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Items: 1 to 50 of 241


Visualization of breast cancer metabolism using multimodal non-linear optical microscopy of cellular lipids and redox state.

Hou J, Williams J, Botvinick E, Potma E, Tromberg BJ.

Cancer Res. 2018 Mar 13. pii: canres.2618.2017. doi: 10.1158/0008-5472.CAN-17-2618. [Epub ahead of print]


Sprouting angiogenesis induces significant mechanical heterogeneities and ECM stiffening across length scales in fibrin hydrogels.

Juliar BA, Keating MT, Kong YP, Botvinick EL, Putnam AJ.

Biomaterials. 2018 Apr;162:99-108. doi: 10.1016/j.biomaterials.2018.02.012. Epub 2018 Feb 6.


A combined static-dynamic single-dose imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT.

Sciammarella M, Shrestha UM, Seo Y, Gullberg GT, Botvinick EH.

J Nucl Cardiol. 2017 Aug 3. doi: 10.1007/s12350-017-1016-7. [Epub ahead of print]


Spatial distributions of pericellular stiffness in natural extracellular matrices are dependent on cell-mediated proteolysis and contractility.

Keating M, Kurup A, Alvarez-Elizondo M, Levine AJ, Botvinick E.

Acta Biomater. 2017 Jul 15;57:304-312. doi: 10.1016/j.actbio.2017.05.008. Epub 2017 May 5.


Vascularization and innervation of slits within polydimethylsiloxane sheets in the subcutaneous space of athymic nude mice.

Gurlin RE, Keating MT, Li S, Lakey JR, de Feraudy S, Shergill BS, Botvinick EL.

J Tissue Eng. 2017 Jan 30;8:2041731417691645. doi: 10.1177/2041731417691645. eCollection 2017 Jan-Dec.


Noninvasive PET quantitative myocardial blood flow with regadenoson for assessing cardiac allograft vasculopathy in orthotopic heart transplantation patients.

Pampaloni MH, Shrestha UM, Sciammarella M, Seo Y, Gullberg GT, Botvinick EH.

J Nucl Cardiol. 2017 Aug;24(4):1134-1144. doi: 10.1007/s12350-016-0761-3. Epub 2017 Jan 30.


Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth.

Romero-López M, Trinh AL, Sobrino A, Hatch MM, Keating MT, Fimbres C, Lewis DE, Gershon PD, Botvinick EL, Digman M, Lowengrub JS, Hughes CC.

Biomaterials. 2017 Feb;116:118-129. doi: 10.1016/j.biomaterials.2016.11.034. Epub 2016 Nov 24.


Evolution of Multivalent Nanoparticle Adhesion via Specific Molecular Interactions.

Wang M, Ravindranath SR, Rahim MK, Botvinick EL, Haun JB.

Langmuir. 2016 Dec 13;32(49):13124-13136. Epub 2016 Dec 5.


Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen.

Hsieh JY, Smith TD, Meli VS, Tran TN, Botvinick EL, Liu WF.

Acta Biomater. 2017 Jan 1;47:14-24. doi: 10.1016/j.actbio.2016.09.024. Epub 2016 Sep 20.


Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering.

Arulmoli J, Wright HJ, Phan DTT, Sheth U, Que RA, Botten GA, Keating M, Botvinick EL, Pathak MM, Zarembinski TI, Yanni DS, Razorenova OV, Hughes CCW, Flanagan LA.

Acta Biomater. 2016 Oct 1;43:122-138. doi: 10.1016/j.actbio.2016.07.043. Epub 2016 Jul 27.


Utility of Equilibrium Radionuclide Angiogram-Derived Measures of Dyssynchrony to Predict Outcomes in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy.

Badhwar N, James J, Hoffmayer KS, O'Connell JW, Green D, De Marco T, Botvinick EH.

J Nucl Med. 2016 Dec;57(12):1880-1886. Epub 2016 Jul 14.


Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Fong AH, Romero-López M, Heylman CM, Keating M, Tran D, Sobrino A, Tran AQ, Pham HH, Fimbres C, Gershon PD, Botvinick EL, George SC, Hughes CC.

Tissue Eng Part A. 2016 Aug;22(15-16):1016-25. doi: 10.1089/ten.TEA.2016.0027.


Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin: Method and validation.

Shrestha U, Sciammarella M, Alhassen F, Yeghiazarians Y, Ellin J, Verdin E, Boyle A, Seo Y, Botvinick EH, Gullberg GT.

J Nucl Cardiol. 2017 Feb;24(1):268-277. doi: 10.1007/s12350-015-0320-3. Epub 2015 Dec 29.


Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization.

Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL.

Sci Rep. 2015 Oct 16;5:15153. doi: 10.1038/srep15153.


Image reconstruction in higher dimensions: myocardial perfusion imaging of tracer dynamics with cardiac motion due to deformation and respiration.

Shrestha UM, Seo Y, Botvinick EH, Gullberg GT.

Phys Med Biol. 2015 Nov 7;60(21):8275-301. doi: 10.1088/0031-9155/60/21/8275. Epub 2015 Oct 9.


Comparison of radionuclide angiographic synchrony analysis to echocardiography and magnetic resonance imaging for the diagnosis of arrhythmogenic right ventricular cardiomyopathy.

Johnson CJ, Roberts JD, James JH, Hoffmayer KS, Badhwar N, Ku IA, Zhao S, Naeger DM, Rao RK, O'Connell JW, De Marco T, Botvinick EH, Scheinman MM.

Heart Rhythm. 2015 Jun;12(6):1268-75. doi: 10.1016/j.hrthm.2015.02.033. Epub 2015 Mar 2.


Molecular interference of fibrin's divalent polymerization mechanism enables modulation of multiscale material properties.

Brown AC, Baker SR, Douglas AM, Keating M, Alvarez-Elizondo MB, Botvinick EL, Guthold M, Barker TH.

Biomaterials. 2015 May;49:27-36. doi: 10.1016/j.biomaterials.2015.01.010. Epub 2015 Feb 11.


Distinct mechanisms regulating mechanical force-induced Ca²⁺ signals at the plasma membrane and the ER in human MSCs.

Kim TJ, Joo C, Seong J, Vafabakhsh R, Botvinick EL, Berns MW, Palmer AE, Wang N, Ha T, Jakobsson E, Sun J, Wang Y.

Elife. 2015 Feb 10;4:e04876. doi: 10.7554/eLife.04876.


Quantitative Signature of Coronary Steal in a Patient with Occluded Coronary Arteries Supported by Collateral Circulation Using Dynamic SPECT.

Shrestha U, Botvinick EH, Yeghiazarians Y, Seo Y, Gullberg GT.

IEEE Nucl Sci Symp Conf Rec (1997). 2014 Nov;2014. doi: 10.1109/NSSMIC.2014.7430923.


Erratum to: Isolated right ventricular cardiac sarcoidosis demonstrated by (18)FDG positron emission tomography.

Pampaloni MH, Nazer B, Botvinick E.

J Nucl Cardiol. 2015 Feb;22(1):221. doi: 10.1007/s12350-014-9953-x. No abstract available.


High-throughput optical screening of cellular mechanotransduction.

Compton JL, Luo JC, Ma H, Botvinick E, Venugopalan V.

Nat Photonics. 2014 Sep 1;8:710-715.


Method measuring oxygen tension and transport within subcutaneous devices.

Weidling J, Sameni S, Lakey JR, Botvinick E.

J Biomed Opt. 2014 Aug;19(8):087006. doi: 10.1117/1.JBO.19.8.087006.


Isolated right ventricular cardiac sarcoidosis demonstrated by ¹⁸FDG positron emission tomography.

Hernandez Pampaloni M, Nazer B, Botvinick E.

J Nucl Cardiol. 2014 Jun;21(3):652-4. doi: 10.1007/s12350-013-9848-2. Epub 2014 Jan 16. No abstract available. Erratum in: J Nucl Cardiol. 2015 Feb;22(1):221. Nazar, Babek [corrected to Nazer, Babek].


MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis.

Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ.

Dev Cell. 2013 May 28;25(4):402-16. doi: 10.1016/j.devcel.2013.04.011. Epub 2013 May 16.


Lens-free computational imaging of capillary morphogenesis within three-dimensional substrates.

Weidling J, Isikman SO, Greenbaum A, Ozcan A, Botvinick E.

J Biomed Opt. 2012 Dec;17(12):126018. doi: 10.1117/1.JBO.17.12.126018.


Adenosine A(1) and prostaglandin E receptor 3 receptors mediate global airway contraction after local epithelial injury.

Zhou J, Alvarez-Elizondo MB, Botvinick E, George SC.

Am J Respir Cell Mol Biol. 2013 Mar;48(3):299-305. doi: 10.1165/rcmb.2012-0174OC. Epub 2012 Dec 6.


Characterizing the collagen fiber orientation in pericardial leaflets under mechanical loading conditions.

Alavi SH, Ruiz V, Krasieva T, Botvinick EL, Kheradvar A.

Ann Biomed Eng. 2013 Mar;41(3):547-61. doi: 10.1007/s10439-012-0696-z. Epub 2012 Nov 21.


Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin.

Meloty-Kapella L, Shergill B, Kuon J, Botvinick E, Weinmaster G.

Dev Cell. 2012 Jun 12;22(6):1299-312. doi: 10.1016/j.devcel.2012.04.005. Epub 2012 May 31.


Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis.

Shergill B, Meloty-Kapella L, Musse AA, Weinmaster G, Botvinick E.

Dev Cell. 2012 Jun 12;22(6):1313-20. doi: 10.1016/j.devcel.2012.04.007. Epub 2012 May 31.


Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D.

Kniazeva E, Weidling JW, Singh R, Botvinick EL, Digman MA, Gratton E, Putnam AJ.

Integr Biol (Camb). 2012 Apr;4(4):431-9. doi: 10.1039/c2ib00120a. Epub 2012 Jan 26.


Extending vaterite microviscometry to ex vivo blood vessels by serial calibration.

Shreim SG, Steward E, Botvinick EL.

Biomed Opt Express. 2012 Jan 1;3(1):37-47. doi: 10.1364/BOE.3.000037. Epub 2011 Dec 5.


Local small airway epithelial injury induces global smooth muscle contraction and airway constriction.

Zhou J, Alvarez-Elizondo MB, Botvinick E, George SC.

J Appl Physiol (1985). 2012 Feb;112(4):627-37. doi: 10.1152/japplphysiol.00739.2011. Epub 2011 Nov 23.


Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives.

Chen A, Lieu DK, Freschauf L, Lew V, Sharma H, Wang J, Nguyen D, Karakikes I, Hajjar RJ, Gopinathan A, Botvinick E, Fowlkes CC, Li RA, Khine M.

Adv Mater. 2011 Dec 22;23(48):5785-91. doi: 10.1002/adma.201103463. Epub 2011 Nov 8.


Sequential shrink photolithography for plastic microlens arrays.

Dyer D, Shreim S, Jayadev S, Lew V, Botvinick E, Khine M.

Appl Phys Lett. 2011 Jul 18;99(3):34102-341023. Epub 2011 Jul 19.


VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF.

Anderson SM, Shergill B, Barry ZT, Manousiouthakis E, Chen TT, Botvinick E, Platt MO, Iruela-Arispe ML, Segura T.

Integr Biol (Camb). 2011 Sep;3(9):887-96. doi: 10.1039/c1ib00037c. Epub 2011 Aug 8.


Concentration independent modulation of local micromechanics in a fibrin gel.

Kotlarchyk MA, Shreim SG, Alvarez-Elizondo MB, Estrada LC, Singh R, Valdevit L, Kniazeva E, Gratton E, Putnam AJ, Botvinick EL.

PLoS One. 2011;6(5):e20201. doi: 10.1371/journal.pone.0020201. Epub 2011 May 23.


An intact centrosome is required for the maintenance of polarization during directional cell migration.

Wakida NM, Botvinick EL, Lin J, Berns MW.

PLoS One. 2010 Dec 23;5(12):e15462. doi: 10.1371/journal.pone.0015462.


An interdisciplinary systems approach to study sperm physiology and evolution.

Shi LZ, Nascimento J, Botvinick E, Durrant B, Berns MW.

Wiley Interdiscip Rev Syst Biol Med. 2011 Jan-Feb;3(1):36-47. doi: 10.1002/wsbm.106. Review.


Characterization of hydrogel microstructure using laser tweezers particle tracking and confocal reflection imaging.

Kotlarchyk MA, Botvinick EL, Putnam AJ.

J Phys Condens Matter. 2010 May 19;22(19):194121. doi: 10.1088/0953-8984/22/19/194121.


Imaging synchrony.

Botvinick EH, O'Connell JW, Badhwar N.

J Nucl Cardiol. 2009 Nov-Dec;16(6):846-8. doi: 10.1007/s12350-009-9151-4. No abstract available.


Live Cells Exert 3-Dimensional Traction Forces on Their Substrata.

Hur SS, Zhao Y, Li YS, Botvinick E, Chien S.

Cell Mol Bioeng. 2009 Sep;2(3):425-436. Epub 2009 Aug 26.


The variable functional effects of the pacing site in normal and scarred ventricles.

del Romeral LM, Stillson C, Lesh M, Botvinick E.

J Nucl Cardiol. 2009 Nov-Dec;16(6):904-13. doi: 10.1007/s12350-009-9135-4.


A pilot study of changes in (18)F-FDG uptake, calcification and global metabolic activity of the aorta with aging.

Bural GG, Torigian DA, Botvinick E, Houseni M, Basu S, Chen W, Alavi A.

Hell J Nucl Med. 2009 May-Aug;12(2):123-8.


The relationship of myocardial contraction and electrical excitation--the correlation between scintigraphic phase image analysis and electrophysiologic mapping.

del Romeral LM, Stillson C, Lesh M, Dae M, Botvinick E.

J Nucl Cardiol. 2009 Sep-Oct;16(5):792-800. doi: 10.1007/s12350-009-9114-9. Epub 2009 Jul 28.


Localization of ventricular tachycardia exit site and subsequent contraction sequence and functional effects with bedside radionuclide angiography.

Botvinick E, Davis J, Dae M, O'Connell J, Schechtmann N, Abbott J, Morady F, Lanzer P, Iskikian J, Scheinman M.

JACC Cardiovasc Imaging. 2008 Sep;1(5):605-13. doi: 10.1016/j.jcmg.2008.05.013.


Current methods of pharmacologic stress testing and the potential advantages of new agents.

Botvinick EH.

J Nucl Med Technol. 2009 Mar;37(1):14-25. doi: 10.2967/jnmt.108.057802. Review.


Independent polarisation control of multiple optical traps.

Preece D, Keen S, Botvinick E, Bowman R, Padgett M, Leach J.

Opt Express. 2008 Sep 29;16(20):15897-902.


Comparison of glycolysis and oxidative phosphorylation as energy sources for mammalian sperm motility, using the combination of fluorescence imaging, laser tweezers, and real-time automated tracking and trapping.

Nascimento JM, Shi LZ, Tam J, Chandsawangbhuwana C, Durrant B, Botvinick EL, Berns MW.

J Cell Physiol. 2008 Dec;217(3):745-51. doi: 10.1002/jcp.21549.


Use of laser tweezers to analyze sperm motility and mitochondrial membrane potential.

Nascimento JM, Shi LZ, Chandsawangbhuwana C, Tam J, Durrant B, Botvinick EL, Berns MW.

J Biomed Opt. 2008 Jan-Feb;13(1):014002. doi: 10.1117/1.2839051.


An automatic system to study sperm motility and energetics.

Shi LZ, Nascimento JM, Chandsawangbhuwana C, Botvinick EL, Berns MW.

Biomed Microdevices. 2008 Aug;10(4):573-83. doi: 10.1007/s10544-008-9169-4.

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