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Items: 1 to 50 of 148

1.

Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes.

Czyzyk J, Henegariu O, Preston-Hurlburt P, Baldzizhar R, Fedorchuk C, Esplugues E, Bottomly K, Gorus FK, Herold K, Flavell RA.

J Immunol. 2012 Jun 15;188(12):6319-27. doi: 10.4049/jimmunol.1200467. Epub 2012 May 16.

2.

EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation.

Dokmeci E, Xu L, Robinson E, Golubets K, Bottomly K, Herrick CA.

Immunology. 2011 Apr;132(4):559-66. doi: 10.1111/j.1365-2567.2010.03401.x. Epub 2011 Jan 24.

3.

Targeting Toll-like receptors on dendritic cells modifies the T(H)2 response to peanut allergens in vitro.

Pochard P, Vickery B, Berin MC, Grishin A, Sampson HA, Caplan M, Bottomly K.

J Allergy Clin Immunol. 2010 Jul;126(1):92-7.e5. doi: 10.1016/j.jaci.2010.04.003. Epub 2010 Jun 9.

4.

Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation.

Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K, Elias JA.

Clin Immunol. 2009 Sep;132(3):371-84. doi: 10.1016/j.clim.2009.05.016. Epub 2009 Jun 24.

5.

p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells.

Czyzyk J, Chen HC, Bottomly K, Flavell RA.

J Biol Chem. 2008 Aug 22;283(34):23004-15. doi: 10.1074/jbc.M804084200. Epub 2008 Jun 24.

6.

Measurement of human and murine interleukin 2 and interleukin 4.

Davis LS, Lipsky PE, Bottomly K.

Curr Protoc Immunol. 2001 May;Chapter 6:Unit 6.3. doi: 10.1002/0471142735.im0603s37.

PMID:
18432816
7.
8.

Innate immune control of pulmonary dendritic cell trafficking.

Cook DN, Bottomly K.

Proc Am Thorac Soc. 2007 Jul;4(3):234-9. Review.

9.

CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets.

Jackman RP, Balamuth F, Bottomly K.

J Immunol. 2007 May 1;178(9):5543-51.

10.

MyD88-dependent induction of allergic Th2 responses to intranasal antigen.

Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA, Bottomly K.

J Clin Invest. 2005 Feb;115(2):459-67.

11.

Understanding asthma pathogenesis: linking innate and adaptive immunity.

Eisenbarth SC, Cassel S, Bottomly K.

Curr Opin Pediatr. 2004 Dec;16(6):659-66. Review.

PMID:
15548929
12.

Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells.

Meyer zum Bueschenfelde CO, Unternaehrer J, Mellman I, Bottomly K.

J Immunol. 2004 Nov 15;173(10):6119-24.

13.

CD4 raft association and signaling regulate molecular clustering at the immunological synapse site.

Balamuth F, Brogdon JL, Bottomly K.

J Immunol. 2004 May 15;172(10):5887-92.

14.

IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88.

Eisenbarth SC, Zhadkevich A, Ranney P, Herrick CA, Bottomly K.

J Immunol. 2004 Apr 1;172(7):4527-34.

15.

The master regulators of allergic inflammation: dendritic cells in Th2 sensitization.

Eisenbarth SC, Piggott DA, Bottomly K.

Curr Opin Immunol. 2003 Dec;15(6):620-6. Review.

PMID:
14630194
16.

Cytolytic CD4(+)-T-cell clones reactive to EBNA1 inhibit Epstein-Barr virus-induced B-cell proliferation.

Nikiforow S, Bottomly K, Miller G, Münz C.

J Virol. 2003 Nov;77(22):12088-104.

17.

Human gamma/delta T-cell proliferation and IFN-gamma production induced by hexamethylene diisocyanate.

Wisnewski AV, Herrick CA, Liu Q, Chen L, Bottomly K, Redlich CA.

J Allergy Clin Immunol. 2003 Sep;112(3):538-46.

PMID:
13679813
18.

To respond or not to respond: T cells in allergic asthma.

Herrick CA, Bottomly K.

Nat Rev Immunol. 2003 May;3(5):405-12. Review.

PMID:
12766762
19.

Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: genetic control of TH2-induced lung inflammation.

Herrick CA, Das J, Xu L, Wisnewski AV, Redlich CA, Bottomly K.

J Allergy Clin Immunol. 2003 May;111(5):1087-94.

PMID:
12743574
20.

Activation of CD4 T cells by Raf-independent effectors of Ras.

Czyzyk J, Brogdon JL, Badou A, Henegariu O, Preston Hurlburt P, Flavell R, Bottomly K.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):6003-8. Epub 2003 Apr 29.

21.

An important regulatory role for CD4+CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease.

Das G, Augustine MM, Das J, Bottomly K, Ray P, Ray A.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5324-9. Epub 2003 Apr 14.

22.
23.
24.

A pool of central memory-like CD4 T cells contains effector memory precursors.

Blander JM, Sant'Angelo DB, Metz D, Kim SW, Flavell RA, Bottomly K, Janeway CA Jr.

J Immunol. 2003 Mar 15;170(6):2940-8.

25.

IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen.

Herrick CA, Xu L, McKenzie AN, Tigelaar RE, Bottomly K.

J Immunol. 2003 Mar 1;170(5):2488-95.

26.
27.

Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen.

Eisenbarth SC, Piggott DA, Huleatt JW, Visintin I, Herrick CA, Bottomly K.

J Exp Med. 2002 Dec 16;196(12):1645-51.

28.

Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ.

Constant SL, Brogdon JL, Piggott DA, Herrick CA, Visintin I, Ruddle NH, Bottomly K.

J Clin Invest. 2002 Nov;110(10):1441-8.

29.
30.

A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge.

Herrick CA, Xu L, Wisnewski AV, Das J, Redlich CA, Bottomly K.

J Allergy Clin Immunol. 2002 May;109(5):873-8.

PMID:
11994714
31.
32.

Dual receptor T cells extend the immune repertoire for foreign antigens.

He X, Janeway CA Jr, Levine M, Robinson E, Preston-Hurlburt P, Viret C, Bottomly K.

Nat Immunol. 2002 Feb;3(2):127-34. Epub 2002 Jan 7.

PMID:
11812989
33.

Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells.

Balamuth F, Leitenberg D, Unternaehrer J, Mellman I, Bottomly K.

Immunity. 2001 Nov;15(5):729-38.

34.

Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation.

Leitenberg D, Balamuth F, Bottomly K.

Semin Immunol. 2001 Apr;13(2):129-38. Review.

PMID:
11308296
35.

CD4+ T-cell effectors inhibit Epstein-Barr virus-induced B-cell proliferation.

Nikiforow S, Bottomly K, Miller G.

J Virol. 2001 Apr;75(8):3740-52.

36.

The PTK-STAT signaling pathway has essential roles in T-cell activation in response to antigen stimulation.

Welte T, Leitenberg D, Dittel BN, al-Ramadi BK, Hansen WR, Xie B, Janeway CA Jr, Bothwell AL, Bottomly K, Fu XY.

Cold Spring Harb Symp Quant Biol. 1999;64:291-302. Review. No abstract available.

PMID:
11232299
38.

Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo.

Wisnewski AV, Srivastava R, Herick C, Xu L, Lemus R, Cain H, Magoski NM, Karol MH, Bottomly K, Redlich CA.

Am J Respir Crit Care Med. 2000 Dec;162(6):2330-6.

PMID:
11112159
39.
41.
42.

Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4.

Herrick CA, MacLeod H, Glusac E, Tigelaar RE, Bottomly K.

J Clin Invest. 2000 Mar;105(6):765-75.

43.

T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production.

Cohn L, Homer RJ, Niu N, Bottomly K.

J Exp Med. 1999 Nov 1;190(9):1309-18.

44.

Function and regulation of memory CD4 T cells.

Metz DP, Bottomly K.

Immunol Res. 1999;19(2-3):127-41. Review.

PMID:
10493168
45.

Regulation of naive T cell differentiation by varying the potency of TCR signal transduction.

Leitenberg D, Bottomly K.

Semin Immunol. 1999 Aug;11(4):283-92. Review.

PMID:
10441214
46.
47.

Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.

Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F, Bottomly K.

J Immunol. 1999 May 15;162(10):6178-83.

48.
49.

T cells and dendritic cells get intimate.

Bottomly K.

Science. 1999 Feb 19;283(5405):1124-5. No abstract available.

PMID:
10075571
50.

Stability of naive and memory phenotypes on resting CD4 T cells in vivo.

Boursalian TE, Bottomly K.

J Immunol. 1999 Jan 1;162(1):9-16.

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