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Oxidative stress, caspase-3 activation and cleavage of ROCK-1 play an essential role in MeHg-induced cell death in primary astroglial cells.

Dos Santos AA, López-Granero C, Farina M, Rocha JBT, Bowman AB, Aschner M.

Food Chem Toxicol. 2018 Mar;113:328-336. doi: 10.1016/j.fct.2018.01.057. Epub 2018 Feb 8.


Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming.

Armstrong LC, Westlake G, Snow JP, Cawthon B, Armour E, Bowman AB, Ess KC.

Hum Mol Genet. 2017 Dec 1;26(23):4629-4641. doi: 10.1093/hmg/ddx345.


From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons.

Neely MD, Davison CA, Aschner M, Bowman AB.

Toxicol Sci. 2017 Oct 1;159(2):366-379. doi: 10.1093/toxsci/kfx145.


Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders.

Bryan MR, Bowman AB.

Adv Neurobiol. 2017;18:113-142. doi: 10.1007/978-3-319-60189-2_6. Review.


Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line.

Bryan MR, Uhouse MA, Nordham KD, Joshi P, Rose DIR, O'Brien MT, Aschner M, Bowman AB.

Neurotoxicology. 2018 Jan;64:185-194. doi: 10.1016/j.neuro.2017.07.026. Epub 2017 Aug 2.


Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.

Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely DM, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V.

Sci Rep. 2017 Jul 13;7(1):5280. doi: 10.1038/s41598-017-05709-y.


Phenotypic Discordance in Siblings with Identical Compound Heterozygous PARK2 Mutations.

Isaacs D, Claassen D, Bowman AB, Hedera P.

Brain Sci. 2017 Jun 24;7(7). pii: E71. doi: 10.3390/brainsci7070071.


Relationships Between Essential Manganese Biology and Manganese Toxicity in Neurological Disease.

Pfalzer AC, Bowman AB.

Curr Environ Health Rep. 2017 Jun;4(2):223-228. doi: 10.1007/s40572-017-0136-1. Review.


Accelerated differentiation of human induced pluripotent stem cells to blood-brain barrier endothelial cells.

Hollmann EK, Bailey AK, Potharazu AV, Neely MD, Bowman AB, Lippmann ES.

Fluids Barriers CNS. 2017 Apr 13;14(1):9. doi: 10.1186/s12987-017-0059-0.


BXD recombinant inbred strains participate in social preference, anxiety and depression behaviors along sex-differences in cytokines and tactile allodynia.

López-Granero C, Antunes Dos Santos A, Ferrer B, Culbreth M, Chakraborty S, Barrasa A, Gulinello M, Bowman AB, Aschner M.

Psychoneuroendocrinology. 2017 Jun;80:92-98. doi: 10.1016/j.psyneuen.2017.03.006. Epub 2017 Mar 6.


Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model.

Bichell TJV, Wegrzynowicz M, Tipps KG, Bradley EM, Uhouse MA, Bryan M, Horning K, Fisher N, Dudek K, Halbesma T, Umashanker P, Stubbs AD, Holt HK, Kwakye GF, Tidball AM, Colbran RJ, Aschner M, Neely MD, Di Pardo A, Maglione V, Osmand A, Bowman AB.

Biochim Biophys Acta. 2017 Jun;1863(6):1596-1604. doi: 10.1016/j.bbadis.2017.02.013. Epub 2017 Feb 16.


Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit.

Brown JA, Codreanu SG, Shi M, Sherrod SD, Markov DA, Neely MD, Britt CM, Hoilett OS, Reiserer RS, Samson PC, McCawley LJ, Webb DJ, Bowman AB, McLean JA, Wikswo JP.

J Neuroinflammation. 2016 Dec 12;13(1):306.


Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington's Disease.

Osmand AP, Bichell TJ, Bowman AB, Bates GP.

J Huntingtons Dis. 2016 Dec 15;5(4):343-346.


"Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies".

Peres TV, Schettinger MR, Chen P, Carvalho F, Avila DS, Bowman AB, Aschner M.

BMC Pharmacol Toxicol. 2016 Nov 4;17(1):57. Review.


Sex- and structure-specific differences in antioxidant responses to methylmercury during early development.

Ruszkiewicz JA, Bowman AB, Farina M, Rocha JBT, Aschner M.

Neurotoxicology. 2016 Sep;56:118-126. doi: 10.1016/j.neuro.2016.07.009. Epub 2016 Jul 22.


Linear and Curvilinear Trajectories of Cortical Loss with Advancing Age and Disease Duration in Parkinson's Disease.

Claassen DO, Dobolyi DG, Isaacs DA, Roman OC, Herb J, Wylie SA, Neimat JS, Donahue MJ, Hedera P, Zald DH, Landman BA, Bowman AB, Dawant BM, Rane S.

Aging Dis. 2016 May 27;7(3):220-9. doi: 10.14336/AD.2015.1110. eCollection 2016 May.


Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells.

Tidball AM, Neely MD, Chamberlin R, Aboud AA, Kumar KK, Han B, Bryan MR, Aschner M, Ess KC, Bowman AB.

PLoS One. 2016 Mar 16;11(3):e0150372. doi: 10.1371/journal.pone.0150372. eCollection 2016.


Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor.

Brown JA, Pensabene V, Markov DA, Allwardt V, Neely MD, Shi M, Britt CM, Hoilett OS, Yang Q, Brewer BM, Samson PC, McCawley LJ, May JM, Webb DJ, Li D, Bowman AB, Reiserer RS, Wikswo JP.

Biomicrofluidics. 2015 Oct 26;9(5):054124. doi: 10.1063/1.4934713. eCollection 2015 Sep.


Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.

Pancani T, Foster DJ, Moehle MS, Bichell TJ, Bradley E, Bridges TM, Klar R, Poslusney M, Rook JM, Daniels JS, Niswender CM, Jones CK, Wood MR, Bowman AB, Lindsley CW, Xiang Z, Conn PJ.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14078-83. doi: 10.1073/pnas.1512812112. Epub 2015 Oct 27.


SLC30A10: A novel manganese transporter.

Chen P, Bowman AB, Mukhopadhyay S, Aschner M.

Worm. 2015 May 11;4(3):e1042648. doi: 10.1080/21624054.2015.1042648. eCollection 2015 Jul-Sep.


Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.

Wegrzynowicz M, Bichell TJ, Soares BD, Loth MK, McGlothan JS, Mori S, Alikhan FS, Hua K, Coughlin JM, Holt HK, Jetter CS, Pomper MG, Osmand AP, Guilarte TR, Bowman AB.

J Huntingtons Dis. 2015;4(1):17-36.


RNASeq in C. elegans Following Manganese Exposure.

Parmalee NL, Maqbool SB, Ye B, Calder B, Bowman AB, Aschner M.

Curr Protoc Toxicol. 2015 Aug 6;65:11.20.1-17. doi: 10.1002/0471140856.tx1120s65.


Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes.

Chun YW, Balikov DA, Feaster TK, Williams CH, Sheng CC, Lee JB, Boire TC, Neely MD, Bellan LM, Ess KC, Bowman AB, Sung HJ, Hong CC.

Biomaterials. 2015 Oct;67:52-64. doi: 10.1016/j.biomaterials.2015.07.004. Epub 2015 Jul 14.


Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features.

Kwakye GF, Paoliello MM, Mukhopadhyay S, Bowman AB, Aschner M.

Int J Environ Res Public Health. 2015 Jul 6;12(7):7519-40. doi: 10.3390/ijerph120707519. Review.


Manganese homeostasis in the nervous system.

Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello MM, Bowman AB, Aschner M.

J Neurochem. 2015 Aug;134(4):601-10. doi: 10.1111/jnc.13170. Epub 2015 Jun 16. Review.


Manganese Is Essential for Neuronal Health.

Horning KJ, Caito SW, Tipps KG, Bowman AB, Aschner M.

Annu Rev Nutr. 2015;35:71-108. doi: 10.1146/annurev-nutr-071714-034419. Epub 2015 May 13. Review.


Manganese-induced Neurotoxicity: From C. elegans to Humans.

Chen P, Chakraborty S, Peres TV, Bowman AB, Aschner M.

Toxicol Res (Camb). 2015 Mar 1;4(2):191-202.


Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans.

Chakraborty S, Chen P, Bornhorst J, Schwerdtle T, Schumacher F, Kleuser B, Bowman AB, Aschner M.

Metallomics. 2015 May;7(5):847-56. doi: 10.1039/c5mt00052a. Epub 2015 Mar 13.


Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status.

Kumar KK, Goodwin CR, Uhouse MA, Bornhorst J, Schwerdtle T, Aschner M, McLean JA, Bowman AB.

Metallomics. 2015 Feb;7(2):363-70. doi: 10.1039/c4mt00223g.


Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease.

Chen P, DeWitt MR, Bornhorst J, Soares FA, Mukhopadhyay S, Bowman AB, Aschner M.

Metallomics. 2015 Feb;7(2):289-98. doi: 10.1039/c4mt00292j.


A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease.

Tidball AM, Bryan MR, Uhouse MA, Kumar KK, Aboud AA, Feist JE, Ess KC, Neely MD, Aschner M, Bowman AB.

Hum Mol Genet. 2015 Apr 1;24(7):1929-44. doi: 10.1093/hmg/ddu609. Epub 2014 Dec 8.


Cellular manganese content is developmentally regulated in human dopaminergic neurons.

Kumar KK, Lowe EW Jr, Aboud AA, Neely MD, Redha R, Bauer JA, Odak M, Weaver CD, Meiler J, Aschner M, Bowman AB.

Sci Rep. 2014 Oct 28;4:6801. doi: 10.1038/srep06801.


SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity.

Leyva-Illades D, Chen P, Zogzas CE, Hutchens S, Mercado JM, Swaim CD, Morrisett RA, Bowman AB, Aschner M, Mukhopadhyay S.

J Neurosci. 2014 Oct 15;34(42):14079-95. doi: 10.1523/JNEUROSCI.2329-14.2014.


PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper.

Aboud AA, Tidball AM, Kumar KK, Neely MD, Han B, Ess KC, Hong CC, Erikson KM, Hedera P, Bowman AB.

Neurobiol Dis. 2015 Jan;73:204-12. doi: 10.1016/j.nbd.2014.10.002. Epub 2014 Oct 12.


BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity.

Stansfield KH, Bichell TJ, Bowman AB, Guilarte TR.

J Neurochem. 2014 Dec;131(5):655-66. doi: 10.1111/jnc.12926. Epub 2014 Sep 2.


Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension.

West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM.

Am J Physiol Cell Physiol. 2014 Sep 1;307(5):C415-30. doi: 10.1152/ajpcell.00057.2014. Epub 2014 May 28.


Considerations on manganese (Mn) treatments for in vitro studies.

Bowman AB, Aschner M.

Neurotoxicology. 2014 Mar;41:141-2. doi: 10.1016/j.neuro.2014.01.010. Epub 2014 Feb 5.


Gammaretroviral vector encoding a fluorescent marker to facilitate detection of reprogrammed human fibroblasts during iPSC generation.

Srinivasakumar N, Zaboikin M, Tidball AM, Aboud AA, Neely MD, Ess KC, Bowman AB, Schuening FG.

PeerJ. 2013 Dec 10;1:e224. doi: 10.7717/peerj.224. eCollection 2013.


Optimization of fluorescence assay of cellular manganese status for high throughput screening.

Kumar KK, Aboud AA, Patel DK, Aschner M, Bowman AB.

J Biochem Mol Toxicol. 2013 Jan;27(1):42-9. doi: 10.1002/jbt.21457. Epub 2012 Nov 20.


Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects.

Aboud AA, Tidball AM, Kumar KK, Neely MD, Ess KC, Erikson KM, Bowman AB.

Neurotoxicology. 2012 Dec;33(6):1443-9. doi: 10.1016/j.neuro.2012.10.009. Epub 2012 Oct 22.


DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.

Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB.

ACS Chem Neurosci. 2012 Jun 20;3(6):482-91. doi: 10.1021/cn300029t. Epub 2012 Mar 5.


Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism.

Madison JL, Wegrzynowicz M, Aschner M, Bowman AB.

PLoS One. 2012;7(2):e31024. doi: 10.1371/journal.pone.0031024. Epub 2012 Feb 17.


The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk.

Kumar KK, Aboud AA, Bowman AB.

Neurotoxicology. 2012 Jun;33(3):518-29. doi: 10.1016/j.neuro.2012.02.005. Epub 2012 Feb 11. Review.


Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese.

Wegrzynowicz M, Holt HK, Friedman DB, Bowman AB.

J Proteome Res. 2012 Feb 3;11(2):1118-32. doi: 10.1021/pr200839d. Epub 2012 Jan 20.


DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model.

Xu L, Mirnics K, Bowman AB, Liu W, Da J, Porter NA, Korade Z.

Neurobiol Dis. 2012 Mar;45(3):923-9. doi: 10.1016/j.nbd.2011.12.011. Epub 2011 Dec 11.


ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.

Lee Y, Fryer JD, Kang H, Crespo-Barreto J, Bowman AB, Gao Y, Kahle JJ, Hong JS, Kheradmand F, Orr HT, Finegold MJ, Zoghbi HY.

Dev Cell. 2011 Oct 18;21(4):746-57. doi: 10.1016/j.devcel.2011.08.017.


Role of manganese in neurodegenerative diseases.

Bowman AB, Kwakye GF, Herrero Hernández E, Aschner M.

J Trace Elem Med Biol. 2011 Dec;25(4):191-203. doi: 10.1016/j.jtemb.2011.08.144. Epub 2011 Oct 1. Review.


Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response.

Grover VK, Valadez JG, Bowman AB, Cooper MK.

PLoS One. 2011;6(7):e21353. doi: 10.1371/journal.pone.0021353. Epub 2011 Jul 1.


Gender and manganese exposure interactions on mouse striatal neuron morphology.

Madison JL, Wegrzynowicz M, Aschner M, Bowman AB.

Neurotoxicology. 2011 Dec;32(6):896-906. doi: 10.1016/j.neuro.2011.05.007. Epub 2011 May 27.


Cellular fura-2 manganese extraction assay (CFMEA).

Kwakye GF, Li D, Kabobel OA, Bowman AB.

Curr Protoc Toxicol. 2011 May;Chapter 12:Unit12.18. doi: 10.1002/0471140856.tx1218s48.

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