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Items: 20


Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis.

Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K.

Cancer Res. 2018 Mar 13. pii: canres.2316.2017. doi: 10.1158/0008-5472.CAN-17-2316. [Epub ahead of print]


Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.

Alam A, Küng R, Kowal J, McLeod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E1973-E1982. doi: 10.1073/pnas.1717044115. Epub 2018 Feb 13.


CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.

Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10208-10213. doi: 10.1073/pnas.1710467114. Epub 2017 Aug 30.


Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer.

McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Győrffy B, Roninson IB, Broude EV.

Oncotarget. 2017 Feb 21;8(8):12558-12575. doi: 10.18632/oncotarget.14894.


Cellular Model of p21-Induced Senescence.

Shtutman M, Chang BD, Schools GP, Broude EV.

Methods Mol Biol. 2017;1534:31-39.


Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer.

Broude EV, Győrffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB.

Curr Cancer Drug Targets. 2015;15(8):739-49. Review.


Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells.

Levina E, Ji H, Chen M, Baig M, Oliver D, Ohouo P, Lim CU, Schools G, Carmack S, Ding Y, Broude EV, Roninson IB, Buttyan R, Shtutman M.

Oncotarget. 2015 May 30;6(15):13088-104.


Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.

Porter DC, Farmaki E, Altilia S, Schools GP, West DK, Chen M, Chang BD, Puzyrev AT, Lim CU, Rokow-Kittell R, Friedhoff LT, Papavassiliou AG, Kalurupalle S, Hurteau G, Shi J, Baran PS, Gyorffy B, Wentland MP, Broude EV, Kiaris H, Roninson IB.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13799-804. doi: 10.1073/pnas.1206906109. Epub 2012 Aug 6.


Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells.

Gonzalez RE, Lim CU, Cole K, Bianchini CH, Schools GP, Davis BE, Wada I, Roninson IB, Broude EV.

Cell Cycle. 2011 Oct 15;10(20):3505-14. doi: 10.4161/cc.10.20.17778.


Function-based gene identification using enzymatically generated normalized shRNA library and massive parallel sequencing.

Shtutman M, Maliyekkel A, Shao Y, Carmack CS, Baig M, Warholic N, Cole K, Broude EV, Harkins TT, Ding Y, Roninson IB.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7377-82. doi: 10.1073/pnas.1003055107. Epub 2010 Apr 5.


p21 (CDKN1A) is a negative regulator of p53 stability.

Broude EV, Demidenko ZN, Vivo C, Swift ME, Davis BM, Blagosklonny MV, Roninson IB.

Cell Cycle. 2007 Jun 15;6(12):1468-71. Epub 2007 Apr 12.


p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation.

Broude EV, Swift ME, Vivo C, Chang BD, Davis BM, Kalurupalle S, Blagosklonny MV, Roninson IB.

Oncogene. 2007 Oct 18;26(48):6954-8. Epub 2007 May 7.


Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection.

Demidenko ZN, Vivo C, Halicka HD, Li CJ, Bhalla K, Broude EV, Blagosklonny MV.

Cell Death Differ. 2006 Sep;13(9):1434-41. Epub 2005 Nov 25.


If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells.

Roninson IB, Broude EV, Chang BD.

Drug Resist Updat. 2001 Oct;4(5):303-13. Review.


Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent.

Chang BD, Swift ME, Shen M, Fang J, Broude EV, Roninson IB.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):389-94. Epub 2001 Dec 18.


A combination of genetic suppressor elements produces resistance to drugs inhibiting DNA replication.

Levenson VV, Lausch E, Kirschling DJ, Broude EV, Davidovich IA, Libants S, Fedosova V, Roninson IB.

Somat Cell Mol Genet. 1999 Jan;25(1):9-26.


p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells.

Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC, Roninson IB.

Oncogene. 2000 Apr 20;19(17):2165-70.


Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases.

Chang BD, Watanabe K, Broude EV, Fang J, Poole JC, Kalinichenko TV, Roninson IB.

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4291-6.


Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs.

Chang BD, Xuan Y, Broude EV, Zhu H, Schott B, Fang J, Roninson IB.

Oncogene. 1999 Aug 26;18(34):4808-18.


A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.

Chang BD, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y, Kandel ES, Lausch E, Christov K, Roninson IB.

Cancer Res. 1999 Aug 1;59(15):3761-7.

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