Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 197

1.

Metabolic Imaging of the Human Brain with Hyperpolarized 13C Pyruvate Demonstrates 13C Lactate Production in Brain Tumor Patients.

Miloushev VZ, Granlund KL, Boltyanskiy R, Lyashchenko SK, DeAngelis LM, Mellinghoff IK, Brennan CW, Tabar V, Yang TJ, Holodny AI, Sosa RE, Guo YW, Chen AP, Tropp J, Robb F, Keshari KR.

Cancer Res. 2018 May 16. pii: canres.0221.2018. doi: 10.1158/0008-5472.CAN-18-0221. [Epub ahead of print]

PMID:
29769199
2.

In vivo hyperpolarization transfer in a clinical MRI scanner.

von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME.

Magn Reson Med. 2018 Aug;80(2):480-487. doi: 10.1002/mrm.27154. Epub 2018 Feb 27.

PMID:
29488244
3.

Simultaneous multislice acquisition without trajectory modification for hyperpolarized 13 C experiments.

Lau AZ, Lau JYC, Chen AP, Cunningham CH.

Magn Reson Med. 2018 Feb 9. doi: 10.1002/mrm.27136. [Epub ahead of print]

PMID:
29427366
4.

Improved tolerance to off-resonance in spectral-spatial EPI of hyperpolarized [1-13 C]pyruvate and metabolites.

Lau JYC, Geraghty BJ, Chen AP, Cunningham CH.

Magn Reson Med. 2018 Jan 29. doi: 10.1002/mrm.27086. [Epub ahead of print]

PMID:
29380423
5.

Phase 1 trial evaluating cisplatin, gemcitabine, and veliparib in 2 patient cohorts: Germline BRCA mutation carriers and wild-type BRCA pancreatic ductal adenocarcinoma.

O'Reilly EM, Lee JW, Lowery MA, Capanu M, Stadler ZK, Moore MJ, Dhani N, Kindler HL, Estrella H, Maynard H, Golan T, Segal A, Salo-Mullen EE, Yu KH, Epstein AS, Segal M, Brenner R, Do RK, Chen AP, Tang LH, Kelsen DP.

Cancer. 2018 Apr 1;124(7):1374-1382. doi: 10.1002/cncr.31218. Epub 2018 Jan 16.

PMID:
29338080
6.

Magnetization Reversal Modes in Short Nanotubes with Chiral Vortex Domain Walls.

Chen AP, Gonzalez J, Guslienko K.

Materials (Basel). 2018 Jan 10;11(1). pii: E101. doi: 10.3390/ma11010101.

7.

Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway.

Chen X, Wang S, Zhou Y, Han Y, Li S, Xu Q, Xu L, Zhu Z, Deng Y, Yu L, Song L, Chen AP, Song J, Takahashi E, He G, He L, Li W, Chen CD.

Nat Commun. 2018 Jan 9;9(1):114. doi: 10.1038/s41467-017-02531-y.

8.

Clinical outcome and long-term survival of 150 consecutive patients with pancreatic neuroendocrine tumors: A comprehensive analysis by the World Health Organization 2010 grading classification.

Deng BY, Liu F, Yin SN, Chen AP, Xu L, Li B.

Clin Res Hepatol Gastroenterol. 2018 Jan 4. pii: S2210-7401(17)30213-9. doi: 10.1016/j.clinre.2017.09.004. [Epub ahead of print]

PMID:
29307515
9.

Phase II trial of veliparib in patients with previously treated BRCA-mutated pancreas ductal adenocarcinoma.

Lowery MA, Kelsen DP, Capanu M, Smith SC, Lee JW, Stadler ZK, Moore MJ, Kindler HL, Golan T, Segal A, Maynard H, Hollywood E, Moynahan M, Salo-Mullen EE, Do RKG, Chen AP, Yu KH, Tang LH, O'Reilly EM.

Eur J Cancer. 2018 Jan;89:19-26. doi: 10.1016/j.ejca.2017.11.004. Epub 2017 Dec 8.

PMID:
29223478
10.

Sensitivity enhancement for detection of hyperpolarized 13 C MRI probes with 1 H spin coupling introduced by enzymatic transformation in vivo.

von Morze C, Tropp J, Chen AP, Marco-Rius I, Van Criekinge M, Skloss TW, Mammoli D, Kurhanewicz J, Vigneron DB, Ohliger MA, Merritt ME.

Magn Reson Med. 2018 Jul;80(1):36-41. doi: 10.1002/mrm.27000. Epub 2017 Nov 28.

PMID:
29193287
11.

Hidradenitis Suppurativa-Like Lesions Associated with Pharmacologic Inhibition of Gamma-Secretase.

O'Sullivan Coyne G, Woodring TS, Lee CR, Chen AP, Kong HH.

J Invest Dermatol. 2018 Apr;138(4):979-981. doi: 10.1016/j.jid.2017.09.051. Epub 2017 Nov 11. No abstract available.

PMID:
29138057
12.

Probing the cardiac malate-aspartate shuttle non-invasively using hyperpolarized [1,2-13 C2 ]pyruvate.

Chen AP, Lau AZ, Gu YP, Schroeder MA, Barry J, Cunningham CH.

NMR Biomed. 2018 Jan;31(1). doi: 10.1002/nbm.3845. Epub 2017 Nov 6.

PMID:
29106770
13.

First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile.

Speranza G, Anderson L, Chen AP, Do K, Eugeni M, Weil M, Rubinstein L, Majerova E, Collins J, Horneffer Y, Juwara L, Zlott J, Bishop R, Conley BA, Streicher H, Tomaszewski J, Doroshow JH, Kummar S.

Invest New Drugs. 2018 Apr;36(2):230-239. doi: 10.1007/s10637-017-0495-3. Epub 2017 Aug 12.

PMID:
28808818
14.

Epitaxial thin films of pyrochlore iridate Bi2+xIr2-yO7-δ: structure, defects and transport properties.

Yang WC, Xie YT, Zhu WK, Park K, Chen AP, Losovyj Y, Li Z, Liu HM, Starr M, Acosta JA, Tao CG, Li N, Jia QX, Heremans JJ, Zhang SX.

Sci Rep. 2017 Aug 10;7(1):7740. doi: 10.1038/s41598-017-06785-w.

15.

Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds.

Li TT, Lou CW, Chen AP, Lee MC, Ho TF, Chen YS, Lin JH.

Materials (Basel). 2016 Sep 21;9(9). pii: E793. doi: 10.3390/ma9090793.

16.

T1 nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13 C.

Martínez-Santiesteban FM, Dang TP, Lim H, Chen AP, Scholl TJ.

NMR Biomed. 2017 Sep;30(9). doi: 10.1002/nbm.3749. Epub 2017 Jun 27.

PMID:
28653507
17.

Black Tungsten Nitride as a Metallic Photocatalyst for Overall Water Splitting Operable at up to 765 nm.

Wang YL, Nie T, Li YH, Wang XL, Zheng LR, Chen AP, Gong XQ, Yang HG.

Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7430-7434. doi: 10.1002/anie.201702943. Epub 2017 May 30.

PMID:
28544453
18.

Plasmon-enhanced Raman spectroscopic metrics for in situ quantitative and dynamic assays of cell apoptosis and necrosis.

Kang B, Li SS, Guan QY, Chen AP, Zhang PK, Zhang LB, Wei JW, Xu JJ, Chen HY.

Chem Sci. 2017 Feb 1;8(2):1243-1250. doi: 10.1039/c6sc02486f. Epub 2016 Oct 3.

19.

Dual-Echo EPI sequence for integrated distortion correction in 3D time-resolved hyperpolarized 13 C MRI.

Geraghty BJ, Lau JYC, Chen AP, Cunningham CH.

Magn Reson Med. 2018 Feb;79(2):643-653. doi: 10.1002/mrm.26698. Epub 2017 Apr 10.

PMID:
28394085
20.

Defining precision: The precision medicine initiative trials NCI-MPACT and NCI-MATCH.

Coyne GO, Takebe N, Chen AP.

Curr Probl Cancer. 2017 May - Jun;41(3):182-193. doi: 10.1016/j.currproblcancer.2017.02.001. Epub 2017 Feb 11.

PMID:
28372823
21.

Subcellular-Scale Drug Transport via Ultrasound-Degradable Mesoporous Nanosilicon to Bypass Cancer Drug Resistance.

Kang B, Zheng MB, Song P, Chen AP, Wei JW, Xu JJ, Shi Y, Chen HY.

Small. 2017 May;13(20). doi: 10.1002/smll.201604228. Epub 2017 Mar 30.

PMID:
28370987
22.

Efficacy of the PARP Inhibitor Veliparib with Carboplatin or as a Single Agent in Patients with Germline BRCA1- or BRCA2-Associated Metastatic Breast Cancer: California Cancer Consortium Trial NCT01149083.

Somlo G, Frankel PH, Arun BK, Ma CX, Garcia AA, Cigler T, Cream LV, Harvey HA, Sparano JA, Nanda R, Chew HK, Moynihan TJ, Vahdat LT, Goetz MP, Beumer JH, Hurria A, Mortimer J, Piekarz R, Sand S, Herzog J, Van Tongeren LR, Ferry-Galow KV, Chen AP, Ruel C, Newman EM, Gandara DR, Weitzel JN.

Clin Cancer Res. 2017 Aug 1;23(15):4066-4076. doi: 10.1158/1078-0432.CCR-16-2714. Epub 2017 Mar 29.

PMID:
28356425
23.

Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).

Kummar S, O'Sullivan Coyne G, Do KT, Turkbey B, Meltzer PS, Polley E, Choyke PL, Meehan R, Vilimas R, Horneffer Y, Juwara L, Lih A, Choudhary A, Mitchell SA, Helman LJ, Doroshow JH, Chen AP.

J Clin Oncol. 2017 May 10;35(14):1561-1569. doi: 10.1200/JCO.2016.71.1994. Epub 2017 Mar 28.

24.

Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay.

Ji J, Zhang Y, Redon CE, Reinhold WC, Chen AP, Fogli LK, Holbeck SL, Parchment RE, Hollingshead M, Tomaszewski JE, Dudon Q, Pommier Y, Doroshow JH, Bonner WM.

PLoS One. 2017 Feb 3;12(2):e0171582. doi: 10.1371/journal.pone.0171582. eCollection 2017.

25.

PARP Inhibitors in Reproductive System Cancers: Current Use and Developments.

O'Sullivan Coyne G, Chen AP, Meehan R, Doroshow JH.

Drugs. 2017 Feb;77(2):113-130. doi: 10.1007/s40265-016-0688-7. Review.

26.

Controllable Synthesis of Hexagonal WO3 Nanoplates for Efficient Visible-Light-Driven Photocatalytic Oxygen Production.

Wang YL, Wang XL, Li YH, Fang LJ, Zhao JJ, Du XL, Chen AP, Yang HG.

Chem Asian J. 2017 Feb 16;12(4):387-391. doi: 10.1002/asia.201601471. Epub 2017 Jan 23.

PMID:
28035735
27.

Pediatric Sepsis.

Prusakowski MK, Chen AP.

Emerg Med Clin North Am. 2017 Feb;35(1):123-138. doi: 10.1016/j.emc.2016.08.008. Review.

PMID:
27908329
28.

Utility of 18F-fluoroestradiol (18F-FES) PET/CT imaging as a pharmacodynamic marker in patients with refractory estrogen receptor-positive solid tumors receiving Z-endoxifen therapy.

Lin FI, Gonzalez EM, Kummar S, Do K, Shih J, Adler S, Kurdziel KA, Ton A, Turkbey B, Jacobs PM, Bhattacharyya S, Chen AP, Collins JM, Doroshow JH, Choyke PL, Lindenberg ML.

Eur J Nucl Med Mol Imaging. 2017 Mar;44(3):500-508. doi: 10.1007/s00259-016-3561-8. Epub 2016 Nov 21.

PMID:
27872957
29.

Diffusion-weighted J-resolved spectroscopy.

Landheer K, Schulte R, Geraghty B, Hanstock C, Chen AP, Cunningham CH, Graham SJ.

Magn Reson Med. 2017 Oct;78(4):1235-1245. doi: 10.1002/mrm.26514. Epub 2016 Oct 31.

PMID:
27797114
30.
31.

Global Analysis of Truncated RNA Ends Reveals New Insights into Ribosome Stalling in Plants.

Hou CY, Lee WC, Chou HC, Chen AP, Chou SJ, Chen HM.

Plant Cell. 2016 Oct;28(10):2398-2416. Epub 2016 Oct 14.

32.

The root causes of pharmacodynamic assay failure.

Ferry-Galow KV, Makhlouf HR, Wilsker DF, Lawrence SM, Pfister TD, Marrero AM, Bigelow KM, Yutzy WH, Ji JJ, Butcher DO, Gouker BA, Kummar S, Chen AP, Kinders RJ, Parchment RE, Doroshow JH.

Semin Oncol. 2016 Aug;43(4):484-91. doi: 10.1053/j.seminoncol.2016.06.006. Epub 2016 Jun 15. Review.

PMID:
27663480
33.

Promise and limits of the CellSearch platform for evaluating pharmacodynamics in circulating tumor cells.

Wang L, Balasubramanian P, Chen AP, Kummar S, Evrard YA, Kinders RJ.

Semin Oncol. 2016 Aug;43(4):464-75. doi: 10.1053/j.seminoncol.2016.06.004. Epub 2016 Jun 15. Review.

34.

Hyperpolarized 13C Metabolic MRI of the Human Heart: Initial Experience.

Cunningham CH, Lau JY, Chen AP, Geraghty BJ, Perks WJ, Roifman I, Wright GA, Connelly KA.

Circ Res. 2016 Nov 11;119(11):1177-1182. doi: 10.1161/CIRCRESAHA.116.309769. Epub 2016 Sep 15.

35.

A rapid inversion technique for the measurement of longitudinal relaxation times of brain metabolites: application to lactate in high-grade gliomas at 3 T.

Landheer K, Sahgal A, Myrehaug S, Chen AP, Cunningham CH, Graham SJ.

NMR Biomed. 2016 Oct;29(10):1381-90. doi: 10.1002/nbm.3580. Epub 2016 Jul 25.

PMID:
27455374
36.

Voxel-by-voxel correlations of perfusion, substrate, and metabolite signals in dynamic hyperpolarized (13) C imaging.

Lau JY, Chen AP, Gu YP, Cunningham CH.

NMR Biomed. 2016 Aug;29(8):1038-47. doi: 10.1002/nbm.3564. Epub 2016 Jun 13.

PMID:
27295304
37.

New treatment option for ovarian cancer: PARP inhibitors.

Meehan RS, Chen AP.

Gynecol Oncol Res Pract. 2016 Feb 26;3:3. doi: 10.1186/s40661-016-0024-7. eCollection 2016. Review.

38.

[Research on the Highly Stable White LED with CdSe/ZnS Quantum Dot as Light Conversion Layer].

Cao J, Zhou J, Xie JW, Chen AP, Zhang X, Yin LQ, Zhang JH.

Guang Pu Xue Yu Guang Pu Fen Xi. 2016 Feb;36(2):349-54. Chinese.

PMID:
27209729
39.

Randomized phase II trial of cyclophosphamide and the oral poly (ADP-ribose) polymerase inhibitor veliparib in patients with recurrent, advanced triple-negative breast cancer.

Kummar S, Wade JL, Oza AM, Sullivan D, Chen AP, Gandara DR, Ji J, Kinders RJ, Wang L, Allen D, Coyne GO, Steinberg SM, Doroshow JH.

Invest New Drugs. 2016 Jun;34(3):355-63. doi: 10.1007/s10637-016-0335-x. Epub 2016 Mar 21.

40.

Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors.

LoRusso PM, Li J, Burger A, Heilbrun LK, Sausville EA, Boerner SA, Smith D, Pilat MJ, Zhang J, Tolaney SM, Cleary JM, Chen AP, Rubinstein L, Boerner JL, Bowditch A, Cai D, Bell T, Wolanski A, Marrero AM, Zhang Y, Ji J, Ferry-Galow K, Kinders RJ, Parchment RE, Shapiro GI.

Clin Cancer Res. 2016 Jul 1;22(13):3227-37. doi: 10.1158/1078-0432.CCR-15-0652. Epub 2016 Feb 3.

41.

Accelerated 3D echo-planar imaging with compressed sensing for time-resolved hyperpolarized 13 C studies.

Geraghty BJ, Lau JY, Chen AP, Cunningham CH.

Magn Reson Med. 2017 Feb;77(2):538-546. doi: 10.1002/mrm.26125. Epub 2016 Jan 24.

PMID:
26806525
42.

Intensity correction for multichannel hyperpolarized 13C imaging of the heart.

Dominguez-Viqueira W, Geraghty BJ, Lau JY, Robb FJ, Chen AP, Cunningham CH.

Magn Reson Med. 2016 Feb;75(2):859-65. doi: 10.1002/mrm.26042. Epub 2015 Dec 1.

PMID:
26619820
43.

Analytical Validation and Application of a Targeted Next-Generation Sequencing Mutation-Detection Assay for Use in Treatment Assignment in the NCI-MPACT Trial.

Lih CJ, Sims DJ, Harrington RD, Polley EC, Zhao Y, Mehaffey MG, Forbes TD, Das B, Walsh WD, Datta V, Harper KN, Bouk CH, Rubinstein LV, Simon RM, Conley BA, Chen AP, Kummar S, Doroshow JH, Williams PM.

J Mol Diagn. 2016 Jan;18(1):51-67. doi: 10.1016/j.jmoldx.2015.07.006. Epub 2015 Nov 18.

44.

N of 2 Responders with LMNA-NTRK1.

Lih CJ, Chen AP.

J Natl Cancer Inst. 2015 Nov 12;108(1). pii: djv376. doi: 10.1093/jnci/djv376. Print 2016 Jan. No abstract available.

PMID:
26563357
45.

An overview of the NCI precision medicine trials-NCI MATCH and MPACT.

Do K, O'Sullivan Coyne G, Chen AP.

Chin Clin Oncol. 2015 Sep;4(3):31. doi: 10.3978/j.issn.2304-3865.2015.08.01. Review.

46.

Orange Zinc Germanate with Metallic Ge-Ge Bonds as a Chromophore-Like Center for Visible-Light-Driven Water Splitting.

Qian L, Chen JF, Li YH, Wu L, Wang HF, Chen AP, Hu P, Zheng LR, Yang HG.

Angew Chem Int Ed Engl. 2015 Sep 21;54(39):11467-71. doi: 10.1002/anie.201505988. Epub 2015 Aug 20.

PMID:
26291331
47.

Single voxel localization for dynamic hyperpolarized (13)C MR spectroscopy.

Chen AP, Cunningham CH.

J Magn Reson. 2015 Sep;258:81-5. doi: 10.1016/j.jmr.2015.07.002. Epub 2015 Jul 17.

PMID:
26232365
48.

Hyperpolarized [1-(13) C]pyruvate MRI for noninvasive examination of placental metabolism and nutrient transport: A feasibility study in pregnant guinea pigs.

Friesen-Waldner LJ, Sinclair KJ, Wade TP, Michael B, Chen AP, de Vrijer B, Regnault TR, McKenzie CA.

J Magn Reson Imaging. 2016 Mar;43(3):750-5. doi: 10.1002/jmri.25009. Epub 2015 Jul 31.

PMID:
26227963
49.

Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors.

Do K, Speranza G, Chang LC, Polley EC, Bishop R, Zhu W, Trepel JB, Lee S, Lee MJ, Kinders RJ, Phillips L, Collins J, Lyons J, Jeong W, Antony R, Chen AP, Neckers L, Doroshow JH, Kummar S.

Invest New Drugs. 2015 Aug;33(4):921-30. doi: 10.1007/s10637-015-0255-1. Epub 2015 Jun 18.

PMID:
26082332
50.

Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors.

Do K, Wilsker D, Ji J, Zlott J, Freshwater T, Kinders RJ, Collins J, Chen AP, Doroshow JH, Kummar S.

J Clin Oncol. 2015 Oct 20;33(30):3409-15. doi: 10.1200/JCO.2014.60.4009. Epub 2015 May 11.

Supplemental Content

Support Center