Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 38

1.

Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis.

Kalson NS, Brock TM, Mangino M, Fabiane SM, Mann DA, Borthwick LA, Deehan DJ, Williams FMK.

PLoS One. 2018 Jan 2;13(1):e0190120. doi: 10.1371/journal.pone.0190120. eCollection 2018.

2.

Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2.

Paish HL, Kalson NS, Smith GR, Del Carpio Pons A, Baldock TE, Smith N, Swist-Szulik K, Weir DJ, Bardgett M, Deehan DJ, Mann DA, Borthwick LA.

Am J Pathol. 2017 Dec 15. pii: S0002-9440(17)30614-4. doi: 10.1016/j.ajpath.2017.11.007. [Epub ahead of print]

3.

Epigenetic reprogramming in liver fibrosis and cancer.

Wilson CL, Mann DA, Borthwick LA.

Adv Drug Deliv Rev. 2017 Nov 1;121:124-132. doi: 10.1016/j.addr.2017.10.011. Epub 2017 Oct 25. Review.

4.

Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β.

Hart KM, Fabre T, Sciurba JC, Gieseck RL 3rd, Borthwick LA, Vannella KM, Acciani TH, de Queiroz Prado R, Thompson RW, White S, Soucy G, Bilodeau M, Ramalingam TR, Arron JR, Shoukry NH, Wynn TA.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3694. doi: 10.1126/scitranslmed.aal3694.

PMID:
28659437
5.

The role of interleukin-1β as a predictive biomarker and potential therapeutic target during clinical ex vivo lung perfusion.

Andreasson ASI, Borthwick LA, Gillespie C, Jiwa K, Scott J, Henderson P, Mayes J, Romano R, Roman M, Ali S, Fildes JE, Marczin N, Dark JH, Fisher AJ; DEVELOP-UK Investigators.

J Heart Lung Transplant. 2017 Sep;36(9):985-995. doi: 10.1016/j.healun.2017.05.012. Epub 2017 May 12.

6.

Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion.

Andreasson AS, Karamanou DM, Gillespie CS, Özalp F, Butt T, Hill P, Jiwa K, Walden HR, Green NJ, Borthwick LA, Clark SC, Pauli H, Gould KF, Corris PA, Ali S, Dark JH, Fisher AJ.

Eur J Cardiothorac Surg. 2017 Mar 1;51(3):577-586. doi: 10.1093/ejcts/ezw358.

7.

International consensus on the definition and classification of fibrosis of the knee joint.

Kalson NS, Borthwick LA, Mann DA, Deehan DJ, Lewis P, Mann C, Mont MA, Morgan-Jones R, Oussedik S, Williams FM, Toms A, Argenson JN, Bellemans J, Bhave A, Furnes O, Gollwitzer H, Haddad FS, Hofmann S, Krenn V.

Bone Joint J. 2016 Nov;98-B(11):1479-1488.

PMID:
27803223
8.

Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis.

Vannella KM, Ramalingam TR, Borthwick LA, Barron L, Hart KM, Thompson RW, Kindrachuk KN, Cheever AW, White S, Budelsky AL, Comeau MR, Smith DE, Wynn TA.

Sci Transl Med. 2016 May 4;8(337):337ra65. doi: 10.1126/scitranslmed.aaf1938.

PMID:
27147589
9.

Liver: Osteopontin and HMGB1: novel regulators of HSC activation.

Borthwick LA, Mann DA.

Nat Rev Gastroenterol Hepatol. 2016 Jun;13(6):320-2. doi: 10.1038/nrgastro.2016.58. Epub 2016 Apr 14. No abstract available.

PMID:
27075262
10.

Acidic chitinase primes the protective immune response to gastrointestinal nematodes.

Vannella KM, Ramalingam TR, Hart KM, de Queiroz Prado R, Sciurba J, Barron L, Borthwick LA, Smith AD, Mentink-Kane M, White S, Thompson RW, Cheever AW, Bock K, Moore I, Fitz LJ, Urban JF Jr, Wynn TA.

Nat Immunol. 2016 May;17(5):538-44. doi: 10.1038/ni.3417. Epub 2016 Apr 4.

11.

The IL-1 cytokine family and its role in inflammation and fibrosis in the lung.

Borthwick LA.

Semin Immunopathol. 2016 Jul;38(4):517-34. doi: 10.1007/s00281-016-0559-z. Epub 2016 Mar 21. Review.

12.

Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A.

Borthwick LA, Kerbiriou M, Taylor CJ, Cozza G, Lascu I, Postel EH, Cassidy D, Trouvé P, Mehta A, Robson L, Muimo R.

PLoS One. 2016 Mar 7;11(3):e0149097. doi: 10.1371/journal.pone.0149097. eCollection 2016.

13.

Pseudomonas aeruginosa Induced Airway Epithelial Injury Drives Fibroblast Activation: A Mechanism in Chronic Lung Allograft Dysfunction.

Borthwick LA, Suwara MI, Carnell SC, Green NJ, Mahida R, Dixon D, Gillespie CS, Cartwright TN, Horabin J, Walker A, Olin E, Rangar M, Gardner A, Mann J, Corris PA, Mann DA, Fisher AJ.

Am J Transplant. 2016 Jun;16(6):1751-65. doi: 10.1111/ajt.13690. Epub 2016 Feb 26.

14.

Fibrosis is a common outcome following total knee arthroplasty.

Abdul N, Dixon D, Walker A, Horabin J, Smith N, Weir DJ, Brewster NT, Deehan DJ, Mann DA, Borthwick LA.

Sci Rep. 2015 Nov 10;5:16469. doi: 10.1038/srep16469.

15.

A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty.

Dixon D, Coates J, del Carpio Pons A, Horabin J, Walker A, Abdul N, Kalson NS, Brewster NT, Weir DJ, Deehan DJ, Mann DA, Borthwick LA.

Sci Rep. 2015 Nov 10;5:16466. doi: 10.1038/srep16466.

16.

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.

Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S, Jia G, Ohri CM, Doran E, Vannella KM, Butler CA, Hargadon B, Sciurba JC, Gieseck RL, Thompson RW, White S, Abbas AR, Jackman J, Wu LC, Egen JG, Heaney LG, Ramalingam TR, Arron JR, Wynn TA, Bradding P.

Sci Transl Med. 2015 Aug 19;7(301):301ra129. doi: 10.1126/scitranslmed.aab3142.

PMID:
26290411
17.

Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis.

Borthwick LA, Barron L, Hart KM, Vannella KM, Thompson RW, Oland S, Cheever A, Sciurba J, Ramalingam TR, Fisher AJ, Wynn TA.

Mucosal Immunol. 2016 Jan;9(1):38-55. doi: 10.1038/mi.2015.34. Epub 2015 Apr 29.

18.

How reliable are sino-nasal cell lines for studying the pathophysiology of chronic rhinosinusitis?

Ball SL, Suwara MI, Borthwick LA, Wilson JA, Mann DA, Fisher AJ.

Ann Otol Rhinol Laryngol. 2015 Jun;124(6):437-42. doi: 10.1177/0003489414565003. Epub 2014 Dec 23.

19.

Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis.

Vannella KM, Barron L, Borthwick LA, Kindrachuk KN, Narasimhan PB, Hart KM, Thompson RW, White S, Cheever AW, Ramalingam TR, Wynn TA.

PLoS Pathog. 2014 Sep 11;10(9):e1004372. doi: 10.1371/journal.ppat.1004372. eCollection 2014 Sep.

20.

TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction.

Badalyan V, Thompson R, Addo K, Borthwick LA, Fisher AJ, Ort T, Myers TG, Wynn TA, Ramalingam TR.

J Allergy Clin Immunol. 2014 Oct;134(4):975-8.e5. doi: 10.1016/j.jaci.2014.05.019. Epub 2014 Jun 20. No abstract available.

21.

Mechanistic differences between phenotypes of chronic lung allograft dysfunction after lung transplantation.

Suwara MI, Vanaudenaerde BM, Verleden SE, Vos R, Green NJ, Ward C, Borthwick LA, Vandermeulen E, Lordan J, Van Raemdonck DE, Corris PA, Verleden GM, Fisher AJ.

Transpl Int. 2014 Aug;27(8):857-67. doi: 10.1111/tri.12341. Epub 2014 Jun 17.

22.

IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts.

Suwara MI, Green NJ, Borthwick LA, Mann J, Mayer-Barber KD, Barron L, Corris PA, Farrow SN, Wynn TA, Fisher AJ, Mann DA.

Mucosal Immunol. 2014 May;7(3):684-93. doi: 10.1038/mi.2013.87. Epub 2013 Oct 30.

23.

Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.

Barron L, Smith AM, El Kasmi KC, Qualls JE, Huang X, Cheever A, Borthwick LA, Wilson MS, Murray PJ, Wynn TA.

PLoS One. 2013 Apr 24;8(4):e61961. doi: 10.1371/journal.pone.0061961. Print 2013.

24.

TNFα from classically activated macrophages accentuates epithelial to mesenchymal transition in obliterative bronchiolitis.

Borthwick LA, Corris PA, Mahida R, Walker A, Gardner A, Suwara M, Johnson GE, Moisey EJ, Brodlie M, Ward C, Perry JD, De Soyza A, Mann DA, Fisher AJ.

Am J Transplant. 2013 Mar;13(3):621-33. doi: 10.1111/ajt.12065. Epub 2013 Jan 17.

25.

Cytokine mediated tissue fibrosis.

Borthwick LA, Wynn TA, Fisher AJ.

Biochim Biophys Acta. 2013 Jul;1832(7):1049-60. doi: 10.1016/j.bbadis.2012.09.014. Epub 2012 Oct 6. Review.

26.

The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation.

Gardner A, Fisher AJ, Richter C, Johnson GE, Moisey EJ, Brodlie M, Ward C, Krippner-Heidenreich A, Mann DA, Borthwick LA.

Am J Pathol. 2012 Jun;180(6):2293-308. doi: 10.1016/j.ajpath.2012.02.022. Epub 2012 Apr 21.

27.

Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-β1-dependent mechanism.

Gorowiec MR, Borthwick LA, Parker SM, Kirby JA, Saretzki GC, Fisher AJ.

Free Radic Biol Med. 2012 Mar 15;52(6):1024-32. doi: 10.1016/j.freeradbiomed.2011.12.020. Epub 2012 Jan 2.

PMID:
22240154
28.

Is CFTR-delF508 really absent from the apical membrane of the airway epithelium?

Borthwick LA, Botha P, Verdon B, Brodlie MJ, Gardner A, Bourn D, Johnson GE, Gray MA, Fisher AJ.

PLoS One. 2011;6(8):e23226. doi: 10.1371/journal.pone.0023226. Epub 2011 Aug 3.

29.

Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways.

Borthwick LA, Gardner A, De Soyza A, Mann DA, Fisher AJ.

Cancer Microenviron. 2012 Apr;5(1):45-57. doi: 10.1007/s12307-011-0080-9. Epub 2011 Jul 27.

30.

Lung epithelial wound healing in health and disease.

Gardner A, Borthwick LA, Fisher AJ.

Expert Rev Respir Med. 2010 Oct;4(5):647-60. doi: 10.1586/ers.10.62. Review.

PMID:
20923342
31.

Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway.

Borthwick LA, Sunny SS, Oliphant V, Perry J, Brodlie M, Johnson GE, Ward C, Gould K, Corris PA, De Soyza A, Fisher AJ.

Eur Respir J. 2011 May;37(5):1237-47. doi: 10.1183/09031936.00088410. Epub 2010 Sep 16.

32.

Inflammation and epithelial to mesenchymal transition in lung transplant recipients: role in dysregulated epithelial wound repair.

Borthwick LA, McIlroy EI, Gorowiec MR, Brodlie M, Johnson GE, Ward C, Lordan JL, Corris PA, Kirby JA, Fisher AJ.

Am J Transplant. 2010 Mar;10(3):498-509. doi: 10.1111/j.1600-6143.2009.02953.x. Epub 2010 Jan 5.

33.

Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation.

Borthwick LA, Parker SM, Brougham KA, Johnson GE, Gorowiec MR, Ward C, Lordan JL, Corris PA, Kirby JA, Fisher AJ.

Thorax. 2009 Sep;64(9):770-7. doi: 10.1136/thx.2008.104133. Epub 2009 Feb 12.

PMID:
19213777
34.

Airway epithelial cell senescence in the lung allograft.

Parker SM, Goriwiec MR, Borthwick LA, Johnson G, Ward C, Lordan JL, Corris PA, Saretzki GC, Fisher AJ.

Am J Transplant. 2008 Jul;8(7):1544-9. doi: 10.1111/j.1600-6143.2008.02284.x.

35.

Defective formation of PKA/CnA-dependent annexin 2-S100A10/CFTR complex in DeltaF508 cystic fibrosis cells.

Borthwick LA, Riemen C, Goddard C, Colledge WH, Mehta A, Gerke V, Muimo R.

Cell Signal. 2008 Jun;20(6):1073-83. doi: 10.1016/j.cellsig.2008.01.021. Epub 2008 Feb 5.

PMID:
18346874
36.

The annexin 2-S100A10 complex and its association with TRPV6 is regulated by cAMP/PKA/CnA in airway and gut epithelia.

Borthwick LA, Neal A, Hobson L, Gerke V, Robson L, Muimo R.

Cell Calcium. 2008 Aug;44(2):147-57. doi: 10.1016/j.ceca.2007.11.001. Epub 2008 Jan 9.

PMID:
18187190
37.

The formation of the cAMP/protein kinase A-dependent annexin 2-S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function.

Borthwick LA, McGaw J, Conner G, Taylor CJ, Gerke V, Mehta A, Robson L, Muimo R.

Mol Biol Cell. 2007 Sep;18(9):3388-97. Epub 2007 Jun 20.

38.

Reciprocal actions of interleukin-6 and brain-derived neurotrophic factor on rat and mouse primary sensory neurons.

Murphy PG, Borthwick LA, Altares M, Gauldie J, Kaplan D, Richardson PM.

Eur J Neurosci. 2000 Jun;12(6):1891-9.

PMID:
10886330

Supplemental Content

Loading ...
Support Center