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Items: 1 to 50 of 131

1.

Characteristic single glucosinolates from Moringa oleifera: Induction of detoxifying enzymes and lack of genotoxic activity in various model systems.

Förster N, Mewis I, Glatt H, Haack M, Brigelius-Flohé R, Schreiner M, Ulrichs C.

Food Funct. 2016 Nov 9;7(11):4660-4674.

PMID:
27775133
2.

Selenoprotein Gene Nomenclature.

Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonović M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y.

J Biol Chem. 2016 Nov 11;291(46):24036-24040. Epub 2016 Sep 19.

3.

Selenium and redox signaling.

Brigelius-Flohé R, Flohé L.

Arch Biochem Biophys. 2017 Mar 1;617:48-59. doi: 10.1016/j.abb.2016.08.003. Epub 2016 Aug 3. Review.

PMID:
27495740
4.

Mixed results with mixed disulfides.

Brigelius-Flohé R.

Arch Biochem Biophys. 2016 Apr 1;595:81-7. doi: 10.1016/j.abb.2015.11.011. Review.

PMID:
27095221
5.

The evolving versatility of selenium in biology.

Brigelius-Flohé R.

Antioxid Redox Signal. 2015 Oct 1;23(10):757-60. doi: 10.1089/ars.2015.6469.

PMID:
26406357
6.

Revised reference values for selenium intake.

Kipp AP, Strohm D, Brigelius-Flohé R, Schomburg L, Bechthold A, Leschik-Bonnet E, Heseker H; German Nutrition Society (DGE).

J Trace Elem Med Biol. 2015 Oct;32:195-9. doi: 10.1016/j.jtemb.2015.07.005. Epub 2015 Jul 17. Review.

7.

GPx2 Induction Is Mediated Through STAT Transcription Factors During Acute Colitis.

Hiller F, Besselt K, Deubel S, Brigelius-Flohé R, Kipp AP.

Inflamm Bowel Dis. 2015 Sep;21(9):2078-89. doi: 10.1097/MIB.0000000000000464.

PMID:
26115075
8.

Even free radicals should follow some rules: a guide to free radical research terminology and methodology.

Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ 2nd, Vina J, Davies KJ.

Free Radic Biol Med. 2015 Jan;78:233-5. doi: 10.1016/j.freeradbiomed.2014.10.504. Epub 2014 Oct 23.

PMID:
25462642
9.

GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer.

Emmink BL, Laoukili J, Kipp AP, Koster J, Govaert KM, Fatrai S, Verheem A, Steller EJ, Brigelius-Flohé R, Jimenez CR, Borel Rinkes IH, Kranenburg O.

Cancer Res. 2014 Nov 15;74(22):6717-30. doi: 10.1158/0008-5472.CAN-14-1645. Epub 2014 Sep 26.

10.

Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently.

Lippmann D, Lehmann C, Florian S, Barknowitz G, Haack M, Mewis I, Wiesner M, Schreiner M, Glatt H, Brigelius-Flohé R, Kipp AP.

Food Funct. 2014 Jun;5(6):1073-81. doi: 10.1039/c3fo60676g. Epub 2014 Apr 9.

PMID:
24714741
11.

Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development.

Müller MF, Florian S, Pommer S, Osterhoff M, Esworthy RS, Chu FF, Brigelius-Flohé R, Kipp AP.

PLoS One. 2013 Aug 19;8(8):e72055. doi: 10.1371/journal.pone.0072055. eCollection 2013.

12.

A derivatization method for the simultaneous detection of glucosinolates and isothiocyanates in biological samples.

Budnowski J, Hanschen FS, Lehmann C, Haack M, Brigelius-Flohé R, Kroh LW, Blaut M, Rohn S, Hanske L.

Anal Biochem. 2013 Oct 15;441(2):199-207. doi: 10.1016/j.ab.2013.07.002. Epub 2013 Jul 16.

PMID:
23872004
13.

Introduction to serial reviews on selenium and diabetes type 2--an unexpected link.

Brigelius-Flohé R.

Free Radic Biol Med. 2013 Dec;65:1536-7. doi: 10.1016/j.freeradbiomed.2013.07.018. Epub 2013 Jul 15. No abstract available.

PMID:
23867155
14.

Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis.

Kipp AP, Frombach J, Deubel S, Brigelius-Flohé R.

Methods Enzymol. 2013;527:87-112. doi: 10.1016/B978-0-12-405882-8.00005-2.

PMID:
23830627
15.

Selenium in the redox regulation of the Nrf2 and the Wnt pathway.

Brigelius-Flohé R, Kipp AP.

Methods Enzymol. 2013;527:65-86. doi: 10.1016/B978-0-12-405882-8.00004-0.

PMID:
23830626
16.

Glutathione peroxidases.

Brigelius-Flohé R, Maiorino M.

Biochim Biophys Acta. 2013 May;1830(5):3289-303. doi: 10.1016/j.bbagen.2012.11.020. Epub 2012 Nov 29. Review.

PMID:
23201771
17.

TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death.

Barrera LN, Cassidy A, Wang W, Wei T, Belshaw NJ, Johnson IT, Brigelius-Flohé R, Bao Y.

Biochim Biophys Acta. 2012 Oct;1823(10):1914-24. doi: 10.1016/j.bbamcr.2012.07.007. Epub 2012 Jul 20.

18.

Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis.

Brigelius-Flohé R, Kipp AP.

Ann N Y Acad Sci. 2012 Jul;1259:19-25. doi: 10.1111/j.1749-6632.2012.06574.x. Review.

PMID:
22758632
19.

The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium.

Kipp AP, Müller MF, Göken EM, Deubel S, Brigelius-Flohé R.

Biochim Biophys Acta. 2012 Oct;1820(10):1588-96. doi: 10.1016/j.bbagen.2012.05.016. Epub 2012 Jun 7.

PMID:
22683372
20.

The yin and yang of nrf2-regulated selenoproteins in carcinogenesis.

Brigelius-Flohé R, Müller M, Lippmann D, Kipp AP.

Int J Cell Biol. 2012;2012:486147. doi: 10.1155/2012/486147. Epub 2012 May 8.

21.

The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.

Jaschke A, Chung B, Hesse D, Kluge R, Zahn C, Moser M, Petzke KJ, Brigelius-Flohé R, Puchkov D, Koepsell H, Heeren J, Joost HG, Schürmann A.

Hum Mol Genet. 2012 Jul 15;21(14):3128-42. doi: 10.1093/hmg/dds140. Epub 2012 Apr 14.

22.

Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply.

Krehl S, Loewinger M, Florian S, Kipp AP, Banning A, Wessjohann LA, Brauer MN, Iori R, Esworthy RS, Chu FF, Brigelius-Flohé R.

Carcinogenesis. 2012 Mar;33(3):620-8. doi: 10.1093/carcin/bgr288. Epub 2011 Dec 17.

23.

Marginal selenium deficiency down-regulates inflammation-related genes in splenic leukocytes of the mouse.

Kipp AP, Banning A, van Schothorst EM, Méplan C, Coort SL, Evelo CT, Keijer J, Hesketh J, Brigelius-Flohé R.

J Nutr Biochem. 2012 Sep;23(9):1170-7. doi: 10.1016/j.jnutbio.2011.06.011. Epub 2011 Dec 1.

PMID:
22137268
24.

Basic principles and emerging concepts in the redox control of transcription factors.

Brigelius-Flohé R, Flohé L.

Antioxid Redox Signal. 2011 Oct 15;15(8):2335-81. doi: 10.1089/ars.2010.3534. Epub 2011 Apr 5. Review.

25.

Nrf2 target genes are induced under marginal selenium-deficiency.

Müller M, Banning A, Brigelius-Flohé R, Kipp A.

Genes Nutr. 2010 Dec;5(4):297-307. doi: 10.1007/s12263-010-0168-8. Epub 2010 Jan 29.

26.

Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products.

Haack M, Löwinger M, Lippmann D, Kipp A, Pagnotta E, Iori R, Monien BH, Glatt H, Brauer MN, Wessjohann LA, Brigelius-Flohé R.

Biol Chem. 2010 Nov;391(11):1281-93. doi: 10.1515/BC.2010.134.

PMID:
20868228
27.

Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice.

Florian S, Krehl S, Loewinger M, Kipp A, Banning A, Esworthy S, Chu FF, Brigelius-Flohé R.

Free Radic Biol Med. 2010 Dec 1;49(11):1694-702. doi: 10.1016/j.freeradbiomed.2010.08.029. Epub 2010 Sep 7.

28.

Vitamin E: a vitamin still awaiting the detection of its biological function.

Brigelius-Flohé R, Galli F.

Mol Nutr Food Res. 2010 May;54(5):583-7. doi: 10.1002/mnfr.201000091. No abstract available.

PMID:
20458704
29.

Widened horizon of vitamin E research.

Brigelius-Flohé R.

Mol Nutr Food Res. 2010 May;54(5):581. doi: 10.1002/mnfr.201090018. No abstract available.

PMID:
20458703
30.

alpha-Tocopherol enhances degranulation in RBL-2H3 mast cells.

Hemmerling J, Nell S, Kipp A, Schumann S, Deubel S, Haack M, Brigelius-Flohé R.

Mol Nutr Food Res. 2010 May;54(5):652-60. doi: 10.1002/mnfr.200900462.

PMID:
20169586
31.

Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon.

Kipp A, Banning A, van Schothorst EM, Méplan C, Schomburg L, Evelo C, Coort S, Gaj S, Keijer J, Hesketh J, Brigelius-Flohé R.

Mol Nutr Food Res. 2009 Dec;53(12):1561-72. doi: 10.1002/mnfr.200900105.

PMID:
19810021
32.

Commentary: oxidative stress reconsidered.

Brigelius-Flohé R.

Genes Nutr. 2009 Sep;4(3):161-3. doi: 10.1007/s12263-009-0131-8. Epub 2009 Jul 16.

33.

The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E-selectin independently of haem oxygenase-1 expression.

Song H, Bergstrasser C, Rafat N, Höger S, Schmidt M, Endres N, Goebeler M, Hillebrands JL, Brigelius-Flohé R, Banning A, Beck G, Loesel R, Yard BA.

Br J Pharmacol. 2009 Jul;157(5):769-80. doi: 10.1111/j.1476-5381.2009.00215.x. Epub 2009 May 5.

34.

Glutathione peroxidases in different stages of carcinogenesis.

Brigelius-Flohé R, Kipp A.

Biochim Biophys Acta. 2009 Nov;1790(11):1555-68. doi: 10.1016/j.bbagen.2009.03.006. Epub 2009 Mar 13. Review.

PMID:
19289149
35.

Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat.

Meinl W, Sczesny S, Brigelius-Flohé R, Blaut M, Glatt H.

Drug Metab Dispos. 2009 Jun;37(6):1179-86. doi: 10.1124/dmd.108.025916. Epub 2009 Mar 12.

36.

Vitamin E: the shrew waiting to be tamed.

Brigelius-Flohé R.

Free Radic Biol Med. 2009 Mar 1;46(5):543-54. doi: 10.1016/j.freeradbiomed.2008.12.007. Epub 2008 Dec 24. Review.

PMID:
19133328
37.

Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice.

Banning A, Kipp A, Schmitmeier S, Löwinger M, Florian S, Krehl S, Thalmann S, Thierbach R, Steinberg P, Brigelius-Flohé R.

Cancer Res. 2008 Dec 1;68(23):9746-53. doi: 10.1158/0008-5472.CAN-08-1321.

38.

Adverse effects of vitamin E by induction of drug metabolism.

Brigelius-Flohé R.

Genes Nutr. 2007 Dec;2(3):249-56. doi: 10.1007/s12263-007-0055-0. Epub 2007 Oct 16.

39.

The gastrointestinal microbiota affects the selenium status and selenoprotein expression in mice.

Hrdina J, Banning A, Kipp A, Loh G, Blaut M, Brigelius-Flohé R.

J Nutr Biochem. 2009 Aug;20(8):638-48. doi: 10.1016/j.jnutbio.2008.06.009. Epub 2008 Sep 30.

PMID:
18829286
40.

GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells.

Banning A, Florian S, Deubel S, Thalmann S, Müller-Schmehl K, Jacobasch G, Brigelius-Flohé R.

Antioxid Redox Signal. 2008 Sep;10(9):1491-500. doi: 10.1089/ars.2008.2047.

PMID:
18479189
41.

Selenium compounds and selenoproteins in cancer.

Brigelius-Flohé R.

Chem Biodivers. 2008 Mar;5(3):389-95. doi: 10.1002/cbdv.200890039. Review.

PMID:
18357548
42.

Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin.

Kipp A, Banning A, Brigelius-Flohé R.

Biol Chem. 2007 Oct;388(10):1027-33.

PMID:
17937616
43.

Cytoprotective properties of alpha-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes.

González R, Collado JA, Nell S, Briceño J, Tamayo MJ, Fraga E, Bernardos A, López-Cillero P, Pascussi JM, Rufián S, Vilarem MJ, De la Mata M, Brigelius-Flohe R, Maurel P, Muntané J.

Free Radic Biol Med. 2007 Nov 15;43(10):1439-52. Epub 2007 Aug 3.

PMID:
17936189
44.

Improved glucose metabolism in mice lacking alpha-tocopherol transfer protein.

Birringer M, Kuhlow D, Pfluger PT, Landes N, Schulz TJ, Glaubitz M, Florian S, Pfeiffer A, Schuelke M, Brigelius-Flohé R, Ristow M.

Eur J Nutr. 2007 Oct;46(7):397-405. Epub 2007 Sep 19.

PMID:
17882348
45.

PCR-verified microarray analysis and functional in vitro studies indicate a role of alpha-tocopherol in vesicular transport.

Nell S, Bahtz R, Bossecker A, Kipp A, Landes N, Bumke-Vogt C, Halligan E, Lunec J, Brigelius-Flohé R.

Free Radic Res. 2007 Aug;41(8):930-42.

PMID:
17654050
47.

Modulation of pregnane X receptor- and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds.

Kluth D, Banning A, Paur I, Blomhoff R, Brigelius-Flohé R.

Free Radic Biol Med. 2007 Feb 1;42(3):315-25. Epub 2006 Oct 11.

PMID:
17210444
48.

Bioactivity of vitamin E.

Brigelius-Flohé R.

Nutr Res Rev. 2006 Dec;19(2):174-86. doi: 10.1017/S0954422407202938.

PMID:
19079884
49.

Glutathione peroxidases and redox-regulated transcription factors.

Brigelius-Flohé R.

Biol Chem. 2006 Oct-Nov;387(10-11):1329-35. Review.

PMID:
17081103

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