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Items: 1 to 50 of 96

1.

Dullard deficiency causes hemorrhage in the adult ovarian follicles.

Hayata T, Chiga M, Ezura Y, Asashima M, Katabuchi H, Nishinakamura R, Noda M.

Genes Cells. 2018 May;23(5):345-356. doi: 10.1111/gtc.12575. Epub 2018 Mar 9.

PMID:
29521016
2.

Kidney enlargement and multiple liver cyst formation implicate mutations in PKD1/2 in adult sporadic polycystic kidney disease.

Fujimaru T, Mori T, Sekine A, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Nomura N, Iimori S, Naito S, Okado T, Rai T, Hoshino J, Ubara Y, Uchida S, Sohara E.

Clin Genet. 2018 Mar 9. doi: 10.1111/cge.13249. [Epub ahead of print]

PMID:
29520754
3.

Nebulized hypertonic saline in infants hospitalized with moderately severe bronchiolitis due to RSV infection: A multicenter randomized controlled trial.

Morikawa Y, Miura M, Furuhata MY, Morino S, Omori T, Otsuka M, Chiga M, Obonai T, Hataya H, Kaneko T, Ishikura K, Honda M, Hasegawa Y; Tokyo Pediatric Clinical Research Network.

Pediatr Pulmonol. 2018 Mar;53(3):358-365. doi: 10.1002/ppul.23945. Epub 2018 Jan 12.

PMID:
29327810
4.

The proteasome inhibitor bortezomib attenuates renal fibrosis in mice via the suppression of TGF-β1.

Zeniya M, Mori T, Yui N, Nomura N, Mandai S, Isobe K, Chiga M, Sohara E, Rai T, Uchida S.

Sci Rep. 2017 Oct 12;7(1):13086. doi: 10.1038/s41598-017-13486-x.

5.

Renal histology and MRI findings in a 37-year-old Japanese patient with autosomal recessive polycystic kidney disease
.

Ito Y, Sekine A, Takada D, Yabuuchi J, Kogure Y, Ueno T, Sumida K, Yamanouchi M, Hayami N, Suwabe T, Hoshino J, Sawa N, Takaichi K, Kinowaki K, Fujii T, Ohashi K, Kikuchi H, Mandai S, Chiga M, Mori T, Sohara E, Uchida S, Ubara Y.

Clin Nephrol. 2017 Nov;88(11):292-297. doi: 10.5414/CN109179.

PMID:
28933340
6.

Post-infectious Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Deposits Associated with Complement Factor H Mutation.

Takehara E, Mandai S, Shikuma S, Akita W, Chiga M, Mori T, Oda T, Kuwahara M, Uchida S.

Intern Med. 2017;56(7):811-817. doi: 10.2169/internalmedicine.56.7778. Epub 2017 Apr 1.

7.

WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice.

Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S.

EBioMedicine. 2017 Apr;18:118-127. doi: 10.1016/j.ebiom.2017.03.011. Epub 2017 Mar 8.

8.

Acquired Gitelman Syndrome in an Anti-SSA Antibody-positive Patient with a SLC12A3 Heterozygous Mutation.

Kusuda T, Hosoya T, Mori T, Ihara K, Nishida H, Chiga M, Sohara E, Rai T, Koike R, Uchida S, Kohsaka H.

Intern Med. 2016;55(21):3201-3204. Epub 2016 Nov 1.

9.

A patient with pseudohypoaldosteronism type II complicated by congenital hypopituitarism carrying a KLHL3 mutation.

Mitani M, Furuichi M, Narumi S, Hasegawa T, Chiga M, Uchida S, Sato S.

Clin Pediatr Endocrinol. 2016 Oct;25(4):127-134. Epub 2016 Oct 18.

10.

Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel.

Mori T, Hosomichi K, Chiga M, Mandai S, Nakaoka H, Sohara E, Okado T, Rai T, Sasaki S, Inoue I, Uchida S.

Clin Exp Nephrol. 2017 Feb;21(1):63-75. doi: 10.1007/s10157-016-1252-1. Epub 2016 Feb 26.

PMID:
26920127
11.

Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.

Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E.

Biochem Biophys Res Commun. 2015 Nov 13;467(2):229-34. doi: 10.1016/j.bbrc.2015.09.184. Epub 2015 Oct 3.

PMID:
26435498
12.

Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model.

Inoue Y, Sohara E, Kobayashi K, Chiga M, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S.

J Am Soc Nephrol. 2014 Dec;25(12):2789-99. doi: 10.1681/ASN.2013060614. Epub 2014 May 22.

13.

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.

Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S.

Hum Mol Genet. 2014 Oct 1;23(19):5052-60. doi: 10.1093/hmg/ddu217. Epub 2014 May 12.

PMID:
24821705
14.

Effect of eculizumab and recombinant human soluble thrombomodulin combination therapy in a 7-year-old girl with atypical hemolytic uremic syndrome due to anti-factor H autoantibodies.

Udagawa T, Motoyoshi Y, Matsumura Y, Takei A, Ariji S, Ito E, Chiga M, Nagasawa M, Morio T, Mizutani S.

CEN Case Rep. 2014 May;3(1):110-117. doi: 10.1007/s13730-013-0097-7. Epub 2013 Sep 12.

15.

Evaluation of Phosphorylated Urinary Na-Cl Cotransporter Is Potentially Useful in a Patient With Pseudohypoaldosteronism Type II due to Mutation in CUL3.

Nagahara K, Abe Y, Hojo A, Dobashi K, Chiga M, Isobe K, Uchida S, Itabashi K.

Glob Pediatr Health. 2014 Sep 26;1:2333794X14552899. doi: 10.1177/2333794X14552899. eCollection 2014. No abstract available.

16.

Preformed Wolffian duct regulates Müllerian duct elongation independently of canonical Wnt signaling or Lhx1 expression.

Chiga M, Ohmori T, Ohba T, Katabuchi H, Nishinakamura R.

Int J Dev Biol. 2014;58(9):663-8. doi: 10.1387/ijdb.140261rn.

17.

Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type IV caused by mutated Bsnd in mice.

Nomura N, Kamiya K, Ikeda K, Yui N, Chiga M, Sohara E, Rai T, Sakaki S, Uchida S.

Biochem Biophys Res Commun. 2013 Nov 22;441(3):544-9. doi: 10.1016/j.bbrc.2013.10.129. Epub 2013 Nov 1.

PMID:
24189473
18.

Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II.

Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S.

Hypertension. 2013 Nov;62(5):872-8. doi: 10.1161/HYPERTENSIONAHA.113.01543. Epub 2013 Sep 9.

19.

A young child with pseudohypoaldosteronism type II by a mutation of Cullin 3.

Tsuji S, Yamashita M, Unishi G, Takewa R, Kimata T, Isobe K, Chiga M, Uchida S, Kaneko K.

BMC Nephrol. 2013 Jul 31;14:166. doi: 10.1186/1471-2369-14-166.

20.

Sall4 Is Transiently Expressed in the Caudal Wolffian Duct and the Ureteric Bud, but Dispensable for Kidney Development.

Toyoda D, Taguchi A, Chiga M, Ohmori T, Nishinakamura R.

PLoS One. 2013 Jun 18;8(6):e68508. doi: 10.1371/journal.pone.0068508. Print 2013.

21.

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.

Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Matsuo H, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S.

Cell Rep. 2013 Mar 28;3(3):858-68. doi: 10.1016/j.celrep.2013.02.024. Epub 2013 Feb 28.

22.

Characterization of AQP-2 gene mutation (R254Q) in a family with dominant nephrogenic DI.

Shida Y, Matsuoka H, Chiga M, Uchida S, Sasaki S, Sugihara S.

Pediatr Int. 2013 Feb;55(1):105-7. doi: 10.1111/j.1442-200X.2012.03614.x.

PMID:
23409988
23.

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo.

Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S.

Biol Open. 2012 Feb 15;1(2):120-7. doi: 10.1242/bio.2011048. Epub 2011 Nov 24.

24.

Hereditary nephrogenic diabetes insipidus in Japanese patients: analysis of 78 families and report of 22 new mutations in AVPR2 and AQP2.

Sasaki S, Chiga M, Kikuchi E, Rai T, Uchida S.

Clin Exp Nephrol. 2013 Jun;17(3):338-44. doi: 10.1007/s10157-012-0726-z. Epub 2012 Nov 14.

PMID:
23150186
25.

WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone.

Susa K, Sohara E, Isobe K, Chiga M, Rai T, Sasaki S, Uchida S.

Biochem Biophys Res Commun. 2012 Nov 2;427(4):743-7. doi: 10.1016/j.bbrc.2012.09.130. Epub 2012 Oct 5.

PMID:
23044422
26.

Does a β2-adrenergic receptor-WNK4-Na-Cl co-transporter signal cascade exist in the in vivo kidney?

Uchida S, Chiga M, Sohara E, Rai T, Sasaki S.

Nat Med. 2012 Sep;18(9):1324-5; author reply 1325-7. doi: 10.1038/nm.2809. No abstract available.

PMID:
22961153
27.

Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.

Nishida H, Sohara E, Nomura N, Chiga M, Alessi DR, Rai T, Sasaki S, Uchida S.

Hypertension. 2012 Oct;60(4):981-90. doi: 10.1161/HYPERTENSIONAHA.112.201509. Epub 2012 Sep 4.

28.

Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination.

Hossain Khan MZ, Sohara E, Ohta A, Chiga M, Inoue Y, Isobe K, Wakabayashi M, Oi K, Rai T, Sasaki S, Uchida S.

Biochem Biophys Res Commun. 2012 Aug 24;425(2):456-61. doi: 10.1016/j.bbrc.2012.07.124. Epub 2012 Jul 27.

PMID:
22846565
29.

Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney.

Sohara E, Rai T, Yang SS, Ohta A, Naito S, Chiga M, Nomura N, Lin SH, Vandewalle A, Ohta E, Sasaki S, Uchida S.

PLoS One. 2011;6(8):e24277. doi: 10.1371/journal.pone.0024277. Epub 2011 Aug 31.

30.

Immunolocalization of WNK4 in mouse kidney.

Ohno M, Uchida K, Ohashi T, Nitta K, Ohta A, Chiga M, Sasaki S, Uchida S.

Histochem Cell Biol. 2011 Jul;136(1):25-35. doi: 10.1007/s00418-011-0827-x. Epub 2011 Jun 10.

PMID:
21660484
31.

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.

Chiga M, Rafiqi FH, Alessi DR, Sohara E, Ohta A, Rai T, Sasaki S, Uchida S.

J Cell Sci. 2011 May 1;124(Pt 9):1391-5. doi: 10.1242/jcs.084111. Epub 2011 Apr 12.

32.

Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice.

Yang SS, Hsu YJ, Chiga M, Rai T, Sasaki S, Uchida S, Lin SH.

Endocrinology. 2010 Apr;151(4):1829-36. doi: 10.1210/en.2009-0951. Epub 2010 Feb 24.

PMID:
20181799
33.

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure.

Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S.

Hum Mol Genet. 2009 Oct 15;18(20):3978-86. doi: 10.1093/hmg/ddp344. Epub 2009 Jul 24.

PMID:
19633012
34.

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone.

Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, Uchida S.

Kidney Int. 2008 Dec;74(11):1403-9. doi: 10.1038/ki.2008.451. Epub 2008 Sep 17.

35.

Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.

Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S.

Cell Metab. 2007 May;5(5):331-44.

36.

Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells.

Ohta A, Yang SS, Rai T, Chiga M, Sasaki S, Uchida S.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):804-8. Epub 2006 Aug 24.

PMID:
16949040
37.
38.

Profile of prostatic-specific antigen in prostatic carcinomas.

Tomita T, Dalton T, Kwok S, Lee S, Noble M, Chiga M.

Mod Pathol. 1993 May;6(3):259-64.

PMID:
7688461
39.

Successful treatment of a malignant rat glioma with cytotoxic T lymphocytes.

Holladay FP, Heitz T, Chen YL, Chiga M, Wood GW.

Neurosurgery. 1992 Sep;31(3):528-33.

PMID:
1407433
40.

Identification of herpes simplex virus infection by immunoperoxidase and in situ hybridization methods.

Tomita T, Chiga M, Lenahan M, Balachandran N.

Virchows Arch A Pathol Anat Histopathol. 1991;419(2):99-105.

PMID:
1651584
41.

Identification of cytomegalovirus infection in acquired immunodeficiency syndrome.

Tomita T, Chiga M, Lenahan M, Balachandran N.

Virchows Arch A Pathol Anat Histopathol. 1990;416(6):497-503.

PMID:
2159674
42.

Idiopathic dilated cardiomyopathy--an evidence of abnormal lipid accumulation accumulation in myocardium.

Tomita T, Wilson L, Chiga M.

Am J Cardiovasc Pathol. 1990;3(1):81-5.

PMID:
2139573
43.

Disseminated histoplasmosis in the acquired immunodeficiency syndrome.

Tomita T, Lotuaco L, Watanabe I, Chiga M.

Prog AIDS Pathol. 1990;2:127-35. No abstract available.

PMID:
2103856
44.
45.

Part A reimbursement: what is your role in medical quality assurance?

Bernstein LH, Kleinman GM, Davis GL, Chiga M.

Pathologist. 1986 Apr;40(4):24-9. No abstract available.

PMID:
10300736
46.

Different ionic forms of estrogen receptor in rat uterus and human breast carcinoma.

Tilzer LL, McFarland RT, Plapp FV, Evans JP, Chiga M.

Cancer Res. 1981 Mar;41(3):1058-63.

47.

The role of membrane phospholipid in expression of erythrocyte RhO(D) antigen activity.

Plapp FV, Kowalski MM, Evans JP, Tilzer LL, Chiga M.

Proc Soc Exp Biol Med. 1980 Sep;164(4):561-8. No abstract available.

PMID:
6158058
48.

Partial purification of Rho (D) antigen from Rh positive and negative erythrocytes.

Plapp FV, Kowalski MM, Tilzer L, Brown PJ, Evans BJ, Chiga M.

Proc Natl Acad Sci U S A. 1979 Jun;76(6):2964-8.

49.

Production in vivo of falloff monosomes in mouse liver by sparsomycin.

Hayes LC, Plapp FV, Tilzer LL, Reddy JK, Chiga M.

Biochem Pharmacol. 1977 Feb 1;26(3):255-6. No abstract available.

PMID:
843395
50.

Electrophoresis of human multiple myeloma and Waldenström's macroglobulinemia sera in sodium dodecyl sulfate polyacrylamide gels.

Hayes LC, Plapp FV, Brewer GJ, Rucker M, Moore D, Tilzer LL, Chiga M.

Clin Chim Acta. 1976 Jan 2;66(1):119-23.

PMID:
816578

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