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Comparison of hepatic and serum lipid signatures in hepatocellular carcinoma patients leads to the discovery of diagnostic and prognostic biomarkers.

Lu Y, Chen J, Huang C, Li N, Zou L, Chia SE, Chen S, Yu K, Ling Q, Cheng Q, Zhu M, Zhang W, Chen M, Ong CN.

Oncotarget. 2017 Dec 13;9(4):5032-5043. doi: 10.18632/oncotarget.23494. eCollection 2018 Jan 12.


Patient preferences for types of community-based cardiac rehabilitation programme.

Chia S, Wong XY, Toon ML, Seah Y, Yap AF, Lim C, Tay HY, Fong W, Low LL, Kwan YH.

Heart Asia. 2018 Jan 26;10(1):e010976. doi: 10.1136/heartasia-2017-010976. eCollection 2018.


Comparison of the outcome measures from different pathways post total knee arthroplasty.

Chan HY, Sultana R, Yeo SJ, Chia SL, Pang HN, Lo NN.

Singapore Med J. 2018 Jan 26. doi: 10.11622/smedj.2018011. [Epub ahead of print]


Analysis of Economic and Environmental Aspects of Microalgae Biorefinery for Biofuels Production: A Review.

Chia SR, Chew KW, Show PL, Yap YJ, Ong HC, Ling TC, Chang JS.

Biotechnol J. 2018 Jan 22. doi: 10.1002/biot.201700618. [Epub ahead of print] Review.


Polyphenol-rich curry made with mixed spices and vegetables increases postprandial plasma GLP-1 concentration in a dose-dependent manner.

Haldar S, Chia SC, Henry CJ.

Eur J Clin Nutr. 2018 Feb;72(2):297-300. doi: 10.1038/s41430-017-0069-7. Epub 2017 Dec 28.


Tailoring the mechanical and biodegradable properties of binary blends of biomedical thermoplastic elastomer.

Ang HY, Chan J, Toong D, Venkatraman SS, Chia SJ, Huang YY.

J Mech Behav Biomed Mater. 2018 Mar;79:64-72. doi: 10.1016/j.jmbbm.2017.12.013. Epub 2017 Dec 15.


Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer.

Zhao EY, Shen Y, Pleasance E, Kasaian K, Leelakumari S, Jones M, Bose P, Ch'ng C, Reisle C, Eirew P, Corbett R, Mungall KL, Thiessen N, Ma Y, Schein JE, Mungall AJ, Zhao Y, Moore RA, Den Brok W, Wilson S, Villa D, Shenkier T, Lohrisch C, Chia S, Yip S, Gelmon K, Lim H, Renouf D, Sun S, Schrader KA, Young S, Bosdet I, Karsan A, Laskin J, Marra MA, Jones SJM.

Clin Cancer Res. 2017 Dec 15;23(24):7521-7530. doi: 10.1158/1078-0432.CCR-17-1941.


Polyphenol-rich curry made with mixed spices and vegetables benefits glucose homeostasis in Chinese males (Polyspice Study): a dose-response randomized controlled crossover trial.

Haldar S, Chia SC, Lee SH, Lim J, Leow MK, Chan ECY, Henry CJ.

Eur J Nutr. 2017 Dec 13. doi: 10.1007/s00394-017-1594-9. [Epub ahead of print]


Long-term efficacy analysis of the randomised, phase II TRYPHAENA cardiac safety study: Evaluating pertuzumab and trastuzumab plus standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer.

Schneeweiss A, Chia S, Hickish T, Harvey V, Eniu A, Waldron-Lynch M, Eng-Wong J, Kirk S, Cortés J.

Eur J Cancer. 2018 Jan;89:27-35. doi: 10.1016/j.ejca.2017.10.021. Epub 2017 Dec 8.


Predictors of Midterm Outcomes after Medial Unicompartmental Knee Arthroplasty in Asians.

Bin Abd Razak HR, Acharyya S, Tan SM, Pang HN, Tay KD, Chia SL, Lo NN, Yeo SJ.

Clin Orthop Surg. 2017 Dec;9(4):432-438. doi: 10.4055/cios.2017.9.4.432. Epub 2017 Nov 10.


Change in Body Mass Index After Total Knee Arthroplasty and Its Influence on Functional Outcome.

Chen JY, Xu S, Pang HN, Tay DKJ, Chia SL, Lo NN, Yeo SJ.

J Arthroplasty. 2018 Mar;33(3):718-722. doi: 10.1016/j.arth.2017.10.046. Epub 2017 Oct 31.


Factors affecting compliance with confirmatory colonoscopy after a positive fecal immunochemical test in a national colorectal screening program.

Cheng SY, Li MC, Chia SL, Huang KC, Chiu TY, Chan DC, Chiu HM.

Cancer. 2018 Mar 1;124(5):907-915. doi: 10.1002/cncr.31145. Epub 2017 Nov 22.


Age and ejection fraction modify the impact of atrial fibrillation on acute heart failure outcomes.

Go YY, Sugimoto T, Bulluck H, Acharyya S, Allen JC, Chia SY, Jaufeerally FR, Sim D, Lim TK, Liew R, Lam CSP.

Eur J Heart Fail. 2017 Nov 16. doi: 10.1002/ejhf.1075. [Epub ahead of print] No abstract available.


Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

Martin M, Holmes FA, Ejlertsen B, Delaloge S, Moy B, Iwata H, von Minckwitz G, Chia SKL, Mansi J, Barrios CH, Gnant M, Tomašević Z, Denduluri N, Šeparović R, Gokmen E, Bashford A, Ruiz Borrego M, Kim SB, Jakobsen EH, Ciceniene A, Inoue K, Overkamp F, Heijns JB, Armstrong AC, Link JS, Joy AA, Bryce R, Wong A, Moran S, Yao B, Xu F, Auerbach A, Buyse M, Chan A; ExteNET Study Group.

Lancet Oncol. 2017 Dec;18(12):1688-1700. doi: 10.1016/S1470-2045(17)30717-9. Epub 2017 Nov 13.


IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease.

Qian X, Aboushousha R, van de Wetering C, Chia SB, Amiel E, Schneider RW, van der Velden JLJ, Lahue KG, Hoagland DA, Casey DT, Daphtary N, Ather JL, Randall MJ, Aliyeva M, Black KE, Chapman DG, Lundblad LKA, McMillan DH, Dixon AE, Anathy V, Irvin CG, Poynter ME, Wouters EFM, Vacek PM, Henket M, Schleich F, Louis R, van der Vliet A, Janssen-Heininger YMW.

J Allergy Clin Immunol. 2017 Nov 3. pii: S0091-6749(17)31663-9. doi: 10.1016/j.jaci.2017.08.043. [Epub ahead of print]


Management of penile cancer in a Singapore tertiary hospital.

Tan TW, Chia SJ, Chong KT.

Arab J Urol. 2017 Mar 30;15(2):123-130. doi: 10.1016/j.aju.2017.03.001. eCollection 2017 Jun.


LAG-3+ tumor infiltrating lymphocytes in breast cancer: clinical correlates and association with PD-1/PD-L1+ tumors.

Burugu S, Gao D, Leung S, Chia SK, Nielsen TO.

Ann Oncol. 2017 Dec 1;28(12):2977-2984. doi: 10.1093/annonc/mdx557.


Postoperative fixed flexion deformity greater than 10° lead to poorer functional outcome 10 years after unicompartmental knee arthroplasty.

Yeh JZY, Chen JY, Lim JW, Pang HN, Tay DKJ, Chia SL, Lo NN, Yeo SJ.

Knee Surg Sports Traumatol Arthrosc. 2017 Oct 9. doi: 10.1007/s00167-017-4749-6. [Epub ahead of print]


RNA Binding Protein Ybx2 Regulates RNA Stability During Cold-Induced Brown Fat Activation.

Xu D, Xu S, Kyaw AMM, Lim YC, Chia SY, Chee Siang DT, Alvarez-Dominguez JR, Chen P, Leow MK, Sun L.

Diabetes. 2017 Dec;66(12):2987-3000. doi: 10.2337/db17-0655. Epub 2017 Sep 29.


Revision total knee arthroplasty for failed high tibial osteotomy and unicompartmental knee arthroplasty have similar patient-reported outcome measures in a two-year follow-up study.

Lim JBT, Chong HC, Pang HN, Tay KJD, Chia SL, Lo NN, Yeo SJ.

Bone Joint J. 2017 Oct;99-B(10):1329-1334. doi: 10.1302/0301-620X.99B10.BJJ-2017-0034.R1.


Successful targeting of the NRG1 pathway indicates novel treatment strategy for metastatic cancer.

Jones MR, Lim H, Shen Y, Pleasance E, Ch'ng C, Reisle C, Leelakumari S, Zhao C, Yip S, Ho J, Zhong E, Ng T, Ionescu D, Schaeffer DF, Mungall AJ, Mungall KL, Zhao Y, Moore RA, Ma Y, Chia S, Ho C, Renouf DJ, Gelmon K, Jones SJM, Marra MA, Laskin J.

Ann Oncol. 2017 Dec 1;28(12):3092-3097. doi: 10.1093/annonc/mdx523.


No Difference in Functional Outcomes after Total Knee Arthroplasty with or without Pinless Navigation.

Zhu M, Chen JY, Chong HC, Pang HN, Tay DKJ, Chia SL, Lo NN, Yeo SJ.

J Knee Surg. 2017 Sep 8. doi: 10.1055/s-0037-1606375. [Epub ahead of print] No abstract available.


Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time.

Chia S, Low JL, Zhang X, Kwang XL, Chong FT, Sharma A, Bertrand D, Toh SY, Leong HS, Thangavelu MT, Hwang JSG, Lim KH, Skanthakumar T, Tan HK, Su Y, Hui Choo S, Hentze H, Tan IBH, Lezhava A, Tan P, Tan DSW, Periyasamy G, Koh JLY, Gopalakrishna Iyer N, DasGupta R.

Nat Commun. 2017 Sep 5;8(1):435. doi: 10.1038/s41467-017-00451-5.


Development of a Multiplexed Assay for Oral Cancer Candidate Biomarkers Using Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry.

Hsiao YC, Chi LM, Chien KY, Chiang WF, Chen SF, Chuang YN, Lin SY, Wu CC, Chang YT, Chu LJ, Chen YT, Chia SL, Chien CY, Chang KP, Chang YS, Yu JS.

Mol Cell Proteomics. 2017 Oct;16(10):1829-1849. doi: 10.1074/mcp.RA117.000147. Epub 2017 Aug 18.


Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators.

Bai Z, Chai XR, Yoon MJ, Kim HJ, Lo KA, Zhang ZC, Xu D, Siang DTC, Walet ACE, Xu SH, Chia SY, Chen P, Yang H, Ghosh S, Sun L.

PLoS Biol. 2017 Aug 1;15(8):e2002176. doi: 10.1371/journal.pbio.2002176. eCollection 2017 Aug.


Ectopic parathyroid adenoma in the pyriform sinus.

Kim J, Cubangbang M, Adkins L, Chia S, DeKlotz TR, Boyle L, Davidson B.

Head Neck. 2017 Oct;39(10):E110-E113. doi: 10.1002/hed.24878. Epub 2017 Jul 25.


Return to Work is an Important Therapeutic Goal.

See B, Chia SE, Chia KS.

Ann Acad Med Singapore. 2017 Jun;46(6):245-247. No abstract available.


Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.

Chia S, Flagmeier P, Habchi J, Lattanzi V, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8005-8010. doi: 10.1073/pnas.1700239114. Epub 2017 Jul 11.


Comfort and exertion while using filtering facepiece respirators with exhalation valve and an active venting system among male military personnel.

Seng M, Wee LE, Zhao X, Cook AR, Chia SE, Lee VJ.

Singapore Med J. 2017 Jul 6. doi: 10.11622/smedj.2017054. [Epub ahead of print]


Sequential versus concurrent chemotherapy for adjuvant breast cancer: does dose intensity matter?

LeVasseur N, Chia SK.

Br J Cancer. 2017 Jul 11;117(2):157-300. doi: 10.1038/bjc.2017.176. Epub 2017 Jun 22. No abstract available.


Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, phase 3 trial.

Baselga J, Im SA, Iwata H, Cortés J, De Laurentiis M, Jiang Z, Arteaga CL, Jonat W, Clemons M, Ito Y, Awada A, Chia S, Jagiełło-Gruszfeld A, Pistilli B, Tseng LM, Hurvitz S, Masuda N, Takahashi M, Vuylsteke P, Hachemi S, Dharan B, Di Tomaso E, Urban P, Massacesi C, Campone M.

Lancet Oncol. 2017 Jul;18(7):904-916. doi: 10.1016/S1470-2045(17)30376-5. Epub 2017 May 30.


The cost and cost trajectory of whole-genome analysis guiding treatment of patients with advanced cancers.

Weymann D, Laskin J, Roscoe R, Schrader KA, Chia S, Yip S, Cheung WY, Gelmon KA, Karsan A, Renouf DJ, Marra M, Regier DA.

Mol Genet Genomic Med. 2017 Mar 12;5(3):251-260. doi: 10.1002/mgg3.281. eCollection 2017 May.


A phase-I study of lapatinib in combination with foretinib, a c-MET, AXL and vascular endothelial growth factor receptor inhibitor, in human epidermal growth factor receptor 2 (HER-2)-positive metastatic breast cancer.

Chia SK, Ellard SL, Mates M, Welch S, Mihalcioiu C, Miller WH Jr, Gelmon K, Lohrisch C, Kumar V, Taylor S, Hagerman L, Goodwin R, Wang T, Sakashita S, Tsao MS, Eisenhauer E, Bradbury P.

Breast Cancer Res. 2017 May 2;19(1):54. doi: 10.1186/s13058-017-0836-3.


Long-Term Prognostic Value of Appropriate Myocardial Perfusion Imaging.

Koh AS, Lye WK, Chia SY, Salunat-Flores J, Sim LL, Keng FYJ, Tan RS, Chua TSJ.

Am J Cardiol. 2017 Jun 15;119(12):1957-1962. doi: 10.1016/j.amjcard.2017.03.026. Epub 2017 Mar 29.


Protecting microRNAs from RNase degradation with steric DNA nanostructures.

Qian H, Tay CY, Setyawati MI, Chia SL, Lee DS, Leong DT.

Chem Sci. 2017 Feb 1;8(2):1062-1067. doi: 10.1039/c6sc01829g. Epub 2016 Sep 14.


Externalised locking compression plate as an alternative to the unilateral external fixator: a biomechanical comparative study of axial and torsional stiffness.

Ang BFH, Chen JY, Yew AKS, Chua SK, Chou SM, Chia SL, Koh JSB, Howe TS.

Bone Joint Res. 2017 Apr;6(4):216-223. doi: 10.1302/2046-3758.64.2000470.


Energetic ultrafast fiber laser sources tunable in 1030-1215 nm for deep tissue multi-photon microscopy.

Liu W, Chia SH, Chung HY, Greinert R, Kärtner FX, Chang G.

Opt Express. 2017 Mar 20;25(6):6822-6831. doi: 10.1364/OE.25.006822.


Association Between Colorectal Cancer Mortality and Gradient Fecal Hemoglobin Concentration in Colonoscopy Noncompliers.

Lee YC, Li-Sheng Chen S, Ming-Fang Yen A, Yueh-Hsia Chiu S, Ching-Yuan Fann J, Chuang SL, Chiang TH, Chou CK, Chiu HM, Wu MS, Wu CY, Chia SL, Chiou ST, Chen HH.

J Natl Cancer Inst. 2017 May 1;109(5). doi: 10.1093/jnci/djw269.


Does obesity influence early outcome of fixed-bearing unicompartmental knee arthroplasty?

Woo YL, Chen YQ, Lai MC, Tay KJ, Chia SL, Lo NN, Yeo SJ.

J Orthop Surg (Hong Kong). 2017 Jan 1;25(1):2309499016684297. doi: 10.1177/2309499016684297.


Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators.

Dyer A, Di Y, Calderon H, Illingworth S, Kueberuwa G, Tedcastle A, Jakeman P, Chia SL, Brown A, Silva MA, Barlow D, Beadle J, Hermiston T, Ferguson DJ, Champion B, Fisher KD, Seymour LW.

Mol Ther Oncolytics. 2016 Dec 10;4:18-30. doi: 10.1016/j.omto.2016.11.003. eCollection 2017 Mar 17.


Candidemia in a major regional tertiary referral hospital - epidemiology, practice patterns and outcomes.

Teo JQ, Candra SR, Lee SJ, Chia SY, Leck H, Tan AL, Neo HP, Leow KW, Cai Y, Ee RP, Lim TP, Lee W, Kwa AL.

Antimicrob Resist Infect Control. 2017 Mar 11;6:27. doi: 10.1186/s13756-017-0184-1. eCollection 2017.


Group B adenovirus enadenotucirev infects polarised colorectal cancer cells efficiently from the basolateral surface expected to be encountered during intravenous delivery to treat disseminated cancer.

Chia SL, Lei J, Ferguson DJP, Dyer A, Fisher KD, Seymour LW.

Virology. 2017 May;505:162-171. doi: 10.1016/j.virol.2017.02.011. Epub 2017 Mar 3.


Reply to letter to the editor on "Intravenous versus intra-articular tranexamic acid in total knee arthroplasty: A double-blinded randomised controlled noninferiority trial".

Chen JY, Chin PL, Moo IH, Pang HN, Tay DKJ, Chia SL, Lo NN, Yeo SJ.

Knee. 2017 Jun;24(3):700-701. doi: 10.1016/j.knee.2016.07.006. Epub 2017 Feb 16. No abstract available.


HOXC10 suppresses browning of white adipose tissues.

Ng Y, Tan SX, Chia SY, Tan HY, Gun SY, Sun L, Hong W, Han W.

Exp Mol Med. 2017 Feb 10;49(2):e292. doi: 10.1038/emm.2016.144.


Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial.

Shi W, Jiang T, Nuciforo P, Hatzis C, Holmes E, Harbeck N, Sotiriou C, Peña L, Loi S, Rosa DD, Chia S, Wardley A, Ueno T, Rossari J, Eidtmann H, Armour A, Piccart-Gebhart M, Rimm DL, Baselga J, Pusztai L.

Ann Oncol. 2017 Jan 1;28(1):128-135. doi: 10.1093/annonc/mdw434.


The accuracy of a hand-held navigation system in total knee arthroplasty.

Loh B, Chen JY, Yew AK, Pang HN, Tay DK, Chia SL, Lo NN, Yeo SJ.

Arch Orthop Trauma Surg. 2017 Mar;137(3):381-386. doi: 10.1007/s00402-016-2612-8. Epub 2017 Jan 24.


Clinical outcomes of computer-assisted total knee arthroplasty using pinless navigation.

Jiang L, Chen JY, Chong HC, Chia SL, Lo NN, Yeo SJ.

J Orthop Surg (Hong Kong). 2017 Jan;25(1):2309499016684319. doi: 10.1177/2309499016684319.


Phase I Study of ONT-380, a HER2 Inhibitor, in Patients with HER2+-Advanced Solid Tumors, with an Expansion Cohort in HER2+ Metastatic Breast Cancer (MBC).

Moulder SL, Borges VF, Baetz T, Mcspadden T, Fernetich G, Murthy RK, Chavira R, Guthrie K, Barrett E, Chia SK.

Clin Cancer Res. 2017 Jul 15;23(14):3529-3536. doi: 10.1158/1078-0432.CCR-16-1496. Epub 2017 Jan 4.


Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.

Habchi J, Chia S, Limbocker R, Mannini B, Ahn M, Perni M, Hansson O, Arosio P, Kumita JR, Challa PK, Cohen SI, Linse S, Dobson CM, Knowles TP, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E200-E208. doi: 10.1073/pnas.1615613114. Epub 2016 Dec 23.

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