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Items: 1 to 50 of 85

1.

Structural homologies between phenformin, lipitor and gleevec aim the same metabolic oncotarget in leukemia and melanoma.

Somlyai G, Collins TQ, Meuillet EJ, Hitendra P, D'Agostino DP, Boros LG.

Oncotarget. 2017 Jul 25;8(30):50187-50192. doi: 10.18632/oncotarget.16238. Review.

2.

What to eat or what not to eat-that is still the question.

Boros LG, Collins TQ, Somlyai G.

Neuro Oncol. 2017 Apr 1;19(4):595-596. doi: 10.1093/neuonc/now284. No abstract available.

3.

Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle.

Boros LG, D'Agostino DP, Katz HE, Roth JP, Meuillet EJ, Somlyai G.

Med Hypotheses. 2016 Feb;87:69-74. doi: 10.1016/j.mehy.2015.11.016. Epub 2015 Nov 26.

4.

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.

Montal ED, Dewi R, Bhalla K, Ou L, Hwang BJ, Ropell AE, Gordon C, Liu WJ, DeBerardinis RJ, Sudderth J, Twaddel W, Boros LG, Shroyer KR, Duraisamy S, Drapkin R, Powers RS, Rohde JM, Boxer MB, Wong KK, Girnun GD.

Mol Cell. 2015 Nov 19;60(4):571-83. doi: 10.1016/j.molcel.2015.09.025. Epub 2015 Oct 17.

5.

Fructose Alters Intermediary Metabolism of Glucose in Human Adipocytes and Diverts Glucose to Serine Oxidation in the One-Carbon Cycle Energy Producing Pathway.

Varma V, Boros LG, Nolen GT, Chang CW, Wabitsch M, Beger RD, Kaput J.

Metabolites. 2015 Jun 16;5(2):364-85. doi: 10.3390/metabo5020364.

6.

Metabolic fate of fructose in human adipocytes: a targeted 13C tracer fate association study.

Varma V, Boros LG, Nolen GT, Chang CW, Wabitsch M, Beger RD, Kaput J.

Metabolomics. 2015;11(3):529-544. Epub 2014 Aug 3.

7.

A roadmap for interpreting (13)C metabolite labeling patterns from cells.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM.

Curr Opin Biotechnol. 2015 Aug;34:189-201. doi: 10.1016/j.copbio.2015.02.003. Epub 2015 Feb 28. Review.

8.

5'-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors.

Laderoute KR, Calaoagan JM, Chao WR, Dinh D, Denko N, Duellman S, Kalra J, Liu X, Papandreou I, Sambucetti L, Boros LG.

J Biol Chem. 2014 Aug 15;289(33):22850-64. doi: 10.1074/jbc.M114.576371. Epub 2014 Jul 3.

9.

Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.

Reitman ZJ, Duncan CG, Poteet E, Winters A, Yan LJ, Gooden DM, Spasojevic I, Boros LG, Yang SH, Yan H.

J Biol Chem. 2014 Aug 22;289(34):23318-28. doi: 10.1074/jbc.M114.575183. Epub 2014 Jul 1.

10.

Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells.

Cantoria MJ, Boros LG, Meuillet EJ.

Metabolomics. 2014;10(1):91-104. doi: 10.1007/s11306-013-0555-4. Epub 2013 Jun 26.

11.

Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress.

Lamonte G, Tang X, Chen JL, Wu J, Ding CK, Keenan MM, Sangokoya C, Kung HN, Ilkayeva O, Boros LG, Newgard CB, Chi JT.

Cancer Metab. 2013 Dec 23;1(1):23. doi: 10.1186/2049-3002-1-23.

12.

AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes.

Jenkins Y, Sun TQ, Markovtsov V, Foretz M, Li W, Nguyen H, Li Y, Pan A, Uy G, Gross L, Baltgalvis K, Yung SL, Gururaja T, Kinoshita T, Owyang A, Smith IJ, McCaughey K, White K, Godinez G, Alcantara R, Choy C, Ren H, Basile R, Sweeny DJ, Xu X, Issakani SD, Carroll DC, Goff DA, Shaw SJ, Singh R, Boros LG, Laplante MA, Marcotte B, Kohen R, Viollet B, Marette A, Payan DG, Kinsella TM, Hitoshi Y.

PLoS One. 2013 Dec 5;8(12):e81870. doi: 10.1371/journal.pone.0081870. eCollection 2013.

13.

Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells.

Tedeschi PM, Markert EK, Gounder M, Lin H, Dvorzhinski D, Dolfi SC, Chan LL, Qiu J, DiPaola RS, Hirshfield KM, Boros LG, Bertino JR, Oltvai ZN, Vazquez A.

Cell Death Dis. 2013 Oct 24;4:e877. doi: 10.1038/cddis.2013.393.

14.

Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma.

Yang Y, Lane AN, Ricketts CJ, Sourbier C, Wei MH, Shuch B, Pike L, Wu M, Rouault TA, Boros LG, Fan TW, Linehan WM.

PLoS One. 2013 Aug 15;8(8):e72179. doi: 10.1371/journal.pone.0072179. eCollection 2013.

15.

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis.

Singh A, Happel C, Manna SK, Acquaah-Mensah G, Carrerero J, Kumar S, Nasipuri P, Krausz KW, Wakabayashi N, Dewi R, Boros LG, Gonzalez FJ, Gabrielson E, Wong KK, Girnun G, Biswal S.

J Clin Invest. 2013 Jul;123(7):2921-34. doi: 10.1172/JCI66353. Epub 2013 Jun 10.

16.

Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice.

Huang J, Simcox J, Mitchell TC, Jones D, Cox J, Luo B, Cooksey RC, Boros LG, McClain DA.

FASEB J. 2013 Jul;27(7):2845-54. doi: 10.1096/fj.12-216929. Epub 2013 Mar 20.

17.
18.

Assessment of usnic acid toxicity in rat primary hepatocytes using ¹³C isotopomer distribution analysis of lactate, glutamate and glucose.

Sonko BJ, Schmitt TC, Guo L, Shi Q, Boros LG, Leakey JE, Beger RD.

Food Chem Toxicol. 2011 Nov;49(11):2968-74. doi: 10.1016/j.fct.2011.07.047. Epub 2011 Jul 23.

19.

Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice.

Gu W, Lloyd DJ, Chinookswong N, Komorowski R, Sivits G Jr, Graham M, Winters KA, Yan H, Boros LG, Lindberg RA, Véniant MM.

J Pharmacol Exp Ther. 2011 Jul;338(1):70-81. doi: 10.1124/jpet.111.179986. Epub 2011 Apr 6.

20.

Fructose impairs glucose-induced hepatic triglyceride synthesis.

Huang D, Dhawan T, Young S, Yong WH, Boros LG, Heaney AP.

Lipids Health Dis. 2011 Jan 24;10:20. doi: 10.1186/1476-511X-10-20.

21.

Fructose induces transketolase flux to promote pancreatic cancer growth.

Liu H, Huang D, McArthur DL, Boros LG, Nissen N, Heaney AP.

Cancer Res. 2010 Aug 1;70(15):6368-76. doi: 10.1158/0008-5472.CAN-09-4615. Epub 2010 Jul 20.

22.

Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes.

Espinoza DO, Boros LG, Crunkhorn S, Gami H, Patti ME.

FASEB J. 2010 Apr;24(4):1003-14. doi: 10.1096/fj.09-133728. Epub 2009 Nov 11.

23.

Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the [U-C(6)]-d-glucose tracer in mice.

Beger RD, Hansen DK, Schnackenberg LK, Cross BM, Fatollahi JJ, Lagunero FT, Sarnyai Z, Boros LG.

Metabolomics. 2009 Sep;5(3):336-345. Epub 2009 Mar 31.

24.

Direct spectrophotometric determination of serum fructose in pancreatic cancer patients.

Hui H, Huang D, McArthur D, Nissen N, Boros LG, Heaney AP.

Pancreas. 2009 Aug;38(6):706-12. doi: 10.1097/MPA.0b013e3181a7c6e5.

PMID:
19506535
25.

Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells.

Kominsky DJ, Klawitter J, Brown JL, Boros LG, Melo JV, Eckhardt SG, Serkova NJ.

Clin Cancer Res. 2009 May 15;15(10):3442-50. doi: 10.1158/1078-0432.CCR-08-3291. Epub 2009 Apr 28.

26.
27.

Use of metabolic pathway flux information in anticancer drug design.

Boros LG, Boros TF.

Ernst Schering Found Symp Proc. 2007;(4):189-203. Review.

PMID:
18811058
28.

Impact of the solvent capacity constraint on E. coli metabolism.

Vazquez A, Beg QK, Demenezes MA, Ernst J, Bar-Joseph Z, Barabási AL, Boros LG, Oltvai ZN.

BMC Syst Biol. 2008 Jan 23;2:7. doi: 10.1186/1752-0509-2-7.

29.

Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis.

Huang J, Gabrielsen JS, Cooksey RC, Luo B, Boros LG, Jones DL, Jouihan HA, Soesanto Y, Knecht L, Hazel MW, Kushner JP, McClain DA.

J Biol Chem. 2007 Dec 28;282(52):37501-7. Epub 2007 Oct 30.

30.

In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism.

Rehan VK, Wang Y, Sugano S, Santos J, Patel S, Sakurai R, Boros LG, Lee WP, Torday JS.

Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L323-33. Erratum in: Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L820. Boros, Laszlo W [corrected to Boros, Laszlo G].

32.

[1,2-13C2]-D-glucose profiles of the serum, liver, pancreas, and DMBA-induced pancreatic tumors of rats.

Boros LG, Lerner MR, Morgan DL, Taylor SL, Smith BJ, Postier RG, Brackett DJ.

Pancreas. 2005 Nov;31(4):337-43.

PMID:
16258367
33.

Detection of resistance to imatinib by metabolic profiling: clinical and drug development implications.

Serkova N, Boros LG.

Am J Pharmacogenomics. 2005;5(5):293-302. Review.

PMID:
16196499
34.

Fermented wheat germ extract (Avemar) in the treatment of cancer and autoimmune diseases.

Boros LG, Nichelatti M, Shoenfeld Y.

Ann N Y Acad Sci. 2005 Jun;1051:529-42. Review.

PMID:
16126993
35.

K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts.

Vizan P, Boros LG, Figueras A, Capella G, Mangues R, Bassilian S, Lim S, Lee WN, Cascante M.

Cancer Res. 2005 Jul 1;65(13):5512-5. Erratum in: Cancer Res. 2005 Sep 1;65(17):8057.

36.

Polymorphism of the TNF-alpha, HSP70-2, and CD14 genes increases susceptibility to severe acute pancreatitis.

Balog A, Gyulai Z, Boros LG, Farkas G, Takács T, Lonovics J, Mándi Y.

Pancreas. 2005 Mar;30(2):e46-50.

PMID:
15714129
37.

Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor.

Eibl G, Takata Y, Boros LG, Liu J, Okada Y, Reber HA, Hines OJ.

Cancer Res. 2005 Feb 1;65(3):982-90.

38.
39.

Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment.

Lee WN, Guo P, Lim S, Bassilian S, Lee ST, Boren J, Cascante M, Go VL, Boros LG.

Br J Cancer. 2004 Dec 13;91(12):2094-100.

40.

Chromosomal aberrations in human lymphocytes exposed to the anticholinesterase pesticide isofenphos with mechanisms of leukemogenesis.

Williams RD, Boros LG, Kolanko CJ, Jackman SM, Eggers TR.

Leuk Res. 2004 Sep;28(9):947-58.

PMID:
15234572
41.

Dynamic profiling of the glucose metabolic network in fasted rat hepatocytes using [1,2-13C2]glucose.

Marin S, Lee WN, Bassilian S, Lim S, Boros LG, Centelles JJ, FernAndez-Novell JM, Guinovart JJ, Cascante M.

Biochem J. 2004 Jul 1;381(Pt 1):287-94.

42.

Metabolic biomarker and kinase drug target discovery in cancer using stable isotope-based dynamic metabolic profiling (SIDMAP).

Boros LG, Brackett DJ, Harrigan GG.

Curr Cancer Drug Targets. 2003 Dec;3(6):445-53. Review.

PMID:
14683502
43.

Metabolic strategy of boar spermatozoa revealed by a metabolomic characterization.

Marin S, Chiang K, Bassilian S, Lee WN, Boros LG, Fernández-Novell JM, Centelles JJ, Medrano A, Rodriguez-Gil JE, Cascante M.

FEBS Lett. 2003 Nov 20;554(3):342-6.

44.

Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA).

Boros LG, Steinkamp MP, Fleming JC, Lee WN, Cascante M, Neufeld EJ.

Blood. 2003 Nov 15;102(10):3556-61. Epub 2003 Jul 31.

45.

GLP-1 stimulates glucose-derived de novo fatty acid synthesis and chain elongation during cell differentiation and insulin release.

Bulotta A, Perfetti R, Hui H, Boros LG.

J Lipid Res. 2003 Aug;44(8):1559-65. Epub 2003 Jun 1.

46.

The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation.

Boren J, Lee WN, Bassilian S, Centelles JJ, Lim S, Ahmed S, Boros LG, Cascante M.

J Biol Chem. 2003 Aug 1;278(31):28395-402. Epub 2003 May 15.

47.

Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors.

Guo TB, Boros LG, Chan KC, Hikim AP, Hudson AP, Swerdloff RS, Mitchell AP, Salameh WA.

J Androl. 2003 Mar-Apr;24(2):204-14.

48.

Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1.

Bulotta A, Hui H, Anastasi E, Bertolotto C, Boros LG, Di Mario U, Perfetti R.

J Mol Endocrinol. 2002 Dec;29(3):347-60.

PMID:
12459036
49.

Oxygen-induced metabolic changes and transdifferentiation in immature fetal rat lung lipofibroblasts.

Boros LG, Torday JS, Paul Lee WN, Rehan VK.

Mol Genet Metab. 2002 Nov;77(3):230-6.

PMID:
12409271
50.

Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells.

Comin-Anduix B, Boros LG, Marin S, Boren J, Callol-Massot C, Centelles JJ, Torres JL, Agell N, Bassilian S, Cascante M.

J Biol Chem. 2002 Nov 29;277(48):46408-14. Epub 2002 Sep 25.

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