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AML refractory to primary induction with Ida-FLAG has a poor clinical outcome.

Kavanagh S, Heath E, Hurren R, Gronda M, Barghout SH, Liyanage SU, Siriwardena TP, Claudio J, Zhang T, Sukhai M, Stockley TL, Kamel-Reid S, Rostom A, Lutynski A, Khalaf D, Rydlewski A, Chan SM, Gupta V, Maze D, Sibai H, Schuh AC, Yee K, Minden MD, Schimmer AD.

Leuk Res. 2018 Feb 20;68:22-28. doi: 10.1016/j.leukres.2018.02.012. [Epub ahead of print]


The inositol-requiring enzyme 1 (IRE1α) RNAse inhibitor, 4µ8C, is also a potent cellular antioxidant.

Chan SMH, Lowe MP, Bernard A, Miller AA, Herbert TP.

Biochem J. 2018 Mar 9;475(5):923-929. doi: 10.1042/BCJ20170678.


3',4'-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice.

Lau YS, Mustafa MR, Choy KW, Chan SMH, Potocnik S, Herbert TP, Woodman OL.

Sci Rep. 2018 Jan 29;8(1):1818. doi: 10.1038/s41598-018-19584-8.


A "Stone in the Pond" Approach to Contact Tracing: Responding to a Large-Scale, Nosocomial Tuberculosis Exposure in a Moderate TB-Burden Setting.

Bagdasarian N, Chan HC, Ang S, Isa MS, Chan SM, Fisher DA.

Infect Control Hosp Epidemiol. 2017 Dec;38(12):1509-1511. doi: 10.1017/ice.2017.228. Epub 2017 Nov 28.


Recurrent Mycobacterium fortuitum insulin injection site abscesses.

Han VX, Loke KY, Chan SM.

J Paediatr Child Health. 2018 Mar;54(3):316-318. doi: 10.1111/jpc.13788. Epub 2017 Nov 23. No abstract available.


Moderate iodine deficiency among pregnant women in Hong Kong: revisit the problem after two decades.

Tam WH, Chan RS, Chan MH, Yuen LY, Li L, Sea MM, Woo J.

Hong Kong Med J. 2017 Dec;23(6):586-93. doi: 10.12809/hkmj176841. Epub 2017 Nov 10.


Cognitive Effects of Multi-domain Interventions among Pre-frail and Frail Community-living Older Persons: Randomized Controlled Trial.

Ng TP, Ling A, Feng L, Nyunt MSZ, Feng L, Niti M, Tan BY, Chan G, Khoo SA, Chan SM, Yap P, Yap KB.

J Gerontol A Biol Sci Med Sci. 2017 Oct 24. doi: 10.1093/gerona/glx207. [Epub ahead of print]


Multi-Domains Lifestyle Interventions Reduces Depressive Symptoms among Frail and Pre-Frail Older Persons: Randomized Controlled Trial.

Ng TP, Nyunt MSZ, Feng L, Feng L, Niti M, Tan BY, Chan G, Khoo SA, Chan SM, Yap P, Yap KB.

J Nutr Health Aging. 2017;21(8):918-926. doi: 10.1007/s12603-016-0867-y.


Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication.

Aghamohammadi A, Abolhassani H, Kutukculer N, Wassilak SG, Pallansch MA, Kluglein S, Quinn J, Sutter RW, Wang X, Sanal O, Latysheva T, Ikinciogullari A, Bernatowska E, Tuzankina IA, Costa-Carvalho BT, Franco JL, Somech R, Karakoc-Aydiner E, Singh S, Bezrodnik L, Espinosa-Rosales FJ, Shcherbina A, Lau YL, Nonoyama S, Modell F, Modell V; JMF Centers Network Investigators and Study Collaborators, Barbouche MR, McKinlay MA.

Front Immunol. 2017 Jun 13;8:685. doi: 10.3389/fimmu.2017.00685. eCollection 2017.


Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response.

Chan SMH, Lau YS, Miller AA, Ku JM, Potocnik S, Ye JM, Woodman OL, Herbert TP.

Endocrinology. 2017 Oct 1;158(10):3162-3173. doi: 10.1210/en.2016-1879.


Can we now recommend OTSC as first-line therapy in case of non-variceal upper gastrointestinal bleeding?

Chan SM, Lau JY.

Endosc Int Open. 2017 Sep;5(9):E883-E885. doi: 10.1055/s-0043-111722. Epub 2017 Sep 12. No abstract available.


A46 MERS-CoV in Arabian camels in Africa and Central Asia.

Chu DKW, Chan SMS, Perera RAPM, Miguel E, Roger F, Chevalier V, Poon LLM, Peiris M.

Virus Evol. 2017 Mar 5;3(Suppl 1). pii: vew036.045. doi: 10.1093/ve/vew036.045. eCollection 2017 Mar. No abstract available.


Levobuipivacaine-Induced Dissemination of A549 Lung Cancer Cells.

Chan SM, Lin BF, Wong CS, Chuang WT, Chou YT, Wu ZF.

Sci Rep. 2017 Aug 17;7(1):8646. doi: 10.1038/s41598-017-08885-z.


Randomized controlled trial of EndoWrist-enabled robotic versus human laparoendoscopic single-site access surgery (LESS) in the porcine model.

Teoh AYB, Chan SM, Yip HC, Wong VWY, Chiu PWY, Ng EKW.

Surg Endosc. 2018 Mar;32(3):1273-1279. doi: 10.1007/s00464-017-5803-7. Epub 2017 Aug 11.


Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist.

McKeown MR, Corces MR, Eaton ML, Fiore C, Lee E, Lopez JT, Chen MW, Smith D, Chan SM, Koenig JL, Austgen K, Guenther MG, Orlando DA, Lovén J, Fritz CC, Majeti R.

Cancer Discov. 2017 Oct;7(10):1136-1153. doi: 10.1158/2159-8290.CD-17-0399. Epub 2017 Jul 20.


Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014-2015.

Hemida MG, Alnaeem A, Chu DK, Perera RA, Chan SM, Almathen F, Yau E, Ng BC, Webby RJ, Poon LL, Peiris M.

Emerg Microbes Infect. 2017 Jun 21;6(6):e56. doi: 10.1038/emi.2017.44.


The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells.

Chan SMH, Zhao X, Elfowiris A, Ratnam C, Herbert TP.

Biochimie. 2017 Jul;138:156-167. doi: 10.1016/j.biochi.2017.04.018. Epub 2017 May 4.


Coronavirus infections in horses in Saudi Arabia and Oman.

Hemida MG, Chu DKW, Perera RAPM, Ko RLW, So RTY, Ng BCY, Chan SMS, Chu S, Alnaeem AA, Alhammadi MA, Webby RJ, Poon LLM, Balasuriya UBR, Peiris M.

Transbound Emerg Dis. 2017 Dec;64(6):2093-2103. doi: 10.1111/tbed.12630. Epub 2017 Mar 13.


Planning for operating room efficiency and faster anesthesia wake-up time in open major upper abdominal surgery.

Lai HC, Chan SM, Lu CH, Wong CS, Cherng CH, Wu ZF.

Medicine (Baltimore). 2017 Feb;96(7):e6148. doi: 10.1097/MD.0000000000006148.


Serologic Responses After Hepatitis B Vaccination in Preterm Infants Born to Hepatitis B Surface Antigen-Positive Mothers: Singapore Experience.

Tan CX, Chan SM, Lee LY, Ong C, Phua KB, Aw MM, Saw S, Lee GH, Wong F, Thoon KC.

Pediatr Infect Dis J. 2017 Aug;36(8):e208-e210. doi: 10.1097/INF.0000000000001578.


Biological and clinical consequences of NPM1 mutations in AML.

Heath EM, Chan SM, Minden MD, Murphy T, Shlush LI, Schimmer AD.

Leukemia. 2017 Apr;31(4):798-807. doi: 10.1038/leu.2017.30. Epub 2017 Jan 23. Review.


DDW 2016 review: Advances in therapeutic upper gastrointestinal endoscopy.

Chan SM, Yeung B, Chiu PW.

Dig Endosc. 2017 Mar;29(2):145-148. doi: 10.1111/den.12767. Epub 2017 Jan 22. Review.


Esophageal leakage after surgical repair of spontaneous rupture: successful closure with endoscopic suture device.

Yip HC, Chiu PW, Chan SM, Wong VW, Teoh AY, Wong SK, Ng EK.

Endoscopy. 2016 0;48(S 01):E344-E345. Epub 2016 Nov 16. No abstract available.


Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.

Matre P, Velez J, Jacamo R, Qi Y, Su X, Cai T, Chan SM, Lodi A, Sweeney SR, Ma H, Davis RE, Baran N, Haferlach T, Su X, Flores ER, Gonzalez D, Konoplev S, Samudio I, DiNardo C, Majeti R, Schimmer AD, Li W, Wang T, Tiziani S, Konopleva M.

Oncotarget. 2016 Nov 29;7(48):79722-79735. doi: 10.18632/oncotarget.12944.


Robotic-assisted minimally invasive esophagectomy for treatment of esophageal carcinoma.

Chiu PW, Teoh AY, Wong VW, Yip HC, Chan SM, Wong SK, Ng EK.

J Robot Surg. 2017 Jun;11(2):193-199. doi: 10.1007/s11701-016-0644-2. Epub 2016 Oct 25.


Comparison of Anesthesia-Controlled Operating Room Time between Propofol-Based Total Intravenous Anesthesia and Desflurane Anesthesia in Open Colorectal Surgery: A Retrospective Study.

Chan WH, Lee MS, Lin C, Wu CC, Lai HC, Chan SM, Lu CH, Cherng CH, Wu ZF.

PLoS One. 2016 Oct 25;11(10):e0165407. doi: 10.1371/journal.pone.0165407. eCollection 2016. Erratum in: PLoS One. 2016 Dec 8;11(12 ):e0168310.


Chinese Version of the Healthy Lifestyle Beliefs Scale for Taiwanese Adolescents: A Psychometric Study.

Chan SM, Melnyk BM, Chen AC.

J Pediatr Nurs. 2017 Jan - Feb;32:19-24. doi: 10.1016/j.pedn.2016.10.003. Epub 2016 Oct 17.


Accounting for Ethnicity-Related Differences in Ocular Surface Integrity as a Step Toward Understanding Contact Lens Discomfort.

Chan SM, Svitova TF, Lin MC.

Eye Contact Lens. 2017 Jan;43(1):23-31. doi: 10.1097/ICL.0000000000000342. Review.


Feasibility of per-oral cholecystoscopy and advanced gallbladder interventions after EUS-guided gallbladder stenting (with video).

Chan SM, Teoh AYB, Yip HC, Wong VWY, Chiu PWY, Ng EKW.

Gastrointest Endosc. 2017 Jun;85(6):1225-1232. doi: 10.1016/j.gie.2016.10.014. Epub 2016 Oct 15.


Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells.

Huang M, Garcia JS, Thomas D, Zhu L, Nguyen LX, Chan SM, Majeti R, Medeiros BC, Mitchell BS.

Oncotarget. 2016 Nov 15;7(46):74917-74930. doi: 10.18632/oncotarget.12493.


Isocitrate dehydrogenase mutations in myeloid malignancies.

Medeiros BC, Fathi AT, DiNardo CD, Pollyea DA, Chan SM, Swords R.

Leukemia. 2017 Feb;31(2):272-281. doi: 10.1038/leu.2016.275. Epub 2016 Oct 10. Review.


Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution.

Corces MR, Buenrostro JD, Wu B, Greenside PG, Chan SM, Koenig JL, Snyder MP, Pritchard JK, Kundaje A, Greenleaf WJ, Majeti R, Chang HY.

Nat Genet. 2016 Oct;48(10):1193-203. doi: 10.1038/ng.3646. Epub 2016 Aug 15.


Physical measurements of Chinese children in Hong Kong-A pilot study in preschools and kindergartens.

Mok GT, Chan SS, Chu YW, Chan SM, Wong WH, Chung BH.

Am J Med Genet A. 2016 Aug;170(8):2069-77. doi: 10.1002/ajmg.a.37764. Epub 2016 May 31.


Subacute food bolus obstruction secondary to a migrated Overstitch suture from a previous esophageal perforation repair.

Yeung BP, Chan SM, Chiu PW.

Endoscopy. 2016;48 Suppl 1:E177-8. doi: 10.1055/s-0042-106965. Epub 2016 May 23. No abstract available.


A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis.

Chan JF, Lau SK, Wong SC, To KK, So SY, Leung SS, Chan SM, Pang CM, Xiao C, Hung IF, Cheng VC, Yuen KY, Woo PC.

Emerg Microbes Infect. 2016 Apr 20;5:e37. doi: 10.1038/emi.2016.31.


Human oropharynx as natural reservoir of Streptobacillus hongkongensis.

Lau SK, Chan JF, Tsang CC, Chan SM, Ho ML, Que TL, Lau YL, Woo PC.

Sci Rep. 2016 Apr 14;6:24419. doi: 10.1038/srep24419.


Endoplasmic reticulum stress up-regulates Nedd4-2 to induce autophagy.

Wang H, Sun RQ, Camera D, Zeng XY, Jo E, Chan SM, Herbert TP, Molero JC, Ye JM.

FASEB J. 2016 Jul;30(7):2549-56. doi: 10.1096/fj.201500119. Epub 2016 Mar 28.


Contextual influence of Taiwanese adolescents' sexual attitudes and behavioral intent.

Chen AC, Neilands TB, Chan SM, Lightfoot M.

Nurs Health Sci. 2016 Sep;18(3):355-61. doi: 10.1111/nhs.12278. Epub 2016 Mar 15.


Effects of mechanical stresses on sperm function and fertilization rate in mice.

Shi X, Wang T, Qiu ZL, Li K, Li L, Chan CP, Chan SM, Li TC, Quan S.

Syst Biol Reprod Med. 2016;62(2):152-9. doi: 10.3109/19396368.2015.1115915. Epub 2016 Feb 18.


Erratum to: Severe Mycobacterial Diseases in a Patient with GOF IκBα Mutation Without EDA.

Lee AJ, Moncada-Vélez M, Picard C, Llanora G, Huang CH, Abel L, Chan SM, Lee BW, Casanova JL, Bustamante J, Shek LP, Boisson-Dupuis S.

J Clin Immunol. 2016 Apr;36(3):335. doi: 10.1007/s10875-016-0238-9. No abstract available.


The Worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) point prevalence survey: developing hospital-quality indicators of antibiotic prescribing for children.

Versporten A, Bielicki J, Drapier N, Sharland M, Goossens H; ARPEC project group.

J Antimicrob Chemother. 2016 Apr;71(4):1106-17. doi: 10.1093/jac/dkv418. Epub 2016 Jan 8.


Severe Mycobacterial Diseases in a Patient with GOF IκBα Mutation Without EDA.

Lee AJ, Moncada-Vélez M, Picard C, Llanora G, Huang CH, Abel L, Chan SM, Lee BW, Casanova JL, Bustamante J, Shek LP, Boisson-Dupuis S.

J Clin Immunol. 2016 Jan;36(1):12-5. doi: 10.1007/s10875-015-0223-8. Epub 2015 Dec 21. No abstract available. Erratum in: J Clin Immunol. 2016 Apr;36(3):335.


Surveillance for Coronaviruses in Bats, Lebanon and Egypt, 2013-2015.

Shehata MM, Chu DK, Gomaa MR, AbiSaid M, El Shesheny R, Kandeil A, Bagato O, Chan SM, Barbour EK, Shaib HS, McKenzie PP, Webby RJ, Ali MA, Peiris M, Kayali G.

Emerg Infect Dis. 2016 Jan;22(1):148-50. doi: 10.3201/eid2201.151397. No abstract available.


Ex vivo comparison of the lumen-apposing properties of EUS-specific stents (with video).

Teoh AY, Ng EK, Chan SM, Lai M, Moran S, Binmoeller KF, Moon JH, Ho KY.

Gastrointest Endosc. 2016 Jul;84(1):62-8. doi: 10.1016/j.gie.2015.11.041. Epub 2015 Dec 10.


Emotion socialization practices in Italian and Hong Kong-Chinese mothers.

Fiorilli C, De Stasio S, Di Chicchio C, Chan SM.

Springerplus. 2015 Dec 7;4:758. doi: 10.1186/s40064-015-1550-1. eCollection 2015.


Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria, 2015.

Chu DK, Oladipo JO, Perera RA, Kuranga SA, Chan SM, Poon LL, Peiris M.

Euro Surveill. 2015;20(49). doi: 10.2807/1560-7917.ES.2015.20.49.30086.


System-L amino acid transporters play a key role in pancreatic β-cell signalling and function.

Cheng Q, Beltran VD, Chan SM, Brown JR, Bevington A, Herbert TP.

J Mol Endocrinol. 2016 Apr;56(3):175-87. doi: 10.1530/JME-15-0212. Epub 2015 Dec 8.


Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.

Mazumdar C, Shen Y, Xavy S, Zhao F, Reinisch A, Li R, Corces MR, Flynn RA, Buenrostro JD, Chan SM, Thomas D, Koenig JL, Hong WJ, Chang HY, Majeti R.

Cell Stem Cell. 2015 Dec 3;17(6):675-688. doi: 10.1016/j.stem.2015.09.017. Epub 2015 Oct 22.


Unilateral Proptosis in an Immunocompetent Child From the Middle East.

Fu KX, Tham E, Chao SS, Sundar G, Isa MS, Shek LP, Ang S, Chan SM.

Pediatr Infect Dis J. 2016 Mar;35(3):356-7. doi: 10.1097/INF.0000000000001002. No abstract available.


Does evaluation of the ligamentous compartment enhance diagnostic utility of sacroiliac joint MRI in axial spondyloarthritis?

Weber U, Maksymowych WP, Chan SM, Rufibach K, Pedersen SJ, Zhao Z, Zubler V, Østergaard M, Lambert RG.

Arthritis Res Ther. 2015 Sep 13;17:246. doi: 10.1186/s13075-015-0729-8.

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