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Human beta defensin 3 alters matrix metalloproteinase production in human dendritic cells exposed to Porphyromonas gingivalis hemagglutinin B.

Raina M, Bates AM, Fischer CL, Progulske-Fox A, Abbasi T, Vali S, Brogden KA.

J Periodontol. 2018 Mar;89(3):361-369. doi: 10.1002/JPER.17-0366.


Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy.

Brogden KA, Parashar D, Hallier AR, Braun T, Qian F, Rizvi NA, Bossler AD, Milhem MM, Chan TA, Abbasi T, Vali S.

BMC Cancer. 2018 Feb 27;18(1):225. doi: 10.1186/s12885-018-4134-y.


Cell genomics and immunosuppressive biomarker expression influence PD-L1 immunotherapy treatment responses in HNSCC-a computational study.

Bates AM, Lanzel EA, Qian F, Abbasi T, Vali S, Brogden KA.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Aug;124(2):157-164. doi: 10.1016/j.oooo.2017.05.474. Epub 2017 May 25.


Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice.

Li K, Wohlford-Lenane CL, Channappanavar R, Park JE, Earnest JT, Bair TB, Bates AM, Brogden KA, Flaherty HA, Gallagher T, Meyerholz DK, Perlman S, McCray PB Jr.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3119-E3128. doi: 10.1073/pnas.1619109114. Epub 2017 Mar 27.


PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression.

Brogden KA, Vali S, Abbasi T.

Transl Cancer Res. 2016 Dec;5(Suppl 7):S1396-S1399. doi: 10.21037/tcr.2016.12.43. No abstract available.


Diminished Antimicrobial Peptide and Antifungal Antibiotic Activities against Candida albicans in Denture Adhesive.

Bates AM, Garaicoa JL, Fischer CL, Brogden KA.

Antibiotics (Basel). 2017 Feb 6;6(1). pii: E6. doi: 10.3390/antibiotics6010006.


Promise of Combining Antifungal Agents in Denture Adhesives to Fight Candida Species Infections.

Garaicoa JL, Fischer CL, Bates AM, Holloway J, Avila-Ortiz G, Guthmiller JM, Johnson GK, Stanford C, Brogden KA.

J Prosthodont. 2016 Nov 21. doi: 10.1111/jopr.12565. [Epub ahead of print]


Expression of Membrane-Bound Mucins and p63 in Distinguishing Mucoepidermoid Carcinoma from Papillary Cystadenoma.

Lanzel EA, Pourian A, Sousa Melo SL, Brogden KA, Hellstein JW.

Head Neck Pathol. 2016 Dec;10(4):521-526. Epub 2016 Jun 9.


Predicting PD-L1 expression on human cancer cells using next-generation sequencing information in computational simulation models.

Lanzel EA, Paula Gomez Hernandez M, Bates AM, Treinen CN, Starman EE, Fischer CL, Parashar D, Guthmiller JM, Johnson GK, Abbasi T, Vali S, Brogden KA.

Cancer Immunol Immunother. 2016 Dec;65(12):1511-1522. Epub 2016 Sep 29.


Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells.

Mehalick LA, Poulsen C, Fischer CL, Lanzel EA, Bates AM, Walters KS, Cavanaugh JE, Guthmiller JM, Johnson GK, Wertz PW, Brogden KA.

Data Brief. 2015 Sep 7;5:285-91. doi: 10.1016/j.dib.2015.08.025. eCollection 2015 Dec.


Protein Analysis of Sapienic Acid-Treated Porphyromonas gingivalis Suggests Differential Regulation of Multiple Metabolic Pathways.

Fischer CL, Dawson DV, Blanchette DR, Drake DR, Wertz PW, Brogden KA.

J Bacteriol. 2015 Oct 19;198(1):157-67. doi: 10.1128/JB.00665-15. Print 2016 Jan 1.


Cytotoxicity of HBD3 for dendritic cells, normal human epidermal keratinocytes, hTERT keratinocytes, and primary oral gingival epithelial keratinocytes in cell culture conditions.

Leelakanok N, Fischer CL, Bates AM, Guthmiller JM, Johnson GK, Salem AK, Brogden KA, Brogden NK.

Toxicol Lett. 2015 Dec 3;239(2):90-6. doi: 10.1016/j.toxlet.2015.09.006. Epub 2015 Sep 11.


Novel biomarkers of periodontitis and/or obesity in saliva-An exploratory analysis.

Recker EN, Brogden KA, Avila-Ortiz G, Fischer CL, Pagan-Rivera K, Dawson DV, Smith KM, Elangovan S.

Arch Oral Biol. 2015 Oct;60(10):1503-9. doi: 10.1016/j.archoralbio.2015.07.006. Epub 2015 Jul 14.


Age-dependent variation in cytokines, chemokines, and biologic analytes rinsed from the surface of healthy human skin.

Kinn PM, Holdren GO, Westermeyer BA, Abuissa M, Fischer CL, Fairley JA, Brogden KA, Brogden NK.

Sci Rep. 2015 Jun 2;5:10472. doi: 10.1038/srep10472.


Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells.

Poulsen C, Mehalick LA, Fischer CL, Lanzel EA, Bates AM, Walters KS, Cavanaugh JE, Guthmiller JM, Johnson GK, Wertz PW, Brogden KA.

Toxicol Lett. 2015 Aug 19;237(1):21-9. doi: 10.1016/j.toxlet.2015.05.012. Epub 2015 May 21.


Antimicrobial Activity of Chemokine CXCL10 for Dermal and Oral Microorganisms.

Holdren GO, Rosenthal DJ, Yang J, Bates AM, Fischer CL, Zhang Y, Brogden NK, Brogden KA.

Antibiotics (Basel). 2014 Oct 23;3(4):527-39. doi: 10.3390/antibiotics3040527.


Body fat indices and biomarkers of inflammation: a cross-sectional study with implications for obesity and peri-implant oral health.

Elangovan S, Brogden KA, Dawson DV, Blanchette D, Pagan-Rivera K, Stanford CM, Johnson GK, Recker E, Bowers R, Haynes WG, Avila-Ortiz G.

Int J Oral Maxillofac Implants. 2014 Nov-Dec;29(6):1429-34. doi: 10.11607/jomi.3758.


A cross-sectional assessment of biomarker levels around implants versus natural teeth in periodontal maintenance patients.

Recker EN, Avila-Ortiz G, Fischer CL, Pagan-Rivera K, Brogden KA, Dawson DV, Elangovan S.

J Periodontol. 2015 Feb;86(2):264-72. doi: 10.1902/jop.2014.140354. Epub 2014 Sep 30.


Human β-defensin HBD3 binds to immobilized Bla g2 from the German cockroach (Blattella germanica).

Dietrich DE, Martin AD, Brogden KA.

Peptides. 2014 Mar;53:265-9. doi: 10.1016/j.peptides.2014.01.017. Epub 2014 Feb 2.


Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses.

Borgwardt DS, Martin AD, Van Hemert JR, Yang J, Fischer CL, Recker EN, Nair PR, Vidva R, Chandrashekaraiah S, Progulske-Fox A, Drake D, Cavanaugh JE, Vali S, Zhang Y, Brogden KA.

Sci Rep. 2014 Jan 29;4:3904. doi: 10.1038/srep03904.


Comparison of pro-inflammatory cytokines and bone metabolism mediators around titanium and zirconia dental implant abutments following a minimum of 6 months of clinical function.

Barwacz CA, Brogden KA, Stanford CM, Dawson DV, Recker EN, Blanchette D.

Clin Oral Implants Res. 2015 Apr;26(4):e35-41. doi: 10.1111/clr.12326. Epub 2014 Jan 13.


Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.

Cassel SL, Janczy JR, Bing X, Wilson SP, Olivier AK, Otero JE, Iwakura Y, Shayakhmetov DM, Bassuk AG, Abu-Amer Y, Brogden KA, Burns TL, Sutterwala FS, Ferguson PJ.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1072-7. doi: 10.1073/pnas.1318685111. Epub 2014 Jan 6.


Oral inflammation, a role for antimicrobial peptide modulation of cytokine and chemokine responses.

Brogden KA, Johnson GK, Vincent SD, Abbasi T, Vali S.

Expert Rev Anti Infect Ther. 2013 Oct;11(10):1097-113. doi: 10.1586/14787210.2013.836059. Review.


The roles of cutaneous lipids in host defense.

Fischer CL, Blanchette DR, Brogden KA, Dawson DV, Drake DR, Hill JR, Wertz PW.

Biochim Biophys Acta. 2014 Mar;1841(3):319-22. doi: 10.1016/j.bbalip.2013.08.012. Epub 2013 Aug 29. Review.


Oral mucosal lipids are antibacterial against Porphyromonas gingivalis, induce ultrastructural damage, and alter bacterial lipid and protein compositions.

Fischer CL, Walters KS, Drake DR, Dawson DV, Blanchette DR, Brogden KA, Wertz PW.

Int J Oral Sci. 2013 Sep;5(3):130-40. doi: 10.1038/ijos.2013.28. Epub 2013 Jul 19.


Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus.

Harvey LE, Kohlgraf KG, Mehalick LA, Raina M, Recker EN, Radhakrishnan S, Prasad SA, Vidva R, Progulske-Fox A, Cavanaugh JE, Vali S, Brogden KA.

Sci Rep. 2013;3:1232. doi: 10.1038/srep01232. Epub 2013 Feb 6.


Organization, barrier function and antimicrobial lipids of the oral mucosa.

Dawson DV, Drake DR, Hill JR, Brogden KA, Fischer CL, Wertz PW.

Int J Cosmet Sci. 2013 Jun;35(3):220-3. doi: 10.1111/ics.12038. Epub 2013 Feb 9. Review.


Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage.

Fischer CL, Walters KS, Drake DR, Blanchette DR, Dawson DV, Brogden KA, Wertz PW.

Skin Pharmacol Physiol. 2013;26(1):36-44. doi: 10.1159/000343175. Epub 2012 Oct 30.


Human β-defensin-3 alters, but does not inhibit, the binding of Porphyromonas gingivalis haemagglutinin B to the surface of human dendritic cells.

Van Hemert JR, Recker EN, Dietrich D, Progulske-Fox A, Kurago ZB, Walters KS, Cavanaugh JE, Brogden KA.

Int J Antimicrob Agents. 2012 Jul;40(1):75-9. doi: 10.1016/j.ijantimicag.2012.03.007. Epub 2012 May 9.


The emerging role of peptides and lipids as antimicrobial epidermal barriers and modulators of local inflammation.

Brogden NK, Mehalick L, Fischer CL, Wertz PW, Brogden KA.

Skin Pharmacol Physiol. 2012;25(4):167-81. doi: 10.1159/000337927. Epub 2012 Apr 26. Review.


Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria.

Fischer CL, Drake DR, Dawson DV, Blanchette DR, Brogden KA, Wertz PW.

Antimicrob Agents Chemother. 2012 Mar;56(3):1157-61. doi: 10.1128/AAC.05151-11. Epub 2011 Dec 12.


Inflammatory mediators in fluid extracted from the coronal occlusal dentine of trimmed teeth.

Geraldeli S, Li Y, Hogan MM, Tjaderhane LS, Pashley DH, Morgan TA, Zimmerman MB, Brogden KA.

Arch Oral Biol. 2012 Mar;57(3):264-70. doi: 10.1016/j.archoralbio.2011.08.012. Epub 2011 Sep 18.


Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay.

Kohlgraf KG, Ackermann AR, Burnell KK, Srikantha RN, Joly SA, Bartlett JA, Gakhar L, Johnson GK, McCray PB Jr, Guthmiller JM, Brogden KA.

Arch Oral Biol. 2012 Feb;57(2):197-204. doi: 10.1016/j.archoralbio.2011.08.013. Epub 2011 Sep 16.


Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?

Brogden NK, Brogden KA.

Int J Antimicrob Agents. 2011 Sep;38(3):217-25. doi: 10.1016/j.ijantimicag.2011.05.004. Epub 2011 Jul 5. Review.


Streptococcus mutans strains recovered from caries-active or caries-free individuals differ in sensitivity to host antimicrobial peptides.

Phattarataratip E, Olson B, Broffitt B, Qian F, Brogden KA, Drake DR, Levy SM, Banas JA.

Mol Oral Microbiol. 2011 Jun;26(3):187-99. doi: 10.1111/j.2041-1014.2011.00607.x. Epub 2011 Jan 31.


Presence of wax esters and squalene in human saliva.

Brasser AJ, Barwacz CA, Dawson DV, Brogden KA, Drake DR, Wertz PW.

Arch Oral Biol. 2011 Jun;56(6):588-91. doi: 10.1016/j.archoralbio.2010.12.002. Epub 2011 Jan 17.


Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis.

Tymkiw KD, Thunell DH, Johnson GK, Joly S, Burnell KK, Cavanaugh JE, Brogden KA, Guthmiller JM.

J Clin Periodontol. 2011 Mar;38(3):219-28. doi: 10.1111/j.1600-051X.2010.01684.x. Epub 2010 Dec 29.


Communication: Antimicrobial Activity of SMAP28 with a Targeting Domain for Porphyromonas gingivalis.

Bratt CL, Kohlgraf KG, Yohnke K, Kummet C, Dawson DV, Brogden KA.

Probiotics Antimicrob Proteins. 2010 Mar 1;2(1):21-5. doi: 10.1007/s12602-009-9028-5.


Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.

Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA 4th, Chang EH, Taft PJ, Ludwig PS, Estin M, Hornick EE, Launspach JL, Samuel M, Rokhlina T, Karp PH, Ostedgaard LS, Uc A, Starner TD, Horswill AR, Brogden KA, Prather RS, Richter SS, Shilyansky J, McCray PB Jr, Zabner J, Welsh MJ.

Sci Transl Med. 2010 Apr 28;2(29):29ra31. doi: 10.1126/scitranslmed.3000928.


Defensins attenuate cytokine responses yet enhance antibody responses to Porphyromonas gingivalis adhesins in mice.

Kohlgraf KG, Ackermann A, Lu X, Burnell K, Bélanger M, Cavanaugh JE, Xie H, Progulske-Fox A, Brogden KA.

Future Microbiol. 2010 Jan;5(1):115-25. doi: 10.2217/fmb.09.107.


Defensins as anti-inflammatory compounds and mucosal adjuvants.

Kohlgraf KG, Pingel LC, Dietrich DE, Brogden KA.

Future Microbiol. 2010 Jan;5(1):99-113. doi: 10.2217/fmb.09.104. Review.


A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy.

Thunell DH, Tymkiw KD, Johnson GK, Joly S, Burnell KK, Cavanaugh JE, Brogden KA, Guthmiller JM.

J Periodontal Res. 2010 Feb;45(1):148-52. doi: 10.1111/j.1600-0765.2009.01204.x. Epub 2009 Jul 8.


Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis strain 381.

Carlisle MD, Srikantha RN, Brogden KA.

J Innate Immun. 2009;1(2):118-22. doi: 10.1159/000181015. Epub 2008 Dec 2.


Human alpha- and beta-defensins bind to immobilized adhesins from Porphyromonas gingivalis.

Dietrich DE, Xiao X, Dawson DV, Bélanger M, Xie H, Progulske-Fox A, Brogden KA.

Infect Immun. 2008 Dec;76(12):5714-20. doi: 10.1128/IAI.00997-08. Epub 2008 Oct 13.


Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.

Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB Jr, Zabner J, Prather RS, Welsh MJ.

Science. 2008 Sep 26;321(5897):1837-41. doi: 10.1126/science.1163600.


Targeted antimicrobial activity of a specific IgG-SMAP28 conjugate against Porphyromonas gingivalis in a mixed culture.

Franzman MR, Burnell KK, Dehkordi-Vakil FH, Guthmiller JM, Dawson DV, Brogden KA.

Int J Antimicrob Agents. 2009 Jan;33(1):14-20. doi: 10.1016/j.ijantimicag.2008.05.021. Epub 2008 Sep 7.


Lentivirus vector can be readministered to nasal epithelia without blocking immune responses.

Sinn PL, Arias AC, Brogden KA, McCray PB Jr.

J Virol. 2008 Nov;82(21):10684-92. doi: 10.1128/JVI.00227-08. Epub 2008 Sep 3.


Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response.

Pingel LC, Kohlgraf KG, Hansen CJ, Eastman CG, Dietrich DE, Burnell KK, Srikantha RN, Xiao X, Bélanger M, Progulske-Fox A, Cavanaugh JE, Guthmiller JM, Johnson GK, Joly S, Kurago ZB, Dawson DV, Brogden KA.

Immunol Cell Biol. 2008 Nov-Dec;86(8):643-9. doi: 10.1038/icb.2008.56. Epub 2008 Aug 19.


The porcine lung as a potential model for cystic fibrosis.

Rogers CS, Abraham WM, Brogden KA, Engelhardt JF, Fisher JT, McCray PB Jr, McLennan G, Meyerholz DK, Namati E, Ostedgaard LS, Prather RS, Sabater JR, Stoltz DA, Zabner J, Welsh MJ.

Am J Physiol Lung Cell Mol Physiol. 2008 Aug;295(2):L240-63. doi: 10.1152/ajplung.90203.2008. Epub 2008 May 16. Review.


Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia.

Shah AS, Farmen SL, Moninger TO, Businga TR, Andrews MP, Bugge K, Searby CC, Nishimura D, Brogden KA, Kline JN, Sheffield VC, Welsh MJ.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3380-5. doi: 10.1073/pnas.0712327105. Epub 2008 Feb 25.

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