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Items: 19


Activation of the receptor tyrosine kinase AXL regulates the immune microenvironment in glioblastoma.

Sadahiro H, Kang KD, Gibson JT, Minata M, Yu H, Shi J, Chhipa RR, Chen Z, Lu S, Simoni Y, Furuta T, Sabit H, Zhang S, Bastola S, Yamaguchi S, Alsheikh HA, Komarova S, Wang J, Kim SH, Hambardzumyan D, Lu X, Newell EW, Dasgupta B, Nakada M, Lee LJ, Nabors LB, Norian LA, Nakano I.

Cancer Res. 2018 Mar 12. pii: canres.2433.2017. doi: 10.1158/0008-5472.CAN-17-2433. [Epub ahead of print]


Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway.

Kumari R, Chouhan S, Singh S, Chhipa RR, Ajay AK, Bhat MK.

J Biosci. 2017 Mar;42(1):31-41.


FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells.

Cheng P, Wang J, Waghmare I, Sartini S, Coviello V, Zhang Z, Kim SH, Mohyeldin A, Pavlyukov MS, Minata M, Valentim CL, Chhipa RR, Bhat KP, Dasgupta B, La Motta C, Kango-Singh M, Nakano I.

Cancer Res. 2016 Dec 15;76(24):7219-7230. Epub 2016 Aug 28.


Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer.

Dasgupta B, Chhipa RR.

Trends Pharmacol Sci. 2016 Mar;37(3):192-206. doi: 10.1016/ Epub 2015 Dec 20. Review.


Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.

Liu X, Chhipa RR, Pooya S, Wortman M, Yachyshin S, Chow LM, Kumar A, Zhou X, Sun Y, Quinn B, McPherson C, Warnick RE, Kendler A, Giri S, Poels J, Norga K, Viollet B, Grabowski GA, Dasgupta B.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E435-44. doi: 10.1073/pnas.1311121111. Epub 2014 Jan 13.


The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agent.

Liu X, Chhipa RR, Nakano I, Dasgupta B.

Mol Cancer Ther. 2014 Mar;13(3):596-605. doi: 10.1158/1535-7163.MCT-13-0579. Epub 2014 Jan 13.


Direct inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth.

Karkare S, Chhipa RR, Anderson J, Liu X, Henry H, Gasilina A, Nassar N, Ghosh J, Clark JP, Kumar A, Pauletti GM, Ghosh PK, Dasgupta B.

Clin Cancer Res. 2014 Jan 1;20(1):199-212. doi: 10.1158/1078-0432.CCR-13-0762. Epub 2013 Oct 29.


The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific.

Chhipa RR, Halim D, Cheng J, Zhang HY, Mohler JL, Ip C, Wu Y.

Prostate. 2013 Oct;73(14):1483-94. doi: 10.1002/pros.22696. Epub 2013 Jun 28.


AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia.

Chhipa RR, Wu Y, Ip C.

Cell Signal. 2011 Sep;23(9):1466-72. doi: 10.1016/j.cellsig.2011.04.008. Epub 2011 Apr 28.


The antiandrogenic effect of finasteride against a mutant androgen receptor.

Wu Y, Chhipa RR, Zhang H, Ip C.

Cancer Biol Ther. 2011 May 15;11(10):902-9. Epub 2011 May 15.


Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival.

Wu Y, Chhipa RR, Cheng J, Zhang H, Mohler JL, Ip C.

Anticancer Res. 2010 Oct;30(10):3895-901.


Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress.

Chhipa RR, Wu Y, Mohler JL, Ip C.

Cell Signal. 2010 Oct;22(10):1554-61. doi: 10.1016/j.cellsig.2010.05.024. Epub 2010 Jun 4.


Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosterone.

Chhipa RR, Lee KS, Onate S, Wu Y, Ip C.

Mol Cancer Res. 2009 Sep;7(9):1543-52. doi: 10.1158/1541-7786.MCR-08-0546. Epub 2009 Sep 8.


Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation.

Chhipa RR, Kumari R, Upadhyay AK, Bhat MK.

Exp Cell Res. 2007 Nov 15;313(19):3945-58. Epub 2007 Sep 4.


Methyl-beta-cyclodextrin enhances the susceptibility of human breast cancer cells to carboplatin and 5-fluorouracil: involvement of Akt, NF-kappaB and Bcl-2.

Upadhyay AK, Singh S, Chhipa RR, Vijayakumar MV, Ajay AK, Bhat MK.

Toxicol Appl Pharmacol. 2006 Oct 15;216(2):177-85. Epub 2006 May 19.


DNA damaging drugs-induced down-regulation of Bcl-2 is essential for induction of apoptosis in high-risk HPV-positive HEp-2 and KB cells.

Singh S, Chhipa RR, Vijayakumar MV, Bhat MK.

Cancer Lett. 2006 May 18;236(2):213-21. Epub 2005 Jul 5.


Doxycycline potentiates antitumor effect of cyclophosphamide in mice.

Chhipa RR, Singh S, Surve SV, Vijayakumar MV, Bhat MK.

Toxicol Appl Pharmacol. 2005 Feb 1;202(3):268-77.


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