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Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules.

Gouveia MJ, Brindley PJ, Gärtner F, Costa JMCD, Vale N.

Pharmaceuticals (Basel). 2018 Feb 5;11(1). pii: E15. doi: 10.3390/ph11010015. Review.


Expression, purification and characterization of two leucine aminopeptidases of the blood fluke, Schistosoma mansoni.

Maggioli G, Rinaldi G, Giaudrone I, Berasain P, Tort JF, Brindley PJ, Carmona C.

Mol Biochem Parasitol. 2018 Jan;219:17-23. doi: 10.1016/j.molbiopara.2017.11.006. Epub 2017 Nov 21.


Suppression of mRNAs encoding CD63 family tetraspanins from the carcinogenic liver fluke Opisthorchis viverrini results in distinct tegument phenotypes.

Chaiyadet S, Krueajampa W, Hipkaeo W, Plosan Y, Piratae S, Sotillo J, Smout M, Sripa B, Brindley PJ, Loukas A, Laha T.

Sci Rep. 2017 Oct 30;7(1):14342. doi: 10.1038/s41598-017-13527-5.


Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model.

Gouveia MJ, Pakharukova MY, Laha T, Sripa B, Maksimova GA, Rinaldi G, Brindley PJ, Mordvinov VA, Amaro T, Santos LL, Costa JMCD, Vale N.

Carcinogenesis. 2017 Sep 1;38(9):929-937. doi: 10.1093/carcin/bgx042.


Parasite Microbiome Project: Systematic Investigation of Microbiome Dynamics within and across Parasite-Host Interactions.

Dheilly NM, Bolnick D, Bordenstein S, Brindley PJ, Figuères C, Holmes EC, Martínez Martínez J, Phillips AJ, Poulin R, Rosario K.

mSystems. 2017 Jul 18;2(4). pii: e00050-17. doi: 10.1128/mSystems.00050-17. eCollection 2017 Jul-Aug.


Helminth infection-induced malignancy.

Brindley PJ, Loukas A.

PLoS Pathog. 2017 Jul 27;13(7):e1006393. doi: 10.1371/journal.ppat.1006393. eCollection 2017 Jul. Review. No abstract available.


Subsets of Inflammatory Cytokine Gene Polymorphisms are Associated with Risk of Carcinogenic Liver Fluke Opisthorchis viverrini-Associated Advanced Periductal Fibrosis and Cholangiocarcinoma.

Surapaitoon A, Suttiprapa S, Mairiang E, Khuntikeo N, Pairojkul C, Bethony J, Brindley PJ, Sripa B.

Korean J Parasitol. 2017 Jun;55(3):295-304. doi: 10.3347/kjp.2017.55.3.295. Epub 2017 Jun 30.


Development of a Potent Wound Healing Agent Based on the Liver Fluke Granulin Structural Fold.

Bansal PS, Smout MJ, Wilson D, Cobos Caceres C, Dastpeyman M, Sotillo J, Seifert J, Brindley PJ, Loukas A, Daly NL.

J Med Chem. 2017 May 25;60(10):4258-4266. doi: 10.1021/acs.jmedchem.7b00047. Epub 2017 May 3.


The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer.

Vale N, Gouveia MJ, Rinaldi G, Santos J, Santos LL, Brindley PJ, da Costa JM.

Tumour Biol. 2017 Mar;39(3):1010428317692247. doi: 10.1177/1010428317692247. Review.


Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum.

Wang J, Yu Y, Shen H, Qing T, Zheng Y, Li Q, Mo X, Wang S, Li N, Chai R, Xu B, Liu M, Brindley PJ, McManus DP, Feng Z, Shi L, Hu W.

Nat Commun. 2017 Mar 13;8:14693. doi: 10.1038/ncomms14693.


Praziquantel for Schistosomiasis: Single-Drug Metabolism Revisited, Mode of Action, and Resistance.

Vale N, Gouveia MJ, Rinaldi G, Brindley PJ, Gärtner F, Correia da Costa JM.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02582-16. doi: 10.1128/AAC.02582-16. Print 2017 May. Review.


Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease.

Deenonpoe R, Mairiang E, Mairiang P, Pairojkul C, Chamgramol Y, Rinaldi G, Loukas A, Brindley PJ, Sripa B.

Sci Rep. 2017 Feb 15;7:42744. doi: 10.1038/srep42744.


Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers.

McNulty SN, Tort JF, Rinaldi G, Fischer K, Rosa BA, Smircich P, Fontenla S, Choi YJ, Tyagi R, Hallsworth-Pepin K, Mann VH, Kammili L, Latham PS, Dell'Oca N, Dominguez F, Carmona C, Fischer PU, Brindley PJ, Mitreva M.

PLoS Genet. 2017 Jan 6;13(1):e1006537. doi: 10.1371/journal.pgen.1006537. eCollection 2017 Jan.


Parasite Infection, Carcinogenesis and Human Malignancy.

van Tong H, Brindley PJ, Meyer CG, Velavan TP.

EBioMedicine. 2017 Feb;15:12-23. doi: 10.1016/j.ebiom.2016.11.034. Epub 2016 Dec 2. Review.


Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma?

Sripa B, Deenonpoe R, Brindley PJ.

Parasitol Int. 2017 Aug;66(4):383-389. doi: 10.1016/j.parint.2016.11.016. Epub 2016 Dec 3. Review.


HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni.

Suttiprapa S, Rinaldi G, Tsai IJ, Mann VH, Dubrovsky L, Yan HB, Holroyd N, Huckvale T, Durrant C, Protasio AV, Pushkarsky T, Iordanskiy S, Berriman M, Bukrinsky MI, Brindley PJ.

PLoS Pathog. 2016 Oct 20;12(10):e1005931. doi: 10.1371/journal.ppat.1005931. eCollection 2016 Oct.


Biliary Microbiota, Gallstone Disease and Infection with Opisthorchis felineus.

Saltykova IV, Petrov VA, Logacheva MD, Ivanova PG, Merzlikin NV, Sazonov AE, Ogorodova LM, Brindley PJ.

PLoS Negl Trop Dis. 2016 Jul 22;10(7):e0004809. doi: 10.1371/journal.pntd.0004809. eCollection 2016 Jul.


Decreased risk of cholangiocarcinogenesis following repeated cycles of Opisthorchis viverrini infection-praziquantel treatment: Magnetic Resonance Imaging (MRI) and histopathological study in a hamster model.

Hanpanich P, Laha T, Sripa B, Mairiang E, Sereerak P, Upontain S, Tangkawattana P, Brindley PJ, Tangkawattana S.

Parasitol Int. 2017 Aug;66(4):464-470. doi: 10.1016/j.parint.2016.04.012. Epub 2016 Apr 30.


Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis.

Teimoori S, Arimatsu Y, Laha T, Kaewkes S, Sereerak P, Sripa M, Tangkawattana S, Brindley PJ, Sripa B.

Parasitol Int. 2017 Aug;66(4):443-447. doi: 10.1016/j.parint.2015.10.011. Epub 2016 Apr 29.


Insight into the molecular basis of Schistosoma haematobium-induced bladder cancer through urine proteomics.

Bernardo C, Cunha MC, Santos JH, da Costa JM, Brindley PJ, Lopes C, Amado F, Ferreira R, Vitorino R, Santos LL.

Tumour Biol. 2016 Aug;37(8):11279-87. doi: 10.1007/s13277-016-4997-y. Epub 2016 Mar 7.


Carbonyl stress phenomena during chronic infection with Opisthorchis felineus.

Saltykova IV, Ogorodova LM, Ivanov VV, Bogdanov AO, Gereng EA, Perina EA, Brindley PJ, Sazonov AE.

Parasitol Int. 2017 Aug;66(4):453-457. doi: 10.1016/j.parint.2016.01.002. Epub 2016 Jan 8.


Functional Analysis of the Unique Cytochrome P450 of the Liver Fluke Opisthorchis felineus.

Pakharukova MY, Vavilin VA, Sripa B, Laha T, Brindley PJ, Mordvinov VA.

PLoS Negl Trop Dis. 2015 Dec 1;9(12):e0004258. doi: 10.1371/journal.pntd.0004258. eCollection 2015 Dec.


Why does infection with some helminths cause cancer?

Brindley PJ, da Costa JM, Sripa B.

Trends Cancer. 2015 Nov 1;1(3):174-182.


Why Does Infection With Some Helminths Cause Cancer?

Brindley PJ, Costa JMCD, Sripa B.

Trends Cancer. 2015 Nov;1(3):174-182. doi: 10.1016/j.trecan.2015.08.011. Epub 2015 Sep 12. Review.


Susceptibility of Snails to Infection with Schistosomes is influenced by Temperature and Expression of Heat Shock Proteins.

Knight M, Elhelu O, Smith M, Haugen B, Miller A, Raghavan N, Wellman C, Cousin C, Dixon F, Mann V, Rinaldi G, Ittiprasert W, Brindley PJ.

Epidemiology (Sunnyvale). 2015 Jun;5(2). pii: 189. Epub 2015 Jun 21.


Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia.

Smout MJ, Sotillo J, Laha T, Papatpremsiri A, Rinaldi G, Pimenta RN, Chan LY, Johnson MS, Turnbull L, Whitchurch CB, Giacomin PR, Moran CS, Golledge J, Daly N, Sripa B, Mulvenna JP, Brindley PJ, Loukas A.

PLoS Pathog. 2015 Oct 20;11(10):e1005209. doi: 10.1371/journal.ppat.1005209. eCollection 2015 Oct.


Profiling miRNAs in nasopharyngeal carcinoma FFPE tissue by microarray and Next Generation Sequencing.

Peng J, Feng Y, Rinaldi G, Levine P, Easley S, Martinez E, Hashmi S, Sadeghi N, Brindley PJ, Mulvenna JP, Bethony JM, Plieskatt JL.

Genom Data. 2014 Aug 27;2:285-9. doi: 10.1016/j.gdata.2014.08.005. eCollection 2014 Dec.


The miRNAome of Opisthorchis viverrini induced intrahepatic cholangiocarcinoma.

Peng J, Feng Y, Rinaldi G, Yonglitthipagon P, Easley SE, Laha T, Pairojkul C, Bhudhisawasdi V, Sripa B, Brindley PJ, Mulvenna JP, Bethony JM, Plieskatt JL.

Genom Data. 2014 Aug 28;2:274-9. doi: 10.1016/j.gdata.2014.08.007. eCollection 2014 Dec.


Immunodiagnosis of opisthorchiasis using parasite cathepsin F.

Teimoori S, Arimatsu Y, Laha T, Kaewkes S, Sereerak P, Tangkawattana S, Brindley PJ, Sripa B.

Parasitol Res. 2015 Dec;114(12):4571-8. doi: 10.1007/s00436-015-4703-9. Epub 2015 Sep 7.


Comparison of findings using ultrasonography and cystoscopy in urogenital schistosomiasis in a public health centre in rural Angola.

Santos J, Chaves J, Araújo H, Vale N, Costa JM, Brindley PJ, Lopes C, Naples J, Shiff C, Dupret J, Santos LL.

S Afr Med J. 2015 Apr;105(4):312-5.


Viability of developmental stages of Schistosoma mansoni quantified with xCELLigence worm real-time motility assay (xWORM).

Rinaldi G, Loukas A, Brindley PJ, Irelan JT, Smout MJ.

Int J Parasitol Drugs Drug Resist. 2015 Aug 6;5(3):141-8. doi: 10.1016/j.ijpddr.2015.07.002. eCollection 2015 Dec.


Levels of 8-OxodG Predict Hepatobiliary Pathology in Opisthorchis viverrini Endemic Settings in Thailand.

Saichua P, Yakovleva A, Kamamia C, Jariwala AR, Sithithaworn J, Sripa B, Brindley PJ, Laha T, Mairiang E, Pairojkul C, Khuntikeo N, Mulvenna J, Sithithaworn P, Bethony JM.

PLoS Negl Trop Dis. 2015 Jul 31;9(7):e0003949. doi: 10.1371/journal.pntd.0003949. eCollection 2015.


Apoptosis of cholangiocytes modulated by thioredoxin of carcinogenic liver fluke.

Matchimakul P, Rinaldi G, Suttiprapa S, Mann VH, Popratiloff A, Laha T, Pimenta RN, Cochran CJ, Kaewkes S, Sripa B, Brindley PJ.

Int J Biochem Cell Biol. 2015 Aug;65:72-80. doi: 10.1016/j.biocel.2015.05.014. Epub 2015 May 23.


Carcinogenic Liver Fluke Secretes Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype.

Chaiyadet S, Sotillo J, Smout M, Cantacessi C, Jones MK, Johnson MS, Turnbull L, Whitchurch CB, Potriquet J, Laohaviroj M, Mulvenna J, Brindley PJ, Bethony JM, Laha T, Sripa B, Loukas A.

J Infect Dis. 2015 Nov 15;212(10):1636-45. doi: 10.1093/infdis/jiv291. Epub 2015 May 17.


Intake of Erythrocytes Required for Reproductive Development of Female Schistosoma japonicum.

Wang J, Wang S, Liu X, Xu B, Chai R, Zhou P, Ju C, Sun J, Brindley PJ, Hu W.

PLoS One. 2015 May 15;10(5):e0126822. doi: 10.1371/journal.pone.0126822. eCollection 2015.


Gene function in schistosomes: recent advances toward a cure.

Jurberg AD, Brindley PJ.

Front Genet. 2015 Apr 15;6:144. doi: 10.3389/fgene.2015.00144. eCollection 2015. No abstract available.


Cytometric analysis, genetic manipulation and antibiotic selection of the snail embryonic cell line Bge from Biomphalaria glabrata, the intermediate host of Schistosoma mansoni.

Rinaldi G, Yan H, Nacif-Pimenta R, Matchimakul P, Bridger J, Mann VH, Smout MJ, Brindley PJ, Knight M.

Int J Parasitol. 2015 Jul;45(8):527-35. doi: 10.1016/j.ijpara.2015.02.012. Epub 2015 Apr 20.


A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma.

Plieskatt J, Rinaldi G, Feng Y, Peng J, Easley S, Jia X, Potriquet J, Pairojkul C, Bhudhisawasdi V, Sripa B, Brindley PJ, Bethony J, Mulvenna J.

BMC Cancer. 2015 Apr 23;15:309. doi: 10.1186/s12885-015-1270-5.


The role of estrogens and estrogen receptor signaling pathways in cancer and infertility: the case of schistosomes.

Botelho MC, Alves H, Barros A, Rinaldi G, Brindley PJ, Sousa M.

Trends Parasitol. 2015 Jun;31(6):246-50. doi: 10.1016/ Epub 2015 Mar 30. Review.


Opisthorchiasis: an overlooked danger.

Ogorodova LM, Fedorova OS, Sripa B, Mordvinov VA, Katokhin AV, Keiser J, Odermatt P, Brindley PJ, Mayboroda OA, Velavan TP, Freidin MB, Sazonov AE, Saltykova IV, Pakharukova MY, Kovshirina YV, Kaloulis K, Krylova OY, Yazdanbakhsh M; TOPIC Consortium.

PLoS Negl Trop Dis. 2015 Apr 2;9(4):e0003563. doi: 10.1371/journal.pntd.0003563. eCollection 2015 Apr. No abstract available.


Genome-wide characterization of microsatellites and marker development in the carcinogenic liver fluke Clonorchis sinensis.

Nguyen TT, Arimatsu Y, Hong SJ, Brindley PJ, Blair D, Laha T, Sripa B.

Parasitol Res. 2015 Jun;114(6):2263-72. doi: 10.1007/s00436-015-4419-x. Epub 2015 Mar 19.


The carcinogenic liver fluke Opisthorchis viverrini is a reservoir for species of Helicobacter.

Deenonpoe R, Chomvarin C, Pairojkul C, Chamgramol Y, Loukas A, Brindley PJ, Sripa B.

Asian Pac J Cancer Prev. 2015;16(5):1751-8.


Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer.

Gouveia MJ, Santos J, Brindley PJ, Rinaldi G, Lopes C, Santos LL, da Costa JM, Vale N.

Cancer Lett. 2015 Apr 10;359(2):226-32. doi: 10.1016/j.canlet.2015.01.018. Epub 2015 Jan 20.


Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers.

Correia da Costa JM, Vale N, Gouveia MJ, Botelho MC, Sripa B, Santos LL, Santos JH, Rinaldi G, Brindley PJ.

Front Genet. 2014 Dec 23;5:444. doi: 10.3389/fgene.2014.00444. eCollection 2014. Review.


P53 and cancer-associated sialylated glycans are surrogate markers of cancerization of the bladder associated with Schistosoma haematobium infection.

Santos J, Fernandes E, Ferreira JA, Lima L, Tavares A, Peixoto A, Parreira B, Correia da Costa JM, Brindley PJ, Lopes C, Santos LL.

PLoS Negl Trop Dis. 2014 Dec 11;8(12):e3329. doi: 10.1371/journal.pntd.0003329. eCollection 2014 Dec.


Suppression of Ov-grn-1 encoding granulin of Opisthorchis viverrini inhibits proliferation of biliary epithelial cells.

Papatpremsiri A, Smout MJ, Loukas A, Brindley PJ, Sripa B, Laha T.

Exp Parasitol. 2015 Jan;148:17-23. doi: 10.1016/j.exppara.2014.11.004. Epub 2014 Nov 13.

47. expansions to and an introduction to

Martin J, Rosa BA, Ozersky P, Hallsworth-Pepin K, Zhang X, Bhonagiri-Palsikar V, Tyagi R, Wang Q, Choi YJ, Gao X, McNulty SN, Brindley PJ, Mitreva M.

Nucleic Acids Res. 2015 Jan;43(Database issue):D698-706. doi: 10.1093/nar/gku1128. Epub 2014 Nov 11.


Immunization and challenge shown by hamsters infected with Opisthorchis viverrini following exposure to gamma-irradiated metacercariae of this carcinogenic liver fluke.

Papatpremsiri A, Junpue P, Loukas A, Brindley PJ, Bethony JM, Sripa B, Laha T.

J Helminthol. 2016 Jan;90(1):39-47. doi: 10.1017/S0022149X14000741. Epub 2014 Oct 15.


RNA interference in Fasciola hepatica newly excysted juveniles: long dsRNA induces more persistent silencing than siRNA.

Dell'Oca N, Basika T, Corvo I, Castillo E, Brindley PJ, Rinaldi G, Tort JF.

Mol Biochem Parasitol. 2014 Oct;197(1-2):28-35. doi: 10.1016/j.molbiopara.2014.10.001. Epub 2014 Oct 12.


Medicine. Halting harmful helminths.

Hoffmann KF, Brindley PJ, Berriman M.

Science. 2014 Oct 10;346(6206):168-9. doi: 10.1126/science.1261139. No abstract available.


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