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High Level of Tobacco Carcinogen-Derived DNA Damage in Oral Cells Is an Independent Predictor of Oral/Head and Neck Cancer Risk in Smokers.

Khariwala SS, Ma B, Ruszczak C, Carmella SG, Lindgren B, Hatsukami DK, Hecht SS, Stepanov I.

Cancer Prev Res (Phila). 2017 Sep;10(9):507-513. doi: 10.1158/1940-6207.CAPR-17-0140. Epub 2017 Jul 5.


Acrolein Exposure in Hookah Smokers and Non-Smokers Exposed to Hookah Tobacco Secondhand Smoke: Implications for Regulating Hookah Tobacco Products.

Kassem NOF, Kassem NO, Liles S, Zarth AT, Jackson SR, Daffa RM, Chatfield DA, Carmella SG, Hecht SS, Hovell MF.

Nicotine Tob Res. 2018 Mar 6;20(4):492-501. doi: 10.1093/ntr/ntx133.


CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study.

Yuan JM, Nelson HH, Carmella SG, Wang R, Kuriger-Laber J, Jin A, Adams-Haduch J, Hecht SS, Koh WP, Murphy SE.

Carcinogenesis. 2017 Apr 1;38(4):411-418. doi: 10.1093/carcin/bgx012.


Analysis of N'-nitrosonornicotine enantiomers in human urine by chiral stationary phase liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry.

Yang J, Carmella SG, Hecht SS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Feb 15;1044-1045:127-131. doi: 10.1016/j.jchromb.2017.01.008. Epub 2017 Jan 9.


Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for Brassica Vegetable Consumption Using Urinary 3,3'-Diindolylmethane.

Fujioka N, Ransom BW, Carmella SG, Upadhyaya P, Lindgren BR, Roper-Batker A, Hatsukami DK, Fritz VA, Rohwer C, Hecht SS.

Cancer Prev Res (Phila). 2016 Oct;9(10):788-793. Epub 2016 Aug 18.


Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

Patel YM, Park SL, Carmella SG, Paiano V, Olvera N, Stram DO, Haiman CA, Le Marchand L, Hecht SS.

PLoS One. 2016 Jun 8;11(6):e0156203. doi: 10.1371/journal.pone.0156203. eCollection 2016.


A Randomized Controlled Trial of Progressively Reduced Nicotine Content Cigarettes on Smoking Behaviors, Biomarkers of Exposure, and Subjective Ratings.

Mercincavage M, Souprountchouk V, Tang KZ, Dumont RL, Wileyto EP, Carmella SG, Hecht SS, Strasser AA.

Cancer Epidemiol Biomarkers Prev. 2016 Jul;25(7):1125-33. doi: 10.1158/1055-9965.EPI-15-1088. Epub 2016 Apr 27.


2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke.

Yuan JM, Murphy SE, Stepanov I, Wang R, Carmella SG, Nelson HH, Hatsukami D, Hecht SS.

Cancer Prev Res (Phila). 2016 Jul;9(7):598-606. doi: 10.1158/1940-6207.CAPR-16-0032. Epub 2016 Apr 20.


Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort.

Haiman CA, Patel YM, Stram DO, Carmella SG, Chen M, Wilkens LR, Le Marchand L, Hecht SS.

PLoS One. 2016 Mar 9;11(3):e0150641. doi: 10.1371/journal.pone.0150641. eCollection 2016.


Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification.

Narayanapillai SC, von Weymarn LB, Carmella SG, Leitzman P, Paladino J, Upadhyaya P, Hecht SS, Murphy SE, Xing C.

Drug Metab Dispos. 2016 Mar;44(3):422-7. doi: 10.1124/dmd.115.068387. Epub 2016 Jan 7.


Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines.

Hecht SS, Stepanov I, Carmella SG.

Acc Chem Res. 2016 Jan 19;49(1):106-14. doi: 10.1021/acs.accounts.5b00472. Epub 2015 Dec 17.


Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study.

Yuan JM, Nelson HH, Butler LM, Carmella SG, Wang R, Kuriger-Laber JK, Adams-Haduch J, Hecht SS, Gao YT, Murphy SE.

Int J Cancer. 2016 May 1;138(9):2161-71. doi: 10.1002/ijc.29963. Epub 2016 Jan 21.


Dietary Consumption of Black Raspberries or Their Anthocyanin Constituents Alters Innate Immune Cell Trafficking in Esophageal Cancer.

Peiffer DS, Wang LS, Zimmerman NP, Ransom BW, Carmella SG, Kuo CT, Chen JH, Oshima K, Huang YW, Hecht SS, Stoner GD.

Cancer Immunol Res. 2016 Jan;4(1):72-82. doi: 10.1158/2326-6066.CIR-15-0091. Epub 2015 Nov 24.


Combined analysis of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in the urine of cigarette smokers and e-cigarette users.

Kotandeniya D, Carmella SG, Pillsbury ME, Hecht SS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Dec 15;1007:121-6. doi: 10.1016/j.jchromb.2015.10.012. Epub 2015 Oct 31.


Randomized Trial of Reduced-Nicotine Standards for Cigarettes.

Donny EC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG, al'Absi M, Carmella SG, Cinciripini PM, Dermody SS, Drobes DJ, Hecht SS, Jensen J, Lane T, Le CT, McClernon FJ, Montoya ID, Murphy SE, Robinson JD, Stitzer ML, Strasser AA, Tindle H, Hatsukami DK.

N Engl J Med. 2015 Oct;373(14):1340-9. doi: 10.1056/NEJMsa1502403.


Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

Park SL, Carmella SG, Chen M, Patel Y, Stram DO, Haiman CA, Le Marchand L, Hecht SS.

PLoS One. 2015 Jun 8;10(6):e0124841. doi: 10.1371/journal.pone.0124841. eCollection 2015.


Self-reported Tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancer.

Khariwala SS, Carmella SG, Stepanov I, Bandyopadhyay D, Nelson HH, Yueh B, Hatsukami DK, Hecht SS.

Laryngoscope. 2015 Aug;125(8):1844-8. doi: 10.1002/lary.25290. Epub 2015 Apr 15.


Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home.

Hecht SS, Koh WP, Wang R, Chen M, Carmella SG, Murphy SE, Yuan JM.

PLoS One. 2015 Mar 25;10(3):e0120023. doi: 10.1371/journal.pone.0120023. eCollection 2015.


Combined analysis of the tobacco metabolites cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine.

Kotandeniya D, Carmella SG, Ming X, Murphy SE, Hecht SS.

Anal Chem. 2015 Feb 3;87(3):1514-7. doi: 10.1021/ac504047j. Epub 2015 Jan 14.


Variation in levels of the lung carcinogen NNAL and its glucuronides in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer.

Park SL, Carmella SG, Ming X, Vielguth E, Stram DO, Le Marchand L, Hecht SS.

Cancer Epidemiol Biomarkers Prev. 2015 Mar;24(3):561-9. doi: 10.1158/1055-9965.EPI-14-1054. Epub 2014 Dec 26.


Evidence supporting product standards for carcinogens in smokeless tobacco products.

Hatsukami DK, Stepanov I, Severson H, Jensen JA, Lindgren BR, Horn K, Khariwala SS, Martin J, Carmella SG, Murphy SE, Hecht SS.

Cancer Prev Res (Phila). 2015 Jan;8(1):20-6. doi: 10.1158/1940-6207.CAPR-14-0250. Epub 2014 Dec 18.


Benzene uptake in Hookah smokers and non-smokers attending Hookah social events: regulatory implications.

Kassem NO, Kassem NO, Jackson SR, Liles S, Daffa RM, Zarth AT, Younis MA, Carmella SG, Hofstetter CR, Chatfield DA, Matt GE, Hecht SS, Hovell MF.

Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2793-809.


Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers.

Hecht SS, Carmella SG, Kotandeniya D, Pillsbury ME, Chen M, Ransom BW, Vogel RI, Thompson E, Murphy SE, Hatsukami DK.

Nicotine Tob Res. 2015 Jun;17(6):704-9. doi: 10.1093/ntr/ntu218. Epub 2014 Oct 21.


Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China.

Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW.

Cancer Prev Res (Phila). 2014 Aug;7(8):813-823. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.


Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid.

Peiffer DS, Zimmerman NP, Wang LS, Ransom BW, Carmella SG, Kuo CT, Siddiqui J, Chen JH, Oshima K, Huang YW, Hecht SS, Stoner GD.

Cancer Prev Res (Phila). 2014 Jun;7(6):574-84. doi: 10.1158/1940-6207.CAPR-14-0003. Epub 2014 Mar 25.


Effect of cigarette smoking on urinary 2-hydroxypropylmercapturic acid, a metabolite of propylene oxide.

Zarth AT, Carmella SG, Le CT, Hecht SS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 15;953-954:126-31. doi: 10.1016/j.jchromb.2014.02.001. Epub 2014 Feb 14.


Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers.

Kassem NO, Daffa RM, Liles S, Jackson SR, Kassem NO, Younis MA, Mehta S, Chen M, Jacob P 3rd, Carmella SG, Chatfield DA, Benowitz NL, Matt GE, Hecht SS, Hovell MF.

Nicotine Tob Res. 2014 Jul;16(7):961-75. doi: 10.1093/ntr/ntu016. Epub 2014 Mar 3.


Urinary 3,3'-diindolylmethane: a biomarker of glucobrassicin exposure and indole-3-carbinol uptake in humans.

Fujioka N, Ainslie-Waldman CE, Upadhyaya P, Carmella SG, Fritz VA, Rohwer C, Fan Y, Rauch D, Le C, Hatsukami DK, Hecht SS.

Cancer Epidemiol Biomarkers Prev. 2014 Feb;23(2):282-7. doi: 10.1158/1055-9965.EPI-13-0645. Epub 2013 Dec 19.


Urinary metabolites of a polycyclic aromatic hydrocarbon and volatile organic compounds in relation to lung cancer development in lifelong never smokers in the Shanghai Cohort Study.

Yuan JM, Butler LM, Gao YT, Murphy SE, Carmella SG, Wang R, Nelson HH, Hecht SS.

Carcinogenesis. 2014 Feb;35(2):339-45. doi: 10.1093/carcin/bgt352. Epub 2013 Oct 22.


Contamination of deconjugation enzymes derived from Helix pomatia with the plant bioactive compounds 3,3'-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen.

Ainslie-Waldman CE, Simpkins SW, Upadhyaya P, Carmella SG, Hecht SS, Trudo SP.

Food Chem Toxicol. 2013 Dec;62:188-93. doi: 10.1016/j.fct.2013.08.055. Epub 2013 Aug 30.


High throughput liquid chromatography-tandem mass spectrometry assay for mercapturic acids of acrolein and crotonaldehyde in cigarette smokers' urine.

Carmella SG, Chen M, Zarth A, Hecht SS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 15;935:36-40. doi: 10.1016/j.jchromb.2013.07.004. Epub 2013 Jul 15.


Thirdhand tobacco smoke: a tobacco-specific lung carcinogen on surfaces in smokers' homes.

Thomas JL, Hecht SS, Luo X, Ming X, Ahluwalia JS, Carmella SG.

Nicotine Tob Res. 2014 Jan;16(1):26-32. doi: 10.1093/ntr/ntt110. Epub 2013 Jul 26.


High throughput liquid and gas chromatography-tandem mass spectrometry assays for tobacco-specific nitrosamine and polycyclic aromatic hydrocarbon metabolites associated with lung cancer in smokers.

Carmella SG, Ming X, Olvera N, Brookmeyer C, Yoder A, Hecht SS.

Chem Res Toxicol. 2013 Aug 19;26(8):1209-17. doi: 10.1021/tx400121n. Epub 2013 Jul 24.


Reduced nicotine content cigarettes and nicotine patch.

Hatsukami DK, Hertsgaard LA, Vogel RI, Jensen JA, Murphy SE, Hecht SS, Carmella SG, al'Absi M, Joseph AM, Allen SS.

Cancer Epidemiol Biomarkers Prev. 2013 Jun;22(6):1015-24. doi: 10.1158/1055-9965.EPI-12-1439. Epub 2013 Apr 19.


Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers.

Hecht SS, Hochalter JB, Carmella SG, Zhang Y, Rauch DM, Fujioka N, Jensen J, Hatsukami DK.

Biomarkers. 2013 Mar;18(2):144-50. doi: 10.3109/1354750X.2012.753553. Epub 2013 Jan 22.


Elevated levels of 1-hydroxypyrene and N'-nitrosonornicotine in smokers with head and neck cancer: A matched control study.

Khariwala SS, Carmella SG, Stepanov I, Fernandes P, Lassig AA, Yueh B, Hatsukami D, Hecht SS.

Head Neck. 2013 Aug;35(8):1096-100. doi: 10.1002/hed.23085. Epub 2012 Jul 17.


Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation.

Wang J, Zhong Y, Carmella SG, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami DK, Upadhyaya P, Hecht SS, Zimmerman CL.

J Pharmacol Exp Ther. 2012 Sep;342(3):750-60. doi: 10.1124/jpet.112.194118. Epub 2012 Jun 6.


Tobacco-specific nitrosamine exposures in smokers and nonsmokers exposed to cigarette or waterpipe tobacco smoke.

Radwan G, Hecht SS, Carmella SG, Loffredo CA.

Nicotine Tob Res. 2013 Jan;15(1):130-8. doi: 10.1093/ntr/nts099. Epub 2012 May 9.


Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers.

Yuan JM, Gao YT, Wang R, Chen M, Carmella SG, Hecht SS.

Carcinogenesis. 2012 Apr;33(4):804-9. doi: 10.1093/carcin/bgs026. Epub 2012 Jan 31.


Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.

Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman JD, Yuan JM, Hecht SS.

Carcinogenesis. 2012 Jan;33(1):101-7. doi: 10.1093/carcin/bgr229. Epub 2011 Nov 1. Erratum in: Carcinogenesis. 2012 Mar;33(3):722.


Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers.

Yuan JM, Gao YT, Murphy SE, Carmella SG, Wang R, Zhong Y, Moy KA, Davis AB, Tao L, Chen M, Han S, Nelson HH, Yu MC, Hecht SS.

Cancer Res. 2011 Nov 1;71(21):6749-57. doi: 10.1158/0008-5472.CAN-11-0209. Epub 2011 Oct 25.


The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers.

Vogel RI, Carmella SG, Stepanov I, Hatsukami DK, Hecht SS.

Biomarkers. 2011 Sep;16(6):491-7. doi: 10.3109/1354750X.2011.598565. Epub 2011 Aug 3.


Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).

Ter-Minassian M, Asomaning K, Zhao Y, Chen F, Su L, Carmella SG, Lin X, Hecht SS, Christiani DC.

Int J Cancer. 2012 Mar 15;130(6):1338-46. doi: 10.1002/ijc.26162. Epub 2011 Aug 3.


Metabolism of [D10]phenanthrene to tetraols in smokers for potential lung cancer susceptibility assessment: comparison of oral and inhalation routes of administration.

Zhong Y, Wang J, Carmella SG, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami DK, Upadhyaya P, Zimmerman C, Hecht SS.

J Pharmacol Exp Ther. 2011 Jul;338(1):353-61. doi: 10.1124/jpet.111.181719. Epub 2011 Apr 22.


Metabolites of a tobacco-specific lung carcinogen in children exposed to secondhand or thirdhand tobacco smoke in their homes.

Thomas JL, Guo H, Carmella SG, Balbo S, Han S, Davis A, Yoder A, Murphy SE, An LC, Ahluwalia JS, Hecht SS.

Cancer Epidemiol Biomarkers Prev. 2011 Jun;20(6):1213-21. doi: 10.1158/1055-9965.EPI-10-1027. Epub 2011 Apr 5.


Quantitation of a minor enantiomer of phenanthrene tetraol in human urine: correlations with levels of overall phenanthrene tetraol, benzo[a]pyrene tetraol, and 1-hydroxypyrene.

Hochalter JB, Zhong Y, Han S, Carmella SG, Hecht SS.

Chem Res Toxicol. 2011 Feb 18;24(2):262-8. doi: 10.1021/tx100391z. Epub 2011 Jan 13.


Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level.

Strasser AA, Benowitz NL, Pinto AG, Tang KZ, Hecht SS, Carmella SG, Tyndale RF, Lerman CE.

Cancer Epidemiol Biomarkers Prev. 2011 Feb;20(2):234-8. doi: 10.1158/1055-9965.EPI-10-0674. Epub 2011 Jan 6.


Immediate consequences of cigarette smoking: rapid formation of polycyclic aromatic hydrocarbon diol epoxides.

Zhong Y, Carmella SG, Upadhyaya P, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami D, Wang J, Zimmerman C, Hecht SS.

Chem Res Toxicol. 2011 Feb 18;24(2):246-52. doi: 10.1021/tx100345x. Epub 2010 Dec 27.


Effect of oral snus and medicinal nicotine in smokers on toxicant exposure and withdrawal symptoms: a feasibility study.

Kotlyar M, Hertsgaard LA, Lindgren BR, Jensen JA, Carmella SG, Stepanov I, Murphy SE, Hecht SS, Hatsukami DK.

Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):91-100. doi: 10.1158/1055-9965.EPI-10-0349. Epub 2010 Nov 10. Erratum in: Cancer Epidemiol Biomarkers Prev. 2011 May;20(5):1048.


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