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CRISPR/Cas9 for cancer research and therapy.

Zhan T, Rindtorff N, Betge J, Ebert MP, Boutros M.

Semin Cancer Biol. 2018 Apr 16. pii: S1044-579X(17)30274-2. doi: 10.1016/j.semcancer.2018.04.001. [Epub ahead of print] Review.


The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division.

Dix CL, Matthews HK, Uroz M, McLaren S, Wolf L, Heatley N, Win Z, Almada P, Henriques R, Boutros M, Trepat X, Baum B.

Dev Cell. 2018 Apr 9;45(1):132-145.e3. doi: 10.1016/j.devcel.2018.03.009.


Systematic characterization of pan-cancer mutation clusters.

Buljan M, Blattmann P, Aebersold R, Boutros M.

Mol Syst Biol. 2018 Mar 23;14(3):e7974. doi: 10.15252/msb.20177974.


A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment.

Shen J, Najafi S, Stäble S, Fabian J, Koeneke E, Kolbinger FR, Wrobel JK, Meder B, Distel M, Heimburg T, Sippl W, Jung M, Peterziel H, Kranz D, Boutros M, Westermann F, Witt O, Oehme I.

Cell Death Differ. 2018 Mar 7. doi: 10.1038/s41418-018-0080-0. [Epub ahead of print]


RNA Interference (RNAi) Screening in Drosophila.

Heigwer F, Port F, Boutros M.

Genetics. 2018 Mar;208(3):853-874. doi: 10.1534/genetics.117.300077.


Toward an integrated map of genetic interactions in cancer cells.

Rauscher B, Heigwer F, Henkel L, Hielscher T, Voloshanenko O, Boutros M.

Mol Syst Biol. 2018 Feb 21;14(2):e7656. doi: 10.15252/msb.20177656.


β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells.

Voloshanenko O, Schwartz U, Kranz D, Rauscher B, Linnebacher M, Augustin I, Boutros M.

Sci Rep. 2018 Feb 16;8(1):3178. doi: 10.1038/s41598-018-20641-5.


Clinical and Economic Impact of an Enhanced Recovery Pathway for Open and Laparoscopic Rectal Surgery.

Garfinkle R, Boutros M, Ghitulescu G, Vasilevsky CA, Charlebois P, Liberman S, Stein B, Feldman LS, Lee L.

J Laparoendosc Adv Surg Tech A. 2018 Feb 16. doi: 10.1089/lap.2017.0677. [Epub ahead of print]


ERAD-dependent control of the Wnt secretory factor Evi.

Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M.

EMBO J. 2018 Feb 15;37(4). pii: e97311. doi: 10.15252/embj.201797311. Epub 2018 Jan 29.


Widespread Rewiring of Genetic Networks upon Cancer Signaling Pathway Activation.

Billmann M, Chaudhary V, ElMaghraby MF, Fischer B, Boutros M.

Cell Syst. 2018 Jan 24;6(1):52-64.e4. doi: 10.1016/j.cels.2017.10.015. Epub 2017 Nov 30.


Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane.

Menck K, Sönmezer C, Worst TS, Schulz M, Dihazi GH, Streit F, Erdmann G, Kling S, Boutros M, Binder C, Gross JC.

J Extracell Vesicles. 2017 Sep 26;6(1):1378056. doi: 10.1080/20013078.2017.1378056. eCollection 2017.


The Authors Reply.

Garfinkle R, Boutros M.

Dis Colon Rectum. 2017 Dec;60(12):e641. doi: 10.1097/DCR.0000000000000952. No abstract available.


Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice.

Leibing T, Géraud C, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS.

Hepatology. 2017 Oct 23. doi: 10.1002/hep.29613. [Epub ahead of print]


An RNAi Screen Reveals an Essential Role for HIPK4 in Human Skin Epithelial Differentiation from iPSCs.

Larribère L, Galach M, Novak D, Arévalo K, Volz HC, Stark HJ, Boukamp P, Boutros M, Utikal J.

Stem Cell Reports. 2017 Oct 10;9(4):1234-1245. doi: 10.1016/j.stemcr.2017.08.023. Epub 2017 Sep 28.


Incidence Rates and Predictors of Colectomy for Ulcerative Colitis in the Era of Biologics: Results from a Provincial Database.

Abou Khalil M, Boutros M, Nedjar H, Morin N, Ghitulescu G, Vasilevsky CA, Gordon P, Rahme E.

J Gastrointest Surg. 2018 Jan;22(1):124-132. doi: 10.1007/s11605-017-3530-y. Epub 2017 Aug 14.


Clinical practice guideline for enhanced recovery after colon and rectal surgery from the American Society of Colon and Rectal Surgeons (ASCRS) and Society of American Gastrointestinal and Endoscopic Surgeons (SAGES).

Carmichael JC, Keller DS, Baldini G, Bordeianou L, Weiss E, Lee L, Boutros M, McClane J, Steele SR, Feldman LS.

Surg Endosc. 2017 Sep;31(9):3412-3436. doi: 10.1007/s00464-017-5722-7. Epub 2017 Aug 3. No abstract available.


The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction.

Meyer IS, Jungmann A, Dieterich C, Zhang M, Lasitschka F, Werkmeister S, Haas J, Müller OJ, Boutros M, Nahrendorf M, Katus HA, Hardt SE, Leuschner F.

EMBO Mol Med. 2017 Sep;9(9):1279-1293. doi: 10.15252/emmm.201707565.


Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

Voloshanenko O, Gmach P, Winter J, Kranz D, Boutros M.

FASEB J. 2017 Nov;31(11):4832-4844. doi: 10.1096/fj.201700144R. Epub 2017 Jul 21.


Cost of Ulcerative Colitis in Quebec, Canada: A Retrospective Cohort Study.

Dan A, Boutros M, Nedjar H, Kopylov U, Afif W, Khalil MA, Rahme E.

Inflamm Bowel Dis. 2017 Aug;23(8):1262-1271. doi: 10.1097/MIB.0000000000001147.


Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and Society of American Gastrointestinal and Endoscopic Surgeons.

Carmichael JC, Keller DS, Baldini G, Bordeianou L, Weiss E, Lee L, Boutros M, McClane J, Feldman LS, Steele SR.

Dis Colon Rectum. 2017 Aug;60(8):761-784. doi: 10.1097/DCR.0000000000000883. No abstract available.


Clinical and Histopathologic Features of Colorectal Adenocarcinoma in Crohn's Disease.

Galata C, Hirsch D, Reindl W, Post S, Kienle P, Boutros M, Gaiser T, Horisberger K.

J Clin Gastroenterol. 2017 Jun 26. doi: 10.1097/MCG.0000000000000817. [Epub ahead of print]


Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks.

Merk K, Breinig M, Böttcher R, Krebs S, Blum H, Boutros M, Förstemann K.

PLoS Genet. 2017 Jun 19;13(6):e1006861. doi: 10.1371/journal.pgen.1006861. eCollection 2017 Jun.


Phenotype databases for genetic screens in human cells.

Rauscher B, Valentini E, Hardeland U, Boutros M.

J Biotechnol. 2017 Nov 10;261:63-69. doi: 10.1016/j.jbiotec.2017.06.008. Epub 2017 Jun 16.


Is There a Role for Oral Antibiotic Preparation Alone Before Colorectal Surgery? ACS-NSQIP Analysis by Coarsened Exact Matching.

Garfinkle R, Abou-Khalil J, Morin N, Ghitulescu G, Vasilevsky CA, Gordon P, Demian M, Boutros M.

Dis Colon Rectum. 2017 Jul;60(7):729-737. doi: 10.1097/DCR.0000000000000851.


The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells.

Nötzold L, Frank L, Gandhi M, Polycarpou-Schwarz M, Groß M, Gunkel M, Beil N, Erfle H, Harder N, Rohr K, Trendel J, Krijgsveld J, Longerich T, Schirmacher P, Boutros M, Erhardt S, Diederichs S.

Sci Rep. 2017 May 23;7(1):2265. doi: 10.1038/s41598-017-02357-0.


Oxygenation and adenosine deaminase support growth and proliferation of ex vivo cultured Drosophila wing imaginal discs.

Strassburger K, Lorbeer FK, Lutz M, Graf F, Boutros M, Teleman AA.

Development. 2017 Jul 1;144(13):2529-2538. doi: 10.1242/dev.147538. Epub 2017 May 19.


HTSvis: a web app for exploratory data analysis and visualization of arrayed high-throughput screens.

Scheeder C, Heigwer F, Boutros M.

Bioinformatics. 2017 Sep 15;33(18):2960-2962. doi: 10.1093/bioinformatics/btx319.


Study protocol evaluating the use of bowel stimulation before loop ileostomy closure to reduce postoperative ileus: a multicenter randomized controlled trial.

Garfinkle R, Trabulsi N, Morin N, Phang T, Liberman S, Feldman L, Fried G, Boutros M.

Colorectal Dis. 2017 Nov;19(11):1024-1029. doi: 10.1111/codi.13720.


Incidence of incisional hernia in the specimen extraction site for laparoscopic colorectal surgery: systematic review and meta-analysis.

Lee L, Abou-Khalil M, Liberman S, Boutros M, Fried GM, Feldman LS.

Surg Endosc. 2017 Dec;31(12):5083-5093. doi: 10.1007/s00464-017-5573-2. Epub 2017 Apr 25.


Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker.

Worst TS, von Hardenberg J, Gross JC, Erben P, Schnölzer M, Hausser I, Bugert P, Michel MS, Boutros M.

Mol Cell Proteomics. 2017 Jun;16(6):998-1008. doi: 10.1074/mcp.M117.068577. Epub 2017 Apr 9.


ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration.

Zhou J, Edgar BA, Boutros M.

Nat Commun. 2017 Mar 8;8:14289. doi: 10.1038/ncomms14289.


The lncRNA VELUCT strongly regulates viability of lung cancer cells despite its extremely low abundance.

Seiler J, Breinig M, Caudron-Herger M, Polycarpou-Schwarz M, Boutros M, Diederichs S.

Nucleic Acids Res. 2017 May 19;45(9):5458-5469. doi: 10.1093/nar/gkx076.


The State of Systems Genetics in 2017.

Baliga NS, Björkegren JL, Boeke JD, Boutros M, Crawford NP, Dudley AM, Farber CR, Jones A, Levey AI, Lusis AJ, Mak HC, Nadeau JH, Noyes MB, Petretto E, Seyfried NT, Steinmetz LM, Vonesch SC.

Cell Syst. 2017 Jan 25;4(1):7-15. doi: 10.1016/j.cels.2017.01.005.


Systematic epistatic mapping of cellular processes.

Billmann M, Boutros M.

Cell Div. 2017 Jan 6;12:2. doi: 10.1186/s13008-016-0028-z. eCollection 2017.


Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells.

Augustin I, Dewi DL, Hundshammer J, Erdmann G, Kerr G, Boutros M.

Sci Signal. 2017 Jan 10;10(461). pii: eaah6829. doi: 10.1126/scisignal.aah6829.


Immune cell recruitment in teratomas is impaired by increased Wnt secretion.

Augustin I, Dewi DL, Hundshammer J, Rempel E, Brunk F, Boutros M.

Stem Cell Res. 2016 Nov;17(3):607-615. doi: 10.1016/j.scr.2016.10.010. Epub 2016 Oct 29.


Pharmacological Inhibition of Centrosome Clustering by Slingshot-Mediated Cofilin Activation and Actin Cortex Destabilization.

Konotop G, Bausch E, Nagai T, Turchinovich A, Becker N, Benner A, Boutros M, Mizuno K, Krämer A, Raab MS.

Cancer Res. 2016 Nov 15;76(22):6690-6700. doi: 10.1158/0008-5472.CAN-16-1144. Epub 2016 Sep 13.


GenomeCRISPR - a database for high-throughput CRISPR/Cas9 screens.

Rauscher B, Heigwer F, Breinig M, Winter J, Boutros M.

Nucleic Acids Res. 2017 Jan 4;45(D1):D679-D686. doi: 10.1093/nar/gkw997. Epub 2016 Oct 26.


Laparoscopic colorectal cancer resections in the obese: a systematic review.

Fung A, Trabulsi N, Morris M, Garfinkle R, Saleem A, Wexner SD, Vasilevsky CA, Boutros M.

Surg Endosc. 2017 May;31(5):2072-2088. doi: 10.1007/s00464-016-5209-y. Epub 2016 Oct 24. Review.


Methods for High-Throughput RNAi Screening in Drosophila Cells.

Billmann M, Boutros M.

Methods Mol Biol. 2016;1478:95-116. Review.


A global genetic interaction network maps a wiring diagram of cellular function.

Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, Pelechano V, Styles EB, Billmann M, van Leeuwen J, van Dyk N, Lin ZY, Kuzmin E, Nelson J, Piotrowski JS, Srikumar T, Bahr S, Chen Y, Deshpande R, Kurat CF, Li SC, Li Z, Usaj MM, Okada H, Pascoe N, San Luis BJ, Sharifpoor S, Shuteriqi E, Simpkins SW, Snider J, Suresh HG, Tan Y, Zhu H, Malod-Dognin N, Janjic V, Przulj N, Troyanskaya OG, Stagljar I, Xia T, Ohya Y, Gingras AC, Raught B, Boutros M, Steinmetz LM, Moore CL, Rosebrock AP, Caudy AA, Myers CL, Andrews B, Boone C.

Science. 2016 Sep 23;353(6306). pii: aaf1420.


Wnt signaling in cancer.

Zhan T, Rindtorff N, Boutros M.

Oncogene. 2017 Mar;36(11):1461-1473. doi: 10.1038/onc.2016.304. Epub 2016 Sep 12. Review.


Recurrent Versus Persistent Diverticulitis: An Important Distinction.

Garfinkle R, Boutros M.

Dis Colon Rectum. 2016 Oct;59(10):e437. doi: 10.1097/DCR.0000000000000674. No abstract available.


Biochemical Methods to Analyze Wnt Protein Secretion.

Glaeser K, Boutros M, Gross JC.

Methods Mol Biol. 2016;1481:17-28. doi: 10.1007/978-1-4939-6393-5_3.


A Protocol for a High-Throughput Multiplex Cell Viability Assay.

Gilbert DF, Boutros M.

Methods Mol Biol. 2016;1470:75-84. doi: 10.1007/978-1-4939-6337-9_6.


Diverticular Abscess Managed With Long-term Definitive Nonoperative Intent Is Safe.

Garfinkle R, Kugler A, Pelsser V, Vasilevsky CA, Morin N, Gordon P, Feldman L, Boutros M.

Dis Colon Rectum. 2016 Jul;59(7):648-55. doi: 10.1097/DCR.0000000000000624.


Clinical Practice Guidelines for Colon Volvulus and Acute Colonic Pseudo-Obstruction.

Vogel JD, Feingold DL, Stewart DB, Turner JS, Boutros M, Chun J, Steele SR.

Dis Colon Rectum. 2016 Jul;59(7):589-600. doi: 10.1097/DCR.0000000000000602. No abstract available.


Refining Pathways: A Model Comparison Approach.

Moffa G, Erdmann G, Voloshanenko O, Hundsrucker C, Sadeh MJ, Boutros M, Spang R.

PLoS One. 2016 Jun 1;11(6):e0155999. doi: 10.1371/journal.pone.0155999. eCollection 2016.


Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.

Chatterjee N, Tian M, Spirohn K, Boutros M, Bohmann D.

PLoS Genet. 2016 May 27;12(5):e1006072. doi: 10.1371/journal.pgen.1006072. eCollection 2016 May.


CT-based adaptive high-dose-rate endorectal brachytherapy in the preoperative treatment of locally advanced rectal cancer: Technical and practical aspects.

Nout RA, Devic S, Niazi T, Wyse J, Boutros M, Pelsser V, Vuong T.

Brachytherapy. 2016 Jul-Aug;15(4):477-484. doi: 10.1016/j.brachy.2016.03.004. Epub 2016 Apr 16.


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