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Items: 40


Modulation of cabozantinib efficacy by the prostate tumor microenvironment.

Tripathi M, Nandana S, Billet S, Cavassani KA, Mishra R, Chung LWK, Posadas EM, Bhowmick NA.

Oncotarget. 2017 Sep 23;8(50):87891-87902. doi: 10.18632/oncotarget.21248. eCollection 2017 Oct 20.


Recognition of Candida albicans by gingival fibroblasts: The role of TLR2, TLR4/CD14, and MyD88.

Pinheiro CR, Coelho AL, de Oliveira CE, Gasparoto TH, Garlet GP, Silva JS, Santos CF, Cavassani KA, Hogaboam CM, Campanelli AP.

Cytokine. 2017 Nov 8. pii: S1043-4666(17)30318-6. doi: 10.1016/j.cyto.2017.10.013. [Epub ahead of print]


CCR5-Dependent Homing of T Regulatory Cells to the Tumor Microenvironment Contributes to Skin Squamous Cell Carcinoma Development.

de Oliveira CE, Gasparoto TH, Pinheiro CR, Amôr NG, Nogueira MRS, Kaneno R, Garlet GP, Lara VS, Silva JS, Cavassani KA, Campanelli AP.

Mol Cancer Ther. 2017 Dec;16(12):2871-2880. doi: 10.1158/1535-7163.MCT-17-0341. Epub 2017 Sep 13.


The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages.

Carson WF 4th, Cavassani KA, Soares EM, Hirai S, Kittan NA, Schaller MA, Scola MM, Joshi A, Matsukawa A, Aronoff DM, Johnson CN, Dou Y, Gallagher KA, Kunkel SL.

J Immunol. 2017 Sep 1;199(5):1865-1874. doi: 10.4049/jimmunol.1601272. Epub 2017 Jul 21.


SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer.

Gururajan M, Cavassani KA, Sievert M, Duan P, Lichterman J, Huang JM, Smith B, You S, Nandana S, Chu GC, Mink S, Josson S, Liu C, Morello M, Jones LW, Kim J, Freeman MR, Bhowmick N, Zhau HE, Chung LW, Posadas EM.

Oncotarget. 2015 Dec 29;6(42):44072-83. doi: 10.18632/oncotarget.6398.


Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection.

Nagata DE, Ting HA, Cavassani KA, Schaller MA, Mukherjee S, Ptaschinski C, Kunkel SL, Lukacs NW.

Mucosal Immunol. 2015 Sep;8(5):1131-43. doi: 10.1038/mi.2015.4. Epub 2015 Feb 11.


Inflammasome activation is critical to the protective immune response during chemically induced squamous cell carcinoma.

Gasparoto TH, de Oliveira CE, de Freitas LT, Pinheiro CR, Hori JI, Garlet GP, Cavassani KA, Schillaci R, da Silva JS, Zamboni DS, Campanelli AP.

PLoS One. 2014 Sep 30;9(9):e107170. doi: 10.1371/journal.pone.0107170. eCollection 2014.


Regulatory T cells in the actinic cheilitis.

Gasparoto TH, de Souza Malaspina TS, Damante JH, de Mello EF Jr, Ikoma MR, Garlet GP, Costa MR, Cavassani KA, da Silva JS, Campanelli AP.

J Oral Pathol Med. 2014 Nov;43(10):754-60. doi: 10.1111/jop.12207. Epub 2014 Jul 24.


Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes.

Kittan NA, Allen RM, Dhaliwal A, Cavassani KA, Schaller M, Gallagher KA, Carson WF 4th, Mukherjee S, Grembecka J, Cierpicki T, Jarai G, Westwick J, Kunkel SL, Hogaboam CM.

PLoS One. 2013 Oct 21;8(10):e78045. doi: 10.1371/journal.pone.0078045. eCollection 2013.


PD-1 blockage delays murine squamous cell carcinoma development.

Belai EB, de Oliveira CE, Gasparoto TH, Ramos RN, Torres SA, Garlet GP, Cavassani KA, Silva JS, Campanelli AP.

Carcinogenesis. 2014 Feb;35(2):424-31. doi: 10.1093/carcin/bgt305. Epub 2013 Sep 12.


B cell-deficient mice display enhanced susceptibility to Paracoccidioides brasiliensis Infection.

Tristão FS, Panagio LA, Rocha FA, Cavassani KA, Moreira AP, Rossi MA, Silva JS.

Mycopathologia. 2013 Aug;176(1-2):1-10. doi: 10.1007/s11046-013-9671-y. Epub 2013 Jun 14.


Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity.

Cavassani KA, Moreira AP, Habiel D, Ito T, Coelho AL, Allen RM, Hu B, Raphelson J, Carson WF 4th, Schaller MA, Lukacs NW, Omary MB, Hogaboam CM, Kunkel SL.

PLoS One. 2013 Jun 7;8(6):e65899. doi: 10.1371/journal.pone.0065899. Print 2013.


CD25+ T cell depletion impairs murine squamous cell carcinoma development via modulation of antitumor immune responses.

Ramos RN, Oliveira CE, Gasparoto TH, Malaspina TS, Belai EB, Cavassani KA, Garlet GP, Silva JS, Campanelli AP.

Carcinogenesis. 2012 Apr;33(4):902-9. doi: 10.1093/carcin/bgs103. Epub 2012 Feb 16.


The critical role of Notch ligand Delta-like 1 in the pathogenesis of influenza A virus (H1N1) infection.

Ito T, Allen RM, Carson WF 4th, Schaller M, Cavassani KA, Hogaboam CM, Lukacs NW, Matsukawa A, Kunkel SL.

PLoS Pathog. 2011 Nov;7(11):e1002341. doi: 10.1371/journal.ppat.1002341. Epub 2011 Nov 3.


The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A.

Moreira AP, Cavassani KA, Ismailoglu UB, Hullinger R, Dunleavy MP, Knight DA, Kunkel SL, Uematsu S, Akira S, Hogaboam CM.

J Clin Invest. 2011 Nov;121(11):4420-32. doi: 10.1172/JCI44999. Epub 2011 Oct 17.


Cell-free antigens from Paracoccidioides brasiliensis drive IL-4 production and increase the severity of paracoccidioidomycosis.

Cavassani KA, Tristao FS, Oliveira LL, Rocha FA, Vancim JO, Moreira AP, Campanelli AP, Panagio LA, Milanezi CM, Martinez R, Rossi MA, Silva JS.

PLoS One. 2011;6(6):e21423. doi: 10.1371/journal.pone.0021423. Epub 2011 Jun 22.


Therapeutic DNA vaccine reduces schistosoma mansoni-induced tissue damage through cytokine balance and decreased migration of myofibroblasts.

Frantz FG, Ito T, Cavassani KA, Hogaboam CM, Lopes Silva C, Kunkel SL, Faccioli LH.

Am J Pathol. 2011 Jul;179(1):223-9. doi: 10.1016/j.ajpath.2011.03.012. Epub 2011 May 18.


Dysregulated cytokine expression by CD4+ T cells from post-septic mice modulates both Th1 and Th2-mediated granulomatous lung inflammation.

Carson WF 4th, Ito T, Schaller M, Cavassani KA, Chensue SW, Kunkel SL.

PLoS One. 2011;6(5):e20385. doi: 10.1371/journal.pone.0020385. Epub 2011 May 31.


Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction.

Chen GY, Chen X, King S, Cavassani KA, Cheng J, Zheng X, Cao H, Yu H, Qu J, Fang D, Wu W, Bai XF, Liu JQ, Woodiga SA, Chen C, Sun L, Hogaboam CM, Kunkel SL, Zheng P, Liu Y.

Nat Biotechnol. 2011 May;29(5):428-35. doi: 10.1038/nbt.1846. Epub 2011 Apr 10. Erratum in: Nat Biotechnol. 2012 Feb;30(2):193.


Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma.

Malaspina TS, Gasparoto TH, Costa MR, de Melo EF Jr, Ikoma MR, Damante JH, Cavassani KA, Garlet GP, da Silva JS, Campanelli AP.

Cancer Immunol Immunother. 2011 Jul;60(7):965-74. doi: 10.1007/s00262-011-1007-5. Epub 2011 Mar 27.


CCR6 as a mediator of immunity in the lung and gut.

Ito T, Carson WF 4th, Cavassani KA, Connett JM, Kunkel SL.

Exp Cell Res. 2011 Mar 10;317(5):613-9. doi: 10.1016/j.yexcr.2010.12.018. Review.


Epigenetic regulation of immune cell functions during post-septic immunosuppression.

Carson WF, Cavassani KA, Dou Y, Kunkel SL.

Epigenetics. 2011 Mar;6(3):273-83. Epub 2011 Mar 1. Review.


Delta-like 4 differentially regulates murine CD4 T cell expansion via BMI1.

Schaller MA, Logue H, Mukherjee S, Lindell DM, Coelho AL, Lincoln P, Carson WF 4th, Ito T, Cavassani KA, Chensue SW, Hogaboam CM, Lukacs NW, Kunkel SL.

PLoS One. 2010 Aug 17;5(8):e12172. doi: 10.1371/journal.pone.0012172.


Serum amyloid P attenuates M2 macrophage activation and protects against fungal spore-induced allergic airway disease.

Moreira AP, Cavassani KA, Hullinger R, Rosada RS, Fong DJ, Murray L, Hesson DP, Hogaboam CM.

J Allergy Clin Immunol. 2010 Oct;126(4):712-721.e7. doi: 10.1016/j.jaci.2010.06.010. Epub 2010 Jul 31.


The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth.

Cavassani KA, Carson WF 4th, Moreira AP, Wen H, Schaller MA, Ishii M, Lindell DM, Dou Y, Lukacs NW, Keshamouni VG, Hogaboam CM, Kunkel SL.

Blood. 2010 Jun 3;115(22):4403-11. doi: 10.1182/blood-2009-09-241083. Epub 2010 Feb 3.


Impaired CD4+ T-cell proliferation and effector function correlates with repressive histone methylation events in a mouse model of severe sepsis.

Carson WF 4th, Cavassani KA, Ito T, Schaller M, Ishii M, Dou Y, Kunkel SL.

Eur J Immunol. 2010 Apr;40(4):998-1010. doi: 10.1002/eji.200939739.


Patients with oral squamous cell carcinoma are characterized by increased frequency of suppressive regulatory T cells in the blood and tumor microenvironment.

Gasparoto TH, de Souza Malaspina TS, Benevides L, de Melo EJ Jr, Costa MR, Damante JH, Ikoma MR, Garlet GP, Cavassani KA, da Silva JS, Campanelli AP.

Cancer Immunol Immunother. 2010 Jun;59(6):819-28. doi: 10.1007/s00262-009-0803-7. Epub 2009 Dec 12.


Epigenetic regulation of the alternatively activated macrophage phenotype.

Ishii M, Wen H, Corsa CA, Liu T, Coelho AL, Allen RM, Carson WF 4th, Cavassani KA, Li X, Lukacs NW, Hogaboam CM, Dou Y, Kunkel SL.

Blood. 2009 Oct 8;114(15):3244-54. doi: 10.1182/blood-2009-04-217620. Epub 2009 Jun 30.


TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events.

Cavassani KA, Ishii M, Wen H, Schaller MA, Lincoln PM, Lukacs NW, Hogaboam CM, Kunkel SL.

J Exp Med. 2008 Oct 27;205(11):2609-21. doi: 10.1084/jem.20081370. Epub 2008 Oct 6.


Role of interleukin (IL)-18 in experimental paracoccidioidomycosis.

Panagio LA, Tristao FS, Moreira AP, Pereira MS, Cavassani KA, Milanezi CM, Rossi MA, Silva JS.

Med Mycol. 2008 Aug;46(5):435-42. doi: 10.1080/13693780801895444. Epub 2008 Mar 5.


The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection.

Mariano FS, Gutierrez FR, Pavanelli WR, Milanezi CM, Cavassani KA, Moreira AP, Ferreira BR, Cunha FQ, Cardoso CR, Silva JS.

Microbes Infect. 2008 Jun;10(7):825-33. doi: 10.1016/j.micinf.2008.04.009. Epub 2008 Apr 30.


CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression.

Moreira AP, Cavassani KA, Massafera Tristão FS, Campanelli AP, Martinez R, Rossi MA, Silva JS.

J Immunol. 2008 Mar 1;180(5):3049-56.


Tick saliva inhibits the chemotactic function of MIP-1alpha and selectively impairs chemotaxis of immature dendritic cells by down-regulating cell-surface CCR5.

Oliveira CJ, Cavassani KA, Moré DD, Garlet GP, Aliberti JC, Silva JS, Ferreira BR.

Int J Parasitol. 2008 May;38(6):705-16. Epub 2007 Oct 22.


Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans.

Cavassani KA, Campanelli AP, Moreira AP, Vancim JO, Vitali LH, Mamede RC, Martinez R, Silva JS.

J Immunol. 2006 Nov 1;177(9):5811-8.


Intercellular adhesion molecule-1 is required for the early formation of granulomas and participates in the resistance of mice to the infection with the fungus Paracoccidioides brasiliensis.

Moreira AP, Campanelli AP, Cavassani KA, Souto JT, Ferreira BR, Martinez R, Rossi MA, Silva JS.

Am J Pathol. 2006 Oct;169(4):1270-81.


CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.

Campanelli AP, Roselino AM, Cavassani KA, Pereira MS, Mortara RA, Brodskyn CI, Goncalves HS, Belkaid Y, Barral-Netto M, Barral A, Silva JS.

J Infect Dis. 2006 May 1;193(9):1313-22. Epub 2006 Mar 17.


Potential of KM+ lectin in immunization against Leishmania amazonensis infection.

Teixeira CR, Cavassani KA, Gomes RB, Teixeira MJ, Roque-Barreira MC, Cavada BS, da Silva JS, Barral A, Barral-Netto M.

Vaccine. 2006 Apr 5;24(15):3001-8. Epub 2006 Jan 18.


Tick saliva inhibits differentiation, maturation and function of murine bone-marrow-derived dendritic cells.

Cavassani KA, Aliberti JC, Dias AR, Silva JS, Ferreira BR.

Immunology. 2005 Feb;114(2):235-45.


Cloning and characterization of a gene encoding an immunoglobulin-binding receptor on the cell surface of some members of the family Trypanosomatidae.

Campos-Neto A, Suffia I, Cavassani KA, Jen S, Greeson K, Ovendale P, Silva JS, Reed SG, Skeiky YA.

Infect Immun. 2003 Sep;71(9):5065-76.


Antigens from Rhipicephalus sanguineus ticks elicit potent cell-mediated immune responses in resistant but not in susceptible animals.

Ferreira BR, Szabó MJ, Cavassani KA, Bechara GH, Silva JS.

Vet Parasitol. 2003 Jul 10;115(1):35-48.


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