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Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer.

Cato L, Neeb A, Sharp A, Buzón V, Ficarro SB, Yang L, Muhle-Goll C, Kuznik NC, Riisnaes R, Nava Rodrigues D, Armant O, Gourain V, Adelmant G, Ntim EA, Westerling T, Dolling D, Rescigno P, Figueiredo I, Fauser F, Wu J, Rottenberg JT, Shatkina L, Ester C, Luy B, Puchta H, Troppmair J, Jung N, Bräse S, Strähle U, Marto JA, Nienhaus GU, Al-Lazikani B, Salvatella X, de Bono JS, Cato AC, Brown M.

Elife. 2017 Aug 10;6. pii: e27159. doi: 10.7554/eLife.27159.


An Amyloidogenic Sequence at the N-Terminus of the Androgen Receptor Impacts Polyglutamine Aggregation.

Oppong E, Stier G, Gaal M, Seeger R, Stoeck M, Delsuc MA, Cato ACB, Kieffer B.

Biomolecules. 2017 Jun 19;7(2). pii: E44. doi: 10.3390/biom7020044.


Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy.

Polanco MJ, Parodi S, Piol D, Stack C, Chivet M, Contestabile A, Miranda HC, Lievens PM, Espinoza S, Jochum T, Rocchi A, Grunseich C, Gainetdinov RR, Cato AC, Lieberman AP, La Spada AR, Sambataro F, Fischbeck KH, Gozes I, Pennuto M.

Sci Transl Med. 2016 Dec 21;8(370):370ra181. doi: 10.1126/scitranslmed.aaf9526.


Click-Chemistry Based Allergen Arrays Generated by Polymer Pen Lithography for Mast Cell Activation Studies.

Kumar R, Bonicelli A, Sekula-Neuner S, Cato AC, Hirtz M, Fuchs H.

Small. 2016 Oct;12(38):5330-5338. doi: 10.1002/smll.201601623. Epub 2016 Aug 11.


Superporous Poly(ethylene glycol) Diacrylate Cryogel with a Defined Elastic Modulus for Prostate Cancer Cell Research.

Göppert B, Sollich T, Abaffy P, Cecilia A, Heckmann J, Neeb A, Bäcker A, Baumbach T, Gruhl FJ, Cato AC.

Small. 2016 Aug;12(29):3985-94. doi: 10.1002/smll.201600683. Epub 2016 May 30.


TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer.

Groner AC, Cato L, de Tribolet-Hardy J, Bernasocchi T, Janouskova H, Melchers D, Houtman R, Cato ACB, Tschopp P, Gu L, Corsinotti A, Zhong Q, Fankhauser C, Fritz C, Poyet C, Wagner U, Guo T, Aebersold R, Garraway LA, Wild PJ, Theurillat JP, Brown M.

Cancer Cell. 2016 Jun 13;29(6):846-858. doi: 10.1016/j.ccell.2016.04.012. Epub 2016 May 26.


Effects of Glucocorticoids in the Immune System.

Oppong E, Cato AC.

Adv Exp Med Biol. 2015;872:217-33. doi: 10.1007/978-1-4939-2895-8_9. Review.


Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L.

Cato L, Neeb A, Brown M, Cato AC.

Nucl Recept Signal. 2014 Nov 4;12:e005. doi: 10.1621/nrs.12005. eCollection 2014. Review.


Splice variant transcripts of the anterior gradient 2 gene as a marker of prostate cancer.

Neeb A, Hefele S, Bormann S, Parson W, Adams F, Wolf P, Miernik A, Schoenthaler M, Kroenig M, Wilhelm K, Schultze-Seemann W, Nestel S, Schaefer G, Bu H, Klocker H, Nazarenko I, Cato AC.

Oncotarget. 2014 Sep 30;5(18):8681-9.


Analysis of the conformation of the androgen receptor in spinal bulbar muscular atrophy by atomic force microscopy.

Jochum T, Cato AC.

Methods Mol Biol. 2014;1204:197-204. doi: 10.1007/978-1-4939-1346-6_17.


Localization and dynamics of glucocorticoid receptor at the plasma membrane of activated mast cells.

Oppong E, Hedde PN, Sekula-Neuner S, Yang L, Brinkmann F, Dörlich RM, Hirtz M, Fuchs H, Nienhaus GU, Cato AC.

Small. 2014 May 28;10(10):1991-8. doi: 10.1002/smll.201303677. Epub 2014 Feb 25.


Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif.

Jehle K, Cato L, Neeb A, Muhle-Goll C, Jung N, Smith EW, Buzon V, Carbó LR, Estébanez-Perpiñá E, Schmitz K, Fruk L, Luy B, Chen Y, Cox MB, Bräse S, Brown M, Cato AC.

J Biol Chem. 2014 Mar 28;289(13):8839-51. doi: 10.1074/jbc.M113.534859. Epub 2014 Feb 12.


The p27-Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells.

Kullmann MK, Grubbauer C, Goetsch K, Jäkel H, Podmirseg SR, Trockenbacher A, Ploner C, Cato AC, Weiss C, Kofler R, Hengst L.

Cell Cycle. 2013 Aug 15;12(16):2625-35. doi: 10.4161/cc.25622. Epub 2013 Jul 9.


Stimulated emission depletion-based raster image correlation spectroscopy reveals biomolecular dynamics in live cells.

Hedde PN, Dörlich RM, Blomley R, Gradl D, Oppong E, Cato AC, Nienhaus GU.

Nat Commun. 2013;4:2093. doi: 10.1038/ncomms3093.


"SEGRAs" and beyond.

Cato AC.

Mol Cell Endocrinol. 2013 Nov 5;380(1-2):1. doi: 10.1016/j.mce.2013.06.011. Epub 2013 Jun 18. No abstract available.


Enhanced inhibition of prostate tumor growth by dual targeting the androgen receptor and the regulatory subunit type iα of protein kinase a in vivo.

Eder IE, Egger M, Neuwirt H, Seifarth C, Maddalo D, Desiniotis A, Schäfer G, Puhr M, Bektic J, Cato AC, Klocker H.

Int J Mol Sci. 2013 Jun 4;14(6):11942-62. doi: 10.3390/ijms140611942.


A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.

He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N, Cato AC, Zhang ZY.

J Med Chem. 2013 Jun 27;56(12):4990-5008. doi: 10.1021/jm400248c. Epub 2013 Jun 6.


Molecular mechanisms of glucocorticoid action in mast cells.

Oppong E, Flink N, Cato AC.

Mol Cell Endocrinol. 2013 Nov 5;380(1-2):119-26. doi: 10.1016/j.mce.2013.05.014. Epub 2013 May 22. Review.


Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis.

Bruchmann A, Roller C, Walther TV, Schäfer G, Lehmusvaara S, Visakorpi T, Klocker H, Cato AC, Maddalo D.

BMC Cancer. 2013 Mar 1;13:96. doi: 10.1186/1471-2407-13-96.


Anterior gradient 2 and 3--two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells.

Bu H, Schweiger MR, Manke T, Wunderlich A, Timmermann B, Kerick M, Pasqualini L, Shehu E, Fuchsberger C, Cato AC, Klocker H.

FEBS J. 2013 Mar;280(5):1249-66. doi: 10.1111/febs.12118. Epub 2013 Feb 13.


A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death.

Maddalo D, Neeb A, Jehle K, Schmitz K, Muhle-Goll C, Shatkina L, Walther TV, Bruchmann A, Gopal SM, Wenzel W, Ulrich AS, Cato AC.

PLoS One. 2012;7(10):e45690. doi: 10.1371/journal.pone.0045690. Epub 2012 Oct 1.


Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice.

Matta R, Barnard JA, Wancket LM, Yan J, Xue J, Grieves J, Frazier WJ, Nelin L, Cato AC, Liu Y.

Am J Physiol Gastrointest Liver Physiol. 2012 Jun 1;302(11):G1322-35. doi: 10.1152/ajpgi.00018.2012. Epub 2012 Mar 29.


Toxic and non-toxic aggregates from the SBMA and normal forms of androgen receptor have distinct oligomeric structures.

Jochum T, Ritz ME, Schuster C, Funderburk SF, Jehle K, Schmitz K, Brinkmann F, Hirtz M, Moss D, Cato AC.

Biochim Biophys Acta. 2012 Jun;1822(6):1070-8. doi: 10.1016/j.bbadis.2012.02.006. Epub 2012 Feb 15.


Allergen arrays for antibody screening and immune cell activation profiling generated by parallel lipid dip-pen nanolithography.

Sekula-Neuner S, Maier J, Oppong E, Cato AC, Hirtz M, Fuchs H.

Small. 2012 Feb 20;8(4):585-91. doi: 10.1002/smll.201101694. Epub 2012 Jan 26.


PEST-domain-enriched tyrosine phosphatase and glucocorticoids as regulators of anaphylaxis in mice.

Obiri DD, Flink N, Maier JV, Neeb A, Maddalo D, Thiele W, Menon A, Stassen M, Kulkarni RA, Garabedian MJ, Barrios AM, Cato AC.

Allergy. 2012 Feb;67(2):175-82. doi: 10.1111/j.1398-9995.2011.02731.x. Epub 2011 Oct 8.


What is in a name?

Cato AC, Fuller PJ.

Mol Cell Endocrinol. 2012 Mar 24;350(2):145. doi: 10.1016/j.mce.2011.08.011. Epub 2011 Aug 18. No abstract available.


MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice.

Conradie MM, Cato AC, Ferris WF, de Wet H, Horsch K, Hough S.

Calcif Tissue Int. 2011 Sep;89(3):221-7. doi: 10.1007/s00223-011-9509-x. Epub 2011 Jun 23.


The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection.

Bu H, Bormann S, Schäfer G, Horninger W, Massoner P, Neeb A, Lakshmanan VK, Maddalo D, Nestl A, Sültmann H, Cato AC, Klocker H.

Prostate. 2011 May;71(6):575-87. doi: 10.1002/pros.21273. Epub 2010 Oct 13.


Depletion of the cellular levels of Bag-1 proteins attenuates phorbol ester-induced downregulation of IκBα and nuclear accumulation of NF-κB.

Maier JV, Volz Y, Berger C, Schneider S, Cato AC.

Biochem Biophys Res Commun. 2010 Oct 22;401(3):406-11. doi: 10.1016/j.bbrc.2010.09.067. Epub 2010 Sep 19.


Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation.

Staples CJ, Owens DM, Maier JV, Cato AC, Keyse SM.

J Biol Chem. 2010 Aug 20;285(34):25928-40. doi: 10.1074/jbc.M110.117911. Epub 2010 Jun 11. Erratum in: J Biol Chem. 2011 May 13;286(19):17398.


Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.

Frazier WJ, Wang X, Wancket LM, Li XA, Meng X, Nelin LD, Cato AC, Liu Y.

J Immunol. 2009 Dec 1;183(11):7411-9. doi: 10.4049/jimmunol.0804343. Epub 2009 Nov 4.


The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.

Lemke U, Krones-Herzig A, Berriel Diaz M, Narvekar P, Ziegler A, Vegiopoulos A, Cato AC, Bohl S, Klingmüller U, Screaton RA, Müller-Decker K, Kersten S, Herzig S.

Cell Metab. 2008 Sep;8(3):212-23. doi: 10.1016/j.cmet.2008.08.001.


The androgen receptor as mediator of gene expression and signal transduction pathways.

Cato AC, Peterziel H.

Trends Endocrinol Metab. 1998 May-Jun;9(4):150-4.


Specific N-terminal mutations in the human androgen receptor induce cytotoxicity.

Funderburk SF, Shatkina L, Mink S, Weis Q, Weg-Remers S, Cato AC.

Neurobiol Aging. 2009 Nov;30(11):1851-64. doi: 10.1016/j.neurobiolaging.2007.12.023. Epub 2008 Mar 5.


Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation.

Horsch K, de Wet H, Schuurmans MM, Allie-Reid F, Cato AC, Cunningham J, Burrin JM, Hough FS, Hulley PA.

Mol Endocrinol. 2007 Dec;21(12):2929-40. Epub 2007 Aug 30.


Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids.

Maier JV, Brema S, Tuckermann J, Herzer U, Klein M, Stassen M, Moorthy A, Cato AC.

Mol Endocrinol. 2007 Nov;21(11):2663-71. Epub 2007 Jul 17.


Overexpression and gene amplification of BAG-1L in hormone-refractory prostate cancer.

Mäki HE, Saramäki OR, Shatkina L, Martikainen PM, Tammela TL, van Weerden WM, Vessella RL, Cato AC, Visakorpi T.

J Pathol. 2007 Aug;212(4):395-401.


Light-inducible and clock-controlled expression of MAP kinase phosphatase 1 in mouse central pacemaker neurons.

Doi M, Cho S, Yujnovsky I, Hirayama J, Cermakian N, Cato AC, Sassone-Corsi P.

J Biol Rhythms. 2007 Apr;22(2):127-39.


Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation.

González-Santiago L, Suárez Y, Zarich N, Muñoz-Alonso MJ, Cuadrado A, Martínez T, Goya L, Iradi A, Sáez-Tormo G, Maier JV, Moorthy A, Cato AC, Rojas JM, Muñoz A.

Cell Death Differ. 2006 Nov;13(11):1968-81. Epub 2006 Mar 17.


Corticosteroid co-treatment induces resistance to chemotherapy in surgical resections, xenografts and established cell lines of pancreatic cancer.

Zhang C, Kolb A, Büchler P, Cato AC, Mattern J, Rittgen W, Edler L, Debatin KM, Büchler MW, Friess H, Herr I.

BMC Cancer. 2006 Mar 15;6:61.


Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock.

Hammer M, Mages J, Dietrich H, Servatius A, Howells N, Cato AC, Lang R.

J Exp Med. 2006 Jan 23;203(1):15-20. Epub 2005 Dec 27.


The glucocorticoid receptor as target for classic and novel anti-inflammatory therapy.

Cato AC, Schäcke H, Sterry W, Asadullah K.

Curr Drug Targets Inflamm Allergy. 2004 Dec;3(4):347-53. Review.


Androgen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogens.

Whitaker HC, Hanrahan S, Totty N, Gamble SC, Waxman J, Cato AC, Hurst HC, Bevan CL.

Clin Cancer Res. 2004 Nov 1;10(21):7392-401.


The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor.

Shatkina L, Mink S, Rogatsch H, Klocker H, Langer G, Nestl A, Cato AC.

Mol Cell Biol. 2003 Oct;23(20):7189-97.


Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2.

Imasato A, Desbois-Mouthon C, Han J, Kai H, Cato AC, Akira S, Li JD.

J Biol Chem. 2002 Dec 6;277(49):47444-50. Epub 2002 Sep 27.


Mast cells as targets for glucocorticoids in the treatment of allergic disorders.

Kassel O, Cato AC.

Ernst Schering Res Found Workshop. 2002;(40):153-76. Review. No abstract available.


Rapid actions of steroid receptors in cellular signaling pathways.

Cato AC, Nestl A, Mink S.

Sci STKE. 2002 Jun 25;2002(138):re9. Review.


The amino terminus of the human AR is target for corepressor action and antihormone agonism.

Dotzlaw H, Moehren U, Mink S, Cato AC, Iñiguez Lluhí JA, Baniahmad A.

Mol Endocrinol. 2002 Apr;16(4):661-73.


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