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Items: 36


Temporal efficacy of a sulforaphane-based broccoli sprout diet in prevention of breast cancer through modulation of epigenetic mechanisms.

Li Y, Buckhaults P, Li S, Tollefsbol TO.

Cancer Prev Res (Phila). 2018 May 15. pii: canprevres.0423.2017. doi: 10.1158/1940-6207.CAPR-17-0423. [Epub ahead of print]


PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids.

Liu C, Banister CE, Weige CC, Altomare D, Richardson JH, Contreras CM, Buckhaults PJ.

Proc Natl Acad Sci U S A. 2018 May 14. pii: 201802902. doi: 10.1073/pnas.1802902115. [Epub ahead of print]


Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen.

Oliver D, Ji H, Liu P, Gasparian A, Gardiner E, Lee S, Zenteno A, Perinskaya LO, Chen M, Buckhaults P, Broude E, Wyatt MD, Valafar H, Peña E, Shtutman M.

Sci Rep. 2017 Feb 22;7:43023. doi: 10.1038/srep43023.


O-Linked N-Acetylglucosamine (O-GlcNAc) Expression Levels Epigenetically Regulate Colon Cancer Tumorigenesis by Affecting the Cancer Stem Cell Compartment via Modulating Expression of Transcriptional Factor MYBL1.

Guo H, Zhang B, Nairn AV, Nagy T, Moremen KW, Buckhaults P, Pierce M.

J Biol Chem. 2017 Mar 10;292(10):4123-4137. doi: 10.1074/jbc.M116.763201. Epub 2017 Jan 17.


Identification and characterization of HPV-independent cervical cancers.

Banister CE, Liu C, Pirisi L, Creek KE, Buckhaults PJ.

Oncotarget. 2017 Feb 21;8(8):13375-13386. doi: 10.18632/oncotarget.14533.


Pathway-Structured Predictive Model for Cancer Survival Prediction: A Two-Stage Approach.

Zhang X, Li Y, Akinyemiju T, Ojesina AI, Buckhaults P, Liu N, Xu B, Yi N.

Genetics. 2017 Jan;205(1):89-100. doi: 10.1534/genetics.116.189191. Epub 2016 Nov 9.


Association of FGD1 polymorphisms with early-onset breast cancer.

Beasley S, Buckhaults PJ, Pedigo NG, Farrell CL.

Oncol Lett. 2016 Sep;12(3):2071-2077. Epub 2016 Jul 25.


Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals.

Li Y, Buckhaults P, Cui X, Tollefsbol TO.

Epigenomics. 2016 Aug;8(8):1019-37. doi: 10.2217/epi-2016-0024. Epub 2016 Aug 1.


An epigenetic auto-feedback loop regulates TGF-β type II receptor expression and function in NSCLC.

Yang S, Cho YJ, Jin L, Yuan G, Datta A, Buckhaults P, Datta PK.

Oncotarget. 2015 Oct 20;6(32):33237-52. doi: 10.18632/oncotarget.4893.


Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans.

Weige CC, Birtwistle MR, Mallick H, Yi N, Berrong Z, Cloessner E, Duff K, Tidwell J, Clendenning M, Wilkerson B, Farrell C, Bunz F, Ji H, Shtutman M, Creek KE, Banister CE, Buckhaults PJ.

Mol Cancer Res. 2014 Jul;12(7):1029-41. doi: 10.1158/1541-7786.MCR-13-0286-T. Epub 2014 Apr 17.


Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients.

Shull AY, Clendenning ML, Ghoshal-Gupta S, Farrell CL, Vangapandu HV, Dudas L, Wilkerson BJ, Buckhaults PJ.

PLoS One. 2013;8(3):e58731. doi: 10.1371/journal.pone.0058731. Epub 2013 Mar 7.


Novel somatic mutations to PI3K pathway genes in metastatic melanoma.

Shull AY, Latham-Schwark A, Ramasamy P, Leskoske K, Oroian D, Birtwistle MR, Buckhaults PJ.

PLoS One. 2012;7(8):e43369. doi: 10.1371/journal.pone.0043369. Epub 2012 Aug 17.


Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis.

Xi C, Hu Y, Buckhaults P, Moskophidis D, Mivechi NF.

J Biol Chem. 2012 Oct 12;287(42):35646-57. doi: 10.1074/jbc.M112.377481. Epub 2012 Jul 30.


Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers.

Jiao X, Wood LD, Lindman M, Jones S, Buckhaults P, Polyak K, Sukumar S, Carter H, Kim D, Karchin R, Sjöblom T.

Genes Chromosomes Cancer. 2012 May;51(5):480-9. doi: 10.1002/gcc.21935. Epub 2012 Feb 3.


Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations.

Lauring J, Cosgrove DP, Fontana S, Gustin JP, Konishi H, Abukhdeir AM, Garay JP, Mohseni M, Wang GM, Higgins MJ, Gorkin D, Reis M, Vogelstein B, Polyak K, Cowherd M, Buckhaults PJ, Park BH.

Oncogene. 2010 Apr 22;29(16):2337-45. doi: 10.1038/onc.2009.516. Epub 2010 Jan 25.


Molecular genetic markers in female reproductive cancers.

Wang TL, Davidson B, Buckhaults PJ, Huang CS, Poul G.

J Oncol. 2010;2010:307460. doi: 10.1155/2010/307460. Epub 2011 Apr 18. No abstract available.

Free PMC Article

A gene expression classifier of node-positive colorectal cancer.

Meeh PF, Farrell CL, Croshaw R, Crimm H, Miller SK, Oroian D, Kowli S, Zhu J, Carver W, Wu W, Pena E, Buckhaults PJ.

Neoplasia. 2009 Oct;11(10):1074-83.


Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer.

Lin Y, Buckhaults PJ, Lee JR, Xiong H, Farrell C, Podolsky RH, Schade RR, Dynan WS.

Neoplasia. 2009 Sep;11(9):864-73.


Frequent mutations in the MITF pathway in melanoma.

Cronin JC, Wunderlich J, Loftus SK, Prickett TD, Wei X, Ridd K, Vemula S, Burrell AS, Agrawal NS, Lin JC, Banister CE, Buckhaults P, Rosenberg SA, Bastian BC, Pavan WJ, Samuels Y.

Pigment Cell Melanoma Res. 2009 Aug;22(4):435-44. doi: 10.1111/j.1755-148X.2009.00578.x. Epub 2009 Apr 29.


Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.

Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, Davis S, Wang C, Cronin JC, Agrawal NS, Lin JC, Westbroek W, Hoogstraten-Miller S, Molinolo AA, Fetsch P, Filie AC, O'Connell MP, Banister CE, Howard JD, Buckhaults P, Weeraratna AT, Brody LC, Rosenberg SA, Samuels Y.

Nat Genet. 2009 May;41(5):518-20. doi: 10.1038/ng.340. Epub 2009 Mar 29.


Somatic mutations to CSMD1 in colorectal adenocarcinomas.

Farrell C, Crimm H, Meeh P, Croshaw R, Barbar T, Vandersteenhoven JJ, Butler W, Buckhaults P.

Cancer Biol Ther. 2008 Apr;7(4):609-13.


The genomic landscapes of human breast and colorectal cancers.

Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, Ballinger DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P, Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B.

Science. 2007 Nov 16;318(5853):1108-13. Epub 2007 Oct 11.


The consensus coding sequences of human breast and colorectal cancers.

Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.

Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7.


Gene expression determinants of clinical outcome.

Buckhaults P.

Curr Opin Oncol. 2006 Jan;18(1):57-61. Review.


Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R.

Nanda A, Buckhaults P, Seaman S, Agrawal N, Boutin P, Shankara S, Nacht M, Teicher B, Stampfl J, Singh S, Vogelstein B, Kinzler KW, St Croix B.

Cancer Res. 2004 Dec 1;64(23):8507-11.


Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers.

Koopmann J, Buckhaults P, Brown DA, Zahurak ML, Sato N, Fukushima N, Sokoll LJ, Chan DW, Yeo CJ, Hruban RH, Breit SN, Kinzler KW, Vogelstein B, Goggins M.

Clin Cancer Res. 2004 Apr 1;10(7):2386-92.


Identifying tumor origin using a gene expression-based classification map.

Buckhaults P, Zhang Z, Chen YC, Wang TL, St Croix B, Saha S, Bardelli A, Morin PJ, Polyak K, Hruban RH, Velculescu VE, Shih IeM.

Cancer Res. 2003 Jul 15;63(14):4144-9.


MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.

Brown DA, Ward RL, Buckhaults P, Liu T, Romans KE, Hawkins NJ, Bauskin AR, Kinzler KW, Vogelstein B, Breit SN.

Clin Cancer Res. 2003 Jul;9(7):2642-50.


A phosphatase associated with metastasis of colorectal cancer.

Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, Vogelstein B.

Science. 2001 Nov 9;294(5545):1343-6. Epub 2001 Oct 11.


Secreted and cell surface genes expressed in benign and malignant colorectal tumors.

Buckhaults P, Rago C, St Croix B, Romans KE, Saha S, Zhang L, Vogelstein B, Kinzler KW.

Cancer Res. 2001 Oct 1;61(19):6996-7001.


Human Smad3 and Smad4 are sequence-specific transcription activators.

Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B, Kern SE.

Mol Cell. 1998 Mar;1(4):611-7.


Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.

Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL, Kern SE, Kinzler KW, Vogelstein B.

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2412-6.


Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene.

Buckhaults P, Chen L, Fregien N, Pierce M.

J Biol Chem. 1997 Aug 1;272(31):19575-81.


Cloning and expression of a Xenopus laevis oocyte lectin and characterization of its mRNA levels during early development.

Lee JK, Buckhaults P, Wilkes C, Teilhet M, King ML, Moremen KW, Pierce M.

Glycobiology. 1997 Apr;7(3):367-72.


Isolation, characterization, and expression of a cDNA encoding N-acetylglucosaminyltransferase V.

Shoreibah M, Perng GS, Adler B, Weinstein J, Basu R, Cupples R, Wen D, Browne JK, Buckhaults P, Fregien N, Pierce M.

J Biol Chem. 1993 Jul 25;268(21):15381-5.

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