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Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase.

Brimijoin S, Gao Y, Geng L, Chen VP.

Front Pharmacol. 2018 Feb 27;9:112. doi: 10.3389/fphar.2018.00112. eCollection 2018. Review.


Cholinesterases and the fine line between poison and remedy.

Pope CN, Brimijoin S.

Biochem Pharmacol. 2018 Jan 31. pii: S0006-2952(18)30050-9. doi: 10.1016/j.bcp.2018.01.044. [Epub ahead of print] Review.


17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior.

Steyn FJ, Ngo ST, Chen VP, Bailey-Downs LC, Xie TY, Ghadami M, Brimijoin S, Freeman WM, Rubinstein M, Low MJ, Stout MB.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12703. Epub 2017 Nov 23.


Butyrylcholinesterase gene transfer in obese mice prevents postdieting body weight rebound by suppressing ghrelin signaling.

Chen VP, Gao Y, Geng L, Brimijoin S.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10960-10965. doi: 10.1073/pnas.1706517114. Epub 2017 Sep 25.


Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity.

Larrimore KE, Kazan IC, Kannan L, Kendle RP, Jamal T, Barcus M, Bolia A, Brimijoin S, Zhan CG, Ozkan SB, Mor TS.

Sci Rep. 2017 Sep 5;7(1):10419. doi: 10.1038/s41598-017-10571-z.


Polyionic complexes of butyrylcholinesterase and poly-l-lysine-g-poly(ethylene glycol): Comparative kinetics of catalysis and inhibition and in vitro inactivation by proteases and heat.

Hester K, Liu J, Flynn N, Sultatos LG, Geng L, Brimijoin S, Ramsey JD, Hartson S, Ranjan A, Pope C.

Chem Biol Interact. 2017 Sep 25;275:86-94. doi: 10.1016/j.cbi.2017.07.019. Epub 2017 Jul 27.


Favorable Impact on Stress-Related Behaviors by Modulating Plasma Butyrylcholinesterase.

Brimijoin S, Tye S.

Cell Mol Neurobiol. 2018 Jan;38(1):7-12. doi: 10.1007/s10571-017-0523-z. Epub 2017 Jul 15. Review.


Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice.

Gao Y, Geng L, Chen VP, Brimijoin S.

Molecules. 2017 Jul 8;22(7). pii: E1145. doi: 10.3390/molecules22071145.


Butyrylcholinesterase regulates central ghrelin signaling and has an impact on food intake and glucose homeostasis.

Chen VP, Gao Y, Geng L, Brimijoin S.

Int J Obes (Lond). 2017 Sep;41(9):1413-1419. doi: 10.1038/ijo.2017.123. Epub 2017 May 22.


Monoclonal Antibodies That Recognize Various Folding States of Pure Human Butyrylcholinesterase Can Immunopurify Butyrylcholinesterase from Human Plasma Stored at Elevated Temperatures.

Peng H, Blake TA, Johnson RC, Dafferner AJ, Brimijoin S, Lockridge O.

ACS Omega. 2016 Dec 31;1(6):1182-1191. doi: 10.1021/acsomega.6b00311. Epub 2016 Dec 13.


Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and Hepatic Lipid Accumulation in Male Mice on High-Fat Diet.

Chen VP, Gao Y, Geng L, Stout MB, Jensen MD, Brimijoin S.

Endocrinology. 2016 Aug;157(8):3086-95. doi: 10.1210/en.2016-1166. Epub 2016 Jun 14.


Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector-Delivered Cocaine Hydrolase.

Smethells JR, Swalve N, Brimijoin S, Gao Y, Parks RJ, Greer A, Carroll ME.

J Pharmacol Exp Ther. 2016 May;357(2):375-81. doi: 10.1124/jpet.116.232504. Epub 2016 Mar 11.


Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis.

Brimijoin S, Chen VP, Pang YP, Geng L, Gao Y.

Chem Biol Interact. 2016 Nov 25;259(Pt B):271-275. doi: 10.1016/j.cbi.2016.02.013. Epub 2016 Feb 23. Review.


Cocaine Hydrolase Gene Transfer Demonstrates Cardiac Safety and Efficacy against Cocaine-Induced QT Prolongation in Mice.

Murthy V, Reyes S, Geng L, Gao Y, Brimijoin S.

J Pharmacol Exp Ther. 2016 Mar;356(3):720-5. doi: 10.1124/jpet.115.228825. Epub 2015 Dec 15.


Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma.

Peng H, Brimijoin S, Hrabovska A, Krejci E, Blake TA, Johnson RC, Masson P, Lockridge O.

Chem Biol Interact. 2016 Jan 5;243:82-90. doi: 10.1016/j.cbi.2015.11.011. Epub 2015 Nov 14.


Radiometric assay of ghrelin hydrolase activity and 3H-ghrelin distribution into mouse tissues.

Chen VP, Gao Y, Geng L, Brimijoin S.

Biochem Pharmacol. 2015 Dec 15;98(4):732-9. doi: 10.1016/j.bcp.2015.10.016. Epub 2015 Oct 26.


Comparison of 5 monoclonal antibodies for immunopurification of human butyrylcholinesterase on Dynabeads: KD values, binding pairs, and amino acid sequences.

Peng H, Brimijoin S, Hrabovska A, Targosova K, Krejci E, Blake TA, Johnson RC, Masson P, Lockridge O.

Chem Biol Interact. 2015 Oct 5;240:336-45. doi: 10.1016/j.cbi.2015.08.024. Epub 2015 Sep 3.


Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin.

Schopfer LM, Lockridge O, Brimijoin S.

Gen Comp Endocrinol. 2015 Dec 1;224:61-8. doi: 10.1016/j.ygcen.2015.05.017. Epub 2015 Jun 12.


Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase.

Murthy V, Geng L, Gao Y, Zhang B, Miller JD, Reyes S, Brimijoin S.

Cell Mol Neurobiol. 2015 Aug;35(6):819-26. doi: 10.1007/s10571-015-0175-9. Epub 2015 Mar 27.


Plasma butyrylcholinesterase regulates ghrelin to control aggression.

Chen VP, Gao Y, Geng L, Parks RJ, Pang YP, Brimijoin S.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2251-6. doi: 10.1073/pnas.1421536112. Epub 2015 Feb 2. Erratum in: Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1510.


Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase.

Chen X, Huang X, Geng L, Xue L, Hou S, Zheng X, Brimijoin S, Zheng F, Zhan CG.

Biochem J. 2015 Mar 1;466(2):243-51. doi: 10.1042/BJ20141266.


Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice.

Murthy V, Gao Y, Geng L, LeBrasseur NK, White TA, Parks RJ, Brimijoin S.

Vaccine. 2014 Jul 16;32(33):4155-62. doi: 10.1016/j.vaccine.2014.05.067. Epub 2014 Jun 2.


The future potential for cocaine vaccines.

Orson FM, Wang R, Brimijoin S, Kinsey BM, Singh RA, Ramakrishnan M, Wang HY, Kosten TR.

Expert Opin Biol Ther. 2014 Sep;14(9):1271-83. doi: 10.1517/14712598.2014.920319. Epub 2014 May 16. Review.


Long-term reduction of cocaine self-administration in rats treated with adenoviral vector-delivered cocaine hydrolase: evidence for enzymatic activity.

Zlebnik NE, Brimijoin S, Gao Y, Saykao AT, Parks RJ, Carroll ME.

Neuropsychopharmacology. 2014 May;39(6):1538-46. doi: 10.1038/npp.2014.3. Epub 2014 Jan 10.


Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice.

Murthy V, Gao Y, Geng L, LeBrasseur N, White T, Brimijoin S.

J Mol Neurosci. 2014 Jul;53(3):409-16. doi: 10.1007/s12031-013-0130-5. Epub 2013 Oct 2.


Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity.

Geng L, Gao Y, Chen X, Hou S, Zhan CG, Radic Z, Parks RJ, Russell SJ, Pham L, Brimijoin S.

PLoS One. 2013 Jun 28;8(6):e67446. doi: 10.1371/journal.pone.0067446. Print 2013.


Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse.

Brimijoin S, Shen X, Orson F, Kosten T.

Expert Rev Vaccines. 2013 Mar;12(3):323-32. doi: 10.1586/erv.13.1. Review.


Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity.

Larrimore KE, Barcus M, Kannan L, Gao Y, Zhan CG, Brimijoin S, Mor T.

Chem Biol Interact. 2013 Mar 25;203(1):217-20. doi: 10.1016/j.cbi.2012.09.004. Epub 2012 Sep 20.


Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice.

Brimijoin S, Orson F, Kosten TR, Kinsey B, Shen XY, White SJ, Gao Y.

Chem Biol Interact. 2013 Mar 25;203(1):212-6. doi: 10.1016/j.cbi.2012.08.015. Epub 2012 Aug 31.


Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage.

Gao Y, Geng L, Orson F, Kinsey B, Kosten TR, Shen X, Brimijoin S.

Chem Biol Interact. 2013 Mar 25;203(1):208-11. doi: 10.1016/j.cbi.2012.08.006. Epub 2012 Aug 23.


Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion.

Carroll ME, Zlebnik NE, Anker JJ, Kosten TR, Orson FM, Shen X, Kinsey B, Parks RJ, Gao Y, Brimijoin S.

PLoS One. 2012;7(8):e43536. doi: 10.1371/journal.pone.0043536. Epub 2012 Aug 17.


Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells.

Seo S, Lomberk G, Mathison A, Buttar N, Podratz J, Calvo E, Iovanna J, Brimijoin S, Windebank A, Urrutia R.

J Biol Chem. 2012 Apr 13;287(16):12723-35. doi: 10.1074/jbc.M112.351395. Epub 2012 Feb 28.


Cocaine hydrolase gene therapy for cocaine abuse.

Brimijoin S, Gao Y.

Future Med Chem. 2012 Feb;4(2):151-62. doi: 10.4155/fmc.11.183. Review.


Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides.

Pang YP, Brimijoin S, Ragsdale DW, Zhu KY, Suranyi R.

Curr Drug Targets. 2012 Apr;13(4):471-82. Review.


Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months.

Anker JJ, Brimijoin S, Gao Y, Geng L, Zlebnik NE, Parks RJ, Carroll ME.

Biol Psychiatry. 2012 Apr 15;71(8):700-5. doi: 10.1016/j.biopsych.2011.11.014. Epub 2011 Dec 30.


Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats.

Carroll ME, Gao Y, Brimijoin S, Anker JJ.

Psychopharmacology (Berl). 2011 Feb;213(4):817-29. doi: 10.1007/s00213-010-2040-3. Epub 2010 Oct 23.


The concept of pharmacologic cocaine interception as a treatment for drug abuse.

Gao Y, Orson FM, Kinsey B, Kosten T, Brimijoin S.

Chem Biol Interact. 2010 Sep 6;187(1-3):421-4. doi: 10.1016/j.cbi.2010.02.036. Epub 2010 Feb 26.


Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle.

Polsinelli GA, Singh SK, Mishra RK, Suranyi R, Ragsdale DW, Pang YP, Brimijoin S.

Chem Biol Interact. 2010 Sep 6;187(1-3):142-7. doi: 10.1016/j.cbi.2010.01.036. Epub 2010 Jan 28.


Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases.

Pang YP, Ekström F, Polsinelli GA, Gao Y, Rana S, Hua DH, Andersson B, Andersson PO, Peng L, Singh SK, Mishra RK, Zhu KY, Fallon AM, Ragsdale DW, Brimijoin S.

PLoS One. 2009 Aug 28;4(8):e6851. doi: 10.1371/journal.pone.0006851.


Lasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approach.

Gao Y, Brimijoin S.

J Pharmacol Exp Ther. 2009 Aug;330(2):449-57. doi: 10.1124/jpet.109.152231. Epub 2009 May 28.


Cholinesterase inhibition and acetylcholine accumulation following intracerebral administration of paraoxon in rats.

Ray A, Liu J, Karanth S, Gao Y, Brimijoin S, Pope C.

Toxicol Appl Pharmacol. 2009 May 1;236(3):341-7. doi: 10.1016/j.taap.2009.02.022. Epub 2009 Mar 6.


Type-1 angiotensin receptors are expressed and transported in motor and sensory axons of rat sciatic nerves.

Tang H, Pavel J, Saavedra JM, Brimijoin S.

Neuropeptides. 2009 Apr;43(2):81-92. doi: 10.1016/j.npep.2009.01.001. Epub 2009 Feb 23.


Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides.

Pang YP, Singh SK, Gao Y, Lassiter TL, Mishra RK, Zhu KY, Brimijoin S.

PLoS One. 2009;4(2):e4349. doi: 10.1371/journal.pone.0004349. Epub 2009 Feb 4.


Amyloid-beta alters trafficking of internalized acetylcholinesterase and dextran.

Hu W, Gray NW, Brimijoin S.

Int J Physiol Pathophysiol Pharmacol. 2009 Jan 1;1(1):15-24.


Expression and transport of Angiotensin II AT1 receptors in spinal cord, dorsal root ganglia and sciatic nerve of the rat.

Pavel J, Tang H, Brimijoin S, Moughamian A, Nishioku T, Benicky J, Saavedra JM.

Brain Res. 2008 Dec 30;1246:111-22. doi: 10.1016/j.brainres.2008.09.099. Epub 2008 Oct 17.


An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties.

Gao Y, LaFleur D, Shah R, Zhao Q, Singh M, Brimijoin S.

Chem Biol Interact. 2008 Sep 25;175(1-3):83-7. doi: 10.1016/j.cbi.2008.04.024. Epub 2008 May 1.


Angiotensin II type 1 receptors may not influence response of spinal autonomic neurons to axonal damage.

Tang H, Pavel J, Saavedra JM, Brimijoin S.

Neurol Res. 2008 Sep;30(7):751-60. doi: 10.1179/174313208X298020. Epub 2008 May 21.


A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats.

Brimijoin S, Gao Y, Anker JJ, Gliddon LA, Lafleur D, Shah R, Zhao Q, Singh M, Carroll ME.

Neuropsychopharmacology. 2008 Oct;33(11):2715-25. doi: 10.1038/sj.npp.1301666. Epub 2008 Jan 16.

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