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Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.

Alsina-Beauchamp D, Escós A, Fajardo P, González-Romero D, Díaz-Mora E, Risco A, Martín-Serrano MA, Del Fresno C, Dominguez-Andrés J, Aparicio N, Zur R, Shpiro N, Brown GD, Ardavín C, Netea MG, Alemany S, Sanz-Ezquerro JJ, Cuenda A.

EMBO Mol Med. 2018 Apr 16. pii: e8485. doi: 10.15252/emmm.201708485. [Epub ahead of print]


Aspergillus-induced superoxide production by cystic fibrosis phagocytes is associated with disease severity.

Brunel SF, Willment JA, Brown GD, Devereux G, Warris A.

ERJ Open Res. 2018 Apr 9;4(2). pii: 00068-2017. doi: 10.1183/23120541.00068-2017. eCollection 2018 Apr.


Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages.

Lim J, Coates CJ, Seoane PI, Garelnabi M, Taylor-Smith LM, Monteith P, Macleod CL, Escaron CJ, Brown GD, Hall RA, May RC.

J Immunol. 2018 Apr 11. pii: ji1700790. doi: 10.4049/jimmunol.1700790. [Epub ahead of print]


C-type lectins in immunity and homeostasis.

Brown GD, Willment JA, Whitehead L.

Nat Rev Immunol. 2018 Mar 26. doi: 10.1038/s41577-018-0004-8. [Epub ahead of print] Review.


Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development.

Zimara N, Chanyalew M, Aseffa A, van Zandbergen G, Lepenies B, Schmid M, Weiss R, Rascle A, Wege AK, Jantsch J, Schatz V, Brown GD, Ritter U.

Front Immunol. 2018 Feb 26;9:263. doi: 10.3389/fimmu.2018.00263. eCollection 2018.


Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus.

Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, Plato A, Wallace CA, Yuecel R, Hebecker B, da Glória Teixeira Sousa M, Cunha C, Liu Y, Feizi T, Brakhage AA, Kwon-Chung KJ, Gow NAR, Zanda M, Piras M, Zanato C, Jaeger M, Netea MG, van de Veerdonk FL, Lacerda JF, Campos A, Carvalho A, Willment JA, Latgé JP, Brown GD.

Nature. 2018 Mar 15;555(7696):382-386. doi: 10.1038/nature25974. Epub 2018 Feb 28.


Approximate Bayesian computation for spatial SEIR(S) epidemic models.

Brown GD, Porter AT, Oleson JJ, Hinman JA.

Spat Spatiotemporal Epidemiol. 2018 Feb;24:27-37. doi: 10.1016/j.sste.2017.11.001. Epub 2017 Nov 22.


Microgravity modulation of syncytin-A expression enhance osteoclast formation.

Ethiraj P, Link JR, Sinkway JM, Brown GD, Parler WA, Reddy SV.

J Cell Biochem. 2018 Feb 1. doi: 10.1002/jcb.26750. [Epub ahead of print]


Sensing fungi at the oral epithelium.

Dambuza IM, Brown GD.

Nat Microbiol. 2018 Jan;3(1):4-5. doi: 10.1038/s41564-017-0086-2. No abstract available.


Editorial overview: Host-microbe interactions: fungi.

Brown GD, May RC.

Curr Opin Microbiol. 2017 Dec;40:v-vii. doi: 10.1016/j.mib.2017.11.026. No abstract available.


Impact of programs to reduce antipsychotic and anticholinergic use in nursing homes.

Carnahan RM, Brown GD, Letuchy EM, Rubenstein LM, Gryzlak BM, Smith M, Reist JC, Kelly MW, Schultz SK, Weckmann MT, Chrischilles EA.

Alzheimers Dement (N Y). 2017 Mar 6;3(4):553-561. doi: 10.1016/j.trci.2017.02.003. eCollection 2017 Nov.


Immunotherapeutic approaches to treatment of fungal diseases.

Armstrong-James D, Brown GD, Netea MG, Zelante T, Gresnigt MS, van de Veerdonk FL, Levitz SM.

Lancet Infect Dis. 2017 Dec;17(12):e393-e402. doi: 10.1016/S1473-3099(17)30442-5. Epub 2017 Jul 31. Review.


Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism.

Brown BR, Lee EJ, Snow PE, Vance EE, Iwakura Y, Ohno N, Miura N, Lin X, Brown GD, Wells CA, Smith JR, Caspi RR, Rosenzweig HL.

Clin Exp Immunol. 2017 Dec;190(3):293-303. doi: 10.1111/cei.13021. Epub 2017 Aug 30.


Fungal Recognition and Host Defense Mechanisms.

Dambuza IM, Levitz SM, Netea MG, Brown GD.

Microbiol Spectr. 2017 Jul;5(4). doi: 10.1128/microbiolspec.FUNK-0050-2016. Review.


The CLEC12A receptor marks human basophils: Potential implications for minimal residual disease detection in acute myeloid leukemia.

Toft-Petersen M, Stidsholt Roug A, Plesner T, Ebbesen L, Brown GD, Nederby L.

Cytometry B Clin Cytom. 2017 Jul 17. doi: 10.1002/cyto.b.21540. [Epub ahead of print]


Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88.

Castoldi A, Andrade-Oliveira V, Aguiar CF, Amano MT, Lee J, Miyagi MT, Latância MT, Braga TT, da Silva MB, Ignácio A, Carola Correia Lima JD, Loures FV, Albuquerque JAT, Macêdo MB, Almeida RR, Gaiarsa JW, Luévano-Martínez LA, Belchior T, Hiyane MI, Brown GD, Mori MA, Hoffmann C, Seelaender M, Festuccia WT, Moraes-Vieira PM, Câmara NOS.

Cell Rep. 2017 Jun 13;19(11):2272-2288. doi: 10.1016/j.celrep.2017.05.059.


High-Affinity "Click" RGD Peptidomimetics as Radiolabeled Probes for Imaging αv β3 Integrin.

Piras M, Testa A, Fleming IN, Dall'Angelo S, Andriu A, Menta S, Mori M, Brown GD, Forster D, Williams KJ, Zanda M.

ChemMedChem. 2017 Jul 20;12(14):1142-1151. doi: 10.1002/cmdc.201700328. Epub 2017 Jul 3.


Intestinal fungi contribute to development of alcoholic liver disease.

Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B.

J Clin Invest. 2017 Jun 30;127(7):2829-2841. doi: 10.1172/JCI90562. Epub 2017 May 22.


AIDS-Related Mycoses: Current Progress in the Field and Future Priorities.

Armstrong-James D, Bicanic T, Brown GD, Hoving JC, Meintjes G, Nielsen K; Working Group from the EMBO Workshop on AIDS-Related Mycoses.

Trends Microbiol. 2017 Jun;25(6):428-430. doi: 10.1016/j.tim.2017.02.013. Epub 2017 Apr 25.


Discussing Out-of-Pocket Expenses During Clinical Appointments: An Observational Study of Patient-Psychiatrist Interactions.

Brown GD, Hunter WG, Hesson A, Davis JK, Kirby C, Barnett JA, Byelmac D, Ubel PA.

Psychiatr Serv. 2017 Jun 1;68(6):610-617. doi: 10.1176/ Epub 2017 Mar 15.


Candida albicans Chitin Increases Arginase-1 Activity in Human Macrophages, with an Impact on Macrophage Antimicrobial Functions.

Wagener J, MacCallum DM, Brown GD, Gow NA.

MBio. 2017 Jan 24;8(1). pii: e01820-16. doi: 10.1128/mBio.01820-16.


Lactate signalling regulates fungal β-glucan masking and immune evasion.

Ballou ER, Avelar GM, Childers DS, Mackie J, Bain JM, Wagener J, Kastora SL, Panea MD, Hardison SE, Walker LA, Erwig LP, Munro CA, Gow NA, Brown GD, MacCallum DM, Brown AJ.

Nat Microbiol. 2016 Dec 12;2:16238. doi: 10.1038/nmicrobiol.2016.238.


Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism.

Czechowski T, Larson TR, Catania TM, Harvey D, Brown GD, Graham IA.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15150-15155. doi: 10.1073/pnas.1611567113. Epub 2016 Dec 7.


Unravelling the relevance of CLEC12A as a cancer stem cell marker in myelodysplastic syndrome.

Toft-Petersen M, Nederby L, Kjeldsen E, Kerndrup GB, Brown GD, Hokland P, Stidsholt Roug A.

Br J Haematol. 2016 Nov;175(3):393-401. doi: 10.1111/bjh.14270. Epub 2016 Sep 9.


Lectin Receptors Expressed on Myeloid Cells.

Brown GD, Crocker PR.

Microbiol Spectr. 2016 Oct;4(5). doi: 10.1128/microbiolspec.MCHD-0036-2016. Review.


A rank based social norms model of how people judge their levels of drunkenness whilst intoxicated.

Moore SC, Wood AM, Moore L, Shepherd J, Murphy S, Brown GDA.

BMC Public Health. 2016 Sep 13;16:798. doi: 10.1186/s12889-016-3469-z.


Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.

Xiao Y, Tang J, Guo H, Zhao Y, Tang R, Ouyang S, Zeng Q, Rappleye CA, Rajaram MV, Schlesinger LS, Tao L, Brown GD, Langdon WY, Li BT, Zhang J.

Nat Med. 2016 Aug;22(8):906-14. doi: 10.1038/nm.4141. Epub 2016 Jul 18.


A Cytochrome P450-Mediated Intramolecular Carbon-Carbon Ring Closure in the Biosynthesis of Multidrug-Resistance-Reversing Lathyrane Diterpenoids.

King AJ, Brown GD, Gilday AD, Forestier E, Larson TR, Graham IA.

Chembiochem. 2016 Sep 2;17(17):1593-7. doi: 10.1002/cbic.201600316. Epub 2016 Jul 15.


Prolonged Delirium With Catatonia Following Orthotopic Liver Transplant Responsive to Memantine.

Brown GD, Muzyk AJ, Preud'homme XA.

J Psychiatr Pract. 2016 Mar;22(2):128-32. doi: 10.1097/PRA.0000000000000133.


Trimming Surface Sugars Protects Histoplasma from Immune Attack.

Brown GD.

MBio. 2016 Apr 26;7(2):e00553-16. doi: 10.1128/mBio.00553-16.


β-Glucan exacerbates allergic airway responses to house dust mite allergen.

Hadebe S, Kirstein F, Fierens K, Redelinghuys P, Murray GI, Williams DL, Lambrecht BN, Brombacher F, Brown GD.

Respir Res. 2016 Apr 2;17:35. doi: 10.1186/s12931-016-0352-5.


Being paid relatively well most of the time: Negatively skewed payments are more satisfying.

Tripp J, Brown GD.

Mem Cognit. 2016 Aug;44(6):966-73. doi: 10.3758/s13421-016-0604-0.


Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation.

Kerscher B, Dambuza IM, Christofi M, Reid DM, Yamasaki S, Willment JA, Brown GD.

Microbes Infect. 2016 Jul-Aug;18(7-8):505-9. doi: 10.1016/j.micinf.2016.03.007. Epub 2016 Mar 19.


Rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) for analysis of chromatin complexes.

Mohammed H, Taylor C, Brown GD, Papachristou EK, Carroll JS, D'Santos CS.

Nat Protoc. 2016 Feb;11(2):316-26. doi: 10.1038/nprot.2016.020. Epub 2016 Jan 21.


Do industrial incidents in the chemical sector create equity market contagion?

Brown GD, Corbet S, McMullan C, Sharma R.

J Safety Res. 2015 Dec;55:115-9. doi: 10.1016/j.jsr.2015.08.009. Epub 2015 Sep 13.


Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity.

Brown GD, Shi Q, Delucca GV, Batt DG, Galella MA, Cvijic ME, Liu RQ, Qiu F, Zhao Q, Barrish JC, Carter PH.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):662-666. doi: 10.1016/j.bmcl.2015.11.051. Epub 2015 Nov 17.


Personality, Parasites, Political Attitudes, and Cooperation: A Model of How Infection Prevalence Influences Openness and Social Group Formation.

Brown GD, Fincher CL, Walasek L.

Top Cogn Sci. 2016 Jan;8(1):98-117. doi: 10.1111/tops.12175. Epub 2015 Nov 27.


Preparing to respond: Irish nurses' perceptions of preparedness for an influenza pandemic.

McMullan C, Brown GD, O'Sullivan D.

Int Emerg Nurs. 2016 May;26:3-7. doi: 10.1016/j.ienj.2015.10.004. Epub 2015 Nov 17.


Chromatin Immunoprecipitation-Sequencing (ChIP-seq) for Mapping of Estrogen Receptor-Chromatin Interactions in Breast Cancer.

Holmes KA, Brown GD, Carroll JS.

Methods Mol Biol. 2016;1366:79-98. doi: 10.1007/978-1-4939-3127-9_8.


An empirically adjusted approach to reproductive number estimation for stochastic compartmental models: A case study of two Ebola outbreaks.

Brown GD, Oleson JJ, Porter AT.

Biometrics. 2016 Jun;72(2):335-43. doi: 10.1111/biom.12432. Epub 2015 Nov 17.


Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge.

Kerscher B, Wilson GJ, Reid DM, Mori D, Taylor JA, Besra GS, Yamasaki S, Willment JA, Brown GD.

Eur J Immunol. 2016 Feb;46(2):381-9. doi: 10.1002/eji.201545858. Epub 2015 Dec 8.


Why does Income Relate to Depressive Symptoms? Testing the Income Rank Hypothesis Longitudinally.

Osafo Hounkpatin H, Wood AM, Brown GD, Dunn G.

Soc Indic Res. 2015;124(2):637-655. Epub 2014 Oct 28.


CD4(+) T-cell survival in the GI tract requires dectin-1 during fungal infection.

Drummond RA, Dambuza IM, Vautier S, Taylor JA, Reid DM, Bain CC, Underhill DM, Masopust D, Kaplan DH, Brown GD.

Mucosal Immunol. 2016 Mar;9(2):492-502. doi: 10.1038/mi.2015.79. Epub 2015 Sep 9.


Correction: Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma.

Hadebe S, Kirstein F, Fierens K, Chen K, Drummond RA, Vautier S, Sajaniemi S, Murray G, Williams DL, Redelinghuys P, Reinhart TA, Junecko BA, Kolls JK, Lambrecht BN, Brombacher F, Brown GD.

PLoS One. 2015 Sep 8;10(9):e0137945. doi: 10.1371/journal.pone.0137945. eCollection 2015. No abstract available.


Delinking CARD9 and IL-17: CARD9 Protects against Candida tropicalis Infection through a TNF-α-Dependent, IL-17-Independent Mechanism.

Whibley N, Jaycox JR, Reid D, Garg AV, Taylor JA, Clancy CJ, Nguyen MH, Biswas PS, McGeachy MJ, Brown GD, Gaffen SL.

J Immunol. 2015 Oct 15;195(8):3781-92. doi: 10.4049/jimmunol.1500870. Epub 2015 Sep 2.


MICL controls inflammation in rheumatoid arthritis.

Redelinghuys P, Whitehead L, Augello A, Drummond RA, Levesque JM, Vautier S, Reid DM, Kerscher B, Taylor JA, Nigrovic PA, Wright J, Murray GI, Willment JA, Hocking LJ, Fernandes MJ, De Bari C, Mcinnes IB, Brown GD.

Ann Rheum Dis. 2016 Jul;75(7):1386-91. doi: 10.1136/annrheumdis-2014-206644. Epub 2015 Aug 14.


Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma.

Hadebe S, Kirstein F, Fierens K, Chen K, Drummond RA, Vautier S, Sajaniemi S, Murray G, Williams DL, Redelinghuys P, Reinhart TA, Fallert Junecko BA, Kolls JK, Lambrecht BN, Brombacher F, Brown GD.

PLoS One. 2015 Aug 11;10(8):e0134219. doi: 10.1371/journal.pone.0134219. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0137945.


Corrigendum: Progesterone receptor modulates ERα action in breast cancer.

Mohammed H, Russell IA, Stark R, Rueda OM, Hickey TE, Tarulli GA, Serandour AA, Birrell SN, Bruna A, Saadi A, Menon S, Hadfield J, Pugh M, Raj GV, Brown GD, D'Santos C, Robinson JL, Silva G, Launchbury R, Perou CM, Stingl J, Caldas C, Tilley WD, Carroll JS.

Nature. 2015 Oct 1;526(7571):144. doi: 10.1038/nature14959. Epub 2015 Aug 5. No abstract available.


Asymmetric cyclopropanation of conjugated cyanosulfones using a novel cupreine organocatalyst: rapid access to δ(3)-amino acids.

Aitken LS, Hammond LE, Sundaram R, Shankland K, Brown GD, Cobb AJ.

Chem Commun (Camb). 2015 Sep 11;51(70):13558-61. doi: 10.1039/c5cc05158d.


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