Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 97

1.

Collagen IV-conveyed signals can regulate chemokine production and promote liver metastasis.

Vaniotis G, Rayes RF, Qi S, Milette S, Wang N, Perrino S, Bourdeau F, Nyström H, He Y, Lamarche-Vane N, Brodt P.

Oncogene. 2018 Apr 13. doi: 10.1038/s41388-018-0242-z. [Epub ahead of print]

PMID:
29651051
2.

Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency.

Rayes RF, Milette S, Fernandez MC, Ham B, Wang N, Bourdeau F, Perrino S, Yakar S, Brodt P.

Oncotarget. 2018 Feb 28;9(21):15691-15704. doi: 10.18632/oncotarget.24593. eCollection 2018 Mar 20.

3.

International consensus guidelines for scoring the histopathological growth patterns of liver metastasis.

van Dam PJ, van der Stok EP, Teuwen LA, Van den Eynden GG, Illemann M, Frentzas S, Majeed AW, Eefsen RL, Coebergh van den Braak RRJ, Lazaris A, Fernandez MC, Galjart B, Laerum OD, Rayes R, Grünhagen DJ, Van de Paer M, Sucaet Y, Mudhar HS, Schvimer M, Nyström H, Kockx M, Bird NC, Vidal-Vanaclocha F, Metrakos P, Simoneau E, Verhoef C, Dirix LY, Van Laere S, Gao ZH, Brodt P, Reynolds AR, Vermeulen PB.

Br J Cancer. 2017 Nov 7;117(10):1427-1441. doi: 10.1038/bjc.2017.334. Epub 2017 Oct 5.

PMID:
28982110
4.

The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells.

Fernandez MC, Rayes R, Ham B, Wang N, Bourdeau F, Milette S, Lllemann M, Bird N, Majeed A, Xu J, Kisselova T, Brodt P.

Oncotarget. 2016 Oct 12;8(32):52281-52293. doi: 10.18632/oncotarget.12595. eCollection 2017 Aug 8.

5.

Molecular Pathways: Targeting the Microenvironment of Liver Metastases.

Milette S, Sicklick JK, Lowy AM, Brodt P.

Clin Cancer Res. 2017 Nov 1;23(21):6390-6399. doi: 10.1158/1078-0432.CCR-15-1636. Epub 2017 Jun 14.

PMID:
28615370
6.

The diverse roles of the TNF axis in cancer progression and metastasis.

Ham B, Fernandez MC, D'Costa Z, Brodt P.

Trends Cancer Res. 2016 Jan 1;11(1):1-27.

7.

Role of the Microenvironment in Liver Metastasis: From Pre- to Prometastatic Niches.

Brodt P.

Clin Cancer Res. 2016 Dec 15;22(24):5971-5982. Epub 2016 Oct 19. Review.

8.

TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases.

Ham B, Wang N, D'Costa Z, Fernandez MC, Bourdeau F, Auguste P, Illemann M, Eefsen RL, Høyer-Hansen G, Vainer B, Evrard M, Gao ZH, Brodt P.

Cancer Res. 2015 Dec 15;75(24):5235-47. doi: 10.1158/0008-5472.CAN-14-3173. Epub 2015 Oct 19.

9.

Crosstalk between the TNF and IGF pathways enhances NF-κB activation and signaling in cancer cells.

Li S, Pinard M, Wang Y, Yang L, Lin R, Hiscott J, Su B, Brodt P.

Growth Horm IGF Res. 2015 Oct;25(5):253-61. doi: 10.1016/j.ghir.2015.07.008. Epub 2015 Jul 20.

PMID:
26239406
10.

The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis.

Wang N, Rayes RF, Elahi SM, Lu Y, Hancock MA, Massie B, Rowe GE, Aomari H, Hossain S, Durocher Y, Pinard M, Tabariès S, Siegel PM, Brodt P.

Mol Cancer Ther. 2015 Apr;14(4):982-93. doi: 10.1158/1535-7163.MCT-14-0751. Epub 2015 Feb 11.

11.

Tumor stromal phenotypes define VEGF sensitivity--letter.

Van den Eynden GG, Bird NC, Dirix LY, Eefsen RL, Gao ZH, Høyer-Hansen G, Illemann M, Majeed AW, Metrakos P, Reynolds AR, Vainer B, van Dam PJ, Van Laere SJ, Vermeulen PB, Vidal-Vanaclocha F, Brodt P; Liver Metastasis Research Network.

Clin Cancer Res. 2014 Oct 1;20(19):5140. doi: 10.1158/1078-0432.CCR-14-0158. No abstract available.

12.

The inhibitor of kappa B kinase-epsilon regulates MMP-3 expression levels and can promote lung metastasis.

Seccareccia E, Pinard M, Wang N, Li S, Burnier J, Dankort D, Brodt P.

Oncogenesis. 2014 Aug 18;3:e116. doi: 10.1038/oncsis.2014.28.

13.

The multifaceted role of the microenvironment in liver metastasis: biology and clinical implications.

Van den Eynden GG, Majeed AW, Illemann M, Vermeulen PB, Bird NC, Høyer-Hansen G, Eefsen RL, Reynolds AR, Brodt P.

Cancer Res. 2013 Apr 1;73(7):2031-43. doi: 10.1158/0008-5472.CAN-12-3931. Epub 2013 Mar 27. Review.

14.

Sustained production of a soluble IGF-I receptor by gutless adenovirus-transduced host cells protects from tumor growth in the liver.

Wang N, Lu Y, Pinard M, Pilotte A, Gilbert R, Massie B, Brodt P.

Cancer Gene Ther. 2013 Apr;20(4):229-36. doi: 10.1038/cgt.2013.10. Epub 2013 Mar 8.

PMID:
23470563
15.
16.

The role of the insulin-like growth factor-I receptor in malignancy: an update.

Seccareccia E, Brodt P.

Growth Horm IGF Res. 2012 Dec;22(6):193-9. doi: 10.1016/j.ghir.2012.09.003. Epub 2012 Oct 23. Review.

PMID:
23098677
17.

Histopathological growth pattern, proteolysis and angiogenesis in chemonaive patients resected for multiple colorectal liver metastases.

Eefsen RL, Van den Eynden GG, Høyer-Hansen G, Brodt P, Laerum OD, Vermeulen PB, Christensen IJ, Wettergren A, Federspiel B, Willemoe GL, Vainer B, Osterlind K, Illemann M.

J Oncol. 2012;2012:907971. doi: 10.1155/2012/907971. Epub 2012 Aug 2.

18.

Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer.

Arabzadeh A, Chan C, Nouvion AL, Breton V, Benlolo S, DeMarte L, Turbide C, Brodt P, Ferri L, Beauchemin N.

Oncogene. 2013 Feb 14;32(7):849-60. doi: 10.1038/onc.2012.112. Epub 2012 Apr 2.

PMID:
22469976
19.

Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling.

Li S, Wang N, Brodt P.

Cancer Res. 2012 Feb 15;72(4):865-75. doi: 10.1158/0008-5472.CAN-11-1357. Epub 2011 Dec 22.

20.

Breast cancer cell-derived cytokines, macrophages and cell adhesion: implications for metastasis.

Eichbaum C, Meyer AS, Wang N, Bischofs E, Steinborn A, Bruckner T, Brodt P, Sohn C, Eichbaum MH.

Anticancer Res. 2011 Oct;31(10):3219-27.

PMID:
21965729
21.

Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis.

Burnier JV, Wang N, Michel RP, Hassanain M, Li S, Lu Y, Metrakos P, Antecka E, Burnier MN, Ponton A, Gallinger S, Brodt P.

Oncogene. 2011 Sep 1;30(35):3766-83. doi: 10.1038/onc.2011.89. Epub 2011 Apr 11.

PMID:
21478904
22.

Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis.

Wu Y, Brodt P, Sun H, Mejia W, Novosyadlyy R, Nunez N, Chen X, Mendoza A, Hong SH, Khanna C, Yakar S.

Cancer Res. 2010 Jan 1;70(1):57-67. doi: 10.1158/0008-5472.CAN-09-2472.

23.

The IGF-I receptor can alter the matrix metalloproteinase repertoire of tumor cells through transcriptional regulation of PKC-{alpha}.

Li S, Zhang D, Yang L, Burnier JV, Wang N, Lin R, Lee ER, Glazer RI, Brodt P.

Mol Endocrinol. 2009 Dec;23(12):2013-25. doi: 10.1210/me.2009-0197. Epub 2009 Oct 23.

24.

CD44v6 dependence of premetastatic niche preparation by exosomes.

Jung T, Castellana D, Klingbeil P, Cuesta Hernández I, Vitacolonna M, Orlicky DJ, Roffler SR, Brodt P, Zöller M.

Neoplasia. 2009 Oct;11(10):1093-105.

25.

Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms.

McDonald B, Spicer J, Giannais B, Fallavollita L, Brodt P, Ferri LE.

Int J Cancer. 2009 Sep 15;125(6):1298-305. doi: 10.1002/ijc.24409.

26.

Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases.

Wang N, Fallavollita L, Nguyen L, Burnier J, Rafei M, Galipeau J, Yakar S, Brodt P.

Mol Ther. 2009 Jul;17(7):1241-9. doi: 10.1038/mt.2009.82. Epub 2009 Apr 14.

27.

Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.

Navab R, Pedraza C, Fallavollita L, Wang N, Chevet E, Auguste P, Jenna S, You Z, Bikfalvi A, Hu J, O'Connor R, Erickson A, Mort JS, Brodt P.

Oncogene. 2008 Aug 28;27(37):4973-85. doi: 10.1038/onc.2008.144. Epub 2008 May 12.

PMID:
18469859
28.

The host inflammatory response promotes liver metastasis by increasing tumor cell arrest and extravasation.

Auguste P, Fallavollita L, Wang N, Burnier J, Bikfalvi A, Brodt P.

Am J Pathol. 2007 May;170(5):1781-92.

29.

Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones.

Yakar S, Nunez NP, Pennisi P, Brodt P, Sun H, Fallavollita L, Zhao H, Scavo L, Novosyadlyy R, Kurshan N, Stannard B, East-Palmer J, Smith NC, Perkins SN, Fuchs-Young R, Barrett JC, Hursting SD, LeRoith D.

Endocrinology. 2006 Dec;147(12):5826-34. Epub 2006 Sep 7.

PMID:
16959846
30.

The role of the IGF system in cancer growth and metastasis: overview and recent insights.

Samani AA, Yakar S, LeRoith D, Brodt P.

Endocr Rev. 2007 Feb;28(1):20-47. Epub 2006 Aug 24. Review.

PMID:
16931767
33.

Characterization of the host proinflammatory response to tumor cells during the initial stages of liver metastasis.

Khatib AM, Auguste P, Fallavollita L, Wang N, Samani A, Kontogiannea M, Meterissian S, Brodt P.

Am J Pathol. 2005 Sep;167(3):749-59.

34.

PADMA-28, a traditional Tibetan herbal preparation, blocks cellular responses to bFGF and IGF-I.

Navab R, Aingorn H, Fallavollita L, Sallon S, Mechoulam R, Ginsburg I, Vlodavsky I, Brodt P.

Inflammopharmacology. 2004;12(4):373-89.

PMID:
15901415
35.

The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models.

Yakar S, Leroith D, Brodt P.

Cytokine Growth Factor Rev. 2005 Aug-Oct;16(4-5):407-20. Review.

PMID:
15886048
36.

Expression of chicken ovalbumin upstream promoter-transcription factor II enhances invasiveness of human lung carcinoma cells.

Navab R, Gonzalez-Santos JM, Johnston MR, Liu J, Brodt P, Tsao MS, Hu J.

Cancer Res. 2004 Aug 1;64(15):5097-105.

37.
38.
39.

The role of the IGF-I receptor in the regulation of matrix metalloproteinases, tumor invasion and metastasis.

Zhang D, Samani AA, Brodt P.

Horm Metab Res. 2003 Nov-Dec;35(11-12):802-8. Review.

PMID:
14710361
40.

Inhibition of MMP-1 expression by antisense RNA decreases invasiveness of human chondrosarcoma.

Jiang X, Dutton CM, Qi Wn, Block JA, Brodt P, Durko M, Scully SP.

J Orthop Res. 2003 Nov;21(6):1063-70.

41.
42.
43.

Inhibition of hepatic endothelial E-selectin expression by C-raf antisense oligonucleotides blocks colorectal carcinoma liver metastasis.

Khatib AM, Fallavollita L, Wancewicz EV, Monia BP, Brodt P.

Cancer Res. 2002 Oct 1;62(19):5393-8.

44.
45.
46.

Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit.

Brodt P, Fallavollita L, Khatib AM, Samani AA, Zhang D.

J Biol Chem. 2001 Sep 7;276(36):33608-15. Epub 2001 Jul 9.

47.
48.

Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions.

Navab R, Chevet E, Authier F, Di Guglielmo GM, Bergeron JJ, Brodt P.

J Biol Chem. 2001 Apr 27;276(17):13644-9. Epub 2001 Jan 26.

49.

Regulation of urokinase plasminogen activator/plasmin-mediated invasion of melanoma cells by the integrin vitronectin receptor alphaVbeta3.

Khatib AM, Nip J, Fallavollita L, Lehmann M, Jensen G, Brodt P.

Int J Cancer. 2001 Feb 1;91(3):300-8.

50.

Supplemental Content

Support Center