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Items: 1 to 50 of 216

1.

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells.

Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG.

Elife. 2017 Dec 14;6. pii: e27293. doi: 10.7554/eLife.27293.

2.

Identification of cancer genes that are independent of dominant proliferation and lineage programs.

Selfors LM, Stover DG, Harris IS, Brugge JS, Coloff JL.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11276-E11284. doi: 10.1073/pnas.1714877115. Epub 2017 Dec 11.

3.

Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

Zoeller JJ, Bronson RT, Selfors LM, Mills GB, Brugge JS.

NPJ Breast Cancer. 2017 Sep 22;3:38. doi: 10.1038/s41523-017-0031-9. eCollection 2017.

4.

Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues.

Wang Y, Woehrstein JB, Donoghue N, Dai M, Avendaño MS, Schackmann RCJ, Zoeller JJ, Wang SSH, Tillberg PW, Park D, Lapan SW, Boyden ES, Brugge JS, Kaeser PS, Church GM, Agasti SS, Jungmann R, Yin P.

Nano Lett. 2017 Oct 11;17(10):6131-6139. doi: 10.1021/acs.nanolett.7b02716. Epub 2017 Oct 2.

5.

Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.

Zervantonakis IK, Iavarone C, Chen HY, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis U, Leverson JD, Sampath D, Mills GB, Brugge JS.

Nat Commun. 2017 Aug 28;8(1):365. doi: 10.1038/s41467-017-00263-7.

6.

Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

Zoeller JJ, Bronson RT, Selfors LM, Mills GB, Brugge JS.

NPJ Breast Cancer. 2017 May 1;3:18. doi: 10.1038/s41523-017-0020-z. eCollection 2017. Erratum in: NPJ Breast Cancer. 2017 Sep 22;3:38.

7.

Metabolic changes promote rejection of oncogenic cells.

Coloff JL, Brugge JS.

Nat Cell Biol. 2017 Apr 27;19(5):414-415. doi: 10.1038/ncb3521.

PMID:
28446818
8.

Moving Closer To Victory.

Muranen T, Brugge JS.

Cold Spring Harb Symp Quant Biol. 2016;81:281-288. doi: 10.1101/sqb.2016.81.031179. Epub 2017 Apr 17. No abstract available.

PMID:
28416575
9.

Starved epithelial cells uptake extracellular matrix for survival.

Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY.

Nat Commun. 2017 Jan 10;8:13989. doi: 10.1038/ncomms13989.

10.

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS.

Cancer Res. 2016 Dec 15;76(24):7168-7180. Epub 2016 Oct 20.

11.

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.

Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf GM, English J, Kirschmeier PT, Velculescu VE, Paweletz C, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.

Clin Cancer Res. 2017 Mar 1;23(5):1263-1273. doi: 10.1158/1078-0432.CCR-16-1237. Epub 2016 Aug 29.

PMID:
27573169
12.

Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition.

Iwanicki MP, Chen HY, Iavarone C, Zervantonakis IK, Muranen T, Novak M, Ince TA, Drapkin R, Brugge JS.

JCI Insight. 2016 Jul 7;1(10). pii: e86829.

13.

The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression-Based Meta-Analysis.

Stover DG, Coloff JL, Barry WT, Brugge JS, Winer EP, Selfors LM.

Clin Cancer Res. 2016 Dec 15;22(24):6039-6050. Epub 2016 Jun 21.

14.

A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin.

Gallegos LL, Ng MR, Sowa ME, Selfors LM, White A, Zervantonakis IK, Singh P, Dhakal S, Harper JW, Brugge JS.

Sci Rep. 2016 Jun 3;6:27114. doi: 10.1038/srep27114.

15.

Coping with the metabolic stress of leaving home.

Coloff JL, Brugge JS.

Cell Res. 2016 Jul;26(7):757-8. doi: 10.1038/cr.2016.61. Epub 2016 May 24.

16.

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.

Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS.

Cell Metab. 2016 May 10;23(5):867-80. doi: 10.1016/j.cmet.2016.03.016. Epub 2016 Apr 28.

17.

Corrigendum: Chaperone-mediated autophagy degrades mutant p53.

Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J.

Genes Dev. 2016 Apr 1;30(7):870. doi: 10.1101/gad.280453.116.

18.

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.

Bui DA, Lee W, White AE, Harper JW, Schackmann RC, Overholtzer M, Selfors LM, Brugge JS.

Sci Signal. 2016 Mar 1;9(417):ra23. doi: 10.1126/scisignal.aaa9227.

19.

Cancer: The enemy of my enemy is my friend.

Harris IS, Brugge JS.

Nature. 2015 Nov 12;527(7577):170-1. doi: 10.1038/nature15644. Epub 2015 Oct 21. No abstract available.

PMID:
26503052
20.

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.

Ince TA, Sousa AD, Jones MA, Harrell JC, Agoston ES, Krohn M, Selfors LM, Liu W, Chen K, Yong M, Buchwald P, Wang B, Hale KS, Cohick E, Sergent P, Witt A, Kozhekbaeva Z, Gao S, Agoston AT, Merritt MA, Foster R, Rueda BR, Crum CP, Brugge JS, Mills GB.

Nat Commun. 2015 Jun 17;6:7419. doi: 10.1038/ncomms8419.

21.

Signal transduction in cancer.

Sever R, Brugge JS.

Cold Spring Harb Perspect Med. 2015 Apr 1;5(4). pii: a006098. doi: 10.1101/cshperspect.a006098. Review.

22.

Correction: Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters.

Ng MR, Besser A, Brugge JS, Danuser G.

Elife. 2015 Feb 2;4:e06656. doi: 10.7554/eLife.06656. No abstract available.

23.

Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters.

Ng MR, Besser A, Brugge JS, Danuser G.

Elife. 2014 Dec 5;3:e03282. doi: 10.7554/eLife.03282. Erratum in: Elife. 2015;4:e06656.

24.

Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis.

Gallegos LL, Brugge JS.

Dev Cell. 2014 Jul 14;30(1):3-4. doi: 10.1016/j.devcel.2014.06.031.

25.

Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance.

Davidowitz RA, Selfors LM, Iwanicki MP, Elias KM, Karst A, Piao H, Ince TA, Drage MG, Dering J, Konecny GE, Matulonis U, Mills GB, Slamon DJ, Drapkin R, Brugge JS.

J Clin Invest. 2014 Jun;124(6):2611-25. doi: 10.1172/JCI69815. Epub 2014 Apr 24.

26.

Oncogene-like induction of cellular invasion from centrosome amplification.

Godinho SA, Picone R, Burute M, Dagher R, Su Y, Leung CT, Polyak K, Brugge JS, Théry M, Pellman D.

Nature. 2014 Jun 5;510(7503):167-71. doi: 10.1038/nature13277. Epub 2014 Apr 13.

27.

Evidence for a multipotent mammary progenitor with pregnancy-specific activity.

Kaanta AS, Virtanen C, Selfors LM, Brugge JS, Neel BG.

Breast Cancer Res. 2013;15(4):R65.

28.

Chaperone-mediated autophagy degrades mutant p53.

Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J.

Genes Dev. 2013 Aug 1;27(15):1718-30. doi: 10.1101/gad.220897.113. Erratum in: Genes Dev. 2016 Apr 1;30(7):870. Genes Dev. 2013 Sep 1;27(17):1947.

29.

PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells.

Buchwalter G, Hickey MM, Cromer A, Selfors LM, Gunawardane RN, Frishman J, Jeselsohn R, Lim E, Chi D, Fu X, Schiff R, Brown M, Brugge JS.

Cancer Cell. 2013 Jun 10;23(6):753-67. doi: 10.1016/j.ccr.2013.04.026.

30.

Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals.

Albeck JG, Mills GB, Brugge JS.

Mol Cell. 2013 Jan 24;49(2):249-61. doi: 10.1016/j.molcel.2012.11.002. Epub 2012 Dec 6.

31.

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.

Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS.

Cancer Cell. 2012 Nov 13;22(5):615-30. doi: 10.1016/j.ccr.2012.09.027.

32.

Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility.

Ng MR, Besser A, Danuser G, Brugge JS.

J Cell Biol. 2012 Oct 29;199(3):545-63. doi: 10.1083/jcb.201207148. Epub 2012 Oct 22.

33.

Into the deep: Refocusing on 3D.

Brugge JS.

Nat Cell Biol. 2012 Apr 2;14(4):332. doi: 10.1038/ncb2470. No abstract available.

PMID:
22469826
34.

Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2.

Worster DT, Schmelzle T, Solimini NL, Lightcap ES, Millard B, Mills GB, Brugge JS, Albeck JG.

Sci Signal. 2012 Mar 6;5(214):ra19. doi: 10.1126/scisignal.2001986.

35.

In vitro mesothelial clearance assay that models the early steps of ovarian cancer metastasis.

Davidowitz RA, Iwanicki MP, Brugge JS.

J Vis Exp. 2012 Feb 17;(60). pii: 3888. doi: 10.3791/3888.

36.

Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.

Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS.

Cancer Cell. 2012 Feb 14;21(2):227-39. doi: 10.1016/j.ccr.2011.12.024.

37.

Outgrowth of single oncogene-expressing cells from suppressive epithelial environments.

Leung CT, Brugge JS.

Nature. 2012 Feb 8;482(7385):410-3. doi: 10.1038/nature10826.

38.

Ovarian cancer spheroids use myosin-generated force to clear the mesothelium.

Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, Danuser G, Ince TA, Brugge JS.

Cancer Discov. 2011 Jul;1(2):144-57. doi: 10.1158/2159-8274.CD-11-0010. Erratum in: Cancer Discov. 2011 Dec;1(7):626. Ince, Tan [corrected to Ince, Tan A].

39.

Extracellular matrix regulation of metabolism and implications for tumorigenesis.

Grassian AR, Coloff JL, Brugge JS.

Cold Spring Harb Symp Quant Biol. 2011;76:313-24. doi: 10.1101/sqb.2011.76.010967. Epub 2011 Nov 21. Review.

PMID:
22105806
40.

Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression.

Wang L, Brugge JS, Janes KA.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):E803-12. doi: 10.1073/pnas.1103423108. Epub 2011 Aug 22.

41.

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.

Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS.

Genes Dev. 2011 Aug 15;25(16):1716-33. doi: 10.1101/gad.16771811.

42.

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG.

Nat Genet. 2011 Jul 31;43(9):869-74. doi: 10.1038/ng.890.

43.

The myosin-II-responsive focal adhesion proteome: a tour de force?

Gallegos L, Ng MR, Brugge JS.

Nat Cell Biol. 2011 Apr;13(4):344-6. doi: 10.1038/ncb0411-344. Epub 2011 Mar 20.

PMID:
21460805
44.

Psidin, a conserved protein that regulates protrusion dynamics and cell migration.

Kim JH, Cho A, Yin H, Schafer DA, Mouneimne G, Simpson KJ, Nguyen KV, Brugge JS, Montell DJ.

Genes Dev. 2011 Apr 1;25(7):730-41. doi: 10.1101/gad.2028611. Epub 2011 Mar 15.

45.

Uncovering a tumor suppressor for triple-negative breast cancers.

Albeck JG, Brugge JS.

Cell. 2011 Mar 4;144(5):638-40. doi: 10.1016/j.cell.2011.02.030. Erratum in: Cell. 2011 Apr 29;145(3):483.

46.

A non-genetic route to aneuploidy in human cancers.

Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, Overholtzer M.

Nat Cell Biol. 2011 Mar;13(3):324-30. doi: 10.1038/ncb2174. Epub 2011 Feb 20.

47.

Mechanistic biology in the next quarter century.

Harrison SC, Brugge JS.

Mol Biol Cell. 2010 Nov 15;21(22):3799-800. doi: 10.1091/mbc.E10-05-0441. No abstract available.

48.

Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells.

Knowlton ML, Selfors LM, Wrobel CN, Gu TL, Ballif BA, Gygi SP, Polakiewicz R, Brugge JS.

PLoS One. 2010 Oct 26;5(10):e13587. doi: 10.1371/journal.pone.0013587.

49.

ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells.

Grassian AR, Schafer ZT, Brugge JS.

J Biol Chem. 2011 Jan 7;286(1):79-90. doi: 10.1074/jbc.M110.169821. Epub 2010 Oct 18.

50.

PTK6 regulates IGF-1-induced anchorage-independent survival.

Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, Brugge JS.

PLoS One. 2010 Jul 23;5(7):e11729. doi: 10.1371/journal.pone.0011729.

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