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The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells.

Wilson D, Boyle GM, McIntyre L, Nolan MJ, Parsons PG, Smith JJ, Tribolet L, Loukas A, Liddell MJ, Rash LD, Daly NL.

Toxins (Basel). 2017 Oct 27;9(11). pii: E346. doi: 10.3390/toxins9110346.


MITF and BRN2 contribute to metastatic growth after dissemination of melanoma.

Simmons JL, Pierce CJ, Al-Ejeh F, Boyle GM.

Sci Rep. 2017 Sep 7;7(1):10909. doi: 10.1038/s41598-017-11366-y.


Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis.

Young A, Ngiow SF, Madore J, Reinhardt J, Landsberg J, Chitsazan A, Rautela J, Bald T, Barkauskas DS, Ahern E, Huntington ND, Schadendorf D, Long GV, Boyle GM, Hölzel M, Scolyer RA, Smyth MJ.

Cancer Res. 2017 Sep 1;77(17):4684-4696. doi: 10.1158/0008-5472.CAN-17-0393. Epub 2017 Jun 26.


Furofuran lignans from the Simpson Desert species Eremophila macdonnellii.

Tan YP, Savchenko AI, Broit N, Boyle GM, Parsons PG, Williams CM.

Fitoterapia. 2017 Jul 14. pii: S0367-326X(17)30533-6. doi: 10.1016/j.fitote.2017.06.004. [Epub ahead of print]


Pre-emptive and therapeutic adoptive immunotherapy for nasopharyngeal carcinoma: Phenotype and effector function of T cells impact on clinical response.

Smith C, Lee V, Schuessler A, Beagley L, Rehan S, Tsang J, Li V, Tiu R, Smith D, A Neller M, Matthews KK, Gostick E, Price DA, Burrows J, Boyle GM, Chua D, Panizza B, Porceddu SV, Nicholls J, Kwong D, Khanna R.

Oncoimmunology. 2017 Jan 4;6(2):e1273311. doi: 10.1080/2162402X.2016.1273311. eCollection 2017.


Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.

Shi W, Vu T, Boucher D, Biernacka A, Nde J, Pandita RK, Straube J, Boyle GM, Al-Ejeh F, Nag P, Jeffery J, Harris JL, Bain AL, Grzelak M, Skrzypczak M, Mitra A, Dojer N, Crosetto N, Cloonan N, Becherel OJ, Finnie J, Skaar JR, Walkley CR, Pandita TK, Rowicka M, Ginalski K, Lane SW, Khanna KK.

Blood. 2017 May 4;129(18):2479-2492. doi: 10.1182/blood-2016-06-725093. Epub 2017 Mar 7.


NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF.

Fane ME, Chhabra Y, Hollingsworth DEJ, Simmons JL, Spoerri L, Oh TG, Chauhan J, Chin T, Harris L, Harvey TJ, Muscat GEO, Goding CR, Sturm RA, Haass NK, Boyle GM, Piper M, Smith AG.

EBioMedicine. 2017 Feb;16:63-75. doi: 10.1016/j.ebiom.2017.01.013. Epub 2017 Jan 16.


Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection.

Montes de Oca M, Kumar R, Rivera FL, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Boyle GM, Price RN, Anstey NM, Loughland JR, Burel J, Doolan DL, Haque A, McCarthy JS, Engwerda CR.

Cell Rep. 2016 Oct 4;17(2):399-412. doi: 10.1016/j.celrep.2016.09.015.


Expression profiling of cutaneous squamous cell carcinoma with perineural invasion implicates the p53 pathway in the process.

Warren TA, Broit N, Simmons JL, Pierce CJ, Chawla S, Lambie DL, Quagliotto G, Brown IS, Parsons PG, Panizza BJ, Boyle GM.

Sci Rep. 2016 Sep 26;6:34081. doi: 10.1038/srep34081.


The "melanoma-enriched" microRNA miR-4731-5p acts as a tumour suppressor.

Stark MS, Tom LN, Boyle GM, Bonazzi VF, Soyer HP, Herington AC, Pollock PM, Hayward NK.

Oncotarget. 2016 Aug 2;7(31):49677-49687. doi: 10.18632/oncotarget.10109.


The Complement C3a Receptor Contributes to Melanoma Tumorigenesis by Inhibiting Neutrophil and CD4+ T Cell Responses.

Nabizadeh JA, Manthey HD, Steyn FJ, Chen W, Widiapradja A, Md Akhir FN, Boyle GM, Taylor SM, Woodruff TM, Rolfe BE.

J Immunol. 2016 Jun 1;196(11):4783-92. doi: 10.4049/jimmunol.1600210. Epub 2016 Apr 20.


IL-1 Contributes to the Anti-Cancer Efficacy of Ingenol Mebutate.

Le TT, Skak K, Schroder K, Schroder WA, Boyle GM, Pierce CJ, Suhrbier A.

PLoS One. 2016 Apr 21;11(4):e0153975. doi: 10.1371/journal.pone.0153975. eCollection 2016.


Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.

Chalmers BA, Xing H, Houston S, Clark C, Ghassabian S, Kuo A, Cao B, Reitsma A, Murray CE, Stok JE, Boyle GM, Pierce CJ, Littler SW, Winkler DA, Bernhardt PV, Pasay C, De Voss JJ, McCarthy J, Parsons PG, Walter GH, Smith MT, Cooper HM, Nilsson SK, Tsanaktsidis J, Savage GP, Williams CM.

Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3580-5. doi: 10.1002/anie.201510675. Epub 2016 Feb 5.


Spatiotemporal Characterization of the Cellular and Molecular Contributors to Liver Fibrosis in a Murine Hepatotoxic-Injury Model.

Melino M, Gadd VL, Alexander KA, Beattie L, Lineburg KE, Martinez M, Teal B, Le Texier L, Irvine KM, Miller GC, Boyle GM, Hill GR, Clouston AD, Powell EE, MacDonald KP.

Am J Pathol. 2016 Mar;186(3):524-38. doi: 10.1016/j.ajpath.2015.10.029. Epub 2016 Jan 4.


Novel mouse model for simulating microsurgical tumor excision with facial nerve preservation.

Lim JH, Boyle GM, Panizza B.

Laryngoscope. 2016 Jan;126(1):E1-5. doi: 10.1002/lary.25545. Epub 2015 Aug 8.


Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects.

Gartlan KH, Markey KA, Varelias A, Bunting MD, Koyama M, Kuns RD, Raffelt NC, Olver SD, Lineburg KE, Cheong M, Teal BE, Lor M, Comerford I, Teng MW, Smyth MJ, McCluskey J, Rossjohn J, Stockinger B, Boyle GM, Lane SW, Clouston AD, McColl SR, MacDonald KP, Hill GR.

Blood. 2015 Sep 24;126(13):1609-20. doi: 10.1182/blood-2015-01-622662. Epub 2015 Jul 23.


miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma.

Stark MS, Bonazzi VF, Boyle GM, Palmer JM, Symmons J, Lanagan CM, Schmidt CW, Herington AC, Ballotti R, Pollock PM, Hayward NK.

Oncotarget. 2015 Jul 10;6(19):17753-63.


Mechanisms contributing to differential regulation of PAX3 downstream target genes in normal human epidermal melanocytes versus melanoma cells.

Bartlett D, Boyle GM, Ziman M, Medic S.

PLoS One. 2015 Apr 16;10(4):e0124154. doi: 10.1371/journal.pone.0124154. eCollection 2015.


Autophagy is required for stem cell mobilization by G-CSF.

Leveque-El Mouttie L, Vu T, Lineburg KE, Kuns RD, Bagger FO, Teal BE, Lor M, Boyle GM, Bruedigam C, Mintern JD, Hill GR, MacDonald KP, Lane SW.

Blood. 2015 May 7;125(19):2933-6. doi: 10.1182/blood-2014-03-562660. Epub 2015 Mar 18.


Ectopic expression of protein kinase C-β sensitizes head and neck squamous cell carcinoma to diterpene esters.

Adams RA, D'Souza MM, Pierce CJ, Korica N, Wallwork B, Parsons PG, Panizza B, Boyle GM.

Anticancer Res. 2015 Mar;35(3):1291-6.


Intra-lesional injection of the novel PKC activator EBC-46 rapidly ablates tumors in mouse models.

Boyle GM, D'Souza MM, Pierce CJ, Adams RA, Cantor AS, Johns JP, Maslovskaya L, Gordon VA, Reddell PW, Parsons PG.

PLoS One. 2014 Oct 1;9(10):e108887. doi: 10.1371/journal.pone.0108887. eCollection 2014.


Autologous T-cell therapy for cytomegalovirus as a consolidative treatment for recurrent glioblastoma.

Schuessler A, Smith C, Beagley L, Boyle GM, Rehan S, Matthews K, Jones L, Crough T, Dasari V, Klein K, Smalley A, Alexander H, Walker DG, Khanna R.

Cancer Res. 2014 Jul 1;74(13):3466-76. doi: 10.1158/0008-5472.CAN-14-0296. Epub 2014 May 4.


Modification of T cell responses by stem cell mobilization requires direct signaling of the T cell by G-CSF and IL-10.

MacDonald KP, Le Texier L, Zhang P, Morris H, Kuns RD, Lineburg KE, Leveque L, Don AL, Markey KA, Vuckovic S, Bagger FO, Boyle GM, Blazar BR, Hill GR.

J Immunol. 2014 Apr 1;192(7):3180-9. doi: 10.4049/jimmunol.1302315. Epub 2014 Feb 28.


Multimodal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo.

Rolfe BE, Blakey I, Squires O, Peng H, Boase NR, Alexander C, Parsons PG, Boyle GM, Whittaker AK, Thurecht KJ.

J Am Chem Soc. 2014 Feb 12;136(6):2413-9. doi: 10.1021/ja410351h. Epub 2014 Jan 29.


Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype.

Ohanna M, Cheli Y, Bonet C, Bonazzi VF, Allegra M, Giuliano S, Bille K, Bahadoran P, Giacchero D, Lacour JP, Boyle GM, Hayward NF, Bertolotto C, Ballotti R.

Oncotarget. 2013 Dec;4(12):2212-24.


Evidence for an alternatively spliced MITF exon 2 variant.

Simmons JL, Pierce CJ, Boyle GM.

J Invest Dermatol. 2014 Apr;134(4):1166-1168. doi: 10.1038/jid.2013.426. Epub 2013 Oct 14. No abstract available.


Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment.

Panizza B, Warren TA, Solares CA, Boyle GM, Lambie D, Brown I.

Head Neck. 2014 Nov;36(11):1611-8. doi: 10.1002/hed.23509. Epub 2013 Dec 18.


Plasticity of melanoma in vivo: murine lesions resulting from Trp53, but not Cdk4 or Arf deregulation, display neural transdifferentiation.

Handoko HY, Boyle GM, Ferguson B, Muller HK, Soyer HP, Walker GJ.

Pigment Cell Melanoma Res. 2013 Sep;26(5):731-4. doi: 10.1111/pcmr.12124. Epub 2013 Jun 20.


Loss of T-cadherin (CDH-13) regulates AKT signaling and desensitizes cells to apoptosis in melanoma.

Bosserhoff AK, Ellmann L, Quast AS, Eberle J, Boyle GM, Kuphal S.

Mol Carcinog. 2014 Aug;53(8):635-47. doi: 10.1002/mc.22018. Epub 2013 Apr 26.


REST negatively and ISGF3 positively regulate the human STAT1 gene in melanoma.

Amalraj J, Cutler SJ, Ghazawi I, Boyle GM, Ralph SJ.

Mol Cancer Ther. 2013 Jul;12(7):1288-98. doi: 10.1158/1535-7163.MCT-12-0923. Epub 2013 Apr 18.


Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment.

Dong Y, Stephens C, Walpole C, Swedberg JE, Boyle GM, Parsons PG, McGuckin MA, Harris JM, Clements JA.

PLoS One. 2013;8(2):e57056. doi: 10.1371/journal.pone.0057056. Epub 2013 Feb 25.


UVB-induced melanocyte proliferation in neonatal mice driven by CCR2-independent recruitment of Ly6c(low)MHCII(hi) macrophages.

Handoko HY, Rodero MP, Boyle GM, Ferguson B, Engwerda C, Hill G, Muller HK, Khosrotehrani K, Walker GJ.

J Invest Dermatol. 2013 Jul;133(7):1803-12. doi: 10.1038/jid.2013.9. Epub 2013 Jan 15.


Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms.

Quan J, Johnson NW, Zhou G, Parsons PG, Boyle GM, Gao J.

Cancer Metastasis Rev. 2012 Jun;31(1-2):209-19. doi: 10.1007/s10555-011-9335-7. Review.


A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma.

Yokoyama S, Woods SL, Boyle GM, Aoude LG, MacGregor S, Zismann V, Gartside M, Cust AE, Haq R, Harland M, Taylor JC, Duffy DL, Holohan K, Dutton-Regester K, Palmer JM, Bonazzi V, Stark MS, Symmons J, Law MH, Schmidt C, Lanagan C, O'Connor L, Holland EA, Schmid H, Maskiell JA, Jetann J, Ferguson M, Jenkins MA, Kefford RF, Giles GG, Armstrong BK, Aitken JF, Hopper JL, Whiteman DC, Pharoah PD, Easton DF, Dunning AM, Newton-Bishop JA, Montgomery GW, Martin NG, Mann GJ, Bishop DT, Tsao H, Trent JM, Fisher DE, Hayward NK, Brown KM.

Nature. 2011 Nov 13;480(7375):99-103. doi: 10.1038/nature10630.


Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma.

Bonazzi VF, Nancarrow DJ, Stark MS, Moser RJ, Boyle GM, Aoude LG, Schmidt C, Hayward NK.

PLoS One. 2011;6(10):e26121. doi: 10.1371/journal.pone.0026121. Epub 2011 Oct 20.


Effect of novel marine nutraceuticals on IL-1α-mediated TNF-α release from UVB-irradiated human melanocyte-derived cells.

Muthusamy V, Hodges LD, Macrides TA, Boyle GM, Piva TJ.

Oxid Med Cell Longev. 2011;2011:728645. doi: 10.1155/2011/728645. Epub 2011 Sep 22.


Type I interferons suppress CD4⁺ T-cell-dependent parasite control during blood-stage Plasmodium infection.

Haque A, Best SE, Ammerdorffer A, Desbarrieres L, de Oca MM, Amante FH, de Labastida Rivera F, Hertzog P, Boyle GM, Hill GR, Engwerda CR.

Eur J Immunol. 2011 Sep;41(9):2688-98. doi: 10.1002/eji.201141539. Epub 2011 Aug 8.


Therapy for metastatic melanoma: an overview and update.

Boyle GM.

Expert Rev Anticancer Ther. 2011 May;11(5):725-37. doi: 10.1586/era.11.25. Review.


Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor.

Boyle GM, Woods SL, Bonazzi VF, Stark MS, Hacker E, Aoude LG, Dutton-Regester K, Cook AL, Sturm RA, Hayward NK.

Pigment Cell Melanoma Res. 2011 Jun;24(3):525-37. doi: 10.1111/j.1755-148X.2011.00849.x. Epub 2011 Apr 7.


Serum omega-3 and omega-6 fatty acids and cutaneous p53 expression in an Australian population.

van der Pols JC, Xu C, Boyle GM, Hughes MC, Carr SJ, Parsons PG, Green AC.

Cancer Epidemiol Biomarkers Prev. 2011 Mar;20(3):530-6. doi: 10.1158/1055-9965.EPI-10-0961. Epub 2011 Jan 7.


p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation.

Terzian T, Torchia EC, Dai D, Robinson SE, Murao K, Stiegmann RA, Gonzalez V, Boyle GM, Powell MB, Pollock PM, Lozano G, Robinson WA, Roop DR, Box NF.

Pigment Cell Melanoma Res. 2010 Dec;23(6):781-94. doi: 10.1111/j.1755-148X.2010.00773.x.


Thrombospondin-4 is a putative tumour-suppressor gene in colorectal cancer that exhibits age-related methylation.

Greco SA, Chia J, Inglis KJ, Cozzi SJ, Ramsnes I, Buttenshaw RL, Spring KJ, Boyle GM, Worthley DL, Leggett BA, Whitehall VL.

BMC Cancer. 2010 Sep 16;10:494. doi: 10.1186/1471-2407-10-494.


Caelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian Aplidium caelestis.

Yin S, Boyle GM, Carroll AR, Kotiw M, Dearnaley J, Quinn RJ, Davis RA.

J Nat Prod. 2010 Sep 24;73(9):1586-9. doi: 10.1021/np100329w.


NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1.

Piper M, Barry G, Hawkins J, Mason S, Lindwall C, Little E, Sarkar A, Smith AG, Moldrich RX, Boyle GM, Tole S, Gronostajski RM, Bailey TL, Richards LJ.

J Neurosci. 2010 Jul 7;30(27):9127-39. doi: 10.1523/JNEUROSCI.6167-09.2010.


Pestalactams A-C: novel caprolactams from the endophytic fungus Pestalotiopsis sp.

Davis RA, Carroll AR, Andrews KT, Boyle GM, Tran TL, Healy PC, Kalaitzis JA, Shivas RG.

Org Biomol Chem. 2010 Apr 21;8(8):1785-90. doi: 10.1039/b924169h.


Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma.

Dong Y, Tan OL, Loessner D, Stephens C, Walpole C, Boyle GM, Parsons PG, Clements JA.

Cancer Res. 2010 Apr 1;70(7):2624-33. doi: 10.1158/0008-5472.CAN-09-3415. Epub 2010 Mar 23.


Characterization of the Melanoma miRNAome by Deep Sequencing.

Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, Whiteman DC, Parsons PG, Schmidt C, Sturm RA, Hayward NK.

PLoS One. 2010 Mar 12;5(3):e9685. doi: 10.1371/journal.pone.0009685.


Reduced alphaB-crystallin staining in perineural invasion of head and neck cutaneous squamous cell carcinoma.

Solares CA, Boyle GM, Brown I, Parsons PG, Panizza B.

Otolaryngol Head Neck Surg. 2010 Mar;142(3 Suppl 1):S15-9. doi: 10.1016/j.otohns.2009.12.001.


Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancer.

Merritt MA, Parsons PG, Newton TR, Martyn AC, Webb PM, Green AC, Papadimos DJ, Boyle GM.

BMC Cancer. 2009 Oct 23;9:378. doi: 10.1186/1471-2407-9-378.


The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells.

Mason SA, Cozzi SJ, Pierce CJ, Pavey SJ, Parsons PG, Boyle GM.

Invest New Drugs. 2010 Oct;28(5):575-86. doi: 10.1007/s10637-009-9292-y. Epub 2009 Jul 28.


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