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Items: 12

1.

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms.

Wolach O, Sellar RS, Martinod K, Cherpokova D, McConkey M, Chappell RJ, Silver AJ, Adams D, Castellano CA, Schneider RK, Padera RF, DeAngelo DJ, Wadleigh M, Steensma DP, Galinsky I, Stone RM, Genovese G, McCarroll SA, Iliadou B, Hultman C, Neuberg D, Mullally A, Wagner DD, Ebert BL.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan8292. doi: 10.1126/scitranslmed.aan8292.

PMID:
29643232
2.

GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice.

Gupta S, Cherpokova D, Spindler M, Morowski M, Bender M, Nieswandt B.

Blood. 2018 Mar 8;131(10):1106-1110. doi: 10.1182/blood-2017-08-800136. Epub 2018 Jan 2.

PMID:
29295843
3.

Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.

Hayashi H, Cherpokova D, Martinod K, Witsch T, Wong SL, Gallant M, Cifuni SM, Guarente LP, Wagner DD.

PLoS One. 2017 Dec 13;12(12):e0188341. doi: 10.1371/journal.pone.0188341. eCollection 2017.

4.

CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice.

Haining EJ, Cherpokova D, Wolf K, Becker IC, Beck S, Eble JA, Stegner D, Watson SP, Nieswandt B.

Blood. 2017 Nov 16;130(20):2224-2228. doi: 10.1182/blood-2017-03-771907. Epub 2017 Aug 23.

PMID:
28835437
5.

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B.

Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838.

6.

Peptidylarginine deiminase 4 promotes age-related organ fibrosis.

Martinod K, Witsch T, Erpenbeck L, Savchenko A, Hayashi H, Cherpokova D, Gallant M, Mauler M, Cifuni SM, Wagner DD.

J Exp Med. 2017 Feb;214(2):439-458. doi: 10.1084/jem.20160530. Epub 2016 Dec 28.

7.

Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice.

Devanathan V, Hagedorn I, Köhler D, Pexa K, Cherpokova D, Kraft P, Singh M, Rosenberger P, Stoll G, Birnbaumer L, Piekorz RP, Beer-Hammer S, Nieswandt B, Nürnberg B.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):6491-6. doi: 10.1073/pnas.1505887112. Epub 2015 May 5.

8.

Targeting platelet receptors in thrombotic and thrombo-inflammatory disorders.

Vögtle T, Cherpokova D, Bender M, Nieswandt B.

Hamostaseologie. 2015;35(3):235-43. doi: 10.5482/HAMO-14-10-0049. Epub 2015 Jan 29. Review.

PMID:
25634564
9.

Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets.

Dütting S, Heidenreich J, Cherpokova D, Amin E, Zhang SC, Ahmadian MR, Brakebusch C, Nieswandt B.

J Thromb Haemost. 2015 May;13(5):827-38. doi: 10.1111/jth.12861. Epub 2015 Feb 23.

10.

SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.

Cherpokova D, Bender M, Morowski M, Kraft P, Schuhmann MK, Akbar SM, Sultan CS, Hughes CE, Kleinschnitz C, Stoll G, Dragone LL, Watson SP, Tomlinson MG, Nieswandt B.

Blood. 2015 Jan 1;125(1):185-94. doi: 10.1182/blood-2014-06-580597. Epub 2014 Oct 9.

11.

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.

Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G, Stegner D, Nieswandt B.

J Clin Invest. 2013 Jul 1. pii: 69210. doi: 10.1172/JCI69210. [Epub ahead of print]

12.

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.

Pleines I, Dütting S, Cherpokova D, Eckly A, Meyer I, Morowski M, Krohne G, Schulze H, Gachet C, Debili N, Brakebusch C, Nieswandt B.

Blood. 2013 Oct 31;122(18):3178-87. doi: 10.1182/blood-2013-03-487942. Epub 2013 Jul 16.

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