Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 66

1.

Novel application of pluronic lecithin organogels (PLOs) for local delivery of synergistic combination of docetaxel and cisplatin to improve therapeutic efficacy against ovarian cancer.

Chang CE, Hsieh CM, Chen LC, Su CY, Liu DZ, Jhan HJ, Ho HO, Sheu MT.

Drug Deliv. 2018 Nov;25(1):632-643. doi: 10.1080/10717544.2018.1440444.

PMID:
29463123
2.

Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design.

You W, Huang YM, Kizhake S, Natarajan A, Chang CE.

PLoS Comput Biol. 2016 Aug 25;12(8):e1005057. doi: 10.1371/journal.pcbi.1005057. eCollection 2016 Aug.

3.

Analysis of Ligand-Receptor Association and Intermediate Transfer Rates in Multienzyme Nanostructures with All-Atom Brownian Dynamics Simulations.

Roberts CC, Chang CE.

J Phys Chem B. 2016 Aug 25;120(33):8518-31. doi: 10.1021/acs.jpcb.6b02236. Epub 2016 Jun 24.

PMID:
27248669
4.

Mechanisms of Enhanced Catalysis in Enzyme-DNA Nanostructures Revealed through Molecular Simulations and Experimental Analysis.

Gao Y, Roberts CC, Toop A, Chang CE, Wheeldon I.

Chembiochem. 2016 Aug 3;17(15):1430-6. doi: 10.1002/cbic.201600224. Epub 2016 Jun 20.

PMID:
27173175
5.

Codelivery of doxorubicin-containing thermosensitive hydrogels incorporated with docetaxel-loaded mixed micelles enhances local cancer therapy.

Sheu MT, Jhan HJ, Su CY, Chen LC, Chang CE, Liu DZ, Ho HO.

Colloids Surf B Biointerfaces. 2016 Jul 1;143:260-270. doi: 10.1016/j.colsurfb.2016.03.054. Epub 2016 Mar 18.

PMID:
27022865
6.

Syrbactin Structural Analog TIR-199 Blocks Proteasome Activity and Induces Tumor Cell Death.

Bachmann AS, Opoku-Ansah J, Ibarra-Rivera TR, Yco LP, Ambadi S, Roberts CC, Chang CE, Pirrung MC.

J Biol Chem. 2016 Apr 15;291(16):8350-62. doi: 10.1074/jbc.M115.710053. Epub 2016 Feb 23.

7.

Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis.

Zhang C, Brown MQ, van de Ven W, Zhang ZM, Wu B, Young MC, Synek L, Borchardt D, Harrison R, Pan S, Luo N, Huang YM, Ghang YJ, Ung N, Li R, Isley J, Morikis D, Song J, Guo W, Hooley RJ, Chang CE, Yang Z, Zarsky V, Muday GK, Hicks GR, Raikhel NV.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E41-50. doi: 10.1073/pnas.1521248112. Epub 2015 Nov 25.

8.

Modeling of enhanced catalysis in multienzyme nanostructures: effect of molecular scaffolds, spatial organization, and concentration.

Roberts CC, Chang CE.

J Chem Theory Comput. 2015 Jan 13;11(1):286-92. doi: 10.1021/ct5007482.

PMID:
26574226
9.

Protonation states and catalysis: Molecular dynamics studies of intermediates in tryptophan synthase.

Huang YM, You W, Caulkins BG, Dunn MF, Mueller LJ, Chang CE.

Protein Sci. 2016 Jan;25(1):166-83. doi: 10.1002/pro.2709. Epub 2015 Sep 22.

10.

ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis.

Zhang X, Niu D, Carbonell A, Wang A, Lee A, Tun V, Wang Z, Carrington JC, Chang CE, Jin H.

Nat Commun. 2014 Nov 19;5:5468. doi: 10.1038/ncomms6468.

11.

Protonation states of the tryptophan synthase internal aldimine active site from solid-state NMR spectroscopy: direct observation of the protonated Schiff base linkage to pyridoxal-5'-phosphate.

Caulkins BG, Bastin B, Yang C, Neubauer TJ, Young RP, Hilario E, Huang YM, Chang CE, Fan L, Dunn MF, Marsella MJ, Mueller LJ.

J Am Chem Soc. 2014 Sep 17;136(37):12824-7. doi: 10.1021/ja506267d. Epub 2014 Sep 3.

12.

Switches of hydrogen bonds during ligand-protein association processes determine binding kinetics.

Huang YM, Kang M, Chang CE.

J Mol Recognit. 2014 Sep;27(9):537-48. doi: 10.1002/jmr.2377.

13.

Coronary Diameters in Taiwanese Children Younger than 6 Years Old: Z-Score Regression Equations Derived from Body Surface Area.

Lin MT, Chang CH, Hsieh WC, Chang CE, Chang YM, Chen YC, Hsu JY, Huang YL, Ma JY, Sun LC, Wu CS, Yeh SZ, Fang WQ, Chen CA, Chiu SN, Lu CW, Wang JK, Wu MH.

Acta Cardiol Sin. 2014 Jul;30(4):266-73.

14.

Achieving peptide binding specificity and promiscuity by loops: case of the forkhead-associated domain.

Huang YM, Chang CE.

PLoS One. 2014 May 28;9(5):e98291. doi: 10.1371/journal.pone.0098291. eCollection 2014.

15.

Amino acid networks in a (β/α)₈ barrel enzyme change during catalytic turnover.

Axe JM, Yezdimer EM, O'Rourke KF, Kerstetter NE, You W, Chang CE, Boehr DD.

J Am Chem Soc. 2014 May 14;136(19):6818-21. doi: 10.1021/ja501602t. Epub 2014 May 2.

PMID:
24766576
16.

Protein binding for detection of small changes on a nanoparticle surface.

Zeng S, Huang YM, Chang CE, Zhong W.

Analyst. 2014 Mar 21;139(6):1364-71. doi: 10.1039/c3an02155f.

17.

The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides.

Kumar EA, Chen Q, Kizhake S, Kolar C, Kang M, Chang CE, Borgstahl GE, Natarajan A.

Sci Rep. 2013;3:1639. doi: 10.1038/srep01639.

18.

Ligand Binding Pathway Elucidation for Cryptophane Host-Guest Complexes.

Roberts CC, Chang CE.

J Chem Theory Comput. 2013 Apr 9;9(4):2010-9. doi: 10.1021/ct301023m. Epub 2013 Mar 19.

PMID:
26583550
19.

Agonist and antagonist binding to the nuclear vitamin D receptor: dynamics, mutation effects and functional implications.

Yaghmaei S, Roberts C, Ai R, Mizwicki MT, Chang CE.

In Silico Pharmacol. 2013 Feb 12;1:2. doi: 10.1186/2193-9616-1-2. eCollection 2013.

20.

Ligand-specific homology modeling of human cannabinoid (CB1) receptor.

Ai R, Chang CE.

J Mol Graph Model. 2012 Sep;38:155-64. doi: 10.1016/j.jmgm.2012.05.002. Epub 2012 May 31.

PMID:
23079645
21.

Mechanistic insights into phosphopeptide--BRCT domain association: preorganization, flexibility, and phosphate recognition.

Huang YM, Kang M, Chang CE.

J Phys Chem B. 2012 Aug 30;116(34):10247-58. doi: 10.1021/jp305028d. Epub 2012 Aug 16.

PMID:
22857521
22.

Insights from free-energy calculations: protein conformational equilibrium, driving forces, and ligand-binding modes.

Huang YM, Chen W, Potter MJ, Chang CE.

Biophys J. 2012 Jul 18;103(2):342-51. doi: 10.1016/j.bpj.2012.05.046. Epub 2012 Jul 17.

23.

Homology modeling of cannabinoid receptors: discovery of cannabinoid analogues for therapeutic use.

Chang CE, Ai R, Gutierrez M, Marsella MJ.

Methods Mol Biol. 2012;819:595-613. doi: 10.1007/978-1-61779-465-0_35.

PMID:
22183560
24.

Gating and Intermolecular Interactions in Ligand-Protein Association: Coarse-Grained Modeling of HIV-1 Protease.

Kang M, Roberts C, Cheng Y, Chang CE.

J Chem Theory Comput. 2011 Oct 11;7(10):3438-46. doi: 10.1021/ct2004885. Epub 2011 Sep 14.

PMID:
26598172
25.
26.

X-ray and NMR crystallography in an enzyme active site: the indoline quinonoid intermediate in tryptophan synthase.

Lai J, Niks D, Wang Y, Domratcheva T, Barends TR, Schwarz F, Olsen RA, Elliott DW, Fatmi MQ, Chang CE, Schlichting I, Dunn MF, Mueller LJ.

J Am Chem Soc. 2011 Jan 12;133(1):4-7. doi: 10.1021/ja106555c. Epub 2010 Dec 10.

PMID:
21142052
27.

The role of oligomerization and cooperative regulation in protein function: the case of tryptophan synthase.

Fatmi MQ, Chang CE.

PLoS Comput Biol. 2010 Nov 11;6(11):e1000994. doi: 10.1371/journal.pcbi.1000994.

28.

Structural basis for selective activation of ABA receptors.

Peterson FC, Burgie ES, Park SY, Jensen DR, Weiner JJ, Bingman CA, Chang CE, Cutler SR, Phillips GN Jr, Volkman BF.

Nat Struct Mol Biol. 2010 Sep;17(9):1109-13. doi: 10.1038/nsmb.1898. Epub 2010 Aug 22.

29.

T-Analyst: a program for efficient analysis of protein conformational changes by torsion angles.

Ai R, Qaiser Fatmi M, Chang CE.

J Comput Aided Mol Des. 2010 Oct;24(10):819-27. doi: 10.1007/s10822-010-9376-y. Epub 2010 Aug 6.

30.

Thermal isomerization of cannabinoid analogues.

Garcia A, Borchardt D, Chang CE, Marsella MJ.

J Am Chem Soc. 2009 Nov 25;131(46):16640-1. doi: 10.1021/ja907062v.

PMID:
19919138
31.

Synergistic regulation and ligand-induced conformational changes of tryptophan synthase.

Fatmi MQ, Ai R, Chang CE.

Biochemistry. 2009 Oct 20;48(41):9921-31. doi: 10.1021/bi901358j.

PMID:
19764814
32.

Diffusional channeling in the sulfate-activating complex: combined continuum modeling and coarse-grained brownian dynamics studies.

Cheng Y, Chang CE, Yu Z, Zhang Y, Sun M, Leyh TS, Holst MJ, McCammon JA.

Biophys J. 2008 Nov 15;95(10):4659-67. doi: 10.1529/biophysj.108.140038. Epub 2008 Aug 8.

33.

Entropic contributions and the influence of the hydrophobic environment in promiscuous protein-protein association.

Chang CE, McLaughlin WA, Baron R, Wang W, McCammon JA.

Proc Natl Acad Sci U S A. 2008 May 27;105(21):7456-61. doi: 10.1073/pnas.0800452105. Epub 2008 May 21.

34.

Default-mode function and task-induced deactivation have overlapping brain substrates in children.

Thomason ME, Chang CE, Glover GH, Gabrieli JD, Greicius MD, Gotlib IH.

Neuroimage. 2008 Jul 15;41(4):1493-503. doi: 10.1016/j.neuroimage.2008.03.029. Epub 2008 Apr 1.

35.

A cross-modal system linking primary auditory and visual cortices: evidence from intrinsic fMRI connectivity analysis.

Eckert MA, Kamdar NV, Chang CE, Beckmann CF, Greicius MD, Menon V.

Hum Brain Mapp. 2008 Jul;29(7):848-57. doi: 10.1002/hbm.20560.

36.

Dynamics of the acetylcholinesterase tetramer.

Gorfe AA, Chang CE, Ivanov I, McCammon JA.

Biophys J. 2008 Feb 15;94(4):1144-54. Epub 2007 Oct 5.

37.

HIV-1 protease substrate binding and product release pathways explored with coarse-grained molecular dynamics.

Trylska J, Tozzini V, Chang CE, McCammon JA.

Biophys J. 2007 Jun 15;92(12):4179-87. Epub 2007 Mar 23.

38.

Binding pathways of ligands to HIV-1 protease: coarse-grained and atomistic simulations.

Chang CE, Trylska J, Tozzini V, McCammon JA.

Chem Biol Drug Des. 2007 Jan;69(1):5-13.

PMID:
17313452
39.

The effectiveness of video-telemedicine for screening of patients requesting emergency air medical transport (EAMT).

Tsai SH, Kraus J, Wu HR, Chen WL, Chiang MF, Lu LH, Chang CE, Chiu WT.

J Trauma. 2007 Feb;62(2):504-11.

PMID:
17297342
40.

Ligand configurational entropy and protein binding.

Chang CE, Chen W, Gilson MK.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1534-9. Epub 2007 Jan 22.

41.

Flap opening dynamics in HIV-1 protease explored with a coarse-grained model.

Tozzini V, Trylska J, Chang CE, McCammon JA.

J Struct Biol. 2007 Mar;157(3):606-15. Epub 2006 Aug 23.

PMID:
17029846
42.

Antimicrobial susceptibility and strain prevalence of Korean vaginal Lactobacillus spp.

Choi SY, Chang CE, Kim SC, So JS.

Anaerobe. 2003 Dec;9(6):277-80.

PMID:
16887711
43.

The influence of macromolecular crowding on HIV-1 protease internal dynamics.

Minh DD, Chang CE, Trylska J, Tozzini V, McCammon JA.

J Am Chem Soc. 2006 May 10;128(18):6006-7.

44.

Concepts in receptor optimization: targeting the RGD peptide.

Chen W, Chang CE, Gilson MK.

J Am Chem Soc. 2006 Apr 12;128(14):4675-84.

PMID:
16594704
45.

Gated binding of ligands to HIV-1 protease: Brownian dynamics simulations in a coarse-grained model.

Chang CE, Shen T, Trylska J, Tozzini V, McCammon JA.

Biophys J. 2006 Jun 1;90(11):3880-5. Epub 2006 Mar 13.

46.

Evaluating the Accuracy of the Quasiharmonic Approximation.

Chang CE, Chen W, Gilson MK.

J Chem Theory Comput. 2005 Sep;1(5):1017-28. doi: 10.1021/ct0500904.

PMID:
26641917
47.

The entropic cost of protein-protein association: a case study on acetylcholinesterase binding to fasciculin-2.

Minh DD, Bui JM, Chang CE, Jain T, Swanson JM, McCammon JA.

Biophys J. 2005 Oct;89(4):L25-7. Epub 2005 Aug 12. No abstract available. Erratum in: Biophys J. 2006 Jul 15;91(2):775.

48.
49.

Calculation of cyclodextrin binding affinities: energy, entropy, and implications for drug design.

Chen W, Chang CE, Gilson MK.

Biophys J. 2004 Nov;87(5):3035-49. Epub 2004 Aug 31.

50.

Tork: Conformational analysis method for molecules and complexes.

Chang CE, Gilson MK.

J Comput Chem. 2003 Dec;24(16):1987-98.

PMID:
14531053

Supplemental Content

Loading ...
Support Center