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Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants.

Husaini AM, Morimoto K, Chandrasekar B, Kelly S, Kaschani F, Palmero D, Jiang J, Kaiser M, Ahrazem O, Overkleeft HS, van der Hoorn RAL.

Plant Physiol. 2018 May;177(1):24-37. doi: 10.1104/pp.18.00250. Epub 2018 Mar 19.


Low Protease Content in Medicago truncatula Cell Cultures Facilitates Recombinant Protein Production.

Santos RB, Chandrasekar B, Mandal MK, Kaschani F, Kaiser M, Both L, van der Hoorn RAL, Schiermeyer A, Abranches R.

Biotechnol J. 2018 Mar 12. doi: 10.1002/biot.201800050. [Epub ahead of print]


Nitric oxide synthase 2 enhances the survival of mice during Salmonella Typhimurium infection-induced sepsis by increasing reactive oxygen species, inflammatory cytokines and recruitment of neutrophils to the peritoneal cavity.

Yadav S, Pathak S, Sarikhani M, Majumdar S, Ray S, Chandrasekar BS, Adiga V, Sundaresan NR, Nandi D.

Free Radic Biol Med. 2018 Feb 20;116:73-87. doi: 10.1016/j.freeradbiomed.2017.12.032. Epub 2018 Jan 5.


Dipeptidyl Peptidase-4 Inhibition With Saxagliptin Ameliorates Angiotensin II-Induced Cardiac Diastolic Dysfunction in Male Mice.

Brown SM, Smith CE, Meuth AI, Khan M, Aroor AR, Cleeton HM, Meininger GA, Sowers JR, DeMarco VG, Chandrasekar B, Nistala R, Bender SB.

Endocrinology. 2017 Oct 1;158(10):3592-3604. doi: 10.1210/en.2017-00416.


TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells.

Padilla J, Carpenter AJ, Das NA, Kandikattu HK, López-Ongil S, Martinez-Lemus LA, Siebenlist U, DeMarco VG, Chandrasekar B.

Am J Physiol Heart Circ Physiol. 2018 Jan 1;314(1):H52-H64. doi: 10.1152/ajpheart.00478.2017. Epub 2017 Sep 29.


Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice.

Aroor AR, Habibi J, Kandikattu HK, Garro-Kacher M, Barron B, Chen D, Hayden MR, Whaley-Connell A, Bender SB, Klein T, Padilla J, Sowers JR, Chandrasekar B, DeMarco VG.

Cardiovasc Diabetol. 2017 May 5;16(1):61. doi: 10.1186/s12933-017-0544-4.


Proteasome Activity Profiling Uncovers Alteration of Catalytic β2 and β5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots.

Kovács J, Poór P, Kaschani F, Chandrasekar B, Hong TN, Misas-Villamil JC, Xin BT, Kaiser M, Overkleeft HS, Tari I, van der Hoorn RA.

Front Plant Sci. 2017 Feb 3;8:107. doi: 10.3389/fpls.2017.00107. eCollection 2017.


Targeting TRAF3IP2 by Genetic and Interventional Approaches Inhibits Ischemia/Reperfusion-induced Myocardial Injury and Adverse Remodeling.

Erikson JM, Valente AJ, Mummidi S, Kandikattu HK, DeMarco VG, Bender SB, Fay WP, Siebenlist U, Chandrasekar B.

J Biol Chem. 2017 Feb 10;292(6):2345-2358. doi: 10.1074/jbc.M116.764522. Epub 2017 Jan 4.


Pharmacological Targeting of Plasminogen Activator Inhibitor-1 Decreases Vascular Smooth Muscle Cell Migration and Neointima Formation.

Ji Y, Weng Z, Fish P, Goyal N, Luo M, Myears SP, Strawn TL, Chandrasekar B, Wu J, Fay WP.

Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2167-2175. Epub 2016 Sep 22.


Inhibitor Discovery by Convolution ABPP.

Chandrasekar B, Hong TN, van der Hoorn RA.

Methods Mol Biol. 2017;1491:47-56.


Cardiac-restricted Overexpression of TRAF3 Interacting Protein 2 (TRAF3IP2) Results in Spontaneous Development of Myocardial Hypertrophy, Fibrosis, and Dysfunction.

Yariswamy M, Yoshida T, Valente AJ, Kandikattu HK, Sakamuri SS, Siddesha JM, Sukhanov S, Saifudeen Z, Ma L, Siebenlist U, Gardner JD, Chandrasekar B.

J Biol Chem. 2016 Sep 9;291(37):19425-36. doi: 10.1074/jbc.M116.724138. Epub 2016 Jul 27.


Activity-based protein profiling of hydrolytic enzymes induced by gibberellic acid in isolated aleurone layers of malting barley.

Daneri-Castro SN, Chandrasekar B, Grosse-Holz FM, van der Hoorn RA, Roberts TH.

FEBS Lett. 2016 Sep;590(17):2956-62. doi: 10.1002/1873-3468.12320. Epub 2016 Aug 4.


Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone+salt-induced cardiac fibrosis in vivo.

Mummidi S, Das NA, Carpenter AJ, Kandikattu H, Krenz M, Siebenlist U, Valente AJ, Chandrasekar B.

J Mol Cell Cardiol. 2016 Sep;98:95-102. doi: 10.1016/j.yjmcc.2016.07.006. Epub 2016 Jul 14.


Histone deacetyltransferase inhibitors Trichostatin A and Mocetinostat differentially regulate MMP9, IL-18 and RECK expression, and attenuate Angiotensin II-induced cardiac fibroblast migration and proliferation.

Somanna NK, Valente AJ, Krenz M, McDonald KS, Higashi Y, Noda M, Chandrasekar B.

Hypertens Res. 2016 Oct;39(10):709-716. doi: 10.1038/hr.2016.54. Epub 2016 Jun 9.


Gut Microbiota Conversion of Dietary Ellagic Acid into Bioactive Phytoceutical Urolithin A Inhibits Heme Peroxidases.

Saha P, Yeoh BS, Singh R, Chandrasekar B, Vemula PK, Haribabu B, Vijay-Kumar M, Jala VR.

PLoS One. 2016 Jun 2;11(6):e0156811. doi: 10.1371/journal.pone.0156811. eCollection 2016.


TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE(-/-) mice.

Sakamuri SSVP, Higashi Y, Sukhanov S, Siddesha JM, Delafontaine P, Siebenlist U, Chandrasekar B.

Atherosclerosis. 2016 Sep;252:153-160. doi: 10.1016/j.atherosclerosis.2016.05.029. Epub 2016 May 19.


Characterization of senescence-associated protease activities involved in the efficient protein remobilization during leaf senescence of winter oilseed rape.

Poret M, Chandrasekar B, van der Hoorn RAL, Avice JC.

Plant Sci. 2016 May;246:139-153. doi: 10.1016/j.plantsci.2016.02.011. Epub 2016 Feb 16.


Nicotinamide Cofactors Suppress Active-Site Labeling of Aldehyde Dehydrogenases.

Stiti N, Chandrasekar B, Strubl L, Mohammed S, Bartels D, van der Hoorn RA.

ACS Chem Biol. 2016 Jun 17;11(6):1578-86. doi: 10.1021/acschembio.5b00784. Epub 2016 Mar 25.


Beta galactosidases in Arabidopsis and tomato - a mini review.

Chandrasekar B, van der Hoorn RA.

Biochem Soc Trans. 2016 Feb;44(1):150-8. doi: 10.1042/BST20150217. Review.


The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4.

Somanna NK, Valente AJ, Krenz M, Fay WP, Delafontaine P, Chandrasekar B.

J Cell Physiol. 2016 May;231(5):1130-41. doi: 10.1002/jcp.25210. Epub 2015 Oct 19.


Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2.

Somanna NK, Yariswamy M, Garagliano JM, Siebenlist U, Mummidi S, Valente AJ, Chandrasekar B.

Cell Signal. 2015 Oct;27(10):1928-38. doi: 10.1016/j.cellsig.2015.07.001. Epub 2015 Jul 4.


Subfamily-Specific Fluorescent Probes for Cysteine Proteases Display Dynamic Protease Activities during Seed Germination.

Lu H, Chandrasekar B, Oeljeklaus J, Misas-Villamil JC, Wang Z, Shindo T, Bogyo M, Kaiser M, van der Hoorn RA.

Plant Physiol. 2015 Aug;168(4):1462-75. doi: 10.1104/pp.114.254466. Epub 2015 Jun 5. Erratum in: Plant Physiol. 2017 May;174(1):465-466.


Interferon-gamma and nitric oxide synthase 2 mediate the aggregation of resident adherent peritoneal exudate cells: implications for the host response to pathogens.

Chandrasekar BS, Yadav S, Victor ES, Majumdar S, Deobagkar-Lele M, Wadhwa N, Podder S, Das M, Nandi D.

PLoS One. 2015 Jun 1;10(6):e0128301. doi: 10.1371/journal.pone.0128301. eCollection 2015.


Molecular profiling of sepsis in mice using Fourier Transform Infrared Microspectroscopy.

Gautam R, Deobagkar-Lele M, Majumdar S, Chandrasekar B, Victor E, Ahmed SM, Wadhwa N, Verma T, Kumar S, Sundaresan NR, Umapathy S, Nandi D.

J Biophotonics. 2016 Jan;9(1-2):67-82. doi: 10.1002/jbio.201400089. Epub 2015 Mar 23.


Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death.

Yoshida T, Friehs I, Mummidi S, del Nido PJ, Addulnour-Nakhoul S, Delafontaine P, Valente AJ, Chandrasekar B.

J Mol Cell Cardiol. 2014 Oct;75:141-51. doi: 10.1016/j.yjmcc.2014.07.007. Epub 2014 Aug 7.


Broad-range glycosidase activity profiling.

Chandrasekar B, Colby T, Emran Khan Emon A, Jiang J, Hong TN, Villamor JG, Harzen A, Overkleeft HS, van der Hoorn RA.

Mol Cell Proteomics. 2014 Oct;13(10):2787-800. doi: 10.1074/mcp.O114.041616. Epub 2014 Jul 23.


Promotion of lung tumor growth by interleukin-17.

Xu B, Guenther JF, Pociask DA, Wang Y, Kolls JK, You Z, Chandrasekar B, Shan B, Sullivan DE, Morris GF.

Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15;307(6):L497-508. doi: 10.1152/ajplung.00125.2014. Epub 2014 Jul 18.


Interferon-gamma induced cell death: Regulation and contributions of nitric oxide, cJun N-terminal kinase, reactive oxygen species and peroxynitrite.

Rakshit S, Chandrasekar BS, Saha B, Victor ES, Majumdar S, Nandi D.

Biochim Biophys Acta. 2014 Nov;1843(11):2645-61. doi: 10.1016/j.bbamcr.2014.06.014. Epub 2014 Jun 28.


OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators.

Valente AJ, Irimpen AM, Siebenlist U, Chandrasekar B.

Free Radic Biol Med. 2014 May;70:117-28. doi: 10.1016/j.freeradbiomed.2014.02.014. Epub 2014 Feb 20.


Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration.

Siddesha JM, Valente AJ, Yoshida T, Sakamuri SS, Delafontaine P, Iba H, Noda M, Chandrasekar B.

Cell Signal. 2014 May;26(5):933-41. doi: 10.1016/j.cellsig.2014.01.005. Epub 2014 Jan 19.


Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK.

Siddesha JM, Valente AJ, Sakamuri SS, Gardner JD, Delafontaine P, Noda M, Chandrasekar B.

J Cell Physiol. 2014 Jul;229(7):845-55. doi: 10.1002/jcp.24511.


Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK.

Siddesha JM, Valente AJ, Sakamuri SS, Yoshida T, Gardner JD, Somanna N, Takahashi C, Noda M, Chandrasekar B.

J Mol Cell Cardiol. 2013 Dec;65:9-18. doi: 10.1016/j.yjmcc.2013.09.015. Epub 2013 Oct 2.


TRAF3IP2 mediates interleukin-18-induced cardiac fibroblast migration and differentiation.

Valente AJ, Sakamuri SS, Siddesha JM, Yoshida T, Gardner JD, Prabhu R, Siebenlist U, Chandrasekar B.

Cell Signal. 2013 Nov;25(11):2176-84. doi: 10.1016/j.cellsig.2013.07.013. Epub 2013 Jul 18.


Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin.

Valente AJ, Yoshida T, Izadpanah R, Delafontaine P, Siebenlist U, Chandrasekar B.

Cell Signal. 2013 Jun;25(6):1447-56. doi: 10.1016/j.cellsig.2013.03.007. Epub 2013 Mar 27.


Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling.

Valente AJ, Yoshida T, Clark RA, Delafontaine P, Siebenlist U, Chandrasekar B.

Free Radic Biol Med. 2013 Jul;60:125-35. doi: 10.1016/j.freeradbiomed.2013.02.012. Epub 2013 Feb 20.


Regulation of chemokines, CCL3 and CCL4, by interferon γ and nitric oxide synthase 2 in mouse macrophages and during Salmonella enterica serovar typhimurium infection.

Chandrasekar B, Deobagkar-Lele M, Victor ES, Nandi D.

J Infect Dis. 2013 May 15;207(10):1556-68. doi: 10.1093/infdis/jit067. Epub 2013 Feb 21.


Reevaluation of the reliability and usefulness of the somatic homologous recombination reporter lines.

Ülker B, Hommelsheim CM, Berson T, Thomas S, Chandrasekar B, Olcay AC, Berendzen KW, Frantzeskakis L.

Plant Cell. 2012 Nov;24(11):4314-23. doi: 10.1105/tpc.112.100404. Epub 2012 Nov 9. Review.


CIKS (Act1 or TRAF3IP2) mediates high glucose-induced endothelial dysfunction.

Venkatesan B, Valente AJ, Das NA, Carpenter AJ, Yoshida T, Delafontaine JL, Siebenlist U, Chandrasekar B.

Cell Signal. 2013 Jan;25(1):359-71. doi: 10.1016/j.cellsig.2012.10.009. Epub 2012 Oct 17.


Identification of early biomarkers during acetaminophen-induced hepatotoxicity by fourier transform infrared microspectroscopy.

Gautam R, Chandrasekar B, Deobagkar-Lele M, Rakshit S, Kumar B N V, Umapathy S, Nandi D.

PLoS One. 2012;7(9):e45521. doi: 10.1371/journal.pone.0045521. Epub 2012 Sep 19.


Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.

Valente AJ, Yoshida T, Murthy SN, Sakamuri SS, Katsuyama M, Clark RA, Delafontaine P, Chandrasekar B.

Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H282-96. doi: 10.1152/ajpheart.00231.2012. Epub 2012 May 25.


CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy.

Valente AJ, Clark RA, Siddesha JM, Siebenlist U, Chandrasekar B.

J Mol Cell Cardiol. 2012 Jul;53(1):113-24. doi: 10.1016/j.yjmcc.2012.04.009. Epub 2012 Apr 26.


Cellular signals underlying β-adrenergic receptor mediated salivary gland enlargement.

Yeh CK, Chandrasekar B, Lin AL, Dang H, Kamat A, Zhu B, Katz MS.

Differentiation. 2012 Jan;83(1):68-76. doi: 10.1016/j.diff.2011.09.002. Epub 2011 Oct 8.


Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1.

Valente AJ, Yoshida T, Gardner JD, Somanna N, Delafontaine P, Chandrasekar B.

Cell Signal. 2012 Feb;24(2):560-8. doi: 10.1016/j.cellsig.2011.10.010. Epub 2011 Oct 20.


β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo.

Murray DR, Mummidi S, Valente AJ, Yoshida T, Somanna NK, Delafontaine P, Dinarello CA, Chandrasekar B.

J Mol Cell Cardiol. 2012 Jan;52(1):206-18. doi: 10.1016/j.yjmcc.2011.09.022. Epub 2011 Oct 8.


Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy.

Ismahil MA, Hamid T, Haberzettl P, Gu Y, Chandrasekar B, Srivastava S, Bhatnagar A, Prabhu SD.

Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2050-60. doi: 10.1152/ajpheart.00120.2011. Epub 2011 Sep 9.


Angiotensin II upregulates protein phosphatase 2Cα and inhibits AMP-activated protein kinase signaling and energy balance leading to skeletal muscle wasting.

Tabony AM, Yoshida T, Galvez S, Higashi Y, Sukhanov S, Chandrasekar B, Mitch WE, Delafontaine P.

Hypertension. 2011 Oct;58(4):643-9. doi: 10.1161/HYPERTENSIONAHA.111.174839. Epub 2011 Aug 15.


Tumor necrosis factor receptor 2 signaling limits β-adrenergic receptor-mediated cardiac hypertrophy in vivo.

Garlie JB, Hamid T, Gu Y, Ismahil MA, Chandrasekar B, Prabhu SD.

Basic Res Cardiol. 2011 Nov;106(6):1193-205. doi: 10.1007/s00395-011-0196-6. Epub 2011 Jun 21.


Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy.

Shanmugam P, Valente AJ, Prabhu SD, Venkatesan B, Yoshida T, Delafontaine P, Chandrasekar B.

J Mol Cell Cardiol. 2011 Jun;50(6):928-38. doi: 10.1016/j.yjmcc.2011.02.012. Epub 2011 Mar 2.


Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation.

Reddy VS, Valente AJ, Delafontaine P, Chandrasekar B.

J Cell Physiol. 2011 Dec;226(12):3303-15. doi: 10.1002/jcp.22676.

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