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Can We Manipulate the Evolutionary Biology of Pathogens for Clinical Benefit?

Winstanley C, Brockhurst MA.

Am J Respir Cell Mol Biol. 2018 Apr 30. doi: 10.1165/rcmb.2018-0113ED. [Epub ahead of print] No abstract available.


Transmission and lineage displacement drive rapid population genomic flux in cystic fibrosis airway infections of a Pseudomonas aeruginosa epidemic strain.

Williams D, Fothergill JL, Evans B, Caples J, Haldenby S, Walshaw MJ, Brockhurst MA, Winstanley C, Paterson S.

Microb Genom. 2018 Mar 16. doi: 10.1099/mgen.0.000167. [Epub ahead of print]


Plasmid stability is enhanced by higher-frequency pulses of positive selection.

Stevenson C, Hall JPJ, Brockhurst MA, Harrison E.

Proc Biol Sci. 2018 Jan 10;285(1870). pii: 20172497. doi: 10.1098/rspb.2017.2497.


Variable plasmid fitness effects and mobile genetic element dynamics across Pseudomonas species.

Kottara A, Hall JPJ, Harrison E, Brockhurst MA.

FEMS Microbiol Ecol. 2018 Jan 1;94(1). doi: 10.1093/femsec/fix172.


Sampling the mobile gene pool: innovation via horizontal gene transfer in bacteria.

Hall JPJ, Brockhurst MA, Harrison E.

Philos Trans R Soc Lond B Biol Sci. 2017 Dec 5;372(1735). pii: 20160424. doi: 10.1098/rstb.2016.0424. Review.


Ecological and Evolutionary Benefits of Temperate Phage: What Does or Doesn't Kill You Makes You Stronger.

Harrison E, Brockhurst MA.

Bioessays. 2017 Dec;39(12). doi: 10.1002/bies.201700112. Epub 2017 Oct 6. Review.


Adaptive modulation of antibiotic resistance through intragenomic coevolution.

Bottery MJ, Wood AJ, Brockhurst MA.

Nat Ecol Evol. 2017 Sep;1(9):1364-1369. doi: 10.1038/s41559-017-0242-3. Epub 2017 Jul 24.


Positive selection inhibits gene mobilisation and transfer in soil bacterial communities.

Hall JPJ, Williams D, Paterson S, Harrison E, Brockhurst MA.

Nat Ecol Evol. 2017 Sep;1(9):1348-1353. doi: 10.1038/s41559-017-0250-3. Epub 2017 Jul 31. No abstract available.


The evolution of plasmid stability: Are infectious transmission and compensatory evolution competing evolutionary trajectories?

Hall JPJ, Brockhurst MA, Dytham C, Harrison E.

Plasmid. 2017 May;91:90-95. doi: 10.1016/j.plasmid.2017.04.003. Epub 2017 Apr 28.


Gene mobility promotes the spread of resistance in bacterial populations.

Stevenson C, Hall JP, Harrison E, Wood A, Brockhurst MA.

ISME J. 2017 Aug;11(8):1930-1932. doi: 10.1038/ismej.2017.42. Epub 2017 Mar 31.


Refined analyses suggest that recombination is a minor source of genomic diversity in Pseudomonas aeruginosa chronic cystic fibrosis infections.

Williams D, Paterson S, Brockhurst MA, Winstanley C.

Microb Genom. 2016 Mar 2;2(3):e000051. doi: 10.1099/mgen.0.000051. eCollection 2016 Mar.


Defining the functional traits that drive bacterial decomposer community productivity.

Evans R, Alessi AM, Bird S, McQueen-Mason SJ, Bruce NC, Brockhurst MA.

ISME J. 2017 Jul;11(7):1680-1687. doi: 10.1038/ismej.2017.22. Epub 2017 Mar 21.


Conflicting selection alters the trajectory of molecular evolution in a tripartite bacteria-plasmid-phage interaction.

Harrison E, Hall JPJ, Paterson S, Spiers AJ, Brockhurst MA.

Mol Ecol. 2017 May;26(10):2757-2764. doi: 10.1111/mec.14080. Epub 2017 Apr 3.


High virulence sub-populations in Pseudomonas aeruginosa long-term cystic fibrosis airway infections.

O'Brien S, Williams D, Fothergill JL, Paterson S, Winstanley C, Brockhurst MA.

BMC Microbiol. 2017 Feb 3;17(1):30. doi: 10.1186/s12866-017-0941-6.


Evolutionary diversification of Pseudomonas aeruginosa in an artificial sputum model.

Davies EV, James CE, Brockhurst MA, Winstanley C.

BMC Microbiol. 2017 Jan 5;17(1):3. doi: 10.1186/s12866-016-0916-z.


Ecological conditions determine extinction risk in co-evolving bacteria-phage populations.

Wright RC, Brockhurst MA, Harrison E.

BMC Evol Biol. 2016 Oct 24;16(1):227.


Rapid compensatory evolution promotes the survival of conjugative plasmids.

Harrison E, Dytham C, Hall JP, Guymer D, Spiers AJ, Paterson S, Brockhurst MA.

Mob Genet Elements. 2016 May 4;6(3):e1179074. doi: 10.1080/2159256X.2016.1179074. eCollection 2016 May-Jun.


Source-sink plasmid transfer dynamics maintain gene mobility in soil bacterial communities.

Hall JP, Wood AJ, Harrison E, Brockhurst MA.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8260-5. doi: 10.1073/pnas.1600974113. Epub 2016 Jul 6.


Temperate phages both mediate and drive adaptive evolution in pathogen biofilms.

Davies EV, James CE, Williams D, O'Brien S, Fothergill JL, Haldenby S, Paterson S, Winstanley C, Brockhurst MA.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8266-71. doi: 10.1073/pnas.1520056113. Epub 2016 Jul 5.


Temperate phages enhance pathogen fitness in chronic lung infection.

Davies EV, James CE, Kukavica-Ibrulj I, Levesque RC, Brockhurst MA, Winstanley C.

ISME J. 2016 Oct;10(10):2553-5. doi: 10.1038/ismej.2016.51. Epub 2016 Apr 12.


Metabolic constraints for a novel symbiosis.

Sørensen ME, Cameron DD, Brockhurst MA, Wood AJ.

R Soc Open Sci. 2016 Mar 23;3(3):150708. doi: 10.1098/rsos.150708. eCollection 2016 Mar.


Multi-host environments select for host-generalist conjugative plasmids.

Kottara A, Hall JP, Harrison E, Brockhurst MA.

BMC Evol Biol. 2016 Apr 2;16:70. doi: 10.1186/s12862-016-0642-z.


Rapid evolution of microbe-mediated protection against pathogens in a worm host.

King KC, Brockhurst MA, Vasieva O, Paterson S, Betts A, Ford SA, Frost CL, Horsburgh MJ, Haldenby S, Hurst GD.

ISME J. 2016 Aug;10(8):1915-24. doi: 10.1038/ismej.2015.259. Epub 2016 Mar 15.


Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections.

Winstanley C, O'Brien S, Brockhurst MA.

Trends Microbiol. 2016 May;24(5):327-337. doi: 10.1016/j.tim.2016.01.008. Epub 2016 Mar 3. Review.


Host control and nutrient trading in a photosynthetic symbiosis.

Dean AD, Minter EJ, Sørensen ME, Lowe CD, Cameron DD, Brockhurst MA, Jamie Wood A.

J Theor Biol. 2016 Sep 21;405:82-93. doi: 10.1016/j.jtbi.2016.02.021. Epub 2016 Feb 27.


Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance.

Bottery MJ, Wood AJ, Brockhurst MA.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2524-7. doi: 10.1128/AAC.02441-15. Print 2016 Apr.


Shining a Light on Exploitative Host Control in a Photosynthetic Endosymbiosis.

Lowe CD, Minter EJ, Cameron DD, Brockhurst MA.

Curr Biol. 2016 Jan 25;26(2):207-211. doi: 10.1016/j.cub.2015.11.052. Epub 2015 Dec 31.


Hybridization in Parasites: Consequences for Adaptive Evolution, Pathogenesis, and Public Health in a Changing World.

King KC, Stelkens RB, Webster JP, Smith DF, Brockhurst MA.

PLoS Pathog. 2015 Sep 3;11(9):e1005098. doi: 10.1371/journal.ppat.1005098. eCollection 2015 Sep. Review. No abstract available.


Plasmid carriage can limit bacteria-phage coevolution.

Harrison E, Truman J, Wright R, Spiers AJ, Paterson S, Brockhurst MA.

Biol Lett. 2015 Aug;11(8). pii: 20150361. doi: 10.1098/rsbl.2015.0361.


Coevolution can explain defensive secondary metabolite diversity in plants.

Speed MP, Fenton A, Jones MG, Ruxton GD, Brockhurst MA.

New Phytol. 2015 Dec;208(4):1251-63. doi: 10.1111/nph.13560. Epub 2015 Aug 4.


The effects of spatial structure, frequency dependence and resistance evolution on the dynamics of toxin-mediated microbial invasions.

Libberton B, Horsburgh MJ, Brockhurst MA.

Evol Appl. 2015 Aug;8(7):738-50. doi: 10.1111/eva.12284. Epub 2015 Jul 16.


Parallel compensatory evolution stabilizes plasmids across the parasitism-mutualism continuum.

Harrison E, Guymer D, Spiers AJ, Paterson S, Brockhurst MA.

Curr Biol. 2015 Aug 3;25(15):2034-9. doi: 10.1016/j.cub.2015.06.024. Epub 2015 Jul 16.


Evolutionary rewiring of bacterial regulatory networks.

Taylor TB, Mulley G, McGuffin LJ, Johnson LJ, Brockhurst MA, Arseneault T, Silby MW, Jackson RW.

Microb Cell. 2015 Jul 6;2(7):256-258. doi: 10.15698/mic2015.07.215.


Evolutionary rescue can be impeded by temporary environmental amelioration.

Hao YQ, Brockhurst MA, Petchey OL, Zhang QG.

Ecol Lett. 2015 Sep;18(9):892-8. doi: 10.1111/ele.12465. Epub 2015 Jun 25.


Negative frequency-dependent selection is intensified at higher population densities in protist populations.

Minter EJ, Watts PC, Lowe CD, Brockhurst MA.

Biol Lett. 2015 Jun;11(6):20150192. doi: 10.1098/rsbl.2015.0192.


Bacteriophages limit the existence conditions for conjugative plasmids.

Harrison E, Wood AJ, Dytham C, Pitchford JW, Truman J, Spiers A, Paterson S, Brockhurst MA.

MBio. 2015 Jun 2;6(3):e00586. doi: 10.1128/mBio.00586-15.


Environmentally co-occurring mercury resistance plasmids are genetically and phenotypically diverse and confer variable context-dependent fitness effects.

Hall JP, Harrison E, Lilley AK, Paterson S, Spiers AJ, Brockhurst MA.

Environ Microbiol. 2015 Dec;17(12):5008-22. doi: 10.1111/1462-2920.12901. Epub 2015 Jun 25.


Experimental evolution can unravel the complex causes of natural selection in clinical infections.

Brockhurst MA.

Microbiology. 2015 Jun;161(6):1175-9. doi: 10.1099/mic.0.000107. Epub 2015 May 8.


Social evolution: slimy cheats pay a price.

O'Brien S, Brockhurst MA.

Curr Biol. 2015 May 4;25(9):R378-81. doi: 10.1016/j.cub.2015.03.018.


Evolution. Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system.

Taylor TB, Mulley G, Dills AH, Alsohim AS, McGuffin LJ, Studholme DJ, Silby MW, Brockhurst MA, Johnson LJ, Jackson RW.

Science. 2015 Feb 27;347(6225):1014-7. doi: 10.1126/science.1259145.


Divergent, coexisting Pseudomonas aeruginosa lineages in chronic cystic fibrosis lung infections.

Williams D, Evans B, Haldenby S, Walshaw MJ, Brockhurst MA, Winstanley C, Paterson S.

Am J Respir Crit Care Med. 2015 Apr 1;191(7):775-85. doi: 10.1164/rccm.201409-1646OC.


Hybridization facilitates evolutionary rescue.

Stelkens RB, Brockhurst MA, Hurst GD, Greig D.

Evol Appl. 2014 Dec;7(10):1209-17. doi: 10.1111/eva.12214. Epub 2014 Sep 25.


Lytic activity by temperate phages of Pseudomonas aeruginosa in long-term cystic fibrosis chronic lung infections.

James CE, Davies EV, Fothergill JL, Walshaw MJ, Beale CM, Brockhurst MA, Winstanley C.

ISME J. 2015 Jun;9(6):1391-8. doi: 10.1038/ismej.2014.223. Epub 2014 Dec 2.


The evolution and genetics of virus host shifts.

Longdon B, Brockhurst MA, Russell CA, Welch JJ, Jiggins FM.

PLoS Pathog. 2014 Nov 6;10(11):e1004395. doi: 10.1371/journal.ppat.1004395. eCollection 2014 Nov. Review.


Running with the Red Queen: the role of biotic conflicts in evolution.

Brockhurst MA, Chapman T, King KC, Mank JE, Paterson S, Hurst GD.

Proc Biol Sci. 2014 Dec 22;281(1797). pii: 20141382. doi: 10.1098/rspb.2014.1382. Review.


The effect of hybrid transgression on environmental tolerance in experimental yeast crosses.

Stelkens RB, Brockhurst MA, Hurst GD, Miller EL, Greig D.

J Evol Biol. 2014 Nov;27(11):2507-19. doi: 10.1111/jeb.12494. Epub 2014 Sep 28.


Editorial overview: viral evolution: exploring the frontiers of virus evolution in the lab, the field and the clinic.

Brockhurst MA, Hensley SE.

Curr Opin Virol. 2014 Oct;8:ix-x. doi: 10.1016/j.coviro.2014.09.002. Epub 2014 Sep 13. No abstract available.


Evidence that intraspecific trait variation among nasal bacteria shapes the distribution of Staphylococcus aureus.

Libberton B, Coates RE, Brockhurst MA, Horsburgh MJ.

Infect Immun. 2014 Sep;82(9):3811-5. doi: 10.1128/IAI.02025-14. Epub 2014 Jun 30.


Bacteria-phage coevolution as a driver of ecological and evolutionary processes in microbial communities.

Koskella B, Brockhurst MA.

FEMS Microbiol Rev. 2014 Sep;38(5):916-31. doi: 10.1111/1574-6976.12072. Epub 2014 Mar 27. Review.


Viral host-adaptation: insights from evolution experiments with phages.

Hall JP, Harrison E, Brockhurst MA.

Curr Opin Virol. 2013 Oct;3(5):572-7. doi: 10.1016/j.coviro.2013.07.001. Epub 2013 Jul 25. Review.


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