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Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness.

Butler CC, Francis NA, Thomas-Jones E, Longo M, Wootton M, Llor C, Little P, Moore M, Bates J, Pickles T, Kirby N, Gillespie D, Rumsby K, Brugman C, Gal M, Hood K, Verheij T.

Br J Gen Pract. 2018 Feb 26. pii: bjgp18X695285. doi: 10.3399/bjgp18X695285. [Epub ahead of print]


Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries.

Ieven M, Coenen S, Loens K, Lammens C, Coenjaerts F, Vanderstraeten A, Henriques-Normark B, Crook D, Huygen K, Butler CC, Verheij TJM, Little P, Zlateva K, van Loon A, Claas ECJ, Goossens H; GRACE consortium.

Clin Microbiol Infect. 2018 Feb 12. pii: S1198-743X(18)30152-6. doi: 10.1016/j.cmi.2018.02.004. [Epub ahead of print]


Effectiveness of general practitioner online training and an information booklet for parents on antibiotic prescribing for children with respiratory tract infection in primary care: a cluster randomized controlled trial.

Dekker ARJ, Verheij TJM, Broekhuizen BDL, Butler CC, Cals JWL, Francis NA, Little P, Sanders EAM, Yardley L, Zuithoff NPA, van der Velden AW.

J Antimicrob Chemother. 2018 Feb 9. doi: 10.1093/jac/dkx542. [Epub ahead of print]


Comparison of risk factors for, and prevalence of, antibiotic resistance in contaminating and pathogenic urinary Escherichia coli in children in primary care: prospective cohort study.

Bryce A, Costelloe C, Wootton M, Butler CC, Hay AD.

J Antimicrob Chemother. 2018 Jan 29. doi: 10.1093/jac/dkx525. [Epub ahead of print]


Antibiotic prescribing quality for children in primary care: an observational study.

Williams MR, Greene G, Naik G, Hughes K, Butler CC, Hay AD.

Br J Gen Pract. 2018 Feb;68(667):e90-e96. doi: 10.3399/bjgp18X694409. Epub 2018 Jan 15.


Incidence and antibiotic prescribing for clinically diagnosed urinary tract infection in older adults in UK primary care, 2004-2014.

Ahmed H, Farewell D, Jones HM, Francis NA, Paranjothy S, Butler CC.

PLoS One. 2018 Jan 5;13(1):e0190521. doi: 10.1371/journal.pone.0190521. eCollection 2018.


Adverse Effects of Amoxicillin for Acute Lower Respiratory Tract Infection in Primary Care: Secondary and Subgroup Analysis of a Randomised Clinical Trial.

Tandan M, Vellinga A, Bruyndonckx R, Little P, Verheij T, Butler CC, Goossens H, Coenen S.

Antibiotics (Basel). 2017 Dec 13;6(4). pii: E36. doi: 10.3390/antibiotics6040036.


Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study.

Butler CC, Francis N, Thomas-Jones E, Llor C, Bongard E, Moore M, Little P, Bates J, Lau M, Pickles T, Gal M, Wootton M, Kirby N, Gillespie D, Rumbsy K, Brugman C, Hood K, Verheij T.

Br J Gen Pract. 2017 Dec;67(665):e830-e841. doi: 10.3399/bjgp17X693641.


Amoxicillin for acute lower respiratory tract infection in primary care: subgroup analysis by bacterial and viral aetiology.

Bruyndonckx R, Stuart B, Little P, Hens N, Ieven M, Butler CC, Verheij T, Goossens H, Coenen S; GRACE project group.

Clin Microbiol Infect. 2017 Nov 3. pii: S1198-743X(17)30626-2. doi: 10.1016/j.cmi.2017.10.032. [Epub ahead of print]


General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial.

Bates J, Francis NA, White P, Gillespie D, Thomas-Jones E, Breen R, Kirby N, Hood K, Gal M, Phillips R, Naik G, Cals J, Llor C, Melbye H, Wootton M, Riga E, Cochrane A, Howe R, Fitzsimmons D, Sewell B, Alam MF, Butler CC.

Trials. 2017 Sep 29;18(1):442. doi: 10.1186/s13063-017-2144-8.


Talking to the people that really matter about their participation in pandemic clinical research: A qualitative study in four European countries.

Gobat NH, Gal M, Butler CC, Webb SAR, Francis NA, Stanton H, Anthierens S, Bastiaens H, Godycki-Ćwirko M, Kowalczyk A, Pons-Vigués M, Pujol-Ribera E, Berenguera A, Watkins A, Sukumar P, Moore RG, Hood K, Nichol A.

Health Expect. 2018 Feb;21(1):387-395. doi: 10.1111/hex.12634. Epub 2017 Sep 27.


Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews.

Tonkin-Crine SK, Tan PS, van Hecke O, Wang K, Roberts NW, McCullough A, Hansen MP, Butler CC, Del Mar CB.

Cochrane Database Syst Rev. 2017 Sep 7;9:CD012252. doi: 10.1002/14651858.CD012252.pub2. Review.


Influence of the duration of penicillin prescriptions on outcomes for acute sore throat in adults: the DESCARTE prospective cohort study in UK general practice.

Moore M, Stuart B, Hobbs FR, Butler CC, Hay AD, Campbell J, Delaney BC, Broomfield S, Barratt P, Hood K, Everitt H, Mullee M, Williamson I, Mant D, Little P; DESCARTE investigators.

Br J Gen Pract. 2017 Sep;67(662):e623-e633. doi: 10.3399/bjgp17X692333. Epub 2017 Aug 14.


Symptom response to antibiotic prescribing strategies in acute sore throat in adults: the DESCARTE prospective cohort study in UK general practice.

Moore M, Stuart B, Hobbs FR, Butler CC, Hay AD, Campbell J, Delaney BC, Broomfield S, Barratt P, Hood K, Everitt HA, Mullee M, Williamson I, Mant D, Little P; DESCARTE investigators.

Br J Gen Pract. 2017 Sep;67(662):e634-e642. doi: 10.3399/bjgp17X692321. Epub 2017 Aug 14.


Comparison between treatment effects in a randomised controlled trial and an observational study using propensity scores in primary care.

Stuart BL, Grebel LE, Butler CC, Hood K, Verheij TJM, Little P.

Br J Gen Pract. 2017 Sep;67(662):e643-e649. doi: 10.3399/bjgp17X692153. Epub 2017 Jul 31.


Urine concentration should be taken into account when interpreting pyuria in infants.

Alam S, Voort JV, Butler CC.

Evid Based Med. 2017 Jun;22(3):115. doi: 10.1136/ebmed-2017-110678. Epub 2017 May 19. No abstract available.


Short-course versus long-course oral antibiotic treatment for infections treated in outpatient settings: a review of systematic reviews.

Dawson-Hahn EE, Mickan S, Onakpoya I, Roberts N, Kronman M, Butler CC, Thompson MJ.

Fam Pract. 2017 Sep 1;34(5):511-519. doi: 10.1093/fampra/cmx037.


Comment on Rishu et al. Time required to initiate outbreak and pandemic observational research.

Gobat NH, Butler CC, Webb SAR, Nichol A; PREPARE-EARL Study Team.

J Crit Care. 2017 Aug;40:271. doi: 10.1016/j.jcrc.2017.03.019. Epub 2017 Mar 27. No abstract available.


The Diagnosis of Urinary Tract Infection in Young Children (DUTY) Study Clinical Rule: Economic Evaluation.

Hollingworth W, Busby J, Butler CC, O'Brien K, Sterne JA, Hood K, Little P, Lawton M, Birnie K, Thomas-Jones E, Harman K, Hay AD; DUTY Study Team.

Value Health. 2017 Apr;20(4):556-566. doi: 10.1016/j.jval.2017.01.003. Epub 2017 Feb 22.


Disease Course of Lower Respiratory Tract Infection With a Bacterial Cause.

Teepe J, Broekhuizen BD, Loens K, Lammens C, Ieven M, Goossens H, Little P, Butler CC, Coenen S, Godycki-Cwirko M, Verheij T; GRACE Consortium.

Ann Fam Med. 2016 Nov;14(6):534-539. doi: 10.1370/afm.1974.


Implications of Antibiotic Resistance for Patients' Recovery From Common Infections in the Community: A Systematic Review and Meta-analysis.

van Hecke O, Wang K, Lee JJ, Roberts NW, Butler CC.

Clin Infect Dis. 2017 Aug 1;65(3):371-382. doi: 10.1093/cid/cix233.


Determinants of initiation, implementation, and discontinuation of amoxicillin by adults with acute cough in primary care.

Gillespie D, Farewell D, Brookes-Howell L, Butler CC, Coenen S, Francis NA, Little P, Stuart B, Verheij T, Hood K.

Patient Prefer Adherence. 2017 Mar 15;11:561-569. doi: 10.2147/PPA.S119256. eCollection 2017.


Clinicians' interpretations of point of care urine culture versus laboratory culture results: analysis from the four-country POETIC trial of diagnosis of uncomplicated urinary tract infection in primary care.

Hullegie S, Wootton M, Verheij TJM, Thomas-Jones E, Bates J, Hood K, Gal M, Francis NA, Little P, Moore M, Llor C, Pickles T, Gillespie D, Kirby N, Brugman C, Butler CC.

Fam Pract. 2017 Aug 1;34(4):392-399. doi: 10.1093/fampra/cmx009.


Oral and Topical Antibiotics for Clinically Infected Eczema in Children: A Pragmatic Randomized Controlled Trial in Ambulatory Care.

Francis NA, Ridd MJ, Thomas-Jones E, Butler CC, Hood K, Shepherd V, Marwick CA, Huang C, Longo M, Wootton M, Sullivan F; CREAM Trial Management Group.

Ann Fam Med. 2017 Mar;15(2):124-130. doi: 10.1370/afm.2038.


Comparison of microbiological diagnosis of urinary tract infection in young children by routine health service laboratories and a research laboratory: Diagnostic cohort study.

Birnie K, Hay AD, Wootton M, Howe R, MacGowan A, Whiting P, Lawton M, Delaney B, Downing H, Dudley J, Hollingworth W, Lisles C, Little P, O'Brien K, Pickles T, Rumsby K, Thomas-Jones E, Van der Voort J, Waldron CA, Harman K, Hood K, Butler CC, Sterne JA.

PLoS One. 2017 Feb 15;12(2):e0171113. doi: 10.1371/journal.pone.0171113. eCollection 2017.


Risk of cardiovascular events, arrhythmia and all-cause mortality associated with clarithromycin versus alternative antibiotics prescribed for respiratory tract infections: a retrospective cohort study.

Berni E, de Voogd H, Halcox JP, Butler CC, Bannister CA, Jenkins-Jones S, Jones B, Ouwens M, Currie CJ.

BMJ Open. 2017 Jan 23;7(1):e013398. doi: 10.1136/bmjopen-2016-013398.


Predicting the presence of bacterial pathogens in the airways of primary care patients with acute cough.

Teepe J, Broekhuizen BD, Loens K, Lammens C, Ieven M, Goossens H, Little P, Butler CC, Coenen S, Godycki-Cwirko M, Verheij TJ; GRACE Consortium.

CMAJ. 2016 Oct 24. pii: cmaj.151364. [Epub ahead of print]


Family Practitioners' Advice about Taking Time Off Work for Lower Respiratory Tract Infections: A Prospective Study in Twelve European Primary Care Networks.

Godycki-Cwirko M, Nocun M, Butler CC, Little P, Verheij T, Hood K, Fleten N, Kowalczyk A, Melbye H.

PLoS One. 2016 Oct 19;11(10):e0164779. doi: 10.1371/journal.pone.0164779. eCollection 2016.


The management of acne vulgaris in primary care: a cohort study of consulting and prescribing patterns using the Clinical Practice Research Datalink.

Francis NA, Entwistle K, Santer M, Layton AM, Eady EA, Butler CC.

Br J Dermatol. 2017 Jan;176(1):107-115. doi: 10.1111/bjd.15081. Epub 2016 Dec 27.


Parental perceptions and understanding of information provision, management options and factors influencing the decision-making process in the treatment of children with glue ear.

Gkiousias V, Butler CC, Shepherd V, Kilgour JM, Waldron CA, Thomas-Jones E, Francis N.

Int J Pediatr Otorhinolaryngol. 2016 Oct;89:6-12. doi: 10.1016/j.ijporl.2016.07.021. Epub 2016 Jul 25.


Cost effectiveness of amoxicillin for lower respiratory tract infections in primary care: an economic evaluation accounting for the cost of antimicrobial resistance.

Oppong R, Smith RD, Little P, Verheij T, Butler CC, Goossens H, Coenen S, Moore M, Coast J.

Br J Gen Pract. 2016 Sep;66(650):e633-9. doi: 10.3399/bjgp16X686533. Epub 2016 Jul 11.


The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness.

Hay AD, Birnie K, Busby J, Delaney B, Downing H, Dudley J, Durbaba S, Fletcher M, Harman K, Hollingworth W, Hood K, Howe R, Lawton M, Lisles C, Little P, MacGowan A, O'Brien K, Pickles T, Rumsby K, Sterne JA, Thomas-Jones E, van der Voort J, Waldron CA, Whiting P, Wootton M, Butler CC.

Health Technol Assess. 2016 Jul;20(51):1-294. doi: 10.3310/hta20510.


Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Study.

Hay AD, Sterne JA, Hood K, Little P, Delaney B, Hollingworth W, Wootton M, Howe R, MacGowan A, Lawton M, Busby J, Pickles T, Birnie K, O'Brien K, Waldron CA, Dudley J, Van Der Voort J, Downing H, Thomas-Jones E, Harman K, Lisles C, Rumsby K, Durbaba S, Whiting P, Butler CC.

Ann Fam Med. 2016 Jul;14(4):325-36. doi: 10.1370/afm.1954.


Non-Response to Antibiotic Treatment in Adolescents for Four Common Infections in UK Primary Care 1991-2012: A Retrospective, Longitudinal Study.

Berni E, Scott LA, Jenkins-Jones S, De Voogd H, Rocha MS, Butler CC, Morgan CL, Currie CJ.

Antibiotics (Basel). 2016 Jul 4;5(3). pii: E25. doi: 10.3390/antibiotics5030025.


Nappy pad urine samples for investigation and treatment of UTI in young children: the 'DUTY' prospective diagnostic cohort study.

Butler CC, Sterne JA, Lawton M, O'Brien K, Wootton M, Hood K, Hollingworth W, Little P, Delaney BC, van der Voort J, Dudley J, Birnie K, Pickles T, Waldron CA, Downing H, Thomas-Jones E, Lisles C, Rumsby K, Durbaba S, Whiting P, Harman K, Howe R, MacGowan A, Fletcher M, Hay AD.

Br J Gen Pract. 2016 Jul;66(648):e516-24. doi: 10.3399/bjgp16X685873.


Impact of amoxicillin therapy on resistance selection in patients with community-acquired lower respiratory tract infections: a randomized, placebo-controlled study.

Malhotra-Kumar S, Van Heirstraeten L, Coenen S, Lammens C, Adriaenssens N, Kowalczyk A, Godycki-Cwirko M, Bielicka Z, Hupkova H, Lannering C, Mölstad S, Fernandez-Vandellos P, Torres A, Parizel M, Ieven M, Butler CC, Verheij T, Little P, Goossens H; GRACE study group.

J Antimicrob Chemother. 2016 Nov;71(11):3258-3267. Epub 2016 Jun 26.


Discrepancies between qualitative and quantitative evaluation of randomised controlled trial results: achieving clarity through mixed methods triangulation.

Tonkin-Crine S, Anthierens S, Hood K, Yardley L, Cals JW, Francis NA, Coenen S, van der Velden AW, Godycki-Cwirko M, Llor C, Butler CC, Verheij TJ, Goossens H, Little P; GRACE INTRO/CHAMP consortium.

Implement Sci. 2016 May 12;11:66. doi: 10.1186/s13012-016-0436-0.


Understanding flucloxacillin prescribing trends and treatment non-response in UK primary care: a Clinical Practice Research Datalink (CPRD) study.

Francis NA, Hood K, Lyons R, Butler CC.

J Antimicrob Chemother. 2016 Jul;71(7):2037-46. doi: 10.1093/jac/dkw084. Epub 2016 Apr 18.


How much information about antibiotics do people recall after consulting in primary care?

McNulty CA, Lecky DM, Hawking MK, Roberts C, Quigley A, Butler CC.

Fam Pract. 2016 Aug;33(4):395-400. doi: 10.1093/fampra/cmw022. Epub 2016 Apr 12.


Empiric antibiotic treatment for urinary tract infection in preschool children: susceptibilities of urine sample isolates.

Butler CC, O'Brien K, Wootton M, Pickles T, Hood K, Howe R, Waldron CA, Thomas-Jones E, Dudley J, Van Der Voort J, Rumsby K, Little P, Downing H, Harman K, Hay AD; DUTY Study Team.

Fam Pract. 2016 Apr;33(2):127-32. doi: 10.1093/fampra/cmv104.


A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study.

Francis NA, Ridd MJ, Thomas-Jones E, Shepherd V, Butler CC, Hood K, Huang C, Addison K, Longo M, Marwick C, Wootton M, Howe R, Roberts A, Haq MI, Madhok V, Sullivan F; CREAM team.

Health Technol Assess. 2016 Mar;20(19):i-xxiv, 1-84. doi: 10.3310/hta20190.


Oral steroids for the resolution of otitis media with effusion (OME) in children (OSTRICH): study protocol for a randomised controlled trial.

Waldron CA, Thomas-Jones E, Cannings-John R, Hood K, Powell C, Roberts A, Tomkinson A, Fitzsimmons D, Gal M, Harris D, Shepherd V, Butler CC, Francis N.

Trials. 2016 Mar 1;17(1):115. doi: 10.1186/s13063-016-1236-1.


Comparative estimated effectiveness of antibiotic classes as initial and secondary treatments of respiratory tract infections: longitudinal analysis of routine data from UK primary care 1991-2012.

Berni E, Butler CC, Jenkins-Jones S, de Voogd H, Ouwens M, Morgan CL, Currie CJ.

Curr Med Res Opin. 2016 Jun;32(6):1023-32. doi: 10.1185/03007995.2016.1157459. Epub 2016 Mar 11.


Help-seeking and antibiotic prescribing for acute cough in a Chinese primary care population: a prospective multicentre observational study.

Wong CK, Liu Z, Butler CC, Wong SY, Fung A, Chan D, Yip BH, Kung K.

NPJ Prim Care Respir Med. 2016 Jan 21;26:15080. doi: 10.1038/npjpcrm.2015.80.


Key stakeholder perceptions about consent to participate in acute illness research: a rapid, systematic review to inform epi/pandemic research preparedness.

Gobat NH, Gal M, Francis NA, Hood K, Watkins A, Turner J, Moore R, Webb SA, Butler CC, Nichol A.

Trials. 2015 Dec 29;16:591. doi: 10.1186/s13063-015-1110-6. Review.


Delayed/back up antibiotic prescriptions: what do the public think?

McNulty CA, Lecky DM, Hawking MK, Quigley A, Butler CC.

BMJ Open. 2015 Nov 27;5(11):e009748. doi: 10.1136/bmjopen-2015-009748.


Amoxicillin for clinically unsuspected pneumonia in primary care: subgroup analysis.

Teepe J, Little P, Elshof N, Broekhuizen BD, Moore M, Stuart B, Butler CC, Hood K, Ieven M, Coenen S, Goossens H, Verheij TJ; GRACE consortium.

Eur Respir J. 2016 Jan;47(1):327-30. doi: 10.1183/13993003.00611-2015. Epub 2015 Nov 5. No abstract available.


Effectiveness of a nurse-led intensive home-visitation programme for first-time teenage mothers (Building Blocks): a pragmatic randomised controlled trial.

Robling M, Bekkers MJ, Bell K, Butler CC, Cannings-John R, Channon S, Martin BC, Gregory JW, Hood K, Kemp A, Kenkre J, Montgomery AA, Moody G, Owen-Jones E, Pickett K, Richardson G, Roberts ZE, Ronaldson S, Sanders J, Stamuli E, Torgerson D.

Lancet. 2016 Jan 9;387(10014):146-55. doi: 10.1016/S0140-6736(15)00392-X. Epub 2015 Oct 22.


Eligibility for interventions, co-occurrence and risk factors for unhealthy behaviours in patients consulting for routine primary care: results from the Pre-Empt study.

Randell E, Pickles T, Simpson SA, Spanou C, McCambridge J, Hood K, Butler CC.

BMC Fam Pract. 2015 Oct 9;16:133. doi: 10.1186/s12875-015-0359-x.

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