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Items: 13


Exosome-based Detection of EGFR T790M in Plasma from Non-Small Cell Lung Cancer Patients.

Castellanos-Rizaldos E, Grimm DG, Tadigotla V, Hurley J, Healy J, Neal PL, Sher M, Venkatesan R, Karlovich C, Raponi M, Krug AK, Noerholm M, Tannous J, Tannous BA, Raez LE, Skog J.

Clin Cancer Res. 2018 Mar 13. pii: clincanres.3369.2017. doi: 10.1158/1078-0432.CCR-17-3369. [Epub ahead of print]


Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma.

Krug AK, Enderle D, Karlovich C, Priewasser T, Bentink S, Spiel A, Brinkmann K, Emenegger J, Grimm DG, Castellanos-Rizaldos E, Goldman JW, Sequist LV, Soria JC, Camidge DR, Gadgeel SM, Wakelee HA, Raponi M, Noerholm M, Skog J.

Ann Oncol. 2017 Dec 5. doi: 10.1093/annonc/mdx765. [Epub ahead of print]


Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.

Duquette M, Sadow PM, Husain A, Sims JN, Antonello ZA, Fischer AH, Song C, Castellanos-Rizaldos E, Makrigiorgos GM, Kurebayashi J, Nose V, Van Hummelen P, Bronson RT, Vinco M, Giordano TJ, Dias-Santagata D, Pandolfi PP, Nucera C.

Oncotarget. 2015 Dec 15;6(40):42445-67. doi: 10.18632/oncotarget.6442.


DMSO Increases Mutation Scanning Detection Sensitivity of High-Resolution Melting in Clinical Samples.

Song C, Castellanos-Rizaldos E, Bejar R, Ebert BL, Makrigiorgos GM.

Clin Chem. 2015 Nov;61(11):1354-62. doi: 10.1373/clinchem.2015.245357. Epub 2015 Oct 2.


Enhanced ratio of signals enables digital mutation scanning for rare allele detection.

Castellanos-Rizaldos E, Paweletz C, Song C, Oxnard GR, Mamon H, Jänne PA, Makrigiorgos GM.

J Mol Diagn. 2015 May;17(3):284-92. doi: 10.1016/j.jmoldx.2014.12.003. Epub 2015 Mar 13.


Single-tube, highly parallel mutation enrichment in cancer gene panels by use of temperature-tolerant COLD-PCR.

Castellanos-Rizaldos E, Richardson K, Lin R, Wu G, Makrigiorgos MG.

Clin Chem. 2015 Jan;61(1):267-77. doi: 10.1373/clinchem.2014.228361. Epub 2014 Oct 8.


Enriching mutant sequences by modulating the denaturation time during PCR.

Murphy DM, Castellanos-Rizaldos E, Makrigiorgos GM.

Clin Chem. 2014 Jul;60(7):1014-6. doi: 10.1373/clinchem.2014.221465. Epub 2014 May 5. No abstract available.


COLD-PCR amplification of bisulfite-converted DNA allows the enrichment and sequencing of rare un-methylated genomic regions.

Castellanos-Rizaldos E, Milbury CA, Karatza E, Chen CC, Makrigiorgos GM, Merewood A.

PLoS One. 2014 Apr 11;9(4):e94103. doi: 10.1371/journal.pone.0094103. eCollection 2014.


COLD-PCR enriches low-level variant DNA sequences and increases the sensitivity of genetic testing.

Castellanos-Rizaldos E, Milbury CA, Guha M, Makrigiorgos GM.

Methods Mol Biol. 2014;1102:623-39. doi: 10.1007/978-1-62703-727-3_33.


DISSECT Method Using PNA-LNA Clamp Improves Detection of EGFR T790m Mutation.

Guha M, Castellanos-Rizaldos E, Makrigiorgos GM.

PLoS One. 2013 Jun 21;8(6):e67782. doi: 10.1371/journal.pone.0067782. Print 2013.


Differential strand separation at critical temperature: a minimally disruptive enrichment method for low-abundance unknown DNA mutations.

Guha M, Castellanos-Rizaldos E, Liu P, Mamon H, Makrigiorgos GM.

Nucleic Acids Res. 2013 Feb 1;41(3):e50. doi: 10.1093/nar/gks1250. Epub 2012 Dec 20.


Enrichment of mutations in multiple DNA sequences using COLD-PCR in emulsion.

Castellanos-Rizaldos E, Milbury CA, Makrigiorgos GM.

PLoS One. 2012;7(12):e51362. doi: 10.1371/journal.pone.0051362. Epub 2012 Dec 6.


Temperature-tolerant COLD-PCR reduces temperature stringency and enables robust mutation enrichment.

Castellanos-Rizaldos E, Liu P, Milbury CA, Guha M, Brisci A, Cremonesi L, Ferrari M, Mamon H, Makrigiorgos GM.

Clin Chem. 2012 Jul;58(7):1130-8. doi: 10.1373/clinchem.2012.183095. Epub 2012 May 15.

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