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Items: 1 to 50 of 138

1.

Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites.

Hansson A, Knych H, Stanley S, Berndtson E, Jackson L, Bondesson U, Thevis M, Hedeland M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 1;1074-1075:91-98. doi: 10.1016/j.jchromb.2017.12.010. Epub 2017 Dec 7.

PMID:
29334634
2.

Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control.

Garg N, Hansson A, Knych HK, Stanley SD, Thevis M, Bondesson U, Hedeland M, Globisch D.

Org Biomol Chem. 2018 Jan 31;16(5):698-702. doi: 10.1039/c7ob03030d.

PMID:
29319101
3.

Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'".

Dubbelboer IR, Lilienberg E, Karalli A, Axelsson R, Brismar TB, Ebeling Barbier C, Norén A, Duraj F, Hedeland M, Bondesson U, Sjögren E, Stål P, Nyman R, Lennernäs H.

Mol Pharm. 2018 Jan 2;15(1):336-340. doi: 10.1021/acs.molpharmaceut.7b00840. Epub 2017 Dec 1. No abstract available.

PMID:
29185767
4.

Plasma L-arginine levels distinguish pulmonary arterial hypertension from left ventricular systolic dysfunction.

Sandqvist A, Schneede J, Kylhammar D, Henrohn D, Lundgren J, Hedeland M, Bondesson U, Rådegran G, Wikström G.

Heart Vessels. 2017 Oct 3. doi: 10.1007/s00380-017-1055-7. [Epub ahead of print]

PMID:
28975394
5.

Quantification of dimethylsulfoxide (DMSO) in equine plasma and urine using HILIC-MS/MS.

Salomonsson ML, Bondesson U, Hedeland M.

Drug Test Anal. 2017 Sep;9(9):1472. doi: 10.1002/dta.2265. Epub 2017 Aug 30. No abstract available.

PMID:
28945329
6.

Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses.

Knych HK, Stanley SD, McKemie DS, Arthur RM, Bondesson U, Hedeland M, Thevis M, Kass PH.

Drug Test Anal. 2017 Sep;9(9):1392-1399. doi: 10.1002/dta.2214. Epub 2017 Aug 1.

PMID:
28513092
7.

Pharmacokinetics after a single dose of naloxone administered as a nasal spray in healthy volunteers.

Vanky E, Hellmundt L, Bondesson U, Eksborg S, Lundeberg S.

Acta Anaesthesiol Scand. 2017 Jul;61(6):636-640. doi: 10.1111/aas.12898. Epub 2017 Apr 25.

PMID:
28444856
8.

In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma.

Lilienberg E, Dubbelboer IR, Karalli A, Axelsson R, Brismar TB, Ebeling Barbier C, Norén A, Duraj F, Hedeland M, Bondesson U, Sjögren E, Stål P, Nyman R, Lennernäs H.

Mol Pharm. 2017 Feb 6;14(2):448-458. doi: 10.1021/acs.molpharmaceut.6b00886. Epub 2017 Jan 5.

PMID:
27997198
9.

Investigation of the metabolites of the HIF stabilizer FG-4592 (roxadustat) in five different in vitro models and in a human doping control sample using high resolution mass spectrometry.

Hansson A, Thevis M, Cox H, Miller G, Eichner D, Bondesson U, Hedeland M.

J Pharm Biomed Anal. 2017 Feb 5;134:228-236. doi: 10.1016/j.jpba.2016.11.041. Epub 2016 Nov 27.

PMID:
27918992
10.

Quantification of dimethylsulfoxide (DMSO) in equine plasma and urine using HILIC-MS/MS.

Salomonsson ML, Bondesson U, Hedeland M.

Drug Test Anal. 2017 Jun;9(6):935-941. doi: 10.1002/dta.2098. Epub 2016 Nov 4. Erratum in: Drug Test Anal. 2017 Sep;9(9):1472.

PMID:
27670954
11.

Nickel in equine sports drug testing - pilot study results on urinary nickel concentrations.

Thevis M, Machnik M, Schenk I, Krug O, Piper T, Schänzer W, Düe M, Bondesson U, Hedeland M.

Rapid Commun Mass Spectrom. 2016 Apr 15;30(7):982-4. doi: 10.1002/rcm.7528.

PMID:
26969941
12.

Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry.

Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M.

Rapid Commun Mass Spectrom. 2016 Apr 15;30(7):833-42. doi: 10.1002/rcm.7512.

PMID:
26969924
13.

Seafood sold in Sweden contains BMAA: A study of free and total concentrations with UHPLC-MS/MS and dansyl chloride derivatization.

Salomonsson ML, Fredriksson E, Alfjorden A, Hedeland M, Bondesson U.

Toxicol Rep. 2015 Nov 15;2:1473-1481. doi: 10.1016/j.toxrep.2015.11.002. eCollection 2015.

14.

A quantitative approach to analysing cortisol response in the horse.

Ekstrand C, Ingvast-Larsson C, Olsén L, Hedeland M, Bondesson U, Gabrielsson J.

J Vet Pharmacol Ther. 2016 Jun;39(3):255-63. doi: 10.1111/jvp.12276. Epub 2015 Nov 6.

PMID:
26542753
15.

Clinical Research Abstracts of the British Equine Veterinary Association Congress 2015.

Gröndahl G, Berglund A, Skidell J, Bondesson U, Salomonsson M.

Equine Vet J. 2015 Sep;47 Suppl 48:22. doi: 10.1111/evj.12486_49.

PMID:
26375998
16.

Acute vasodilator response to vardenafil and clinical outcome in patients with pulmonary hypertension.

Sandqvist A, Henrohn D, Egeröd H, Hedeland M, Wernroth L, Bondesson U, Schneede J, Wikström G.

Eur J Clin Pharmacol. 2015 Oct;71(10):1165-73. doi: 10.1007/s00228-015-1914-z. Epub 2015 Aug 5.

PMID:
26242227
17.

Characterization of a non-approved selective androgen receptor modulator drug candidate sold via the Internet and identification of in vitro generated phase-I metabolites for human sports drug testing.

Thevis M, Lagojda A, Kuehne D, Thomas A, Dib J, Hansson A, Hedeland M, Bondesson U, Wigger T, Karst U, Schänzer W.

Rapid Commun Mass Spectrom. 2015 Jun 15;29(11):991-9. doi: 10.1002/rcm.7189.

PMID:
26044265
18.

Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension.

Henrohn D, Sandqvist A, Egeröd H, Hedeland M, Wernroth L, Bondesson U, Wikström G.

Vascul Pharmacol. 2015 Oct;73:71-7. doi: 10.1016/j.vph.2015.04.010. Epub 2015 Apr 29.

PMID:
25934511
19.

Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes.

Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M.

Drug Test Anal. 2015 Aug;7(8):673-83. doi: 10.1002/dta.1768. Epub 2015 Jan 5.

PMID:
25560998
20.

Plasma concentration-dependent suppression of endogenous hydrocortisone in the horse after intramuscular administration of dexamethasone-21-isonicotinate.

Ekstrand C, Bondesson U, Gabrielsson J, Hedeland M, Kallings P, Olsén L, Ingvast-Larsson C.

J Vet Pharmacol Ther. 2015 Jun;38(3):235-42. doi: 10.1111/jvp.12175. Epub 2014 Nov 3.

PMID:
25366540
21.

Validation of the Endopep-MS method for qualitative detection of active botulinum neurotoxins in human and chicken serum.

Björnstad K, Tevell Åberg A, Kalb SR, Wang D, Barr JR, Bondesson U, Hedeland M.

Anal Bioanal Chem. 2014 Nov;406(28):7149-61. doi: 10.1007/s00216-014-8170-4. Epub 2014 Sep 17.

22.

A novel trapping system for the detection of reactive drug metabolites using the fungus Cunninghamella elegans and high resolution mass spectrometry.

Rydevik A, Hansson A, Hellqvist A, Bondesson U, Hedeland M.

Drug Test Anal. 2015 Jul;7(7):626-33. doi: 10.1002/dta.1714. Epub 2014 Sep 10.

PMID:
25209992
23.

Isolation and characterization of a β-glucuronide of hydroxylated SARM S1 produced using a combination of biotransformation and chemical oxidation.

Rydevik A, Lagojda A, Thevis M, Bondesson U, Hedeland M.

J Pharm Biomed Anal. 2014 Sep;98:36-9. doi: 10.1016/j.jpba.2014.05.001. Epub 2014 May 9.

PMID:
24879518
24.

Identification of European mosquito species by MALDI-TOF MS.

Yssouf A, Parola P, Lindström A, Lilja T, L'Ambert G, Bondesson U, Berenger JM, Raoult D, Almeras L.

Parasitol Res. 2014 Jun;113(6):2375-8. doi: 10.1007/s00436-014-3876-y. Epub 2014 Apr 16.

PMID:
24737398
25.

The effects of lipiodol and cyclosporin A on the hepatobiliary disposition of doxorubicin in pigs.

Dubbelboer IR, Lilienberg E, Hedeland M, Bondesson U, Piquette-Miller M, Sjögren E, Lennernäs H.

Mol Pharm. 2014 Apr 7;11(4):1301-13. doi: 10.1021/mp4007612. Epub 2014 Mar 7.

PMID:
24558959
26.

High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile.

Lundahl A, Tevell Åberg A, Bondesson U, Lennernäs H, Hedeland M.

Xenobiotica. 2014 Jun;44(6):498-510. doi: 10.3109/00498254.2013.866298. Epub 2013 Dec 9.

PMID:
24320817
27.

Investigation of hepatobiliary disposition of doxorubicin following intrahepatic delivery of different dosage forms.

Lilienberg E, Ebeling Barbier C, Nyman R, Hedeland M, Bondesson U, Axén N, Lennernäs H.

Mol Pharm. 2014 Jan 6;11(1):131-44. doi: 10.1021/mp4002574. Epub 2013 Nov 21.

PMID:
24171458
28.

Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs.

Sjögren E, Hedeland M, Bondesson U, Lennernäs H.

Eur J Pharm Sci. 2014 Jun 16;57:214-23. doi: 10.1016/j.ejps.2013.09.014. Epub 2013 Sep 27.

PMID:
24075962
29.

Synthesis, characterization, and detection of new oxandrolone metabolites as long-term markers in sports drug testing.

Guddat S, Fußhöller G, Beuck S, Thomas A, Geyer H, Rydevik A, Bondesson U, Hedeland M, Lagojda A, Schänzer W, Thevis M.

Anal Bioanal Chem. 2013 Oct;405(25):8285-94. doi: 10.1007/s00216-013-7218-1. Epub 2013 Jul 23.

PMID:
23877183
30.

Mass spectrometric characterization of glucuronides formed by a new concept, combining Cunninghamella elegans with TEMPO.

Rydevik A, Bondesson U, Thevis M, Hedeland M.

J Pharm Biomed Anal. 2013 Oct;84:278-84. doi: 10.1016/j.jpba.2013.06.012. Epub 2013 Jun 28.

PMID:
23867089
31.

Methadone in healthy goats - pharmacokinetics, behaviour and blood pressure.

Olsén L, Olsson K, Hydbring-Sandberg E, Bondesson U, Ingvast-Larsson C.

Res Vet Sci. 2013 Aug;95(1):231-7. doi: 10.1016/j.rvsc.2013.02.013. Epub 2013 Mar 26.

PMID:
23540608
32.

Intramuscular administration of sodium benzylpenicillin in horses as an alternative to procaine benzylpenicillin.

Olsén L, Bremer H, Olofsson K, Bröjer J, Bondesson U, Bergh A, Nostell K, Broström H, Bengtsson B, Ingvast-Larsson C.

Res Vet Sci. 2013 Aug;95(1):212-8. doi: 10.1016/j.rvsc.2013.01.019. Epub 2013 Feb 15.

PMID:
23419937
33.

Development and in-house validation of an LC-MS/MS method for the quantification of the mycotoxins deoxynivalenol, zearalenone, T-2 and HT-2 toxin, ochratoxin A and fumonisin B1 and B2 in vegetable animal feed.

Åberg AT, Solyakov A, Bondesson U.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(3):541-9. doi: 10.1080/19440049.2012.760208. Epub 2013 Jan 25.

PMID:
23350851
34.

Intraosseous samples can be used for opioid measurements--an experimental study in the anaesthetized pig.

Larsson T, Strandberg G, Eriksson M, Bondesson U, Lipcsey M, Larsson A.

Scand J Clin Lab Invest. 2013 Mar;73(2):102-6. doi: 10.3109/00365513.2012.744088. Epub 2012 Nov 22.

PMID:
23171472
35.

The fungus Cunninghamella elegans can produce human and equine metabolites of selective androgen receptor modulators (SARMs).

Rydevik A, Thevis M, Krug O, Bondesson U, Hedeland M.

Xenobiotica. 2013 May;43(5):409-20. doi: 10.3109/00498254.2012.729102. Epub 2012 Nov 15.

PMID:
23153056
36.

High inter-individual variability of vardenafil pharmacokinetics in patients with pulmonary hypertension.

Sandqvist AM, Henrohn D, Schneede J, Hedeland M, Egeröd HC, Bondesson UG, Wikström BG.

Eur J Clin Pharmacol. 2013 Feb;69(2):197-207. doi: 10.1007/s00228-012-1323-5. Epub 2012 Jun 26.

PMID:
22732766
37.
38.

Detection of recombinant human EPO administered to horses using MAIIA lateral flow isoform test.

Lönnberg M, Bondesson U, Cormant F, Garcia P, Bonnaire Y, Carlsson J, Popot MA, Rollborn N, Råsbo K, Bailly-Chouriberry L.

Anal Bioanal Chem. 2012 Jun;403(6):1619-28. doi: 10.1007/s00216-012-5972-0. Epub 2012 Apr 18.

PMID:
22526650
39.

Acute haemodynamic response in relation to plasma vardenafil concentrations in patients with pulmonary hypertension.

Henrohn D, Sandqvist A, Hedeland M, Egeröd H, Bondesson U, Wikström G.

Br J Clin Pharmacol. 2012 Dec;74(6):990-8. doi: 10.1111/j.1365-2125.2012.04303.x.

40.

A new analytical method based on anti-EPO monolith column and LC-FAIMS-MS/MS for the detection of rHuEPOs in horse plasma and urine samples.

Bailly-Chouriberry L, Cormant F, Garcia P, Lönnberg M, Szwandt S, Bondesson U, Popot MA, Bonnaire Y.

Analyst. 2012 May 21;137(10):2445-53. doi: 10.1039/c2an15662h. Epub 2012 Mar 27.

PMID:
22454833
41.

Confirmation of botulism in birds and cattle by the mouse bioassay and Endopep-MS.

Hedeland M, Moura H, Båverud V, Woolfitt AR, Bondesson U, Barr JR.

J Med Microbiol. 2011 Sep;60(Pt 9):1299-305. doi: 10.1099/jmm.0.031179-0. Epub 2011 May 12.

PMID:
21566090
42.

In vivo investigation in pigs of intestinal absorption, hepatobiliary disposition, and metabolism of the 5α-reductase inhibitor finasteride and the effects of coadministered ketoconazole.

Lundahl A, Hedeland M, Bondesson U, Lennernäs H.

Drug Metab Dispos. 2011 May;39(5):847-57. doi: 10.1124/dmd.110.035311. Epub 2011 Feb 11.

43.

Pharmacokinetics of meloxicam in adult goats and its analgesic effect in disbudded kids.

Ingvast-Larsson C, Högberg M, Mengistu U, Olsén L, Bondesson U, Olsson K.

J Vet Pharmacol Ther. 2011 Feb;34(1):64-9. doi: 10.1111/j.1365-2885.2010.01195.x.

PMID:
21219346
44.

The effect of acute administration of rifampicin and imatinib on the enterohepatic transport of rosuvastatin in vivo.

Bergman E, Hedeland M, Bondesson U, Lennernäs H.

Xenobiotica. 2010 Aug;40(8):558-68. doi: 10.3109/00498254.2010.496498.

PMID:
20583894
45.

Structural elucidation of N-oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification.

Tevell Aberg A, Löfgren H, Bondesson U, Hedeland M.

Rapid Commun Mass Spectrom. 2010 May 30;24(10):1447-56. doi: 10.1002/rcm.4535.

PMID:
20411584
46.

Effect of a single gemfibrozil dose on the pharmacokinetics of rosuvastatin in bile and plasma in healthy volunteers.

Bergman E, Matsson EM, Hedeland M, Bondesson U, Knutson L, Lennernäs H.

J Clin Pharmacol. 2010 Sep;50(9):1039-49. doi: 10.1177/0091270009357432. Epub 2010 Feb 11.

PMID:
20150523
47.

Pharmacokinetics and effects of cetirizine in horses with insect bite hypersensitivity.

Olsén L, Bondesson U, Broström H, Olsson U, Mazogi B, Sundqvist M, Tjälve H, Ingvast-Larsson C.

Vet J. 2011 Mar;187(3):347-51. doi: 10.1016/j.tvjl.2009.12.030. Epub 2010 Jan 25.

PMID:
20097587
48.

Clinical pharmacology of methadone in dogs.

Ingvast-Larsson C, Holgersson A, Bondesson U, Lagerstedt AS, Olsson K.

Vet Anaesth Analg. 2010 Jan;37(1):48-56. doi: 10.1111/j.1467-2995.2009.00476.x.

PMID:
20017819
49.

Enterohepatic disposition of rosuvastatin in pigs and the impact of concomitant dosing with cyclosporine and gemfibrozil.

Bergman E, Lundahl A, Fridblom P, Hedeland M, Bondesson U, Knutson L, Lennernäs H.

Drug Metab Dispos. 2009 Dec;37(12):2349-58. doi: 10.1124/dmd.109.029363. Epub 2009 Sep 22.

50.

Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions.

Thörn HA, Hedeland M, Bondesson U, Knutson L, Yasin M, Dickinson P, Lennernäs H.

Drug Metab Dispos. 2009 Nov;37(11):2186-96. doi: 10.1124/dmd.109.028027. Epub 2009 Aug 17.

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