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PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.

Wang J, Xie T, Wang B, William WN Jr, Heymach JV, El-Naggar AK, Myers JN, Caulin C.

Cancer Prev Res (Phila). 2017 Dec;10(12):684-693. doi: 10.1158/1940-6207.CAPR-17-0108. Epub 2017 Oct 10.


Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H).

Li Z, Gonzalez CL, Wang B, Zhang Y, Mejia O, Katsonis P, Lichtarge O, Myers JN, El-Naggar AK, Caulin C.

J Pathol. 2016 Oct;240(2):224-34. doi: 10.1002/path.4770.


The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer.

Foy JP, Tortereau A, Caulin C, Le Texier V, Lavergne E, Thomas E, Chabaud S, Perol D, Lachuer J, Lang W, Hong WK, Goudot P, Lippman SM, Bertolus C, Saintigny P.

Oncotarget. 2016 Jun 14;7(24):35932-35945. doi: 10.18632/oncotarget.8321.


Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations.

Mitani Y, Liu B, Rao PH, Borra VJ, Zafereo M, Weber RS, Kies M, Lozano G, Futreal PA, Caulin C, El-Naggar AK.

Clin Cancer Res. 2016 Feb 1;22(3):725-33. doi: 10.1158/1078-0432.CCR-15-2867-T. Epub 2015 Dec 2.


Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins.

Tanaka N, Patel AA, Wang J, Frederick MJ, Kalu NN, Zhao M, Fitzgerald AL, Xie TX, Silver NL, Caulin C, Zhou G, Skinner HD, Johnson FM, Myers JN, Osman AA.

Clin Cancer Res. 2015 Nov 1;21(21):4831-44. doi: 10.1158/1078-0432.CCR-15-0279. Epub 2015 Jun 29.


Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.

Neskey DM, Osman AA, Ow TJ, Katsonis P, McDonald T, Hicks SC, Hsu TK, Pickering CR, Ward A, Patel A, Yordy JS, Skinner HD, Giri U, Sano D, Story MD, Beadle BM, El-Naggar AK, Kies MS, William WN, Caulin C, Frederick M, Kimmel M, Myers JN, Lichtarge O.

Cancer Res. 2015 Apr 1;75(7):1527-36. doi: 10.1158/0008-5472.CAN-14-2735. Epub 2015 Jan 29.


Stresses, aging, and age-related disorders.

Li X, Moses RE, Jin J, Cao W, Caulin C.

Oxid Med Cell Longev. 2014;2014:320564. doi: 10.1155/2014/320564. Epub 2014 Dec 30. No abstract available.


Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence.

Osman AA, Monroe MM, Ortega Alves MV, Patel AA, Katsonis P, Fitzgerald AL, Neskey DM, Frederick MJ, Woo SH, Caulin C, Hsu TK, McDonald TO, Kimmel M, Meyn RE, Lichtarge O, Myers JN.

Mol Cancer Ther. 2015 Feb;14(2):608-19. doi: 10.1158/1535-7163.MCT-14-0735-T. Epub 2014 Dec 10.


Alterations associated with androgen receptor gene activation in salivary duct carcinoma of both sexes: potential therapeutic ramifications.

Mitani Y, Rao PH, Maity SN, Lee YC, Ferrarotto R, Post JC, Licitra L, Lippman SM, Kies MS, Weber RS, Caulin C, Lin SH, El-Naggar AK.

Clin Cancer Res. 2014 Dec 15;20(24):6570-81. doi: 10.1158/1078-0432.CCR-14-1746. Epub 2014 Oct 14.


Mutational landscape of aggressive cutaneous squamous cell carcinoma.

Pickering CR, Zhou JH, Lee JJ, Drummond JA, Peng SA, Saade RE, Tsai KY, Curry JL, Tetzlaff MT, Lai SY, Yu J, Muzny DM, Doddapaneni H, Shinbrot E, Covington KR, Zhang J, Seth S, Caulin C, Clayman GL, El-Naggar AK, Gibbs RA, Weber RS, Myers JN, Wheeler DA, Frederick MJ.

Clin Cancer Res. 2014 Dec 15;20(24):6582-92. doi: 10.1158/1078-0432.CCR-14-1768. Epub 2014 Oct 10.


Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.

Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN.

Mol Cell. 2014 Jun 19;54(6):960-74. doi: 10.1016/j.molcel.2014.04.024. Epub 2014 May 22.


Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment.

Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, Caulin C.

Oncogene. 2015 Jan 22;34(4):516-24. doi: 10.1038/onc.2013.585. Epub 2014 Jan 27.


Differential regulation of the REGγ-proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells.

Ali A, Wang Z, Fu J, Ji L, Liu J, Li L, Wang H, Chen J, Caulin C, Myers JN, Zhang P, Xiao J, Zhang B, Li X.

Nat Commun. 2013;4:2667. doi: 10.1038/ncomms3667.


Detailed genome-wide SNP analysis of major salivary carcinomas localizes subtype-specific chromosome sites and oncogenes of potential clinical significance.

Zhang L, Mitani Y, Caulin C, Rao PH, Kies MS, Saintigny P, Zhang N, Weber RS, Lippman SM, El-Naggar AK.

Am J Pathol. 2013 Jun;182(6):2048-57. doi: 10.1016/j.ajpath.2013.02.020. Epub 2013 Apr 10.


Modeling squamous cell carcinoma development and malignant progression in mice.

Caulin C.

BMC Proc. 2013 Apr 4;7 Suppl 2:K3. doi: 10.1186/1753-6561-7-S2-K3. eCollection 2013. No abstract available.


Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome.

Mitani Y, Rao PH, Futreal PA, Roberts DB, Stephens PJ, Zhao YJ, Zhang L, Mitani M, Weber RS, Lippman SM, Caulin C, El-Naggar AK.

Clin Cancer Res. 2011 Nov 15;17(22):7003-14. doi: 10.1158/1078-0432.CCR-11-1870. Epub 2011 Oct 5.


Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma.

Torchia EC, Caulin C, Acin S, Terzian T, Kubick BJ, Box NF, Roop DR.

Oncogene. 2012 May 24;31(21):2680-90. doi: 10.1038/onc.2011.441. Epub 2011 Oct 3.


Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.

Acin S, Li Z, Mejia O, Roop DR, El-Naggar AK, Caulin C.

J Pathol. 2011 Dec;225(4):479-89. doi: 10.1002/path.2971. Epub 2011 Sep 26.


Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer.

Sano D, Xie TX, Ow TJ, Zhao M, Pickering CR, Zhou G, Sandulache VC, Wheeler DA, Gibbs RA, Caulin C, Myers JN.

Clin Cancer Res. 2011 Nov 1;17(21):6658-70. doi: 10.1158/1078-0432.CCR-11-0046. Epub 2011 Sep 8.


Expression and regulation of the ΔN and TAp63 isoforms in salivary gland tumorigenesis clinical and experimental findings.

Mitani Y, Li J, Weber RS, Lippman SL, Flores ER, Caulin C, El-Naggar AK.

Am J Pathol. 2011 Jul;179(1):391-9. doi: 10.1016/j.ajpath.2011.03.037. Epub 2011 May 7.


Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance.

Mitani Y, Li J, Rao PH, Zhao YJ, Bell D, Lippman SM, Weber RS, Caulin C, El-Naggar AK.

Clin Cancer Res. 2010 Oct 1;16(19):4722-31. doi: 10.1158/1078-0432.CCR-10-0463. Epub 2010 Aug 11.


A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors.

Torchia EC, Chen Y, Sheng H, Katayama H, Fitzpatrick J, Brinkley WR, Caulin C, Sen S, Roop DR.

Cancer Res. 2009 Sep 15;69(18):7207-15. doi: 10.1158/0008-5472.CAN-09-1059. Epub 2009 Sep 8.


Amiodarone concentrations in plasma and fat tissue during chronic treatment and related toxicity.

Lafuente-Lafuente C, Alvarez JC, Leenhardt A, Mouly S, Extramiana F, Caulin C, Funck-Brentano C, Bergmann JF.

Br J Clin Pharmacol. 2009 May;67(5):511-9. doi: 10.1111/j.1365-2125.2009.03381.x. Epub 2009 Feb 2.


[History of the evaluation of medicines aiming for marketing authorization].

Caulin C.

J Fr Ophtalmol. 2008 Jan;31(1):71-4. French.


An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.

Caulin C, Nguyen T, Lang GA, Goepfert TM, Brinkley BR, Cai WW, Lozano G, Roop DR.

J Clin Invest. 2007 Jul;117(7):1893-901.


Interaction between paracetamol and warfarin in patients: a double-blind, placebo-controlled, randomized study.

Mahé I, Bertrand N, Drouet L, Bal Dit Sollier C, Simoneau G, Mazoyer E, Caulin C, Bergmann JF.

Haematologica. 2006 Dec;91(12):1621-7.


An unexpected role for keratin 10 end domains in susceptibility to skin cancer.

Chen J, Cheng X, Merched-Sauvage M, Caulin C, Roop DR, Koch PJ.

J Cell Sci. 2006 Dec 15;119(Pt 24):5067-76. Epub 2006 Nov 21.


[What explains the increased rate of thromboses among the elderly? Pathophysiological data].

Mahé I, Caulin C, Bergmann JE.

Presse Med. 2005 Jul 2;34(12):887-95. Review. French.


[Age, an independent risk factor for thrombosis. Epidemiologic data].

Mahé I, Caulin C, Bergmann JF.

Presse Med. 2005 Jul 2;34(12):878-86. Review. French.


Which treatment for patent foramen ovale in cryptogenic stroke?

Mahé I, Caulin C, Bergmann JF.

Curr Treat Options Cardiovasc Med. 2005 Jul;7(3):179-85.


Lack of effect of a low-molecular-weight heparin (nadroparin) on mortality in bedridden medical in-patients: a prospective randomised double-blind study.

Mahé I, Bergmann JF, d'Azémar P, Vaissie JJ, Caulin C.

Eur J Clin Pharmacol. 2005 Jul;61(5-6):347-51. Epub 2005 Jun 25.


Paracetamol: a haemorrhagic risk factor in patients on warfarin.

Mahé I, Bertrand N, Drouet L, Simoneau G, Mazoyer E, Bal dit Sollier C, Caulin C, Bergmann JF.

Br J Clin Pharmacol. 2005 Mar;59(3):371-4.


Management of oral anticoagulant in clinical practice: a retrospective study of 187 patients.

Mahé I, Grenard AS, Joyeux N, Caulin C, Bergmann JF.

J Gerontol A Biol Sci Med Sci. 2004 Dec;59(12):1339-42.


Pharmacokinetic-pharmacodynamic modeling of the effect of triamcinolone acetonide on central macular thickness in patients with diabetic macular edema.

Audren F, Tod M, Massin P, Benosman R, Haouchine B, Erginay A, Caulin C, Gaudric A, Bergmann JF.

Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3435-41.


Fatal interruption of a 3TC-containing regimen in a HIV-infected patient due to re-activation of chronic hepatitis B virus infection.

Sellier P, Clevenbergh P, Mazeron MC, Cazals-Hatem D, Evans J, Cervoni J, Badsi E, Bendenoun M, Diemer M, Vincent V, Caulin C, Bergmann JF.

Scand J Infect Dis. 2004;36(6-7):533-5. No abstract available.


Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity.

Caulin C, Nguyen T, Longley MA, Zhou Z, Wang XJ, Roop DR.

Cancer Res. 2004 Aug 1;64(15):5054-8.


D-dimer can predict survival in patients with chronic atrial fibrillation.

Mahé I, Drouet L, Simoneau G, Minh-Muzeaux S, Caulin C, Bergmann JF.

Blood Coagul Fibrinolysis. 2004 Jul;15(5):413-7.


Does paracetamol potentiate the effects of oral anticoagulants?: a literature review.

Mahé I, Caulin C, Bergmann JF.

Drug Saf. 2004;27(5):325-33. Review.


Intravitreal triamcinolone acetonide for diabetic diffuse macular edema: preliminary results of a prospective controlled trial.

Massin P, Audren F, Haouchine B, Erginay A, Bergmann JF, Benosman R, Caulin C, Gaudric A.

Ophthalmology. 2004 Feb;111(2):218-24; discussion 224-5.


Methadone and edema: a case-report and literature review.

Mahé I, Chassany O, Grenard AS, Caulin C, Bergmann JF.

Eur J Clin Pharmacol. 2004 Feb;59(12):923-4. Epub 2004 Jan 20. Review. No abstract available.


Enhanced saquinavir exposure in human immunodeficiency virus type 1-infected patients with diarrhea and/or wasting syndrome.

Trout H, Mentré F, Panhard X, Kodjo A, Escaut L, Pernet P, Gobert JG, Vittecoq D, Knellwolf AL, Caulin C, Bergmann JF.

Antimicrob Agents Chemother. 2004 Feb;48(2):538-45.


Defining the role of calcium channel antagonists in heart failure due to systolic dysfunction.

Mahé I, Chassany O, Grenard AS, Caulin C, Bergmann JF.

Am J Cardiovasc Drugs. 2003;3(1):33-41. Review.


[What are the criteria for evaluation and prevention of venous thromboembolism?].

Mahé I, Grenard AS, Caulin C, Bergmann JF.

Therapie. 2003 Jul-Aug;58(4):327-31. Review. French.


Clinical trials in paediatric oncology. Recommendations for the development of new anticancer agents.

Vassal G, Méry-Mignard D, Caulin C.

Therapie. 2003 May-Jun;58(3):229-46. English, French.


[Clinical practice guideline: medical and nonmedical therapeutic strategies for smoking cessation. Bit of therapeutic practice: management and current practice in smoking cessation].

Lagrue G, Le Foll B, Melihan-Cheinin P, Rostoker G, Ades J, de Beaurepaire R, Berlin Y, Borgne A, Coninx P, Dautzenberg B, Dally S, Divine C, Denis C, Dumarcet N, Dupont P, Jeanjean A, Lagier G, Lebargy F, Leder JM, Legeron P, Le Pen C, Mallaret M, Menard J, Messina C, Molimard R, Mussetta B, Peiffer G, Pons F, Robine I, Saint-Salvi B, Stoebner A, Bouvenot G, Bergmann JF, Caulin C, Dupuis B, Aubier M, Bannwarth B, Camelli B, Castot A, Funk-Brentano C, Le Jeunne C, Meyer F, Petit M, Reveillaud O, Riche C, Rostoker G, Thery C, Tremolieres F, Trouvin JH, Wong O; AFSSAPS.

Rev Mal Respir. 2003 Nov;20(5 Pt 1):791-4. French. No abstract available.


Aspirin for the prevention of cardiovascular events in the elderly.

Mahé I, Leizorovicz A, Caulin C, Bergmann JF.

Drugs Aging. 2003;20(13):999-1010. Review.


[Which antithrombotic treatment should be used in the treatment of an elderly patient with chronic atrial fibrillation?].

Mahé I, Grenard AS, Caulin C, Bergmann JF.

Presse Med. 2003 Jul 26;32(25):1170-4. Review. French.


Aspirin alters arterial function in patients with chronic heart failure treated with ACE inhibitors: a dose-mediated deleterious effect.

Meune C, Mahé I, Mourad JJ, Cohen-Solal A, Levy B, Kevorkian JP, Jondeau G, Habib A, Lebret M, Knellwolf AL, Simoneau G, Caulin C, Bergmann JF.

Eur J Heart Fail. 2003 Jun;5(3):271-9.


D-dimer: a characteristic of the coagulation state of each patient with chronic atrial fibrillation.

Mahé I, Drouet L, Chassany O, Mazoyer E, Simoneau G, Knellwolf AL, Caulin C, Bergmann JF.

Thromb Res. 2002 Jul 15;107(1-2):1-6.


Low molecular weight heparin for the prevention of deep venous thrombosis: a suitable monitoring in elderly patients?

Mahé I, Drouet L, Chassany O, Grenard AS, Caulin C, Bergmann JF.

Pathophysiol Haemost Thromb. 2002 May-Jun;32(3):134-6.

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