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Items: 1 to 50 of 692

1.

Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring.

Rauniyar N, Yu X, Cantley J, Voss E, Belcher J, Colangelo C, Stone K, Dahl N, Parikh C, Lam TT, Cantley LG.

Proteomics Clin Appl. 2018 Mar 23:e1700157. doi: 10.1002/prca.201700157. [Epub ahead of print]

PMID:
29573172
2.

Chromosomal instability drives metastasis through a cytosolic DNA response.

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC.

Nature. 2018 Jan 25;553(7689):467-472. doi: 10.1038/nature25432. Epub 2018 Jan 17.

PMID:
29342134
3.

Fenofibrate prevents skeletal muscle loss in mice with lung cancer.

Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E743-E752. doi: 10.1073/pnas.1714703115. Epub 2018 Jan 8. Erratum in: Proc Natl Acad Sci U S A. 2018 Feb 20;:.

PMID:
29311302
4.

Assessing Hearing Conservation Program Effectiveness: Results of a Multisite Assessment.

Rabinowitz P, Cantley LF, Galusha D, Trufan S, Swersey A, Dixon-Ernst C, Ramirez V, Neitzel R.

J Occup Environ Med. 2018 Jan;60(1):29-35. doi: 10.1097/JOM.0000000000001125.

PMID:
29309362
5.

Introduction: Understanding Human AKI.

Cantley LG.

Semin Nephrol. 2018 Jan;38(1):1-2. doi: 10.1016/j.semnephrol.2017.09.009. No abstract available.

PMID:
29291756
6.

PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors.

Croessmann S, Sheehan JH, Lee KM, Sliwoski G, He J, Nagy R, Riddle D, Mayer IA, Balko JM, Lanman R, Miller VA, Cantley LC, Meiler J, Arteaga CL.

Clin Cancer Res. 2018 Mar 15;24(6):1426-1435. doi: 10.1158/1078-0432.CCR-17-2141. Epub 2017 Dec 28.

PMID:
29284706
7.

Costs and effectiveness of hearing conservation programs at 14 US metal manufacturing facilities.

Sayler SK, Rabinowitz PM, Cantley LF, Galusha D, Neitzel RL.

Int J Audiol. 2018 Feb;57(sup1):S3-S11. doi: 10.1080/14992027.2017.1410237. Epub 2017 Dec 7.

PMID:
29216778
8.

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer.

Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC.

Cancer Discov. 2018 Mar;8(3):354-369. doi: 10.1158/2159-8290.CD-17-0679. Epub 2017 Dec 4.

PMID:
29203461
9.

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J.

Cell. 2017 Dec 14;171(7):1545-1558.e18. doi: 10.1016/j.cell.2017.10.037. Epub 2017 Nov 16.

PMID:
29153836
10.

Patterns of Opioid Prescribing and Predictors of Chronic Opioid Use in an Industrial Cohort, 2003 to 2013.

Pensa MA, Galusha DH, Cantley LF.

J Occup Environ Med. 2017 Nov 13. doi: 10.1097/JOM.0000000000001231. [Epub ahead of print]

PMID:
29135839
11.

Occupational noise exposure and risk of hypertension in an industrial workforce.

Tessier-Sherman B, Galusha D, Cantley LF, Cullen MR, Rabinowitz PM, Neitzel RL.

Am J Ind Med. 2017 Dec;60(12):1031-1038. doi: 10.1002/ajim.22775. Epub 2017 Sep 22.

PMID:
28940215
12.

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.

Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK.

Cancer Cell. 2017 Sep 11;32(3):392. doi: 10.1016/j.ccell.2017.08.008. No abstract available.

PMID:
28898700
13.

The PI3K Pathway in Human Disease.

Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT.

Cell. 2017 Aug 10;170(4):605-635. doi: 10.1016/j.cell.2017.07.029. Review.

PMID:
28802037
14.

Adhesion, Stiffness, and Instability in Atomically Thin MoS2 Bubbles.

Lloyd D, Liu X, Boddeti N, Cantley L, Long R, Dunn ML, Bunch JS.

Nano Lett. 2017 Sep 13;17(9):5329-5334. doi: 10.1021/acs.nanolett.7b01735. Epub 2017 Aug 3.

PMID:
28762748
15.

Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation.

Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW.

Cell Rep. 2017 Jul 18;20(3):721-736. doi: 10.1016/j.celrep.2017.06.074.

16.

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.

Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK.

Cancer Cell. 2017 Jul 10;32(1):71-87.e7. doi: 10.1016/j.ccell.2017.06.004. Erratum in: Cancer Cell. 2017 Sep 11;32(3):392.

PMID:
28697344
17.

Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of Myofibroblasts.

Montgomery TA, Xu L, Mason S, Chinnadurai A, Lee CG, Elias JA, Cantley LG.

J Am Soc Nephrol. 2017 Nov;28(11):3218-3226. doi: 10.1681/ASN.2017010110. Epub 2017 Jul 5.

PMID:
28679671
18.

PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α.

Thorpe LM, Spangle JM, Ohlson CE, Cheng H, Roberts TM, Cantley LC, Zhao JJ.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7095-7100. doi: 10.1073/pnas.1704706114. Epub 2017 Jun 19.

19.

Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin.

Waldhart AN, Dykstra H, Peck AS, Boguslawski EA, Madaj ZB, Wen J, Veldkamp K, Hollowell M, Zheng B, Cantley LC, McGraw TE, Wu N.

Cell Rep. 2017 Jun 6;19(10):2005-2013. doi: 10.1016/j.celrep.2017.05.041.

20.

Membrane Lipids Speak to Histones.

Zheng Y, Cantley LC.

Mol Cell. 2017 Apr 20;66(2):163-164. doi: 10.1016/j.molcel.2017.04.001.

PMID:
28431227
21.

Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling.

Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR.

J Biol Chem. 2017 Mar 31;292(13):5608. doi: 10.1074/jbc.A117.305602. No abstract available.

22.

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine.

Pauli C, Hopkins BD, Prandi D, Shaw R, Fedrizzi T, Sboner A, Sailer V, Augello M, Puca L, Rosati R, McNary TJ, Churakova Y, Cheung C, Triscott J, Pisapia D, Rao R, Mosquera JM, Robinson B, Faltas BM, Emerling BE, Gadi VK, Bernard B, Elemento O, Beltran H, Demichelis F, Kemp CJ, Grandori C, Cantley LC, Rubin MA.

Cancer Discov. 2017 May;7(5):462-477. doi: 10.1158/2159-8290.CD-16-1154. Epub 2017 Mar 22.

PMID:
28331002
23.

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.

Gupta A, Anjomani-Virmouni S, Koundouros N, Dimitriadi M, Choo-Wing R, Valle A, Zheng Y, Chiu YH, Agnihotri S, Zadeh G, Asara JM, Anastasiou D, Arends MJ, Cantley LC, Poulogiannis G.

Mol Cell. 2017 Mar 16;65(6):999-1013.e7. doi: 10.1016/j.molcel.2017.02.019.

24.

Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity.

Patnaik A, Swanson KD, Csizmadia E, Solanki A, Landon-Brace N, Gehring MP, Helenius K, Olson BM, Pyzer AR, Wang LC, Elemento O, Novak J, Thornley TB, Asara JM, Montaser L, Timmons JJ, Morgan TM, Wang Y, Levantini E, Clohessy JG, Kelly K, Pandolfi PP, Rosenblatt JM, Avigan DE, Ye H, Karp JM, Signoretti S, Balk SP, Cantley LC.

Cancer Discov. 2017 Jul;7(7):750-765. doi: 10.1158/2159-8290.CD-16-0778. Epub 2017 Mar 8.

PMID:
28274958
25.

Use of a Targeted Urine Proteome Assay (TUPA) to identify protein biomarkers of delayed recovery after kidney transplant.

Williams KR, Colangelo CM, Hou L, Chung L, Belcher JM, Abbott T, Hall IE, Zhao H, Cantley LG, Parikh CR.

Proteomics Clin Appl. 2017 Jul;11(7-8). doi: 10.1002/prca.201600132. Epub 2017 Mar 31.

PMID:
28261998
26.

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition.

Mathur D, Stratikopoulos E, Ozturk S, Steinbach N, Pegno S, Schoenfeld S, Yong R, Murty VV, Asara JM, Cantley LC, Parsons R.

Cancer Discov. 2017 Apr;7(4):380-390. doi: 10.1158/2159-8290.CD-16-0612. Epub 2017 Mar 2.

27.

Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer.

de Oliveira Taveira M, Nabavi S, Wang Y, Tonellato P, Esteva FJ, Cantley LC, Wulf GM.

J Cancer Res Clin Oncol. 2017 Jul;143(7):1255-1262. doi: 10.1007/s00432-017-2358-x. Epub 2017 Feb 28.

28.

Macrophages in Renal Injury and Repair.

Huen SC, Cantley LG.

Annu Rev Physiol. 2017 Feb 10;79:449-469. doi: 10.1146/annurev-physiol-022516-034219. Review.

PMID:
28192060
29.

Social, Psychological, And Physical Aspects Of The Work Environment Could Contribute To Hypertension Prevalence.

Rehkopf DH, Modrek S, Cantley LF, Cullen MR.

Health Aff (Millwood). 2017 Feb 1;36(2):258-265. doi: 10.1377/hlthaff.2016.1186.

PMID:
28167714
30.

Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma.

Trousil S, Chen S, Mu C, Shaw FM, Yao Z, Ran Y, Shakuntala T, Merghoub T, Manstein D, Rosen N, Cantley LC, Zippin JH, Zheng B.

J Invest Dermatol. 2017 May;137(5):1135-1143. doi: 10.1016/j.jid.2017.01.013. Epub 2017 Jan 28.

PMID:
28143781
31.

Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death.

You MH, Kim BM, Chen CH, Begley MJ, Cantley LC, Lee TH.

Cell Death Differ. 2017 Feb;24(2):238-250. doi: 10.1038/cdd.2016.114. Epub 2016 Nov 4.

32.

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).

Ravez S, Corbet C, Spillier Q, Dutu A, Robin AD, Mullarky E, Cantley LC, Feron O, Frédérick R.

J Med Chem. 2017 Feb 23;60(4):1591-1597. doi: 10.1021/acs.jmedchem.6b01166. Epub 2017 Jan 27.

33.

Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer.

Matulonis UA, Wulf GM, Barry WT, Birrer M, Westin SN, Farooq S, Bell-McGuinn KM, Obermayer E, Whalen C, Spagnoletti T, Luo W, Liu H, Hok RC, Aghajanian C, Solit DB, Mills GB, Taylor BS, Won H, Berger MF, Palakurthi S, Liu J, Cantley LC, Winer E.

Ann Oncol. 2017 Mar 1;28(3):512-518. doi: 10.1093/annonc/mdw672.

34.

Obesity and Cancer Mechanisms: Cancer Metabolism.

Hopkins BD, Goncalves MD, Cantley LC.

J Clin Oncol. 2016 Dec 10;34(35):4277-4283. Epub 2016 Nov 7. Review.

35.

Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.

Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC.

Nature. 2016 Dec 1;540(7631):150. doi: 10.1038/nature19851. Epub 2016 Oct 5. No abstract available.

PMID:
27706144
36.

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.

Mullarky E, Lairson LL, Cantley LC, Lyssiotis CA.

Mol Cell Oncol. 2016 Mar 30;3(4):e1164280. doi: 10.1080/23723556.2016.1164280. eCollection 2016 Jul.

37.

Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.

Lien EC, Lyssiotis CA, Cantley LC.

Recent Results Cancer Res. 2016;207:39-72. doi: 10.1007/978-3-319-42118-6_3. Review.

PMID:
27557534
38.

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.

Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9810-5. doi: 10.1073/pnas.1606862113. Epub 2016 Aug 15.

39.

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.

Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC.

Nature. 2016 Aug 25;536(7617):479-83. doi: 10.1038/nature19084. Epub 2016 Aug 10. Erratum in: Nature. 2016 Dec 1;540(7631):150.

40.

Band Gap Engineering with Ultralarge Biaxial Strains in Suspended Monolayer MoS2.

Lloyd D, Liu X, Christopher JW, Cantley L, Wadehra A, Kim BL, Goldberg BB, Swan AK, Bunch JS.

Nano Lett. 2016 Sep 14;16(9):5836-41. doi: 10.1021/acs.nanolett.6b02615. Epub 2016 Aug 15.

PMID:
27509768
41.

Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley.

Cantley LC.

Dis Model Mech. 2016 Sep 1;9(9):911-6. doi: 10.1242/dmm.026856. Epub 2016 Aug 4.

42.

Prioritization schema for immunotherapy clinical trials in glioblastoma.

Hodges TR, Ferguson SD, Caruso HG, Kohanbash G, Zhou S, Cloughesy TF, Berger MS, Poste GH, Khasraw M, Ba S, Jiang T, Mikkelson T, Yung WK, de Groot JF, Fine H, Cantley LC, Mellinghoff IK, Mitchell DA, Okada H, Heimberger AB.

Oncoimmunology. 2016 Feb 18;5(6):e1145332. doi: 10.1080/2162402X.2016.1145332. eCollection 2016 Jun. Review.

43.

YKL-40 Associates with Renal Recovery in Deceased Donor Kidney Transplantation.

Puthumana J, Hall IE, Reese PP, Schröppel B, Weng FL, Thiessen-Philbrook H, Doshi MD, Rao V, Lee CG, Elias JA, Cantley LG, Parikh CR.

J Am Soc Nephrol. 2017 Feb;28(2):661-670. doi: 10.1681/ASN.2016010091. Epub 2016 Jul 22.

44.

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.

Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, Wulf GM.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4338-47. doi: 10.1073/pnas.1522223113. Epub 2016 Jul 8.

45.

Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.

Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7596-601. doi: 10.1073/pnas.1600934113. Epub 2016 Jun 16.

46.

Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints.

Candela ME, Wang C, Gunawardena AT, Zhang K, Cantley L, Yasuhara R, Usami Y, Francois N, Iwamoto M, van der Flier A, Zhang Y, Qin L, Han L, Enomoto-Iwamoto M.

PLoS One. 2016 Jun 9;11(6):e0156783. doi: 10.1371/journal.pone.0156783. eCollection 2016.

47.

Association of Urinary Biomarkers of Inflammation, Injury, and Fibrosis with Renal Function Decline: The ACCORD Trial.

Nadkarni GN, Rao V, Ismail-Beigi F, Fonseca VA, Shah SV, Simonson MS, Cantley L, Devarajan P, Parikh CR, Coca SG.

Clin J Am Soc Nephrol. 2016 Aug 8;11(8):1343-52. doi: 10.2215/CJN.12051115. Epub 2016 May 17.

48.

A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2- Metastatic Breast Cancer.

Mayer IA, Abramson VG, Formisano L, Balko JM, Estrada MV, Sanders ME, Juric D, Solit D, Berger MF, Won HH, Li Y, Cantley LC, Winer E, Arteaga CL.

Clin Cancer Res. 2017 Jan 1;23(1):26-34. doi: 10.1158/1078-0432.CCR-16-0134. Epub 2016 Apr 28.

49.

Evaluation of safety climate and employee injury rates in healthcare.

Cook JM, Slade MD, Cantley LF, Sakr CJ.

Occup Environ Med. 2016 Sep;73(9):595-9. doi: 10.1136/oemed-2015-103218. Epub 2016 Apr 27.

PMID:
27121746
50.

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A.

Nat Cell Biol. 2016 May;18(5):572-8. doi: 10.1038/ncb3341. Epub 2016 Apr 18.

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