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Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform.

Cao L, Weetall M, Bombard J, Qi H, Arasu T, Lennox W, Hedrick J, Sheedy J, Risher N, Brooks PC, Trifillis P, Trotta C, Moon YC, Babiak J, Almstead NG, Colacino JM, Davis TW, Peltz SW.

PLoS One. 2016 Dec 16;11(12):e0168366. doi: 10.1371/journal.pone.0168366. eCollection 2016.


Inhibition of Ovarian Tumor Growth by Targeting the HU177 Cryptic Collagen Epitope.

Caron JM, Ames JJ, Contois L, Liebes L, Friesel R, Muggia F, Vary CP, Oxburgh L, Brooks PC.

Am J Pathol. 2016 Jun;186(6):1649-61. doi: 10.1016/j.ajpath.2016.01.015.


Methods for Analyzing Tumor Angiogenesis in the Chick Chorioallantoic Membrane Model.

Ames JJ, Henderson T, Liaw L, Brooks PC.

Methods Mol Biol. 2016;1406:255-69. doi: 10.1007/978-1-4939-3444-7_22.


Identification of an Endogenously Generated Cryptic Collagen Epitope (XL313) That May Selectively Regulate Angiogenesis by an Integrin Yes-associated Protein (YAP) Mechano-transduction Pathway.

Ames JJ, Contois L, Caron JM, Tweedie E, Yang X, Friesel R, Vary C, Brooks PC.

J Biol Chem. 2016 Feb 5;291(6):2731-50. doi: 10.1074/jbc.M115.669614. Epub 2015 Dec 14.


Fibroblast growth factor signaling in the vasculature.

Yang X, Liaw L, Prudovsky I, Brooks PC, Vary C, Oxburgh L, Friesel R.

Curr Atheroscler Rep. 2015 Jun;17(6):509. doi: 10.1007/s11883-015-0509-6. Review.


Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo.

Contois LW, Akalu A, Caron JM, Tweedie E, Cretu A, Henderson T, Liaw L, Friesel R, Vary C, Brooks PC.

Angiogenesis. 2015 Jan;18(1):31-46. doi: 10.1007/s10456-014-9445-2. Epub 2014 Sep 24.


Cryptic collagen IV promotes cell migration and adhesion in myeloid leukemia.

Favreau AJ, Vary CP, Brooks PC, Sathyanarayana P.

Cancer Med. 2014 Apr;3(2):265-72. doi: 10.1002/cam4.203. Epub 2014 Feb 12.


Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src.

Gong Y, Yang X, He Q, Gower L, Prudovsky I, Vary CP, Brooks PC, Friesel RE.

Angiogenesis. 2013 Oct;16(4):861-75. doi: 10.1007/s10456-013-9361-x. Epub 2013 Aug 17.


Escalation of intake under intermittent ethanol access in diverse mouse genotypes.

Rosenwasser AM, Fixaris MC, Crabbe JC, Brooks PC, Ascheid S.

Addict Biol. 2013 May;18(3):496-507. doi: 10.1111/j.1369-1600.2012.00481.x. Epub 2012 Aug 2.


Insulin-like growth factor binding protein-4 differentially inhibits growth factor-induced angiogenesis.

Contois LW, Nugent DP, Caron JM, Cretu A, Tweedie E, Akalu A, Liebes L, Friesel R, Rosen C, Vary C, Brooks PC.

J Biol Chem. 2012 Jan 13;287(3):1779-89. doi: 10.1074/jbc.M111.267732. Epub 2011 Dec 1.


Endoglin regulates cancer-stromal cell interactions in prostate tumors.

Romero D, O'Neill C, Terzic A, Contois L, Young K, Conley BA, Bergan RC, Brooks PC, Vary CP.

Cancer Res. 2011 May 15;71(10):3482-93. doi: 10.1158/0008-5472.CAN-10-2665. Epub 2011 Mar 28. Erratum in: Cancer Res. 2012 Feb 15;72(4):1037.


AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis.

Singh NK, Quyen DV, Kundumani-Sridharan V, Brooks PC, Rao GN.

J Biol Chem. 2010 May 28;285(22):16830-43. doi: 10.1074/jbc.M110.106187. Epub 2010 Mar 29.


Increased shedding of HU177 correlates with worse prognosis in primary melanoma.

Hamilton HK, Rose AE, Christos PJ, Shapiro RL, Berman RS, Mazumdar M, Ma MW, Krich D, Liebes L, Brooks PC, Osman I.

J Transl Med. 2010 Feb 23;8:19. doi: 10.1186/1479-5876-8-19.


Integrins as "functional hubs" in the regulation of pathological angiogenesis.

Contois L, Akalu A, Brooks PC.

Semin Cancer Biol. 2009 Oct;19(5):318-28. doi: 10.1016/j.semcancer.2009.05.002. Epub 2009 May 29. Review.


Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patients.

Yu JZ, Warycha MA, Christos PJ, Darvishian F, Yee H, Kaminio H, Berman RS, Shapiro RL, Buckley MT, Liebes LF, Pavlick AC, Polsky D, Brooks PC, Osman I.

J Transl Med. 2008 Nov 24;6:70. doi: 10.1186/1479-5876-6-70.


Shedding of distinct cryptic collagen epitope (HU177) in sera of melanoma patients.

Ng B, Zakrzewski J, Warycha M, Christos PJ, Bajorin DF, Shapiro RL, Berman RS, Pavlick AC, Polsky D, Mazumdar M, Montgomery A, Liebes L, Brooks PC, Osman I.

Clin Cancer Res. 2008 Oct 1;14(19):6253-8. doi: 10.1158/1078-0432.CCR-07-4992.


Disruption of endothelial cell interactions with the novel HU177 cryptic collagen epitope inhibits angiogenesis.

Cretu A, Roth JM, Caunt M, Akalu A, Policarpio D, Formenti S, Gagne P, Liebes L, Brooks PC.

Clin Cancer Res. 2007 May 15;13(10):3068-78.


Inhibition of angiogenesis and tumor metastasis by targeting a matrix immobilized cryptic extracellular matrix epitope in laminin.

Akalu A, Roth JM, Caunt M, Policarpio D, Liebes L, Brooks PC.

Cancer Res. 2007 May 1;67(9):4353-63.


Matrix metalloproteinases in peripheral vascular disease.

Hobeika MJ, Thompson RW, Muhs BE, Brooks PC, Gagne PJ.

J Vasc Surg. 2007 Apr;45(4):849-57. Review.


The mycobacterium-specific gene Rv2719c is DNA damage inducible independently of RecA.

Brooks PC, Dawson LF, Rand L, Davis EO.

J Bacteriol. 2006 Aug;188(16):6034-8.


The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion.

Oxelmark E, Roth JM, Brooks PC, Braunstein SE, Schneider RJ, Garabedian MJ.

Mol Cell Biol. 2006 Jul;26(14):5205-13.


The vitamin-like dietary supplement para-aminobenzoic acid enhances the antitumor activity of ionizing radiation.

Xavier S, Macdonald S, Roth J, Caunt M, Akalu A, Morais D, Buckley MT, Liebes L, Formenti SC, Brooks PC.

Int J Radiat Oncol Biol Phys. 2006 Jun 1;65(2):517-27.


Inhibition of experimental metastasis by targeting the HUIV26 cryptic epitope in collagen.

Roth JM, Caunt M, Cretu A, Akalu A, Policarpio D, Li X, Gagne P, Formenti S, Brooks PC.

Am J Pathol. 2006 May;168(5):1576-86.


Growth-regulated oncogene is pivotal in thrombin-induced angiogenesis.

Caunt M, Hu L, Tang T, Brooks PC, Ibrahim S, Karpatkin S.

Cancer Res. 2006 Apr 15;66(8):4125-32.


Targeting integrins for the control of tumour angiogenesis.

Akalu A, Cretu A, Brooks PC.

Expert Opin Investig Drugs. 2005 Dec;14(12):1475-86. Review.


Recombinant alpha2(IV)NC1 domain inhibits tumor cell-extracellular matrix interactions, induces cellular senescence, and inhibits tumor growth in vivo.

Roth JM, Akalu A, Zelmanovich A, Policarpio D, Ng B, MacDonald S, Formenti S, Liebes L, Brooks PC.

Am J Pathol. 2005 Mar;166(3):901-11.


Challenges facing antiangiogenic therapy for cancer: impact of the tumor extracellular environment.

Gagne P, Akalu A, Brooks PC.

Expert Rev Anticancer Ther. 2004 Feb;4(1):129-40. Review.


Generation of a monoclonal antibody to a cryptic site common to both integrin beta1 as well as gelatinase MMP9.

Hassanieh L, Rodriguez D, Xu J, Brooks PC, Broek D.

Hybrid Hybridomics. 2003 Oct;22(5):285-92.


Characterization of the two Mycobacterium tuberculosis recA promoters.

Gopaul KK, Brooks PC, Prost JF, Davis EO.

J Bacteriol. 2003 Oct;185(20):6005-15.


Thrombin induces neoangiogenesis in the chick chorioallantoic membrane.

Caunt M, Huang YQ, Brooks PC, Karpatkin S.

J Thromb Haemost. 2003 Oct;1(10):2097-102.


Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix.

Hotary KB, Allen ED, Brooks PC, Datta NS, Long MW, Weiss SJ.

Cell. 2003 Jul 11;114(1):33-45.


Effect of reproductive hormones on ovarian epithelial tumors: II. Effect on angiogenic activity.

Chen C, Petitclerc E, Zhou H, Brooks PC, Sun T, Yu MC, Zheng W, Dubeau L.

Cancer Biol Ther. 2002 May-Jun;1(3):307-12.


Ionizing radiation modulates the exposure of the HUIV26 cryptic epitope within collagen type IV during angiogenesis.

Brooks PC, Roth JM, Lymberis SC, DeWyngaert K, Broek D, Formenti SC.

Int J Radiat Oncol Biol Phys. 2002 Nov 15;54(4):1194-201.


Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis.

Hangai M, Kitaya N, Xu J, Chan CK, Kim JJ, Werb Z, Ryan SJ, Brooks PC.

Am J Pathol. 2002 Oct;161(4):1429-37.


Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo.

Lobov IB, Brooks PC, Lang RA.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11205-10. Epub 2002 Aug 5.


Slow induction of RecA by DNA damage in Mycobacterium tuberculosis.

Papavinasasundaram KG, Anderson C, Brooks PC, Thomas NA, Movahedzadeh F, Jenner PJ, Colston MJ, Davis EO.

Microbiology. 2001 Dec;147(Pt 12):3271-9.


Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo.

Xu J, Rodriguez D, Petitclerc E, Kim JJ, Hangai M, Moon YS, Davis GE, Brooks PC.

J Cell Biol. 2001 Sep 3;154(5):1069-79. Erratum in: J Cell Biol 2001 Nov 26;155(5):859. Yuen SM [corrected to Moon YS].


Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis.

McMahon GA, Petitclerc E, Stefansson S, Smith E, Wong MK, Westrick RJ, Ginsburg D, Brooks PC, Lawrence DA.

J Biol Chem. 2001 Sep 7;276(36):33964-8. Epub 2001 Jul 5.


The chick embryo metastasis model.

Petitclerc E, Brooks PC.

Methods Mol Med. 2001;58:173-87. doi: 10.1385/1-59259-137-X:173.


Generation of monoclonal antibodies to cryptic collagen sites by using subtractive immunization.

Xu J, Rodriguez D, Kim JJ, Brooks PC.

Hybridoma. 2000 Oct;19(5):375-85.


Inhibition of angiogenesis in vivo by plasminogen activator inhibitor-1.

Stefansson S, Petitclerc E, Wong MK, McMahon GA, Brooks PC, Lawrence DA.

J Biol Chem. 2001 Mar 16;276(11):8135-41. Epub 2000 Nov 16.


The chimeric human/mouse model of angiogenesis.

Petitclerc E, von Schalscha T, Brooks PC.

Methods Mol Biol. 2000;137:213-21. No abstract available.


Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1.

Henriet P, Zhong ZD, Brooks PC, Weinberg KI, DeClerck YA.

Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10026-31.


New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo.

Petitclerc E, Boutaud A, Prestayko A, Xu J, Sado Y, Ninomiya Y, Sarras MP Jr, Hudson BG, Brooks PC.

J Biol Chem. 2000 Mar 17;275(11):8051-61.


Contortrostatin, a homodimeric disintegrin, binds to integrin alphavbeta5.

Zhou Q, Nakada MT, Brooks PC, Swenson SD, Ritter MR, Argounova S, Arnold C, Markland FS.

Biochem Biophys Res Commun. 2000 Jan 7;267(1):350-5.


Use of the 10-day-old chick embryo model for studying angiogenesis.

Brooks PC, Montgomery AM, Cheresh DA.

Methods Mol Biol. 1999;129:257-69. No abstract available.


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