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Items: 25


Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy.

Klebanoff CA, Crompton JG, Leonardi AJ, Yamamoto TN, Chandran SS, Eil RL, Sukumar M, Vodnala SK, Hu J, Ji Y, Clever D, Black MA, Gurusamy D, Kruhlak MJ, Jin P, Stroncek DF, Gattinoni L, Feldman SA, Restifo NP.

JCI Insight. 2017 Dec 7;2(23). pii: 95103. doi: 10.1172/jci.insight.95103. [Epub ahead of print]


Treatment of metastatic uveal melanoma with adoptive transfer of tumour-infiltrating lymphocytes: a single-centre, two-stage, single-arm, phase 2 study.

Chandran SS, Somerville RPT, Yang JC, Sherry RM, Klebanoff CA, Goff SL, Wunderlich JR, Danforth DN, Zlott D, Paria BC, Sabesan AC, Srivastava AK, Xi L, Pham TH, Raffeld M, White DE, Toomey MA, Rosenberg SA, Kammula US.

Lancet Oncol. 2017 Jun;18(6):792-802. doi: 10.1016/S1470-2045(17)30251-6. Epub 2017 Apr 7.


Percutaneous Device Closure of Paravalvular Leak: Combined Experience From the United Kingdom and Ireland.

Calvert PA, Northridge DB, Malik IS, Shapiro L, Ludman P, Qureshi SA, Mullen M, Henderson R, Turner M, Been M, Walsh KP, Casserly I, Morrison L, Walker NL, Thomson J, Spence MS, Mahadevan VS, Hoye A, MacCarthy PA, Daniels MJ, Clift P, Davies WR, Adamson PD, Morgan G, Aggarwal SK, Ismail Y, Ormerod JO, Khan HR, Chandran SS, de Giovanni J, Rana BS, Ormerod O, Hildick-Smith D.

Circulation. 2016 Sep 27;134(13):934-44. doi: 10.1161/CIRCULATIONAHA.116.022684. Epub 2016 Sep 1. Erratum in: Circulation. 2016 Nov 1;134(18):e403.


Efficient Multiplexed Integration of Synergistic Alleles and Metabolic Pathways in Yeasts via CRISPR-Cas.

Horwitz AA, Walter JM, Schubert MG, Kung SH, Hawkins K, Platt DM, Hernday AD, Mahatdejkul-Meadows T, Szeto W, Chandran SS, Newman JD.

Cell Syst. 2015 Jul 29;1(1):88-96. doi: 10.1016/j.cels.2015.02.001. Epub 2015 Mar 12.


CRISPR-Cas-Assisted Multiplexing (CAM): Simple Same-Day Multi-Locus Engineering in Yeast.

Walter JM, Chandran SS, Horwitz AA.

J Cell Physiol. 2016 Dec;231(12):2563-9. doi: 10.1002/jcp.25375. Epub 2016 Mar 31. Review.


Identification of an Immunogenic Subset of Metastatic Uveal Melanoma.

Rothermel LD, Sabesan AC, Stephens DJ, Chandran SS, Paria BC, Srivastava AK, Somerville R, Wunderlich JR, Lee CC, Xi L, Pham TH, Raffeld M, Jailwala P, Kasoji M, Kammula US.

Clin Cancer Res. 2016 May 1;22(9):2237-49. doi: 10.1158/1078-0432.CCR-15-2294. Epub 2015 Dec 28.


Tumor-Specific Effector CD8+ T Cells That Can Establish Immunological Memory in Humans after Adoptive Transfer Are Marked by Expression of IL7 Receptor and c-myc.

Chandran SS, Paria BC, Srivastava AK, Rothermel LD, Stephens DJ, Kammula US.

Cancer Res. 2015 Aug 15;75(16):3216-26. doi: 10.1158/0008-5472.CAN-15-0584. Epub 2015 Jun 22.


Persistence of CTL clones targeting melanocyte differentiation antigens was insufficient to mediate significant melanoma regression in humans.

Chandran SS, Paria BC, Srivastava AK, Rothermel LD, Stephens DJ, Dudley ME, Somerville R, Wunderlich JR, Sherry RM, Yang JC, Rosenberg SA, Kammula US.

Clin Cancer Res. 2015 Feb 1;21(3):534-43. doi: 10.1158/1078-0432.CCR-14-2208. Epub 2014 Nov 25.


Rapid and reliable DNA assembly via ligase cycling reaction.

de Kok S, Stanton LH, Slaby T, Durot M, Holmes VF, Patel KG, Platt D, Shapland EB, Serber Z, Dean J, Newman JD, Chandran SS.

ACS Synth Biol. 2014 Feb 21;3(2):97-106. doi: 10.1021/sb4001992. Epub 2014 Jan 15.


Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae.

McIsaac RS, Gibney PA, Chandran SS, Benjamin KR, Botstein D.

Nucleic Acids Res. 2014 Apr;42(6):e48. doi: 10.1093/nar/gkt1402. Epub 2014 Jan 20.


High-throughput, cost-effective verification of structural DNA assembly.

Dharmadi Y, Patel K, Shapland E, Hollis D, Slaby T, Klinkner N, Dean J, Chandran SS.

Nucleic Acids Res. 2014 Feb;42(4):e22. doi: 10.1093/nar/gkt1088. Epub 2013 Nov 6.


Comparative bioavailability of two hydrofluoroalkane formulations of formoterol fumarate both delivered by pressurised metered dose inhaler.

Po CJ, Chandran SS, Syed N, Naidu KR, Rathod M, Sule A, Lulla A, Purandare S.

Arzneimittelforschung. 2010;60(2):81-6. doi: 10.1055/s-0031-1296253.


TLR2 engagement on dendritic cells promotes high frequency effector and memory CD4 T cell responses.

Chandran SS, Verhoeven D, Teijaro JR, Fenton MJ, Farber DL.

J Immunol. 2009 Dec 15;183(12):7832-41. doi: 10.4049/jimmunol.0901683.


Extended-release PEG-luciferin allows for long-term imaging of firefly luciferase activity in vivo.

Chandran SS, Williams SA, Denmeade SR.

Luminescence. 2009 Jan-Feb;24(1):35-8. doi: 10.1002/bio.1060.


Characterization of a targeted nanoparticle functionalized with a urea-based inhibitor of prostate-specific membrane antigen (PSMA).

Chandran SS, Banerjee SR, Mease RC, Pomper MG, Denmeade SR.

Cancer Biol Ther. 2008 Jun;7(6):974-82. Epub 2008 Mar 26.


CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis.

Tang AL, Teijaro JR, Njau MN, Chandran SS, Azimzadeh A, Nadler SG, Rothstein DM, Farber DL.

J Immunol. 2008 Aug 1;181(3):1806-13.


A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells.

Yatzeck MM, Lavis LD, Chao TY, Chandran SS, Raines RT.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5864-6. doi: 10.1016/j.bmcl.2008.06.015. Epub 2008 Jun 10.


A prostate-specific antigen activated N-(2-hydroxypropyl) methacrylamide copolymer prodrug as dual-targeted therapy for prostate cancer.

Chandran SS, Nan A, Rosen DM, Ghandehari H, Denmeade SR.

Mol Cancer Ther. 2007 Nov;6(11):2928-37.


Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

Menzella HG, Reid R, Carney JR, Chandran SS, Reisinger SJ, Patel KG, Hopwood DA, Santi DV.

Nat Biotechnol. 2005 Sep;23(9):1171-6. Epub 2005 Aug 14.


Latent fluorophore based on the trimethyl lock.

Chandran SS, Dickson KA, Raines RT.

J Am Chem Soc. 2005 Feb 16;127(6):1652-3.


Phosphoenolpyruvate availability and the biosynthesis of shikimic acid.

Chandran SS, Yi J, Draths KM, von Daeniken R, Weber W, Frost JW.

Biotechnol Prog. 2003 May-Jun;19(3):808-14.


Hydroaromatic equilibration during biosynthesis of shikimic acid.

Knop DR, Draths KM, Chandran SS, Barker JL, von Daeniken R, Weber W, Frost JW.

J Am Chem Soc. 2001 Oct 24;123(42):10173-82.


Benzene-Free Synthesis of Phenol This research was supported by a grant awarded by the U.S. Department of Agriculture.

Gibson JM, Thomas PS, Thomas JD, Barker JL, Chandran SS, Harrup MK, Draths KM, Frost JW.

Angew Chem Int Ed Engl. 2001 May 18;40(10):1945-1948. No abstract available.


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