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A human endothelial cell-based recycling assay for screening of FcRn targeted molecules.

Grevys A, Nilsen J, Sand KMK, Daba MB, Øynebråten I, Bern M, McAdam MB, Foss S, Schlothauer T, Michaelsen TE, Christianson GJ, Roopenian DC, Blumberg RS, Sandlie I, Andersen JT.

Nat Commun. 2018 Feb 12;9(1):621. doi: 10.1038/s41467-018-03061-x.


Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy.

Sabatos-Peyton CA, Nevin J, Brock A, Venable JD, Tan DJ, Kassam N, Xu F, Taraszka J, Wesemann L, Pertel T, Acharya N, Klapholz M, Etminan Y, Jiang X, Huang YH, Blumberg RS, Kuchroo VK, Anderson AC.

Oncoimmunology. 2017 Nov 9;7(2):e1385690. doi: 10.1080/2162402X.2017.1385690. eCollection 2018.


Correction for Nguyen et al., "Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers".

Nguyen S, Baker K, Padman BS, Patwa R, Dunstan RA, Weston TA, Schlosser K, Bailey B, Lithgow T, Lazarou M, Luque A, Rohwer F, Blumberg RS, Barr JJ.

MBio. 2018 Jan 2;9(1). pii: e02207-17. doi: 10.1128/mBio.02207-17. No abstract available.


The neonatal window of opportunity-early priming for life.

Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW.

J Allergy Clin Immunol. 2017 Dec 14. pii: S0091-6749(17)31895-X. doi: 10.1016/j.jaci.2017.11.019. [Epub ahead of print] No abstract available.


IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells.

Clancy-Thompson E, Ali L, Bruck PT, Exley MA, Blumberg RS, Dranoff G, Dougan M, Dougan SK.

Cancer Immunol Res. 2018 Jan;6(1):25-35. doi: 10.1158/2326-6066.CIR-17-0490. Epub 2017 Nov 29.


Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers.

Nguyen S, Baker K, Padman BS, Patwa R, Dunstan RA, Weston TA, Schlosser K, Bailey B, Lithgow T, Lazarou M, Luque A, Rohwer F, Blumberg RS, Barr JJ.

MBio. 2017 Nov 21;8(6). pii: e01874-17. doi: 10.1128/mBio.01874-17. Erratum in: MBio. 2018 Jan 2;9(1):.


Maternal IgG immune complexes induce food allergen-specific tolerance in offspring.

Ohsaki A, Venturelli N, Buccigrosso TM, Osganian SK, Lee J, Blumberg RS, Oyoshi MK.

J Exp Med. 2018 Jan 2;215(1):91-113. doi: 10.1084/jem.20171163. Epub 2017 Nov 20.


CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation.

Zeissig S, Peuker K, Iyer S, Gensollen T, Dougan SK, Olszak T, Kaser A, Blumberg RS.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10449-10454. doi: 10.1073/pnas.1701428114. Epub 2017 Sep 11.


The road to Crohn's disease.

Kaser A, Blumberg RS.

Science. 2017 Sep 8;357(6355):976-977. doi: 10.1126/science.aao4158. No abstract available.


CEACAM1 as a multi-purpose target for cancer immunotherapy.

Dankner M, Gray-Owen SD, Huang YH, Blumberg RS, Beauchemin N.

Oncoimmunology. 2017 May 16;6(7):e1328336. doi: 10.1080/2162402X.2017.1328336. eCollection 2017. Review.


A role for oncostatin M in inflammatory bowel disease.

Kim WM, Kaser A, Blumberg RS.

Nat Med. 2017 May 5;23(5):535-536. doi: 10.1038/nm.4338. No abstract available.


Correlation between early-life regulation of the immune system by microbiota and allergy development.

Gensollen T, Blumberg RS.

J Allergy Clin Immunol. 2017 Apr;139(4):1084-1091. doi: 10.1016/j.jaci.2017.02.011. Review.


CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells.

Ueshima C, Kataoka TR, Takei Y, Hirata M, Sugimoto A, Hirokawa M, Okayama Y, Blumberg RS, Haga H.

Cancer Med. 2017 Apr;6(4):845-856. doi: 10.1002/cam4.1050. Epub 2017 Mar 23.


Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.

Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2862-E2871. doi: 10.1073/pnas.1618291114. Epub 2017 Mar 22.


The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation.

Schrumpf E, Jiang X, Zeissig S, Pollheimer MJ, Anmarkrud JA, Tan C, Exley MA, Karlsen TH, Blumberg RS, Melum E.

Physiol Rep. 2017 Feb;5(4). pii: e13117. doi: 10.14814/phy2.13117.


Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.

Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A.

J Exp Med. 2017 Feb;214(2):401-422. doi: 10.1084/jem.20160791. Epub 2017 Jan 12.


The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation.

Schrumpf E, Kummen M, Valestrand L, Greiner TU, Holm K, Arulampalam V, Reims HM, Baines J, Bäckhed F, Karlsen TH, Blumberg RS, Hov JR, Melum E.

J Hepatol. 2017 Feb;66(2):382-389. doi: 10.1016/j.jhep.2016.09.020. Epub 2016 Oct 5.


Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι.

Nakanishi Y, Reina-Campos M, Nakanishi N, Llado V, Elmen L, Peterson S, Campos A, De SK, Leitges M, Ikeuchi H, Pellecchia M, Blumberg RS, Diaz-Meco MT, Moscat J.

Cell Rep. 2016 Sep 20;16(12):3297-3310. doi: 10.1016/j.celrep.2016.08.054.


Rare phenotypes in the understanding of autoimmunity.

Zeissig Y, Petersen BS, Franke A, Blumberg RS, Zeissig S.

Immunol Cell Biol. 2016 Nov;94(10):943-948. doi: 10.1038/icb.2016.76. Epub 2016 Oct 11. Review.


Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.

Aden K, Rehman A, Falk-Paulsen M, Secher T, Kuiper J, Tran F, Pfeuffer S, Sheibani-Tezerji R, Breuer A, Luzius A, Jentzsch M, Häsler R, Billmann-Born S, Will O, Lipinski S, Bharti R, Adolph T, Iovanna JL, Kempster SL, Blumberg RS, Schreiber S, Becher B, Chamaillard M, Kaser A, Rosenstiel P.

Cell Rep. 2016 Aug 23;16(8):2208-2218. doi: 10.1016/j.celrep.2016.07.054. Epub 2016 Aug 11.


Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models.

Mudde AC, Lexmond WS, Blumberg RS, Nurko S, Fiebiger E.

World Allergy Organ J. 2016 Jul 15;9:23. doi: 10.1186/s40413-016-0114-3. eCollection 2016. Review.


The unfolded protein response in immunity and inflammation.

Grootjans J, Kaser A, Kaufman RJ, Blumberg RS.

Nat Rev Immunol. 2016 Aug;16(8):469-84. doi: 10.1038/nri.2016.62. Epub 2016 Jun 27. Review.


CEACAM1-Mediated Inhibition of Virus Production.

Vitenshtein A, Weisblum Y, Hauka S, Halenius A, Oiknine-Djian E, Tsukerman P, Bauman Y, Bar-On Y, Stern-Ginossar N, Enk J, Ortenberg R, Tai J, Markel G, Blumberg RS, Hengel H, Jonjic S, Wolf DG, Adler H, Kammerer R, Mandelboim O.

Cell Rep. 2016 Jun 14;15(11):2331-9. doi: 10.1016/j.celrep.2016.05.036. Epub 2016 Jun 2.


How colonization by microbiota in early life shapes the immune system.

Gensollen T, Iyer SS, Kasper DL, Blumberg RS.

Science. 2016 Apr 29;352(6285):539-44. doi: 10.1126/science.aad9378. Review.


Epithelial calcineurin controls microbiota-dependent intestinal tumor development.

Peuker K, Muff S, Wang J, Künzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Röcken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S.

Nat Med. 2016 May;22(5):506-15. doi: 10.1038/nm.4072. Epub 2016 Apr 4.


Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16. No abstract available.


Environment and Genes: What Is the Interaction?

Blumberg RS.

Dig Dis. 2016;34(1-2):20-6. doi: 10.1159/000442920. Epub 2016 Mar 16. Review.



Grover S, Lim RM, Blumberg RS, Syngal S.

J Clin Oncol. 2016 Apr 1;34(10):1154-5. doi: 10.1200/JCO.2015.65.7973. Epub 2016 Feb 1. No abstract available.


Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice.

Krishnamoorthy S, Liu T, Drager D, Patarroyo-White S, Chhabra ES, Peters R, Josephson N, Lillicrap D, Blumberg RS, Pierce GF, Jiang H.

Cell Immunol. 2016 Mar;301:30-9. doi: 10.1016/j.cellimm.2015.12.008. Epub 2015 Dec 29.


Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.

Lin JE, Colon-Gonzalez F, Blomain E, Kim GW, Aing A, Stoecker B, Rock J, Snook AE, Zhan T, Hyslop TM, Tomczak M, Blumberg RS, Waldman SA.

Cancer Res. 2016 Jan 15;76(2):339-46. doi: 10.1158/0008-5472.CAN-15-1467-T.


Leukotrienes and the other airway: Celiac disease and asthma collide.

Grootjans J, Hosomi S, Blumberg RS.

J Exp Med. 2015 Sep 21;212(10):1485. doi: 10.1084/jem.21210insight4. No abstract available.


Control of intestinal homeostasis through crosstalk between natural killer T cells and the intestinal microbiota.

Dowds CM, Blumberg RS, Zeissig S.

Clin Immunol. 2015 Aug;159(2):128-33. doi: 10.1016/j.clim.2015.05.008. Epub 2015 May 16. Review.


FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.

Pyzik M, Rath T, Lencer WI, Baker K, Blumberg RS.

J Immunol. 2015 May 15;194(10):4595-603. doi: 10.4049/jimmunol.1403014. Review.


The biliary epithelium presents antigens to and activates natural killer T cells.

Schrumpf E, Tan C, Karlsen TH, Sponheim J, Björkström NK, Sundnes O, Alfsnes K, Kaser A, Jefferson DM, Ueno Y, Eide TJ, Haraldsen G, Zeissig S, Exley MA, Blumberg RS, Melum E.

Hepatology. 2015 Oct;62(4):1249-59. doi: 10.1002/hep.27840. Epub 2015 May 20.


IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses.

Platzer B, Elpek KG, Cremasco V, Baker K, Stout MM, Schultz C, Dehlink E, Shade KT, Anthony RM, Blumberg RS, Turley SJ, Fiebiger E.

Cell Rep. 2015 Mar 3. pii: S2211-1247(15)00143-6. doi: 10.1016/j.celrep.2015.02.015. [Epub ahead of print]


Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells.

Arabzadeh A, Dupaul-Chicoine J, Breton V, Haftchenary S, Yumeen S, Turbide C, Saleh M, McGregor K, Greenwood CM, Akavia UD, Blumberg RS, Gunning PT, Beauchemin N.

Gut. 2016 May;65(5):821-9. doi: 10.1136/gutjnl-2014-308781. Epub 2015 Feb 9.


Evidence that FcRn mediates the transplacental passage of maternal IgE in the form of IgG anti-IgE/IgE immune complexes.

Bundhoo A, Paveglio S, Rafti E, Dhongade A, Blumberg RS, Matson AP.

Clin Exp Allergy. 2015 Jun;45(6):1085-98. doi: 10.1111/cea.12508.


Regulation of immune responses by the neonatal fc receptor and its therapeutic implications.

Rath T, Baker K, Pyzik M, Blumberg RS.

Front Immunol. 2015 Jan 5;5:664. doi: 10.3389/fimmu.2014.00664. eCollection 2014. Review.


Role of endoplasmic reticulum stress and autophagy as interlinking pathways in the pathogenesis of inflammatory bowel disease.

Hosomi S, Kaser A, Blumberg RS.

Curr Opin Gastroenterol. 2015 Jan;31(1):81-8. doi: 10.1097/MOG.0000000000000144. Review.


Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4.

Zeissig S, Petersen BS, Tomczak M, Melum E, Huc-Claustre E, Dougan SK, Laerdahl JK, Stade B, Forster M, Schreiber S, Weir D, Leichtner AM, Franke A, Blumberg RS.

Gut. 2015 Dec;64(12):1889-97. doi: 10.1136/gutjnl-2014-308541. Epub 2014 Nov 3.


CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2015 Jan 15;517(7534):386-90. doi: 10.1038/nature13848. Epub 2014 Oct 26. Erratum in: Nature. 2016 Aug 18;536(7616):359.


Neonatal Fc receptors for IgG drive CD8+ T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites.

Baker K, Rath T, Pyzik M, Blumberg RS.

Oncoimmunology. 2014 Feb 14;3:e27844. eCollection 2014.


Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites.

Platzer B, Baker K, Vera MP, Singer K, Panduro M, Lexmond WS, Turner D, Vargas SO, Kinet JP, Maurer D, Baron RM, Blumberg RS, Fiebiger E.

Mucosal Immunol. 2015 May;8(3):516-32. doi: 10.1038/mi.2014.85. Epub 2014 Sep 17.


The Role of FcRn in Antigen Presentation.

Baker K, Rath T, Pyzik M, Blumberg RS.

Front Immunol. 2014 Aug 27;5:408. doi: 10.3389/fimmu.2014.00408. eCollection 2014. Review.


Enhanced neonatal Fc receptor function improves protection against primate SHIV infection.

Ko SY, Pegu A, Rudicell RS, Yang ZY, Joyce MG, Chen X, Wang K, Bao S, Kraemer TD, Rath T, Zeng M, Schmidt SD, Todd JP, Penzak SR, Saunders KO, Nason MC, Haase AT, Rao SS, Blumberg RS, Mascola JR, Nabel GJ.

Nature. 2014 Oct 30;514(7524):642-5. doi: 10.1038/nature13612. Epub 2014 Aug 13.


Commensal microbial regulation of natural killer T cells at the frontiers of the mucosal immune system.

Zeissig S, Blumberg RS.

FEBS Lett. 2014 Nov 17;588(22):4188-94. doi: 10.1016/j.febslet.2014.06.042. Epub 2014 Jun 28. Review.


Protective mucosal immunity mediated by epithelial CD1d and IL-10.

Olszak T, Neves JF, Dowds CM, Baker K, Glickman J, Davidson NO, Lin CS, Jobin C, Brand S, Sotlar K, Wada K, Katayama K, Nakajima A, Mizuguchi H, Kawasaki K, Nagata K, Müller W, Snapper SB, Schreiber S, Kaser A, Zeissig S, Blumberg RS.

Nature. 2014 May 22;509(7501):497-502. doi: 10.1038/nature13150. Epub 2014 Apr 6.


Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease.

Zeissig S, Blumberg RS.

Nat Immunol. 2014 Apr;15(4):307-10. doi: 10.1038/ni.2847. No abstract available.


Cell biology: Stressful genetics in Crohn's disease.

Kaser A, Blumberg RS.

Nature. 2014 Feb 27;506(7489):441-2. doi: 10.1038/nature13060. Epub 2014 Feb 19. No abstract available.


Involvement of the iNKT cell pathway is associated with early-onset eosinophilic esophagitis and response to allergen avoidance therapy.

Lexmond WS, Neves JF, Nurko S, Olszak T, Exley MA, Blumberg RS, Fiebiger E.

Am J Gastroenterol. 2014 May;109(5):646-57. doi: 10.1038/ajg.2014.12. Epub 2014 Feb 11.

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