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Bufalin suppresses hepatocarcinogenesis by targeting β-catenin/TCF signaling via cell cycle-related kinase.

Yu Z, Feng H, Sun X, Zhuo Y, Li M, Zhou Z, Huang L, Jiang Y, Zhu X, Zhang X, Le F, Zheng C, Cheng AS, Gao Y.

Sci Rep. 2018 Mar 1;8(1):3891. doi: 10.1038/s41598-018-22113-2.


Breast Cancer Survivors Report Similar Concerns Related to Return to Work in Developed and Developing Nations.

Luo SX, Liu JE, Cheng ASK, Xiao SQ, Su YL, Feuerstein M.

J Occup Rehabil. 2018 Feb 14. doi: 10.1007/s10926-018-9762-1. [Epub ahead of print]


Bartholin Gland Carcinoma: Clinicopathologic Features, Including p16 Expression and Clinical Outcome.

Nazeran T, Cheng AS, Karnezis AN, Tinker AV, Gilks CB.

Int J Gynecol Pathol. 2018 Feb 5. doi: 10.1097/PGP.0000000000000489. [Epub ahead of print]


miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis.

Kang W, Huang T, Zhou Y, Zhang J, Lung RWM, Tong JHM, Chan AWH, Zhang B, Wong CC, Wu F, Dong Y, Wang S, Yang W, Pan Y, Chak WP, Cheung AHK, Pang JCS, Yu J, Cheng ASL, To KF.

Cell Death Dis. 2018 Jan 24;9(2):92. doi: 10.1038/s41419-017-0134-0.


CCRK is a novel signalling hub exploitable in cancer immunotherapy.

Mok MT, Zhou J, Tang W, Zeng X, Oliver AW, Ward SE, Cheng AS.

Pharmacol Ther. 2018 Mar 1. pii: S0163-7258(18)30015-9. doi: 10.1016/j.pharmthera.2018.01.008. [Epub ahead of print] Review.


Diagnostic and prognostic utility of cardiovascular magnetic resonance imaging in heart failure with preserved ejection fraction - implications for clinical trials.

Kanagala P, Cheng ASH, Singh A, McAdam J, Marsh AM, Arnold JR, Squire IB, Ng LL, McCann GP.

J Cardiovasc Magn Reson. 2018 Jan 11;20(1):4. doi: 10.1186/s12968-017-0424-9.


Cumulative IT Use Is Associated with Psychosocial Stress Factors and Musculoskeletal Symptoms.

So BCL, Cheng ASK, Szeto GPY.

Int J Environ Res Public Health. 2017 Dec 8;14(12). pii: E1541. doi: 10.3390/ijerph14121541.


SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis.

Huang T, Zhou Y, Zhang J, Wong CC, Li W, Kwan JSH, Yang R, Chan AKY, Dong Y, Wu F, Zhang B, Cheung AHK, Wu WKK, Cheng ASL, Yu J, Wong N, Kang W, To KF.

Oncogene. 2018 Mar;37(9):1159-1174. doi: 10.1038/s41388-017-0029-7. Epub 2017 Dec 13.


Subjective cognitive impairment and brain structural networks in Chinese gynaecological cancer survivors compared with age-matched controls: a cross-sectional study.

Zeng Y, Cheng ASK, Song T, Sheng X, Zhang Y, Liu X, Chan CCH.

BMC Cancer. 2017 Nov 28;17(1):796. doi: 10.1186/s12885-017-3793-4.


The oncogenic role of Epstein-Barr virus-encoded microRNAs in Epstein-Barr virus-associated gastric carcinoma.

Zhang J, Huang T, Zhou Y, Cheng ASL, Yu J, To KF, Kang W.

J Cell Mol Med. 2018 Jan;22(1):38-45. doi: 10.1111/jcmm.13354. Epub 2017 Oct 9. Review.


Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.

Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS.

Gut. 2017 Sep 22. pii: gutjnl-2017-314032. doi: 10.1136/gutjnl-2017-314032. [Epub ahead of print]


START: a system for flexible analysis of hundreds of genomic signal tracks in few lines of SQL-like queries.

Zhu X, Zhang Q, Ho ED, Yu KH, Liu C, Huang TH, Cheng AS, Kao B, Lo E, Yip KY.

BMC Genomics. 2017 Sep 22;18(1):749. doi: 10.1186/s12864-017-4071-1.


Reconstruction of enhancer-target networks in 935 samples of human primary cells, tissues and cell lines.

Cao Q, Anyansi C, Hu X, Xu L, Xiong L, Tang W, Mok MTS, Cheng C, Fan X, Gerstein M, Cheng ASL, Yip KY.

Nat Genet. 2017 Oct;49(10):1428-1436. doi: 10.1038/ng.3950. Epub 2017 Sep 4.


The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma.

Zhang B, Zhang Y, Zou X, Chan AW, Zhang R, Lee TK, Liu H, Lau EY, Ho NP, Lai PB, Cheung YS, To KF, Wong HK, Choy KW, Keng VW, Chow LM, Chan KK, Cheng AS, Ko BC.

J Pathol. 2017 Dec;243(4):418-430. doi: 10.1002/path.4976. Epub 2017 Oct 27.


TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis.

Zhou Y, Huang T, Zhang J, Wong CC, Zhang B, Dong Y, Wu F, Tong JHM, Wu WKK, Cheng ASL, Yu J, Kang W, To KF.

Oncogene. 2017 Nov 23;36(47):6518-6530. doi: 10.1038/onc.2017.257. Epub 2017 Jul 31.


Clear cell and endometrioid carcinomas: are their differences attributable to distinct cells of origin?

Cochrane DR, Tessier-Cloutier B, Lawrence KM, Nazeran T, Karnezis AN, Salamanca C, Cheng AS, McAlpine JN, Hoang LN, Gilks CB, Huntsman DG.

J Pathol. 2017 Sep;243(1):26-36. doi: 10.1002/path.4934. Epub 2017 Aug 7.


Title: Cervical cancer survivors' perceived cognitive complaints and supportive care needs in mainland China: a qualitative study.

Zeng Y, Cheng AS, Liu X, Chan CC.

BMJ Open. 2017 Jun 22;7(6):e014078. doi: 10.1136/bmjopen-2016-014078.


Return on investment from fuel treatments to reduce severe wildfire and erosion in a watershed investment program in Colorado.

Jones KW, Cannon JB, Saavedra FA, Kampf SK, Addington RN, Cheng AS, MacDonald LH, Wilson C, Wolk B.

J Environ Manage. 2017 Aug 1;198(Pt 2):66-77. doi: 10.1016/j.jenvman.2017.05.023. Epub 2017 May 11.


IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis.

Zhou Y, Huang T, Siu HL, Wong CC, Dong Y, Wu F, Zhang B, Wu WK, Cheng AS, Yu J, To KF, Kang W.

Mol Cancer. 2017 Apr 11;16(1):77. doi: 10.1186/s12943-017-0647-2.


The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP-PKA-EGFR-STAT3 axis.

Zhou M, Mok MT, Sun H, Chan AW, Huang Y, Cheng AS, Xu G.

Oncogene. 2017 Jul 20;36(29):4135-4149. doi: 10.1038/onc.2017.38. Epub 2017 Mar 20.


The Interplay of LncRNA-H19 and Its Binding Partners in Physiological Process and Gastric Carcinogenesis.

Zhang L, Zhou Y, Huang T, Cheng AS, Yu J, Kang W, To KF.

Int J Mol Sci. 2017 Feb 20;18(2). pii: E450. doi: 10.3390/ijms18020450. Review.


Oncogenes without a Neighboring Tumor-Suppressor Gene Are More Prone to Amplification.

Wu WK, Li X, Wang X, Dai RZ, Cheng AS, Wang MH, Kwong T, Chow TC, Yu J, Chan MT, Wong SH.

Mol Biol Evol. 2017 Apr 1;34(4):903-907. doi: 10.1093/molbev/msw295.


NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?

Huang T, Zhou Y, Cheng AS, Yu J, To KF, Kang W.

Mol Cancer. 2016 Dec 9;15(1):80. Review.


Derivation of Patient Specific Pluripotent Stem Cells Using Clinically Discarded Cumulus Cells.

Chang WF, Hwu YM, Xu J, Lin CJ, Wang SW, Cheng AS, Lu J, Lu CH, Sung LY.

PLoS One. 2016 Nov 1;11(11):e0165715. doi: 10.1371/journal.pone.0165715. eCollection 2016.


Understanding the epigenetic regulation of tumours and their microenvironments: opportunities and problems for epigenetic therapy.

Liu M, Zhou J, Chen Z, Cheng AS.

J Pathol. 2017 Jan;241(1):10-24. doi: 10.1002/path.4832. Epub 2016 Nov 29. Review.


High resolution mapping of development in the wildland-urban interface using object based image extraction.

Caggiano MD, Tinkham WT, Hoffman C, Cheng AS, Hawbaker TJ.

Heliyon. 2016 Oct 6;2(10):e00174. eCollection 2016 Oct.


Gender Differences in Adipocyte Metabolism and Liver Cancer Progression.

Cheung OK, Cheng AS.

Front Genet. 2016 Sep 20;7:168. eCollection 2016. Review.


EZH2 coupled with HOTAIR to silence MicroRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma.

Li CH, Xiao Z, Tong JH, To KF, Fang X, Cheng AS, Chen Y.

Int J Cancer. 2017 Jan 1;140(1):120-129. doi: 10.1002/ijc.30414. Epub 2016 Sep 19.


Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis.

Tian Y, Mok MT, Yang P, Cheng AS.

Cancers (Basel). 2016 Aug 20;8(8). pii: E76. doi: 10.3390/cancers8080076. Review.


Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer.

Yeh CM, Chang LY, Lin SH, Chou JL, Hsieh HY, Zeng LH, Chuang SY, Wang HW, Dittner C, Lin CY, Lin JM, Huang YT, Ng EK, Cheng AS, Wu SF, Lin J, Yeh KT, Chan MW.

Sci Rep. 2016 Aug 16;6:31690. doi: 10.1038/srep31690.


Production of Live Offspring from Vitrified-Warmed Oocytes Collected at Metaphase I Stage.

Chang CC, Chang WF, Xu J, Cheng AS, Chang CC, Nagy ZP, Yang CC, Ding ST, Sung LY.

PLoS One. 2016 Jun 22;11(6):e0157785. doi: 10.1371/journal.pone.0157785. eCollection 2016.


Cognitive Limitations at Work Among Employed Breast Cancer Survivors in China.

Zeng Y, Cheng ASK, Feuerstein M.

Rehabil Nurs. 2017 Nov/Dec;42(6):347-353. doi: 10.1002/rnj.279.


Combinatorial epigenetic deregulation by Helicobacter pylori and Epstein-Barr virus infections in gastric tumourigenesis.

Wu WK, Yu J, Chan MT, To KF, Cheng AS.

J Pathol. 2016 Jul;239(3):245-9. doi: 10.1002/path.4731. Epub 2016 May 20.


A novel role of hepatic epithelial transforming growth factor-β signaling in cholangiocarcinogenesis.

Liu M, Mok MT, Cheng AS.

Ann Transl Med. 2016 Mar;4(5):101. doi: 10.21037/atm.2016.03.01. No abstract available.


C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties.

Ng KY, Chai S, Tong M, Guan XY, Lin CH, Ching YP, Xie D, Cheng AS, Ma S.

Oncotarget. 2016 Apr 26;7(17):24005-17. doi: 10.18632/oncotarget.8209.


Emerging role of Hippo pathway in gastric and other gastrointestinal cancers.

Kang W, Cheng AS, Yu J, To KF.

World J Gastroenterol. 2016 Jan 21;22(3):1279-88. doi: 10.3748/wjg.v22.i3.1279. Review.


The TEAD Family and Its Oncogenic Role in Promoting Tumorigenesis.

Zhou Y, Huang T, Cheng AS, Yu J, Kang W, To KF.

Int J Mol Sci. 2016 Jan 21;17(1). pii: E138. doi: 10.3390/ijms17010138. Review.


Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis Through Transcriptional Repression of Interleukin-10.

Bai AH, Wu WK, Xu L, Wong SH, Go MY, Chan AW, Harbord M, Zhang S, Chen M, Wu JC, Chan MW, Chan MT, Chan FK, Sung JJ, Yu J, Cheng AS, Ng SC.

J Crohns Colitis. 2016 Jun;10(6):726-34. doi: 10.1093/ecco-jcc/jjw020. Epub 2016 Jan 22.


miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis.

Huang T, Kang W, Zhang B, Wu F, Dong Y, Tong JH, Yang W, Zhou Y, Zhang L, Cheng AS, Yu J, To KF.

Mol Cancer. 2016 Jan 22;15:9. doi: 10.1186/s12943-016-0493-7.


Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma.

Tsang DP, Wu WK, Kang W, Lee YY, Wu F, Yu Z, Xiong L, Chan AW, Tong JH, Yang W, Li MS, Lau SS, Li X, Lee SD, Yang Y, Lai PB, Yu DY, Xu G, Lo KW, Chan MT, Wang H, Lee TL, Yu J, Wong N, Yip KY, To KF, Cheng AS.

J Pathol. 2016 Apr;238(5):651-64. doi: 10.1002/path.4688.


Impulsivity and risky decision making among taxi drivers in Hong Kong: An event-related potential study.

Cheng ASK, Ting KH, Liu KPY, Ba Y.

Accid Anal Prev. 2016 Oct;95(Pt B):387-394. doi: 10.1016/j.aap.2015.12.021. Epub 2015 Dec 31.


The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers.

Huang T, Kang W, Cheng AS, Yu J, To KF.

BMC Cancer. 2015 Dec 16;15:950. doi: 10.1186/s12885-015-1984-4. Review.


p16 Immunostaining Allows for Accurate Subclassification of Vulvar Squamous Cell Carcinoma Into HPV-Associated and HPV-Independent Cases.

Cheng AS, Karnezis AN, Jordan S, Singh N, McAlpine JN, Gilks CB.

Int J Gynecol Pathol. 2016 Jul;35(4):385-93. doi: 10.1097/PGP.0000000000000263.


Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer.

Yu J, Feng Q, Wong SH, Zhang D, Liang QY, Qin Y, Tang L, Zhao H, Stenvang J, Li Y, Wang X, Xu X, Chen N, Wu WK, Al-Aama J, Nielsen HJ, Kiilerich P, Jensen BA, Yau TO, Lan Z, Jia H, Li J, Xiao L, Lam TY, Ng SC, Cheng AS, Wong VW, Chan FK, Xu X, Yang H, Madsen L, Datz C, Tilg H, Wang J, Brünner N, Kristiansen K, Arumugam M, Sung JJ, Wang J.

Gut. 2017 Jan;66(1):70-78. doi: 10.1136/gutjnl-2015-309800. Epub 2015 Sep 25.


Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma.

Tian Y, Wong VW, Wong GL, Yang W, Sun H, Shen J, Tong JH, Go MY, Cheung YS, Lai PB, Zhou M, Xu G, Huang TH, Yu J, To KF, Cheng AS, Chan HL.

Cancer Res. 2015 Nov 15;75(22):4803-16. doi: 10.1158/0008-5472.CAN-14-3786. Epub 2015 Sep 17.


Assessments of risky driving: a Go/No-Go simulator driving task to evaluate risky decision-making and associated behavioral patterns.

Ba Y, Zhang W, Salvendy G, Cheng AS, Ventsislavova P.

Appl Ergon. 2016 Jan;52:265-74. doi: 10.1016/j.apergo.2015.07.020. Epub 2015 Aug 14.


Advancing the strategic use of HIV operations research to strengthen local policies and programmes: the Research to Prevention Project.

Kerrigan D, Kennedy CE, Cheng AS, Sandison SJ, Fonner VA, Holtgrave DR, Brahmbhatt H.

J Int AIDS Soc. 2015 Aug 18;18:20029. doi: 10.7448/IAS.18.1.20029. eCollection 2015.


Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development.

Yang W, Mok MT, Li MS, Kang W, Wang H, Chan AW, Chou JL, Chen J, Ng EK, To KF, Yu J, Chan MW, Chan FK, Sung JJ, Cheng AS.

Oncogene. 2016 Apr 21;35(16):2133-44. doi: 10.1038/onc.2015.276. Epub 2015 Jul 27.


Correction: FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells.

Ren SX, Shen J, Cheng AS, Lu L, Chan RL, Li ZJ, Wang XJ, Wong CC, Zhang L, Ng SS, Chan FL, Chan FK, Yu J, Sung JJ, Wu WK, Cho CH.

PLoS One. 2015 Jun 25;10(6):e0131750. doi: 10.1371/journal.pone.0131750. eCollection 2015. No abstract available.

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