Min JJ, Park JO, Park S.

Sci Rep. 2013 Dec 2;3:3394. doi: 10.1038/srep03394.


Engineering of bacteria for the visualization of targeted delivery of a cytolytic anticancer agent.

Jiang SN, Park SH, Lee HJ, Zheng JH, Kim HS, Bom HS, Hong Y, Szardenings M, Shin MG, Kim SC, Ntziachristos V, Choy HE, Min JJ.

Mol Ther. 2013 Nov;21(11):1985-95. doi: 10.1038/mt.2013.183. Epub 2013 Aug 7.


Peroxiredoxin V selectively regulates IL-6 production by modulating the Jak2-Stat5 pathway.

Choi HI, Chung KJ, Yang HY, Ren L, Sohn S, Kim PR, Kook MS, Choy HE, Lee TH.

Free Radic Biol Med. 2013 Dec;65:270-9. doi: 10.1016/j.freeradbiomed.2013.06.038. Epub 2013 Jul 3.


Inappropriateness of quinolone in scrub typhus treatment due to gyrA mutation in Orientia tsutsugamushi Boryong strain.

Jang HC, Choi SM, Jang MO, Ahn JH, Kim UJ, Kang SJ, Shin JH, Choy HE, Jung SI, Park KH.

J Korean Med Sci. 2013 May;28(5):667-71. doi: 10.3346/jkms.2013.28.5.667. Epub 2013 May 2.


Cyp1a reporter zebrafish reveals target tissues for dioxin.

Kim KH, Park HJ, Kim JH, Kim S, Williams DR, Kim MK, Jung YD, Teraoka H, Park HC, Choy HE, Shin BA, Choi SY.

Aquat Toxicol. 2013 Jun 15;134-135:57-65. doi: 10.1016/j.aquatox.2013.03.010. Epub 2013 Mar 21.


A novel balanced-lethal host-vector system based on glmS.

Kim K, Jeong JH, Lim D, Hong Y, Yun M, Min JJ, Kwak SJ, Choy HE.

PLoS One. 2013;8(3):e60511. doi: 10.1371/journal.pone.0060511. Epub 2013 Mar 28.


A bacterial RTX toxin causes programmed necrotic cell death through calcium-mediated mitochondrial dysfunction.

Kim YR, Lee SE, Kang IC, Nam KI, Choy HE, Rhee JH.

J Infect Dis. 2013 May 1;207(9):1406-15. doi: 10.1093/infdis/jis746. Epub 2012 Dec 5.


Difference in agr dysfunction and reduced vancomycin susceptibility between MRSA bacteremia involving SCCmec types IV/IVa and I-III.

Jang HC, Kang SJ, Choi SM, Park KH, Shin JH, Choy HE, Jung SI, Kim HB.

PLoS One. 2012;7(11):e49136. doi: 10.1371/journal.pone.0049136. Epub 2012 Nov 12.


Gene silencing by H-NS from distal DNA site.

Shin M, Lagda AC, Lee JW, Bhat A, Rhee JH, Kim JS, Takeyasu K, Choy HE.

Mol Microbiol. 2012 Nov;86(3):707-19. doi: 10.1111/mmi.12012. Epub 2012 Sep 14.


Effect of Salmonella treatment on an implanted tumor (CT26) in a mouse model.

Yun M, Pan S, Jiang SN, Nguyen VH, Park SH, Jung CH, Kim HS, Min JJ, Choy HE, Hong Y.

J Microbiol. 2012 Jun;50(3):502-10. doi: 10.1007/s12275-012-2090-9. Epub 2012 Jun 30.


An unusual feature associated with LEE1 P1 promoters in enteropathogenic Escherichia coli (EPEC).

Jeong JH, Kim HJ, Kim KH, Shin M, Hong Y, Rhee JH, Schneider TD, Choy HE.

Mol Microbiol. 2012 Feb;83(3):612-22. doi: 10.1111/j.1365-2958.2011.07956.x. Epub 2012 Jan 9.


A coupling process for improving purity of bacterial minicells by holin/lysin.

Park SY, Lee JY, Chang WS, Choy HE, Kim GJ.

J Microbiol Methods. 2011 Jul;86(1):108-10. doi: 10.1016/j.mimet.2011.04.003. Epub 2011 Apr 12.


Engineering and visualization of bacteria for targeting infarcted myocardium.

Le UN, Kim HS, Kwon JS, Kim MY, Nguyen VH, Jiang SN, Lee BI, Hong Y, Shin MG, Rhee JH, Bom HS, Ahn Y, Gambhir SS, Choy HE, Min JJ.

Mol Ther. 2011 May;19(5):951-9. doi: 10.1038/mt.2011.25. Epub 2011 Mar 1.


Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery.

Kim HU, Kim SY, Jeong H, Kim TY, Kim JJ, Choy HE, Yi KY, Rhee JH, Lee SY.

Mol Syst Biol. 2011 Jan 18;7:460. doi: 10.1038/msb.2010.115.


Immune response induced by ppGpp-defective Salmonella enterica serovar Gallinarum in chickens.

Park SI, Jeong JH, Choy HE, Rhee JH, Na HS, Lee TH, Her M, Cho KO, Hong Y.

J Microbiol. 2010 Oct;48(5):674-81. doi: 10.1007/s12275-010-0179-6. Epub 2010 Nov 3.


Molecular cloning and characterization of clyA genes in various serotypes of Salmonella enterica.

Huang LJ, Cui J, Piao HH, Hong Y, Choy HE, Ryu PY.

J Microbiol. 2010 Oct;48(5):663-7. doi: 10.1007/s12275-010-9268-9. Epub 2010 Nov 3.


A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses.

Sun D, Lee G, Lee JH, Kim HY, Rhee HW, Park SY, Kim KJ, Kim Y, Kim BY, Hong JI, Park C, Choy HE, Kim JH, Jeon YH, Chung J.

Nat Struct Mol Biol. 2010 Oct;17(10):1188-94. doi: 10.1038/nsmb.1906. Epub 2010 Sep 5.


Immunological responses induced by asd and wzy/asd mutant strains of Salmonella enterica serovar Typhimurium in BALB/c mice.

Piao HH, Tam VT, Na HS, Kim HJ, Ryu PY, Kim SY, Rhee JH, Choy HE, Kim SW, Hong Y.

J Microbiol. 2010 Aug;48(4):486-95. doi: 10.1007/s12275-010-0023-z. Epub 2010 Aug 20.


Outer membrane vesicles of Vibrio vulnificus deliver cytolysin-hemolysin VvhA into epithelial cells to induce cytotoxicity.

Kim YR, Kim BU, Kim SY, Kim CM, Na HS, Koh JT, Choy HE, Rhee JH, Lee SE.

Biochem Biophys Res Commun. 2010 Sep 3;399(4):607-12. doi: 10.1016/j.bbrc.2010.07.122. Epub 2010 Aug 1. Erratum in: Biochem Biophys Res Commun. 2010 Dec 17;403(3-4):491-2.


Identification of genes that are dispensable for animal infection by Salmonella typhimurium.

Kim HJ, Choy HE.

J Microbiol. 2010 Jun;48(3):399-403. doi: 10.1007/s12275-010-9332-5. Epub 2010 Jun 23.


ppGpp-mediated stationary phase induction of the genes encoded by horizontally acquired pathogenicity islands and cob/pdu locus in Salmonella enterica serovar Typhimurium.

Song M, Kim HJ, Ryu S, Yoon H, Yun J, Choy HE.

J Microbiol. 2010 Feb;48(1):89-95. doi: 10.1007/s12275-009-0179-6. Epub 2010 Mar 11.


Caveolae-mediated entry of Salmonella typhimurium into senescent nonphagocytotic host cells.

Lim JS, Choy HE, Park SC, Han JM, Jang IS, Cho KA.

Aging Cell. 2010 Apr;9(2):243-51. doi: 10.1111/j.1474-9726.2010.00554.x. Epub 2010 Jan 20.


Inhibition of tumor growth and metastasis by a combination of Escherichia coli-mediated cytolytic therapy and radiotherapy.

Jiang SN, Phan TX, Nam TK, Nguyen VH, Kim HS, Bom HS, Choy HE, Hong Y, Min JJ.

Mol Ther. 2010 Mar;18(3):635-42. doi: 10.1038/mt.2009.295. Epub 2010 Jan 5.

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