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Items: 37


ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability.

Spear ED, Hsu ET, Nie L, Carpenter EP, Hrycyna CA, Michaelis S.

Dis Model Mech. 2018 May 29. pii: dmm.033670. doi: 10.1242/dmm.033670. [Epub ahead of print]


The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.

Bradley AR, Echalier A, Fairhead M, Strain-Damerell C, Brennan P, Bullock AN, Burgess-Brown NA, Carpenter EP, Gileadi O, Marsden BD, Lee WH, Yue W, Bountra C, von Delft F.

Essays Biochem. 2017 Nov 8;61(5):495-503. doi: 10.1042/EBC20170051. Print 2017 Nov 8. Review.


Asymmetric mechanosensitivity in a eukaryotic ion channel.

Clausen MV, Jarerattanachat V, Carpenter EP, Sansom MSP, Tucker SJ.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8343-E8351. doi: 10.1073/pnas.1708990114. Epub 2017 Sep 18.


Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike ACW, Carpenter EP, Baukrowitz T, Sansom MSP, Tucker SJ.

Structure. 2017 May 2;25(5):708-718.e2. doi: 10.1016/j.str.2017.03.006. Epub 2017 Apr 6.


Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2.

Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S, Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kühlbrandt W, Witzgall R, Ziegler C.

Nat Struct Mol Biol. 2017 Feb;24(2):123-130. doi: 10.1038/nsmb.3357. Epub 2017 Jan 16.


Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).

Grieben M, Pike AC, Shintre CA, Venturi E, El-Ajouz S, Tessitore A, Shrestha L, Mukhopadhyay S, Mahajan P, Chalk R, Burgess-Brown NA, Sitsapesan R, Huiskonen JT, Carpenter EP.

Nat Struct Mol Biol. 2017 Feb;24(2):114-122. doi: 10.1038/nsmb.3343. Epub 2016 Dec 19.


Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24.

Mehmood S, Marcoux J, Gault J, Quigley A, Michaelis S, Young SG, Carpenter EP, Robinson CV.

Nat Chem. 2016 Dec;8(12):1152-1158. doi: 10.1038/nchem.2591. Epub 2016 Aug 15.


Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids.

Hresko RC, Kraft TE, Quigley A, Carpenter EP, Hruz PW.

J Biol Chem. 2016 Aug 12;291(33):17271-82. doi: 10.1074/jbc.M116.730168. Epub 2016 Jun 14.


Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ.

J Gen Physiol. 2016 Jun;147(6):497-505. doi: 10.1085/jgp.201611601.


An overview of heavy-atom derivatization of protein crystals.

Pike AC, Garman EF, Krojer T, von Delft F, Carpenter EP.

Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):303-18. doi: 10.1107/S2059798316000401. Epub 2016 Mar 1. Review.


Structures and functions of mitochondrial ABC transporters.

Schaedler TA, Faust B, Shintre CA, Carpenter EP, Srinivasan V, van Veen HW, Balk J.

Biochem Soc Trans. 2015 Oct;43(5):943-51. doi: 10.1042/BST20150118. Review.


MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes.

Stansfeld PJ, Goose JE, Caffrey M, Carpenter EP, Parker JL, Newstead S, Sansom MS.

Structure. 2015 Jul 7;23(7):1350-61. doi: 10.1016/j.str.2015.05.006. Epub 2015 Jun 11.


ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione.

Qiu W, Liesa M, Carpenter EP, Shirihai OS.

PLoS One. 2015 Jun 8;10(6):e0129772. doi: 10.1371/journal.pone.0129772. eCollection 2015.


K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.

Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP.

Science. 2015 Mar 13;347(6227):1256-9. doi: 10.1126/science.1261512.


Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4.

Deme JC, Hancock MA, Xia X, Shintre CA, Plesa M, Kim JC, Carpenter EP, Rosenblatt DS, Coulton JW.

Mol Membr Biol. 2014 Nov-Dec;31(7-8):250-61. doi: 10.3109/09687688.2014.990998.


Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.

Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9710-5. doi: 10.1073/pnas.1217042110. Epub 2013 May 28.


The structural basis of ZMPSTE24-dependent laminopathies.

Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP.

Science. 2013 Mar 29;339(6127):1604-7. doi: 10.1126/science.1231513.


Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.

Lu D, Silhan J, MacDonald JT, Carpenter EP, Jensen K, Tang CM, Baldwin GS, Freemont PS.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16852-7. doi: 10.1073/pnas.1206563109. Epub 2012 Oct 3.


An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.

Bailey D, Carpenter EP, Coker A, Coker S, Read J, Jones AT, Erskine P, Aguilar CF, Badasso M, Toldo L, Rippmann F, Sanz-Aparicio J, Albert A, Blundell TL, Roberts NB, Wood SP, Cooper JB.

Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):541-52. doi: 10.1107/S0907444912004817. Epub 2012 Apr 17.


Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2.

Newstead S, Drew D, Cameron AD, Postis VL, Xia X, Fowler PW, Ingram JC, Carpenter EP, Sansom MS, McPherson MJ, Baldwin SA, Iwata S.

EMBO J. 2011 Jan 19;30(2):417-26. doi: 10.1038/emboj.2010.309. Epub 2010 Dec 3.


High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins.

Berridge G, Chalk R, D'Avanzo N, Dong L, Doyle D, Kim JI, Xia X, Burgess-Brown N, Deriso A, Carpenter EP, Gileadi O.

Anal Biochem. 2011 Mar 15;410(2):272-80. doi: 10.1016/j.ab.2010.11.008. Epub 2010 Nov 17.


Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS.

Albesa-Jové D, Bertrand T, Carpenter EP, Swain GV, Lim J, Zhang J, Haire LF, Vasisht N, Braun V, Lange A, von Eichel-Streiber C, Svergun DI, Fairweather NF, Brown KA.

J Mol Biol. 2010 Mar 12;396(5):1260-70. doi: 10.1016/j.jmb.2010.01.012. Epub 2010 Jan 11.


Insights into how nucleotide-binding domains power ABC transport.

Newstead S, Fowler PW, Bilton P, Carpenter EP, Sadler PJ, Campopiano DJ, Sansom MS, Iwata S.

Structure. 2009 Sep 9;17(9):1213-22. doi: 10.1016/j.str.2009.07.009.


Crystal structure of the acid-induced arginine decarboxylase from Escherichia coli: reversible decamer assembly controls enzyme activity.

Andréll J, Hicks MG, Palmer T, Carpenter EP, Iwata S, Maher MJ.

Biochemistry. 2009 May 12;48(18):3915-27. doi: 10.1021/bi900075d.


Insights into outer membrane protein crystallization.

Newstead S, Hobbs J, Jordan D, Carpenter EP, Iwata S.

Mol Membr Biol. 2008 Dec;25(8):631-8. doi: 10.1080/09687680802526574.


Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter.

Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD.

Science. 2008 Oct 31;322(5902):709-13. doi: 10.1126/science.1164440. Epub 2008 Oct 16.


Overcoming the challenges of membrane protein crystallography.

Carpenter EP, Beis K, Cameron AD, Iwata S.

Curr Opin Struct Biol. 2008 Oct;18(5):581-6. doi: 10.1016/ Epub 2008 Aug 11. Review.


Thioredoxin A active-site mutants form mixed disulfide dimers that resemble enzyme-substrate reaction intermediates.

Kouwen TR, Andréll J, Schrijver R, Dubois JY, Maher MJ, Iwata S, Carpenter EP, van Dijl JM.

J Mol Biol. 2008 Jun 6;379(3):520-34. doi: 10.1016/j.jmb.2008.03.077. Epub 2008 Apr 10.


High-level bacterial expression and purification of apicomplexan micronemal proteins for structural studies.

Saouros S, Blumenschein TM, Sawmynaden K, Marchant J, Koutroukides T, Liu B, Simpson P, Carpenter EP, Matthews SJ.

Protein Pept Lett. 2007;14(5):411-5.


Atomic resolution insight into host cell recognition by Toxoplasma gondii.

Blumenschein TM, Friedrich N, Childs RA, Saouros S, Carpenter EP, Campanero-Rhodes MA, Simpson P, Chai W, Koutroukides T, Blackman MJ, Feizi T, Soldati-Favre D, Matthews S.

EMBO J. 2007 Jun 6;26(11):2808-20. Epub 2007 May 10.


AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis.

Carpenter EP, Corbett A, Thomson H, Adacha J, Jensen K, Bergeron J, Kasampalidis I, Exley R, Winterbotham M, Tang C, Baldwin GS, Freemont P.

EMBO J. 2007 Mar 7;26(5):1363-72. Epub 2007 Feb 22.


A comparative study of uracil-DNA glycosylases from human and herpes simplex virus type 1.

Krusong K, Carpenter EP, Bellamy SR, Savva R, Baldwin GS.

J Biol Chem. 2006 Feb 24;281(8):4983-92. Epub 2005 Nov 22.


Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus.

Makyio H, Iino R, Ikeda C, Imamura H, Tamakoshi M, Iwata M, Stock D, Bernal RA, Carpenter EP, Yoshida M, Yokoyama K, Iwata S.

EMBO J. 2005 Nov 16;24(22):3974-83. Epub 2005 Nov 10.


Twists and turns: a tale of two shikimate-pathway enzymes.

Brown KA, Carpenter EP, Watson KA, Coggins JR, Hawkins AR, Koch MH, Svergun DI.

Biochem Soc Trans. 2003 Jun;31(Pt 3):543-7. Review.


Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

Gelb MH, Van Voorhis WC, Buckner FS, Yokoyama K, Eastman R, Carpenter EP, Panethymitaki C, Brown KA, Smith DF.

Mol Biochem Parasitol. 2003 Feb;126(2):155-63. Review.


PCR-based gene synthesis as an efficient approach for expression of the A+T-rich malaria genome.

Withers-Martinez C, Carpenter EP, Hackett F, Ely B, Sajid M, Grainger M, Blackman MJ.

Protein Eng. 1999 Dec;12(12):1113-20.


Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.

Carpenter EP, Hawkins AR, Frost JW, Brown KA.

Nature. 1998 Jul 16;394(6690):299-302.


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