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Acetylation within the N- and C-terminal domains of Src regulate distinct roles of STAT3-mediated tumorigenesis.

Huang C, Zhang Z, Chen L, Lee HW, Ayrapetov MK, Zhao TC, Hao Y, Gao J, Yang C, Mehta GU, Zhuang Z, Zhang X, Hu G, Chin YE.

Cancer Res. 2018 Mar 12. pii: canres.2314.2017. doi: 10.1158/0008-5472.CAN-17-2314. [Epub ahead of print]


Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis.

Han T, Zhan W, Gan M, Liu F, Yu B, Chin YE, Wang JB.

Cell Res. 2018 Mar 7. doi: 10.1038/s41422-018-0021-y. [Epub ahead of print]


Role of influenza A virus NP acetylation on viral growth and replication.

Giese S, Ciminski K, Bolte H, Moreira ÉA, Lakdawala S, Hu Z, David Q, Kolesnikova L, Götz V, Zhao Y, Dengjel J, Chin YE, Xu K, Schwemmle M.

Nat Commun. 2017 Nov 2;8(1):1259. doi: 10.1038/s41467-017-01112-3.


JMJD5 cleaves monomethylated histone H3 N-tail under DNA damaging stress.

Shen J, Xiang X, Chen L, Wang H, Wu L, Sun Y, Ma L, Gu X, Liu H, Wang L, Yu YN, Shao J, Huang C, Chin YE.

EMBO Rep. 2017 Dec;18(12):2131-2143. doi: 10.15252/embr.201743892. Epub 2017 Oct 5.


Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.

Cao Y, Lin SH, Wang Y, Chin YE, Kang L, Mi J.

Theranostics. 2017 Jul 22;7(12):3021-3033. doi: 10.7150/thno.18992. eCollection 2017.


Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea.

Chen Q, Quan Y, Wang N, Xie C, Ji Z, He H, Chai R, Li H, Yin S, Chin YE, Wei X, Gao WQ.

Stem Cell Reports. 2017 Jul 11;9(1):231-246. doi: 10.1016/j.stemcr.2017.05.031. Epub 2017 Jun 29.


Re: Bacteriological study in perianal abscess is not useful and not cost-effective.

Bisset CN, Dick L, Chin YR, Summers L, Renwick A.

ANZ J Surg. 2017 May;87(5):420-421. doi: 10.1111/ans.13878. No abstract available.


Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis.

Zhang L, Cai M, Gong Z, Zhang B, Li Y, Guan L, Hou X, Li Q, Liu G, Xue Z, Yang MH, Ye J, Chin YE, You H.

J Clin Invest. 2017 Jun 1;127(6):2159-2175. doi: 10.1172/JCI90077. Epub 2017 Apr 24.


Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injury.

Wang H, Zhao YT, Zhang S, Dubielecka PM, Du J, Yano N, Chin YE, Zhuang S, Qin G, Zhao TC.

J Cell Physiol. 2017 Dec;232(12):3775-3785. doi: 10.1002/jcp.25857. Epub 2017 May 3.


Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells.

Wang XJ, Qiao Y, Xiao MM, Wang L, Chen J, Lv W, Xu L, Li Y, Wang Y, Tan MD, Huang C, Li J, Zhao TC, Hou Z, Jing N, Chin YE.

Cell Rep. 2017 Jan 24;18(4):933-946. doi: 10.1016/j.celrep.2016.12.081.


Sodium Butyrate Protects -Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice.

Zhang L, Du J, Yano N, Wang H, Zhao YT, Dubielecka PM, Zhuang S, Chin YE, Qin G, Zhao TC.

J Cell Biochem. 2017 Aug;118(8):2395-2408. doi: 10.1002/jcb.25902. Epub 2017 Apr 25.


Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation.

Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE.

Mol Cell. 2017 Jan 19;65(2):296-309. doi: 10.1016/j.molcel.2016.12.002. Epub 2017 Jan 5.


PCAF acts as a gastric cancer suppressor through a novel PCAF-p16-CDK4 axis.

Fei HJ, Zu LD, Wu J, Jiang XS, Wang JL, Chin YE, Fu GH.

Am J Cancer Res. 2016 Dec 1;6(12):2772-2786. eCollection 2016.


STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism.

Xu YS, Liang JJ, Wang Y, Zhao XJ, Xu L, Xu YY, Zou QC, Zhang JM, Tu CE, Cui YG, Sun WH, Huang C, Yang JH, Chin YE.

Sci Rep. 2016 Dec 22;6:39517. doi: 10.1038/srep39517.


The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network.

Jia H, Song L, Cong Q, Wang J, Xu H, Chu Y, Li Q, Zhang Y, Zou X, Zhang C, Chin YE, Zhang X, Li Z, Zhu K, Wang B, Peng H, Hou Z.

Oncogene. 2017 May 11;36(19):2655-2666. doi: 10.1038/onc.2016.418. Epub 2016 Nov 28.


SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop.

Yu T, Zuo Y, Cai R, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S, Shen L, Cheng J.

J Mol Cell Biol. 2017 Apr 1;9(2):144-153. doi: 10.1093/jmcb/mjw042.


SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer.

Zhou Z, Wang M, Li J, Xiao M, Chin YE, Cheng J, Yeh ET, Yang J, Yi J.

Oncogene. 2016 Nov 10;35(45):5826-5838. doi: 10.1038/onc.2016.124. Epub 2016 May 16.


Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells.

Shou P, Chen Q, Jiang J, Xu C, Zhang J, Zheng C, Jiang M, Velletri T, Cao W, Huang Y, Yang Q, Han X, Zhang L, Wei L, Rabson AB, Chin YE, Wang Y, Shi Y.

Oncogene. 2016 Nov 17;35(46):5953-5962. doi: 10.1038/onc.2016.128. Epub 2016 Apr 25.


SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability.

Huang C, Cheng J, Bawa-Khalfe T, Yao X, Chin YE, Yeh ETH.

Cell Rep. 2016 Apr 5;15(1):147-157. doi: 10.1016/j.celrep.2016.02.091. Epub 2016 Mar 24.


Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice.

Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y.

Hepatology. 2016 Aug;64(2):425-38. doi: 10.1002/hep.28523. Epub 2016 Apr 15.


The STAT3 HIES mutation is a gain-of-function mutation that activates genes via AGG-element carrying promoters.

Xu L, Ji JJ, Le W, Xu YS, Dou D, Pan J, Jiao Y, Zhong T, Wu D, Wang Y, Wen C, Xie GQ, Yao F, Zhao H, Fan YS, Chin YE.

Nucleic Acids Res. 2015 Oct 15;43(18):8898-912. doi: 10.1093/nar/gkv911. Epub 2015 Sep 17.


The NF-κB p65/miR-23a-27a-24 cluster is a target for leukemia treatment.

Zhang YC, Ye H, Zeng Z, Chin YE, Huang YN, Fu GH.

Oncotarget. 2015 Oct 20;6(32):33554-67. doi: 10.18632/oncotarget.5591.


mTOR and post-translational modifications rely on mitochondrion as the arsenal for cellular metabolism regulation.

Zhuge CJ, Chen SJ, Chin YE.

Sci China Life Sci. 2015 Aug;58(8):810-2. doi: 10.1007/s11427-015-4909-1. Epub 2015 Jul 23. No abstract available.


Leukemia inhibitory factor attenuates renal fibrosis through Stat3-miR-29c.

Yu Y, Wang Y, Niu Y, Fu L, Chin YE, Yu C.

Am J Physiol Renal Physiol. 2015 Oct 1;309(7):F595-603. doi: 10.1152/ajprenal.00634.2014. Epub 2015 Jul 8.


NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis.

Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu XZ, Zheng Y, Shen N, Chin YE, Wang H.

Nat Commun. 2015 Jul 3;6:7652. doi: 10.1038/ncomms8652.


PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression.

Wan J, Zhan J, Li S, Ma J, Xu W, Liu C, Xue X, Xie Y, Fang W, Chin YE, Zhang H.

Nucleic Acids Res. 2015 Apr 20;43(7):3591-604. doi: 10.1093/nar/gkv238. Epub 2015 Mar 23.


EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy.

Liu N, Wang L, Yang T, Xiong C, Xu L, Shi Y, Bao W, Chin YE, Cheng SB, Yan H, Qiu A, Zhuang S.

J Am Soc Nephrol. 2015 Nov;26(11):2716-29. doi: 10.1681/ASN.2014080793. Epub 2015 Mar 18.


Lung Tumor Suppressor GPRC5A Binds EGFR and Restrains Its Effector Signaling.

Zhong S, Yin H, Liao Y, Yao F, Li Q, Zhang J, Jiao H, Zhao Y, Xu D, Liu S, Song H, Gao Y, Liu J, Ma L, Pang Z, Yang R, Ding C, Sun B, Lin X, Ye X, Guo W, Han B, Zhou BP, Chin YE, Deng J.

Cancer Res. 2015 May 1;75(9):1801-14. doi: 10.1158/0008-5472.CAN-14-2005. Epub 2015 Mar 5.


Gprc5a-deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-κB pathway.

Liao Y, Song H, Xu D, Jiao H, Yao F, Liu J, Wu Y, Zhong S, Yin H, Liu S, Wang X, Guo W, Sun B, Han B, Chin YE, Deng J.

Cell Cycle. 2015;14(9):1403-12. doi: 10.1080/15384101.2015.1006006.


AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation.

Qiao Y, Wang X, Wang R, Li Y, Yu F, Yang X, Song L, Xu G, Chin YE, Jing N.

Cell Discov. 2015 Jul 28;1:15017. doi: 10.1038/celldisc.2015.17. eCollection 2015.


EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer.

Lin X, Zhong S, Ye X, Liao Y, Yao F, Yang X, Sun B, Zhang J, Li Q, Gao Y, Wang Y, Liu J, Han B, Chin YE, Zhou BP, Deng J.

Mol Cancer. 2014 Oct 14;13:233. doi: 10.1186/1476-4598-13-233.


Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway.

Li M, Zhang Z, Li X, Ye J, Wu X, Tan Z, Liu C, Shen B, Wang XA, Wu W, Zhou D, Zhang D, Wang T, Liu B, Qu K, Ding Q, Weng H, Ding Q, Mu J, Shu Y, Bao R, Cao Y, Chen P, Liu T, Jiang L, Hu Y, Dong P, Gu J, Lu W, Shi W, Lu J, Gong W, Tang Z, Zhang Y, Wang X, Chin YE, Weng X, Zhang H, Tang W, Zheng Y, He L, Wang H, Liu Y, Liu Y.

Nat Genet. 2014 Aug;46(8):872-6. doi: 10.1038/ng.3030. Epub 2014 Jul 6.


A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells.

Liu S, Sun X, Wang M, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X.

Gastroenterology. 2014 Oct;147(4):847-859.e11. doi: 10.1053/j.gastro.2014.06.006. Epub 2014 Jun 12.


Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells.

Chen J, Xu H, Zou X, Wang J, Zhu Y, Chen H, Shen B, Deng X, Zhou A, Chin YE, Rauscher FJ 3rd, Peng C, Hou Z.

Cancer Res. 2014 Aug 15;74(16):4353-63. doi: 10.1158/0008-5472.CAN-14-0181. Epub 2014 Jun 5.


DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis.

Wang Y, Lei R, Zhuang X, Zhang N, Pan H, Li G, Hu J, Pan X, Tao Q, Fu D, Xiao J, Chin YE, Kang Y, Yang Q, Hu G.

J Clin Invest. 2014 Apr;124(4):1646-59. doi: 10.1172/JCI71812. Epub 2014 Mar 3.


GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis.

Wang Y, Ning H, Ren F, Zhang Y, Rong Y, Wang Y, Su F, Cai C, Jin Z, Li Z, Gong X, Zhai Y, Wang D, Jia B, Qiu Y, Tomita Y, Sung JJ, Yu J, Irwin DM, Yang X, Fu X, Chin YE, Chang Z.

Mol Cell. 2014 Mar 6;53(5):752-65. doi: 10.1016/j.molcel.2014.01.020. Epub 2014 Feb 13.


The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy.

Dong S, Jia C, Zhang S, Fan G, Li Y, Shan P, Sun L, Xiao W, Li L, Zheng Y, Liu J, Wei H, Hu C, Zhang W, Chin YE, Zhai Q, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X, Wang C.

Cell Metab. 2013 Sep 3;18(3):380-91. doi: 10.1016/j.cmet.2013.08.012.


Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis.

Nie H, Zheng Y, Li R, Guo TB, He D, Fang L, Liu X, Xiao L, Chen X, Wan B, Chin YE, Zhang JZ.

Nat Med. 2013 Mar;19(3):322-8. doi: 10.1038/nm.3085. Epub 2013 Feb 10.


CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation.

Chang CC, Yang MH, Lin BR, Chen ST, Pan SH, Hsiao M, Lai TC, Lin SK, Jeng YM, Chu CY, Chen RH, Yang PC, Chin YE, Kuo ML.

Cell Death Differ. 2013 Mar;20(3):443-55. doi: 10.1038/cdd.2012.136. Epub 2012 Nov 23.


PRBC-derived plasma induces non-muscle myosin type IIA-mediated neutrophil migration and morphologic change.

Yu C, Xu L, Chen LF, Guan YJ, Kim M, Biffl WL, Chin YE.

Immunopharmacol Immunotoxicol. 2013 Feb;35(1):71-9. doi: 10.3109/08923973.2012.677046. Epub 2012 Oct 19.


Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted hearts.

Zhang L, Chen B, Zhao Y, Dubielecka PM, Wei L, Qin GJ, Chin YE, Wang Y, Zhao TC.

J Biol Chem. 2012 Nov 16;287(47):39338-48. doi: 10.1074/jbc.M112.379115. Epub 2012 Sep 28.


Reprogramming cancer cells: back to the future.

Lang JY, Shi Y, Chin YE.

Oncogene. 2013 May 2;32(18):2247-8. doi: 10.1038/onc.2012.349. Epub 2012 Aug 6.


Interferon regulatory factor 1 transactivates expression of human DNA polymerase η in response to carcinogen N-methyl-N'-nitro-N-nitrosoguanidine.

Qi H, Zhu H, Lou M, Fan Y, Liu H, Shen J, Li Z, Lv X, Shan J, Zhu L, Chin YE, Shao J.

J Biol Chem. 2012 Apr 13;287(16):12622-33. doi: 10.1074/jbc.M111.313429. Epub 2012 Feb 24.


Histone deacetylase 6 (HDAC6) deacetylates survivin for its nuclear export in breast cancer.

Riolo MT, Cooper ZA, Holloway MP, Cheng Y, Bianchi C, Yakirevich E, Ma L, Chin YE, Altura RA.

J Biol Chem. 2012 Mar 30;287(14):10885-93. doi: 10.1074/jbc.M111.308791. Epub 2012 Feb 9.


SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation.

Van Nguyen T, Angkasekwinai P, Dou H, Lin FM, Lu LS, Cheng J, Chin YE, Dong C, Yeh ET.

Mol Cell. 2012 Jan 27;45(2):210-21. doi: 10.1016/j.molcel.2011.12.026.


Phospho-SXXE/D motif mediated TNF receptor 1-TRADD death domain complex formation for T cell activation and migration.

Guan YJ, Zhang Z, Yu C, Ma L, Hu W, Xu L, Gao JS, Chung CS, Wang L, Yang ZF, Fast LD, Chung AS, Kim M, Ayala A, Zhuang S, Zheng S, Chin YE.

J Immunol. 2011 Aug 1;187(3):1289-97. doi: 10.4049/jimmunol.1003399. Epub 2011 Jul 1.


Acetylation modulates prolactin receptor dimerization.

Ma L, Gao JS, Guan Y, Shi X, Zhang H, Ayrapetov MK, Zhang Z, Xu L, Hyun YM, Kim M, Zhuang S, Chin YE.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19314-9. doi: 10.1073/pnas.1010253107. Epub 2010 Oct 20.


P2X7 receptors mediate deleterious renal epithelial-fibroblast cross talk.

Ponnusamy M, Ma L, Gong R, Pang M, Chin YE, Zhuang S.

Am J Physiol Renal Physiol. 2011 Jan;300(1):F62-70. doi: 10.1152/ajprenal.00473.2010. Epub 2010 Sep 22.


FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways.

Jiao P, Ma J, Feng B, Zhang H, Diehl JA, Chin YE, Yan W, Xu H.

Obesity (Silver Spring). 2011 Mar;19(3):483-91. doi: 10.1038/oby.2010.200. Epub 2010 Sep 9.

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