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The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK).

Mackie TD, Kim BY, Subramanya AR, Bain DJ, O'Donnell AF, Welling PA, Brodsky JL.

J Biol Chem. 2018 Mar 2;293(9):3201-3217. doi: 10.1074/jbc.M117.819086. Epub 2018 Jan 8.


Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100.

Amengual J, Guo L, Strong A, Madrigal-Matute J, Wang H, Kaushik S, Brodsky JL, Rader DJ, Cuervo AM, Fisher EA.

Circ Res. 2018 Feb 16;122(4):568-582. doi: 10.1161/CIRCRESAHA.117.311240. Epub 2018 Jan 4.


N-linked glycans are required on epithelial Na+ channel subunits for maturation and surface expression.

Kashlan OB, Kinlough CL, Myerburg MM, Shi S, Chen J, Blobner BM, Buck TM, Brodsky JL, Hughey RP, Kleyman TR.

Am J Physiol Renal Physiol. 2018 Mar 1;314(3):F483-F492. doi: 10.1152/ajprenal.00195.2017. Epub 2017 Nov 29.


Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.

Nakasone MA, Lewis TA, Walker O, Thakur A, Mansour W, Castañeda CA, Goeckeler-Fried JL, Parlati F, Chou TF, Hayat O, Zhang D, Camara CM, Bonn SM, Nowicka UK, Krueger S, Glickman MH, Brodsky JL, Deshaies RJ, Fushman D.

Structure. 2017 Dec 5;25(12):1839-1855.e11. doi: 10.1016/j.str.2017.10.007. Epub 2017 Nov 16.


Targeting protein quality control pathways in breast cancer.

Sannino S, Brodsky JL.

BMC Biol. 2017 Nov 16;15(1):109. doi: 10.1186/s12915-017-0449-4. Review.


Guardians of the ERAD Galaxy.

Sun Z, Brodsky JL.

Cell. 2017 Oct 5;171(2):267-268. doi: 10.1016/j.cell.2017.09.023.


N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione.

Gleixner AM, Hutchison DF, Sannino S, Bhatia TN, Leak LC, Flaherty PT, Wipf P, Brodsky JL, Leak RK.

Mol Pharmacol. 2017 Nov;92(5):564-575. doi: 10.1124/mol.117.109926. Epub 2017 Aug 22.


Regulation of the epithelial Na+ channel by paraoxonase-2.

Shi S, Buck TM, Kinlough CL, Marciszyn AL, Hughey RP, Chalfie M, Brodsky JL, Kleyman TR.

J Biol Chem. 2017 Sep 22;292(38):15927-15938. doi: 10.1074/jbc.M117.785253. Epub 2017 Aug 2.


Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE.

Zacchi LF, Dittmar JC, Mihalevic MJ, Shewan AM, Schulz BL, Brodsky JL, Bernstein KA.

Dis Model Mech. 2017 Sep 1;10(9):1129-1140. doi: 10.1242/dmm.029926. Epub 2017 Aug 2.


Linking chanelopathies with endoplasmic reticulum associated degradation.

O'Donnell BM, Mackie TD, Brodsky JL.

Channels (Austin). 2017 Nov 2;11(6):499-501. doi: 10.1080/19336950.2017.1357944. Epub 2017 Aug 18. No abstract available.


Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome.

O'Donnell BM, Mackie TD, Subramanya AR, Brodsky JL.

J Biol Chem. 2017 Aug 4;292(31):12813-12827. doi: 10.1074/jbc.M117.786376. Epub 2017 Jun 19.


Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates.

Guerriero CJ, Reutter KR, Augustine AA, Preston GM, Weiberth KF, Mackie TD, Cleveland-Rubeor HC, Bethel NP, Callenberg KM, Nakatsukasa K, Grabe M, Brodsky JL.

Mol Biol Cell. 2017 Jul 15;28(15):2076-2090. doi: 10.1091/mbc.E17-03-0184. Epub 2017 May 24.


Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase.

Ye Z, Needham PG, Estabrooks SK, Whitaker SK, Garcia BL, Misra S, Brodsky JL, Camacho CJ.

Sci Rep. 2017 May 11;7(1):1789. doi: 10.1038/s41598-017-01880-4.


The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation.

Preston GM, Brodsky JL.

Biochem J. 2017 Feb 15;474(4):445-469. doi: 10.1042/BCJ20160582. Review.


UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase.

Braganza A, Li J, Zeng X, Yates NA, Dey NB, Andrews J, Clark J, Zamani L, Wang XH, St Croix C, O'Sullivan R, Garcia-Exposito L, Brodsky JL, Sobol RW.

J Biol Chem. 2017 Feb 10;292(6):2470-2484. doi: 10.1074/jbc.M116.766824. Epub 2016 Dec 21.


Interactions between intersubunit transmembrane domains regulate the chaperone-dependent degradation of an oligomeric membrane protein.

Buck TM, Jordahl AS, Yates ME, Preston GM, Cook E, Kleyman TR, Brodsky JL.

Biochem J. 2017 Feb 1;474(3):357-376. doi: 10.1042/BCJ20160760. Epub 2016 Nov 30.


Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.

Chung WJ, Goeckeler-Fried JL, Havasi V, Chiang A, Rowe SM, Plyler ZE, Hong JS, Mazur M, Piazza GA, Keeton AB, White EL, Rasmussen L, Weissman AM, Denny RA, Brodsky JL, Sorscher EJ.

PLoS One. 2016 Oct 12;11(10):e0163615. doi: 10.1371/journal.pone.0163615. eCollection 2016.


Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members.

Manos-Turvey A, Al-Ashtal HA, Needham PG, Hartline CB, Prichard MN, Wipf P, Brodsky JL.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):5087-5091. doi: 10.1016/j.bmcl.2016.08.080. Epub 2016 Aug 25.


Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications.

McClure ML, Barnes S, Brodsky JL, Sorscher EJ.

Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L719-L733. doi: 10.1152/ajplung.00431.2015. Epub 2016 Jul 29. Review.


Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.

Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9015-20. doi: 10.1073/pnas.1603883113. Epub 2016 Jul 22.


From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

Veit G, Avramescu RG, Chiang AN, Houck SA, Cai Z, Peters KW, Hong JS, Pollard HB, Guggino WB, Balch WE, Skach WR, Cutting GR, Frizzell RA, Sheppard DN, Cyr DM, Sorscher EJ, Brodsky JL, Lukacs GL.

Mol Biol Cell. 2016 Feb 1;27(3):424-33. doi: 10.1091/mbc.E14-04-0935.


Low bone mineral density is a common finding in patients with homocystinuria.

Weber DR, Coughlin C, Brodsky JL, Lindstrom K, Ficicioglu C, Kaplan P, Freehauf CL, Levine MA.

Mol Genet Metab. 2016 Mar;117(3):351-4. doi: 10.1016/j.ymgme.2015.12.003. Epub 2015 Dec 10.


α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis.

Prosser DC, Pannunzio AE, Brodsky JL, Thorner J, Wendland B, O'Donnell AF.

J Cell Sci. 2015 Nov 15;128(22):4220-34. doi: 10.1242/jcs.175372. Epub 2015 Oct 12.


A combination therapy for cystic fibrosis.

Brodsky JL, Frizzell RA.

Cell. 2015 Sep 24;163(1):17. doi: 10.1016/j.cell.2015.09.003.


Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain.

Chen J, Ray EC, Yates ME, Buck TM, Brodsky JL, Kinlough CL, Winarski KL, Hughey RP, Kleyman TR, Sheng S.

J Biol Chem. 2015 Oct 9;290(41):25140-50. doi: 10.1074/jbc.M115.665398. Epub 2015 Aug 25.


Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4).

Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle T Jr, Lu P, Brodsky JL, Hackam DJ.

Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.


Membrane Protein Properties Revealed through Data-Rich Electrostatics Calculations.

Marcoline FV, Bethel N, Guerriero CJ, Brodsky JL, Grabe M.

Structure. 2015 Aug 4;23(8):1526-1537. doi: 10.1016/j.str.2015.05.014. Epub 2015 Jun 25.


Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.

Needham PG, Patel HJ, Chiosis G, Thibodeau PH, Brodsky JL.

J Mol Biol. 2015 Sep 11;427(18):2948-65. doi: 10.1016/j.jmb.2015.04.010. Epub 2015 Apr 23.


Deficits in bone density and structure in children and young adults following Fontan palliation.

Avitabile CM, Goldberg DJ, Zemel BS, Brodsky JL, Dodds K, Hayden-Rush C, Whitehead KK, Goldmuntz E, Rychik J, Leonard MB.

Bone. 2015 Aug;77:12-6. doi: 10.1016/j.bone.2015.04.012. Epub 2015 Apr 14.


Heat shock protein defenses in the neocortex and allocortex of the telencephalon.

Posimo JM, Weilnau JN, Gleixner AM, Broeren MT, Weiland NL, Brodsky JL, Wipf P, Leak RK.

Neurobiol Aging. 2015 May;36(5):1924-37. doi: 10.1016/j.neurobiolaging.2015.02.011. Epub 2015 Feb 18.


Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae.

Buck TM, Jordan R, Lyons-Weiler J, Adelman JL, Needham PG, Kleyman TR, Brodsky JL.

Physiol Genomics. 2015 Jun;47(6):198-214. doi: 10.1152/physiolgenomics.00101.2014. Epub 2015 Mar 10.


The conserved core enzymatic activities and the distinct dynamics of polyomavirus large T antigens.

An P, Brodsky JL, Pipas JM.

Arch Biochem Biophys. 2015 May 1;573:23-31. doi: 10.1016/ Epub 2015 Mar 6.


Intracellular complexes of the early-onset torsion dystonia-associated AAA+ ATPase TorsinA.

Li H, Wu HC, Liu Z, Zacchi LF, Brodsky JL, Zolkiewski M.

Springerplus. 2014 Dec 16;3:743. doi: 10.1186/2193-1801-3-743. eCollection 2014.


Heat shock protein responses to aging and proteotoxicity in the olfactory bulb.

Crum TS, Gleixner AM, Posimo JM, Mason DM, Broeren MT, Heinemann SD, Wipf P, Brodsky JL, Leak RK.

J Neurochem. 2015 Jun;133(6):780-794. doi: 10.1111/jnc.13041. Epub 2015 Mar 5.


Usefulness of insulin like growth factor 1 as a marker of heart failure in children and young adults after the Fontan palliation procedure.

Avitabile CM, Leonard MB, Brodsky JL, Whitehead KK, Ravishankar C, Cohen MS, Gaynor JW, Rychik J, Goldberg DJ.

Am J Cardiol. 2015 Mar 15;115(6):816-20. doi: 10.1016/j.amjcard.2014.12.041. Epub 2015 Jan 6.


Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, Haystead TA.

Chem Biol. 2014 Dec 18;21(12):1648-59. doi: 10.1016/j.chembiol.2014.10.016. Epub 2014 Dec 11.


Protein folding in the cell, from atom to organism.

Brodsky JL, Clark PL.

FASEB J. 2014 Dec;28(12):5034-8. doi: 10.1096/fj.14-1202ufm. No abstract available.


Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target.

Ireland AW, Gobillot TA, Gupta T, Seguin SP, Liang M, Resnick L, Goldberg MT, Manos-Turvey A, Pipas JM, Wipf P, Brodsky JL.

Bioorg Med Chem. 2014 Nov 15;22(22):6490-6502. doi: 10.1016/j.bmc.2014.09.019.


Escaping the endoplasmic reticulum: why does a molecular chaperone leave home for greener pastures?

Buck TM, Brodsky JL.

EMBO J. 2015 Jan 2;34(1):1-3. doi: 10.15252/embj.201490462. Epub 2014 Nov 25. Review. No abstract available.


Teriparatide as a systemic treatment for lower extremity nonunion fractures: a case series.

Mancilla EE, Brodsky JL, Mehta S, Pignolo RJ, Levine MA.

Endocr Pract. 2015 Feb;21(2):136-42. doi: 10.4158/EP14315.OR.


Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation.

Surlow BA, Cooley BM, Needham PG, Brodsky JL, Patton-Vogt J.

J Biol Chem. 2014 Nov 7;289(45):31591-604. doi: 10.1074/jbc.M114.581157. Epub 2014 Sep 25.


Lean mass deficits, vitamin D status and exercise capacity in children and young adults after Fontan palliation.

Avitabile CM, Leonard MB, Zemel BS, Brodsky JL, Lee D, Dodds K, Hayden-Rush C, Whitehead KK, Goldmuntz E, Paridon SM, Rychik J, Goldberg DJ.

Heart. 2014 Nov;100(21):1702-7. doi: 10.1136/heartjnl-2014-305723. Epub 2014 Jun 27.


Recent technical developments in the study of ER-associated degradation.

Nakatsukasa K, Kamura T, Brodsky JL.

Curr Opin Cell Biol. 2014 Aug;29:82-91. doi: 10.1016/ Epub 2014 May 24. Review.


The proteolytic landscape of the yeast vacuole.

Hecht KA, O'Donnell AF, Brodsky JL.

Cell Logist. 2014 Jan 1;4(1):e28023. Epub 2014 Feb 12. Review.


Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2.

Alvaro CG, O'Donnell AF, Prosser DC, Augustine AA, Goldman A, Brodsky JL, Cyert MS, Wendland B, Thorner J.

Mol Cell Biol. 2014 Jul;34(14):2660-81.


The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma.

Adam C, Baeurle A, Brodsky JL, Wipf P, Schrama D, Becker JC, Houben R.

PLoS One. 2014 Apr 2;9(4):e92041. doi: 10.1371/journal.pone.0092041. eCollection 2014.


The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.

Zacchi LF, Wu HC, Bell SL, Millen L, Paton AW, Paton JC, Thomas PJ, Zolkiewski M, Brodsky JL.

J Biol Chem. 2014 May 2;289(18):12727-47. doi: 10.1074/jbc.M113.529123. Epub 2014 Mar 13.


Organelle and proteome quality control mechanisms: how cells are able to keep calm and carry on.

Brodsky JL, Merz A, Serio T.

Mol Biol Cell. 2014 Mar;25(6):733-4. doi: 10.1091/mbc.E13-11-0672. No abstract available.


Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.

Kang Y, Taldone T, Patel HJ, Patel PD, Rodina A, Gozman A, Maharaj R, Clement CC, Patel MR, Brodsky JL, Young JC, Chiosis G.

J Med Chem. 2014 Feb 27;57(4):1188-207. doi: 10.1021/jm401551n. Epub 2014 Feb 18.

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