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Items: 1 to 50 of 190

1.

Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex.

McKenna Iii J, Kapfhamer D, Kinchen JM, Wasek B, Dunworth M, Murray-Stewart T, Bottiglieri T, Casero RA Jr, Gambello MJ.

Hum Mol Genet. 2018 Apr 9. doi: 10.1093/hmg/ddy118. [Epub ahead of print]

PMID:
29635516
2.

Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy.

Murray-Stewart T, Casero RA.

Med Sci (Basel). 2017 Dec 18;5(4). pii: E38. doi: 10.3390/medsci5040038. Review.

3.

Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury.

Zahedi K, Barone S, Destefano-Shields C, Brooks M, Murray-Stewart T, Dunworth M, Li W, Doherty JR, Hall MA, Smith RD, Cleveland JL, Casero RA Jr, Soleimani M.

PLoS One. 2017 Sep 8;12(9):e0184570. doi: 10.1371/journal.pone.0184570. eCollection 2017.

4.

Elucidating the Structure of N1-Acetylisoputreanine: A Novel Polyamine Catabolite in Human Urine.

Fitzgerald BL, Mahapatra S, Farmer DK, McNeil MR, Casero RA Jr, Belisle JT.

ACS Omega. 2017 Jul 31;2(7):3921-3930. doi: 10.1021/acsomega.7b00872. Epub 2017 Jul 25.

5.

Correction: Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.

Murray-Stewart T, Ferrari E, Xie Y, Yu F, Marton LJ, Oupicky D, Casero RA Jr.

PLoS One. 2017 May 16;12(5):e0178102. doi: 10.1371/journal.pone.0178102. eCollection 2017.

6.

Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth.

Liu Y, Murray-Stewart T, Casero RA Jr, Kagiampakis I, Jin L, Zhang J, Wang H, Che Q, Tong H, Ke J, Jiang F, Wang F, Wan X.

Int J Oncol. 2017 Jun;50(6):2011-2023. doi: 10.3892/ijo.2017.3979. Epub 2017 May 2.

7.

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.

Murray-Stewart T, Ferrari E, Xie Y, Yu F, Marton LJ, Oupicky D, Casero RA Jr.

PLoS One. 2017 Apr 19;12(4):e0175917. doi: 10.1371/journal.pone.0175917. eCollection 2017. Erratum in: PLoS One. 2017 May 16;12 (5):e0178102.

8.

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy.

Xie Y, Murray-Stewart T, Wang Y, Yu F, Li J, Marton LJ, Casero RA Jr, Oupický D.

J Control Release. 2017 Jan 28;246:110-119. doi: 10.1016/j.jconrel.2016.12.017. Epub 2016 Dec 23.

9.

Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.

Almaliti J, Al-Hamashi AA, Negmeldin AT, Hanigan CL, Perera L, Pflum MK, Casero RA Jr, Tillekeratne LM.

J Med Chem. 2016 Dec 8;59(23):10642-10660. Epub 2016 Nov 21.

10.

Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer.

Murray-Stewart T, Sierra JC, Piazuelo MB, Mera RM, Chaturvedi R, Bravo LE, Correa P, Schneider BG, Wilson KT, Casero RA.

Oncogene. 2016 Oct 20;35(42):5480-5488. doi: 10.1038/onc.2016.91. Epub 2016 Apr 4.

11.

Targeting polyamine metabolism for cancer therapy and prevention.

Murray-Stewart TR, Woster PM, Casero RA Jr.

Biochem J. 2016 Oct 1;473(19):2937-53. doi: 10.1042/BCJ20160383. Review.

12.

Decrease in acrolein toxicity based on the decline of polyamine oxidases.

Uemura T, Nakamura M, Sakamoto A, Suzuki T, Dohmae N, Terui Y, Tomitori H, Casero RA Jr, Kashiwagi K, Igarashi K.

Int J Biochem Cell Biol. 2016 Oct;79:151-157. doi: 10.1016/j.biocel.2016.08.039. Epub 2016 Aug 30.

PMID:
27590852
13.

MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition.

Luo H, Shenoy AK, Li X, Jin Y, Jin L, Cai Q, Tang M, Liu Y, Chen H, Reisman D, Wu L, Seto E, Qiu Y, Dou Y, Casero RA Jr, Lu J.

Cell Rep. 2016 Jun 21;15(12):2665-78. doi: 10.1016/j.celrep.2016.05.050. Epub 2016 Jun 9.

14.

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.

Hardbower DM, Asim M, Murray-Stewart T, Casero RA Jr, Verriere T, Lewis ND, Chaturvedi R, Piazuelo MB, Wilson KT.

Amino Acids. 2016 Oct;48(10):2375-88. doi: 10.1007/s00726-016-2231-2. Epub 2016 Apr 13.

15.

Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation: A Perfect Combination for Cancer Therapy.

Zahnow CA, Topper M, Stone M, Murray-Stewart T, Li H, Baylin SB, Casero RA Jr.

Adv Cancer Res. 2016;130:55-111. doi: 10.1016/bs.acr.2016.01.007. Epub 2016 Mar 2. Review.

PMID:
27037751
16.

Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment.

DeStefano Shields CE, Van Meerbeke SW, Housseau F, Wang H, Huso DL, Casero RA Jr, O'Hagan HM, Sears CL.

J Infect Dis. 2016 Jul 1;214(1):122-9. doi: 10.1093/infdis/jiw069. Epub 2016 Feb 21.

17.

Metabolism links bacterial biofilms and colon carcinogenesis.

Johnson CH, Dejea CM, Edler D, Hoang LT, Santidrian AF, Felding BH, Ivanisevic J, Cho K, Wick EC, Hechenbleikner EM, Uritboonthai W, Goetz L, Casero RA Jr, Pardoll DM, White JR, Patti GJ, Sears CL, Siuzdak G.

Cell Metab. 2015 Jun 2;21(6):891-7. doi: 10.1016/j.cmet.2015.04.011. Epub 2015 May 7.

18.

Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.

Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA Jr, Woster PM.

Bioorg Med Chem. 2015 Apr 1;23(7):1601-12. doi: 10.1016/j.bmc.2015.01.049. Epub 2015 Feb 7.

19.

Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury.

Zahedi K, Barone S, Wang Y, Murray-Stewart T, Roy-Chaudhury P, Smith RD, Casero RA Jr, Soleimani M.

PLoS One. 2014 Nov 12;9(11):e110161. doi: 10.1371/journal.pone.0110161. eCollection 2014.

20.

Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups.

Bhansali P, Hanigan CL, Perera L, Casero RA Jr, Tillekeratne LM.

Eur J Med Chem. 2014 Oct 30;86:528-41. doi: 10.1016/j.ejmech.2014.09.009. Epub 2014 Sep 6.

21.

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.

Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM Jr, Fox JG, Woster PM, Casero RA Jr, Correa P, Wilson KT.

Oncogene. 2015 Jun;34(26):3429-40. doi: 10.1038/onc.2014.273. Epub 2014 Sep 1.

22.

A selective phenelzine analogue inhibitor of histone demethylase LSD1.

Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA Jr, Taverna SD, Qian J, Tackett AJ, Ratan RR, McDonald OG, Feinberg AP, Cole PA.

ACS Chem Biol. 2014 Jun 20;9(6):1284-93. doi: 10.1021/cb500018s. Epub 2014 Apr 7.

23.

Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage.

Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA Jr, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM Jr, Wilson KT.

Gastroenterology. 2014 Jun;146(7):1739-51.e14. doi: 10.1053/j.gastro.2014.02.005. Epub 2014 Feb 13.

24.
25.

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism.

Murray-Stewart T, Hanigan CL, Woster PM, Marton LJ, Casero RA Jr.

Mol Cancer Ther. 2013 Oct;12(10):2088-99. doi: 10.1158/1535-7163.MCT-13-0418. Epub 2013 Aug 13.

26.

Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine.

Chaturvedi R, Asim M, Barry DP, Frye JW, Casero RA Jr, Wilson KT.

Amino Acids. 2014 Mar;46(3):531-42. doi: 10.1007/s00726-013-1531-z. Epub 2013 Jul 3.

27.

Polyamine catabolism in carcinogenesis: potential targets for chemotherapy and chemoprevention.

Battaglia V, DeStefano Shields C, Murray-Stewart T, Casero RA Jr.

Amino Acids. 2014 Mar;46(3):511-9. doi: 10.1007/s00726-013-1529-6. Epub 2013 Jun 15. Review.

28.

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.

Murray-Stewart T, Woster PM, Casero RA Jr.

Amino Acids. 2014 Mar;46(3):585-94. doi: 10.1007/s00726-013-1485-1. Epub 2013 Mar 19.

29.

Pentamines as substrate for human spermine oxidase.

Takao K, Shirahata A, Samejima K, Casero RA, Igarashi K, Sugita Y.

Biol Pharm Bull. 2013;36(3):407-11.

30.

Polyamines and cancer: implications for chemotherapy and chemoprevention.

Nowotarski SL, Woster PM, Casero RA Jr.

Expert Rev Mol Med. 2013 Feb 22;15:e3. doi: 10.1017/erm.2013.3. Review.

31.

Polyamine-based small molecule epigenetic modulators.

Sharma SK, Hazeldine S, Crowley ML, Hanson A, Beattie R, Varghese S, Senanayake TM, Hirata A, Hirata F, Huang Y, Wu Y, Steinbergs N, Murray-Stewart T, Bytheway I, Casero RA Jr, Woster PM.

Medchemcomm. 2012;3(1):14-21. Epub 2011 Nov 26.

32.
33.

Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells.

Zhu Q, Jin L, Casero RA, Davidson NE, Huang Y.

Breast Cancer Res Treat. 2012 Nov;136(1):57-66. doi: 10.1007/s10549-012-2235-x. Epub 2012 Sep 14.

34.

Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.

Hazeldine S, Pachaiyappan B, Steinbergs N, Nowotarski S, Hanson AS, Casero RA Jr, Woster PM.

J Med Chem. 2012 Sep 13;55(17):7378-91. doi: 10.1021/jm3002845. Epub 2012 Sep 4.

35.

Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury.

Zahedi K, Barone SL, Xu J, Steinbergs N, Schuster R, Lentsch AB, Amlal H, Wang J, Casero RA Jr, Soleimani M.

Am J Physiol Gastrointest Liver Physiol. 2012 Sep 1;303(5):G546-60. doi: 10.1152/ajpgi.00431.2011. Epub 2012 Jun 21.

36.

L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis.

Coburn LA, Gong X, Singh K, Asim M, Scull BP, Allaman MM, Williams CS, Rosen MJ, Washington MK, Barry DP, Piazuelo MB, Casero RA Jr, Chaturvedi R, Zhao Z, Wilson KT.

PLoS One. 2012;7(3):e33546. doi: 10.1371/journal.pone.0033546. Epub 2012 Mar 12.

37.

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.

Schenk T, Chen WC, Göllner S, Howell L, Jin L, Hebestreit K, Klein HU, Popescu AC, Burnett A, Mills K, Casero RA Jr, Marton L, Woster P, Minden MD, Dugas M, Wang JC, Dick JE, Müller-Tidow C, Petrie K, Zelent A.

Nat Med. 2012 Mar 11;18(4):605-11. doi: 10.1038/nm.2661.

38.

Polyamine-regulated translation of spermidine/spermine-N1-acetyltransferase.

Perez-Leal O, Barrero CA, Clarkson AB, Casero RA Jr, Merali S.

Mol Cell Biol. 2012 Apr;32(8):1453-67. doi: 10.1128/MCB.06444-11. Epub 2012 Feb 21.

39.

Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.

Wu Y, Steinbergs N, Murray-Stewart T, Marton LJ, Casero RA.

Biochem J. 2012 Mar 15;442(3):693-701. doi: 10.1042/BJ20111271.

40.

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.

O'Hagan HM, Wang W, Sen S, Destefano Shields C, Lee SS, Zhang YW, Clements EG, Cai Y, Van Neste L, Easwaran H, Casero RA, Sears CL, Baylin SB.

Cancer Cell. 2011 Nov 15;20(5):606-19. doi: 10.1016/j.ccr.2011.09.012.

41.

Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.

Bhansali P, Hanigan CL, Casero RA, Tillekeratne LM.

J Med Chem. 2011 Nov 10;54(21):7453-63. doi: 10.1021/jm200432a. Epub 2011 Oct 10.

42.

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.

Goodwin AC, Destefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, Hacker-Prietz A, Rabizadeh S, Woster PM, Sears CL, Casero RA Jr.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15354-9. doi: 10.1073/pnas.1010203108. Epub 2011 Aug 29.

43.

Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA.

Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA Jr, Correa P, Gobert AP, Polk DB, Peek RM Jr, Wilson KT.

Gastroenterology. 2011 Nov;141(5):1696-708.e1-2. doi: 10.1053/j.gastro.2011.07.045. Epub 2011 Aug 10.

44.

Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.

Fraser AV, Goodwin AC, Hacker-Prietz A, Sugar E, Woster PM, Casero RA Jr.

Amino Acids. 2012 Feb;42(2-3):529-38. doi: 10.1007/s00726-011-1030-z. Epub 2011 Aug 4.

45.

Recent advances in the molecular biology of metazoan polyamine transport.

Poulin R, Casero RA, Soulet D.

Amino Acids. 2012 Feb;42(2-3):711-23. doi: 10.1007/s00726-011-0987-y. Epub 2011 Aug 4. Review.

46.

Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.

Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA Jr.

Amino Acids. 2012 Feb;42(2-3):887-98. doi: 10.1007/s00726-011-1004-1. Epub 2011 Jul 30.

47.

Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.

Barry DP, Asim M, Leiman DA, de Sablet T, Singh K, Casero RA Jr, Chaturvedi R, Wilson KT.

PLoS One. 2011 Feb 28;6(2):e17510. doi: 10.1371/journal.pone.0017510.

48.

A simple assay for mammalian spermine oxidase: a polyamine catabolic enzyme implicated in drug response and disease.

Goodwin AC, Murray-Stewart TR, Casero RA Jr.

Methods Mol Biol. 2011;720:173-81. doi: 10.1007/978-1-61779-034-8_10.

49.

Current status of the polyamine research field.

Pegg AE, Casero RA Jr.

Methods Mol Biol. 2011;720:3-35. doi: 10.1007/978-1-61779-034-8_1. Review.

50.

Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model.

Belinsky SA, Grimes MJ, Picchi MA, Mitchell HD, Stidley CA, Tesfaigzi Y, Channell MM, Liu Y, Casero RA Jr, Baylin SB, Reed MD, Tellez CS, March TH.

Cancer Res. 2011 Jan 15;71(2):454-62. doi: 10.1158/0008-5472.CAN-10-3184. Epub 2011 Jan 11.

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