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Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease.

Patel D, Xu C, Nagarajan S, Liu Z, Hemphill WO, Shi R, Uversky VN, Caldwell GA, Caldwell KA, Witt SN.

Hum Mol Genet. 2018 Feb 14. doi: 10.1093/hmg/ddy059. [Epub ahead of print]


The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.

Kim H, Calatayud C, Guha S, Fernández-Carasa I, Berkowitz L, Carballo-Carbajal I, Ezquerra M, Fernández-Santiago R, Kapahi P, Raya Á, Miranda-Vizuete A, Lizcano JM, Vila M, Caldwell KA, Caldwell GA, Consiglio A, Dalfo E.

Mol Neurobiol. 2018 Feb 10. doi: 10.1007/s12035-018-0881-7. [Epub ahead of print]


Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease.

Martinez BA, Petersen DA, Gaeta AL, Stanley SP, Caldwell GA, Caldwell KA.

J Neurosci. 2017 Nov 15;37(46):11085-11100. doi: 10.1523/JNEUROSCI.1294-17.2017. Epub 2017 Oct 13.


Genetic and Pharmacological Discovery for Alzheimer's Disease Using Caenorhabditis elegans.

Griffin EF, Caldwell KA, Caldwell GA.

ACS Chem Neurosci. 2017 Dec 20;8(12):2596-2606. doi: 10.1021/acschemneuro.7b00361. Epub 2017 Oct 25. Review.


NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease.

Zhang S, Glukhova SA, Caldwell KA, Caldwell GA.

Hum Mol Genet. 2017 Oct 1;26(19):3823-3836. doi: 10.1093/hmg/ddx269.


Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.

Mor DE, Tsika E, Mazzulli JR, Gould NS, Kim H, Daniels MJ, Doshi S, Gupta P, Grossman JL, Tan VX, Kalb RG, Caldwell KA, Caldwell GA, Wolfe JH, Ischiropoulos H.

Nat Neurosci. 2017 Nov;20(11):1560-1568. doi: 10.1038/nn.4641. Epub 2017 Sep 18.


Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism.

Tardiff DF, Brown LE, Yan X, Trilles R, Jui NT, Barrasa MI, Caldwell KA, Caldwell GA, Schaus SE, Lindquist S.

ACS Chem Neurosci. 2017 Sep 20;8(9):2039-2055. doi: 10.1021/acschemneuro.7b00187. Epub 2017 Jul 12.


C. elegans as a model system to accelerate discovery for Parkinson disease.

Martinez BA, Caldwell KA, Caldwell GA.

Curr Opin Genet Dev. 2017 Jun;44:102-109. doi: 10.1016/j.gde.2017.02.011. Epub 2017 Feb 24. Review.


Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease.

Wang S, Zhang S, Xu C, Barron A, Galiano F, Patel D, Lee YJ, Caldwell GA, Caldwell KA, Witt SN.

PLoS One. 2016 Oct 13;11(10):e0164465. doi: 10.1371/journal.pone.0164465. eCollection 2016.


The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp.

Watkins AL, Ray A, R Roberts L, Caldwell KA, Olson JB.

Sci Rep. 2016 Mar 3;6:22566. doi: 10.1038/srep22566.


A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans.

Martinez BA, Kim H, Ray A, Caldwell GA, Caldwell KA.

Cell Death Dis. 2015 Oct 15;6:e1908. doi: 10.1038/cddis.2015.270.


RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway.

Ray A, Zhang S, Rentas C, Caldwell KA, Caldwell GA.

J Neurosci. 2014 Nov 26;34(48):16076-85. doi: 10.1523/JNEUROSCI.1945-14.2014.


Phenazine derivatives cause proteotoxicity and stress in C. elegans.

Ray A, Rentas C, Caldwell GA, Caldwell KA.

Neurosci Lett. 2015 Jan 1;584:23-7. doi: 10.1016/j.neulet.2014.09.055. Epub 2014 Oct 7.


Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease.

Wang S, Zhang S, Liou LC, Ren Q, Zhang Z, Caldwell GA, Caldwell KA, Witt SN.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3976-85. doi: 10.1073/pnas.1411694111. Epub 2014 Sep 8.


Calcineurin determines toxic versus beneficial responses to α-synuclein.

Caraveo G, Auluck PK, Whitesell L, Chung CY, Baru V, Mosharov EV, Yan X, Ben-Johny M, Soste M, Picotti P, Kim H, Caldwell KA, Caldwell GA, Sulzer D, Yue DT, Lindquist S.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3544-52. doi: 10.1073/pnas.1413201111. Epub 2014 Aug 13.


The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.

Knight AL, Yan X, Hamamichi S, Ajjuri RR, Mazzulli JR, Zhang MW, Daigle JG, Zhang S, Borom AR, Roberts LR, Lee SK, DeLeon SM, Viollet-Djelassi C, Krainc D, O'Donnell JM, Caldwell KA, Caldwell GA.

Cell Metab. 2014 Jul 1;20(1):145-57. doi: 10.1016/j.cmet.2014.04.017. Epub 2014 May 29.


Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.

Matlack KE, Tardiff DF, Narayan P, Hamamichi S, Caldwell KA, Caldwell GA, Lindquist S.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4013-8. doi: 10.1073/pnas.1402228111. Epub 2014 Mar 3.


The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.

Bornhorst J, Chakraborty S, Meyer S, Lohren H, Brinkhaus SG, Knight AL, Caldwell KA, Caldwell GA, Karst U, Schwerdtle T, Bowman A, Aschner M.

Metallomics. 2014 Mar;6(3):476-90. doi: 10.1039/c3mt00325f. Epub 2014 Jan 22.


Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.

Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J.

Cell. 2014 Jan 16;156(1-2):170-82. doi: 10.1016/j.cell.2013.11.047.


Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model.

Ray A, Martinez BA, Berkowitz LA, Caldwell GA, Caldwell KA.

Cell Death Dis. 2014 Jan 9;5:e984. doi: 10.1038/cddis.2013.513.


TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS.

Thompson ML, Chen P, Yan X, Kim H, Borom AR, Roberts NB, Caldwell KA, Caldwell GA.

Dis Model Mech. 2014 Feb;7(2):233-43. doi: 10.1242/dmm.013615. Epub 2013 Dec 5.


Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald SL, Lindquist S.

Science. 2013 Nov 22;342(6161):979-83. doi: 10.1126/science.1245321. Epub 2013 Oct 24.


Invertebrate models of dystonia.

Caldwell KA, Shu Y, Roberts NB, Caldwell GA, O'Donnell JM.

Curr Neuropharmacol. 2013 Jan;11(1):16-29. doi: 10.2174/157015913804999504.


Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.

Muñoz-Lobato F, Rodríguez-Palero MJ, Naranjo-Galindo FJ, Shephard F, Gaffney CJ, Szewczyk NJ, Hamamichi S, Caldwell KA, Caldwell GA, Link CD, Miranda-Vizuete A.

Antioxid Redox Signal. 2014 Jan 10;20(2):217-35. doi: 10.1089/ars.2012.5051. Epub 2013 Jul 3.


Lysosomal impairment in Parkinson's disease.

Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, Klein C, Vila M, Bezard E.

Mov Disord. 2013 Jun;28(6):725-32. doi: 10.1002/mds.25462. Epub 2013 Apr 11. Review.


Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling.

Kautu BB, Carrasquilla A, Hicks ML, Caldwell KA, Caldwell GA.

Neurosci Lett. 2013 Apr 29;541:116-9. doi: 10.1016/j.neulet.2013.02.026. Epub 2013 Feb 26.


Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.

Usenovic M, Knight AL, Ray A, Wong V, Brown KR, Caldwell GA, Caldwell KA, Stagljar I, Krainc D.

Hum Mol Genet. 2012 Sep 1;21(17):3785-94. doi: 10.1093/hmg/dds206. Epub 2012 May 29.


A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders.

Dexter PM, Caldwell KA, Caldwell GA.

Neurotherapeutics. 2012 Apr;9(2):393-404. doi: 10.1007/s13311-012-0109-x. Review.


Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.

Harrington AJ, Yacoubian TA, Slone SR, Caldwell KA, Caldwell GA.

J Neurosci. 2012 Feb 8;32(6):2142-53. doi: 10.1523/JNEUROSCI.2606-11.2012.


Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms.

Tardiff DF, Tucci ML, Caldwell KA, Caldwell GA, Lindquist S.

J Biol Chem. 2012 Feb 3;287(6):4107-20. doi: 10.1074/jbc.M111.308668. Epub 2011 Dec 6.


Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.

Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, Olofsson A, DeJager PL, Tanzi RE, Caldwell KA, Caldwell GA, Lindquist S.

Science. 2011 Dec 2;334(6060):1241-5. doi: 10.1126/science.1213210. Epub 2011 Oct 27.


Modeling dopamine neuron degeneration in Caenorhabditis elegans.

Tucci ML, Harrington AJ, Caldwell GA, Caldwell KA.

Methods Mol Biol. 2011;793:129-48. doi: 10.1007/978-1-61779-328-8_9.


Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.

Liu Z, Hamamichi S, Lee BD, Yang D, Ray A, Caldwell GA, Caldwell KA, Dawson TM, Smith WW, Dawson VL.

Hum Mol Genet. 2011 Oct 15;20(20):3933-42. doi: 10.1093/hmg/ddr312. Epub 2011 Jul 18.


TorsinA participates in endoplasmic reticulum-associated degradation.

Nery FC, Armata IA, Farley JE, Cho JA, Yaqub U, Chen P, da Hora CC, Wang Q, Tagaya M, Klein C, Tannous B, Caldwell KA, Caldwell GA, Lencer WI, Ye Y, Breakefield XO.

Nat Commun. 2011 Jul 12;2:393. doi: 10.1038/ncomms1383.


Structural features and chaperone activity of the NudC protein family.

Zheng M, Cierpicki T, Burdette AJ, Utepbergenov D, Janczyk PŁ, Derewenda U, Stukenberg PT, Caldwell KA, Derewenda ZS.

J Mol Biol. 2011 Jun 24;409(5):722-41. doi: 10.1016/j.jmb.2011.04.018. Epub 2011 Apr 21.


Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease.

Harrington AJ, Knight AL, Caldwell GA, Caldwell KA.

Methods. 2011 Mar;53(3):220-5. doi: 10.1016/j.ymeth.2010.12.036. Epub 2010 Dec 31.


Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.

Yacoubian TA, Slone SR, Harrington AJ, Hamamichi S, Schieltz JM, Caldwell KA, Caldwell GA, Standaert DG.

Cell Death Dis. 2010;1:e2. doi: 10.1038/cddis.2009.4.


The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response.

Chen P, Burdette AJ, Porter JC, Ricketts JC, Fox SA, Nery FC, Hewett JW, Berkowitz LA, Breakefield XO, Caldwell KA, Caldwell GA.

Hum Mol Genet. 2010 Sep 15;19(18):3502-15. doi: 10.1093/hmg/ddq266. Epub 2010 Jun 28. Erratum in: Hum Mol Genet. 2012 Mar 1;21(5):1201.


Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction.

Pivtoraiko VN, Harrington AJ, Mader BJ, Luker AM, Caldwell GA, Caldwell KA, Roth KA, Shacka JJ.

J Neurochem. 2010 Aug;114(4):1193-204. doi: 10.1111/j.1471-4159.2010.06838.x. Epub 2010 Jun 1.


Chemical enhancement of torsinA function in cell and animal models of torsion dystonia.

Cao S, Hewett JW, Yokoi F, Lu J, Buckley AC, Burdette AJ, Chen P, Nery FC, Li Y, Breakefield XO, Caldwell GA, Caldwell KA.

Dis Model Mech. 2010 May-Jun;3(5-6):386-96. doi: 10.1242/dmm.003715. Epub 2010 Mar 11.


The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro.

Burdette AJ, Churchill PF, Caldwell GA, Caldwell KA.

Cell Stress Chaperones. 2010 Sep;15(5):605-17. doi: 10.1007/s12192-010-0173-2. Epub 2010 Feb 19.


C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease.

Harrington AJ, Hamamichi S, Caldwell GA, Caldwell KA.

Dev Dyn. 2010 May;239(5):1282-95. doi: 10.1002/dvdy.22231. Review.


Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.

Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet JC, Lindquist S.

Dis Model Mech. 2010 Mar-Apr;3(3-4):194-208. doi: 10.1242/dmm.004267. Epub 2009 Dec 28.


VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.

Ruan Q, Harrington AJ, Caldwell KA, Caldwell GA, Standaert DG.

Neurobiol Dis. 2010 Feb;37(2):330-8. doi: 10.1016/j.nbd.2009.10.011. Epub 2009 Oct 20.


Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.

Caldwell KA, Tucci ML, Armagost J, Hodges TW, Chen J, Memon SB, Blalock JE, DeLeon SM, Findlay RH, Ruan Q, Webber PJ, Standaert DG, Olson JB, Caldwell GA.

PLoS One. 2009 Oct 6;4(10):e7227. doi: 10.1371/journal.pone.0007227.


Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.

Locke CJ, Kautu BB, Berry KP, Lee SK, Caldwell KA, Caldwell GA.

Genetics. 2009 Dec;183(4):1357-72. doi: 10.1534/genetics.109.106880. Epub 2009 Sep 21.


Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models.

Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA, Lindquist S.

Nat Chem Biol. 2009 Sep;5(9):655-63. doi: 10.1038/nchembio.193. Epub 2009 Jul 13.


Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.

Gitler AD, Chesi A, Geddie ML, Strathearn KE, Hamamichi S, Hill KJ, Caldwell KA, Caldwell GA, Cooper AA, Rochet JC, Lindquist S.

Nat Genet. 2009 Mar;41(3):308-15. doi: 10.1038/ng.300. Epub 2009 Feb 1.


Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.

Berkowitz LA, Hamamichi S, Knight AL, Harrington AJ, Caldwell GA, Caldwell KA.

J Vis Exp. 2008 Jul 18;(17). pii: 835. doi: 10.3791/835.


Generation of stable transgenic C. elegans using microinjection.

Berkowitz LA, Knight AL, Caldwell GA, Caldwell KA.

J Vis Exp. 2008 Aug 15;(18). pii: 833. doi: 10.3791/833.

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