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Items: 1 to 50 of 321

1.

DHA Modifies the Size and Composition of Raftlike Domains: A Solid-State 2H NMR Study.

Kinnun JJ, Bittman R, Shaikh SR, Wassall SR.

Biophys J. 2018 Jan 23;114(2):380-391. doi: 10.1016/j.bpj.2017.11.023.

PMID:
29401435
2.

Percutaneous Image-Guided Cryoneurolysis.

Bittman RW, Peters GL, Newsome JM, Friedberg EB, Mitchell JW, Knight JM, Prologo JD.

AJR Am J Roentgenol. 2018 Feb;210(2):454-465. doi: 10.2214/AJR.17.18452. Epub 2017 Dec 8.

PMID:
29220211
3.

HDL particles incorporate into lipid bilayers - a combined AFM and single molecule fluorescence microscopy study.

Plochberger B, Röhrl C, Preiner J, Rankl C, Brameshuber M, Madl J, Bittman R, Ros R, Sezgin E, Eggeling C, Hinterdorfer P, Stangl H, Schütz GJ.

Sci Rep. 2017 Nov 21;7(1):15886. doi: 10.1038/s41598-017-15949-7.

4.

Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier.

Wang X, Maruvada R, Morris AJ, Liu JO, Wolfgang MJ, Baek DJ, Bittman R, Kim KS.

PLoS Pathog. 2016 Oct 6;12(10):e1005926. doi: 10.1371/journal.ppat.1005926. eCollection 2016 Oct.

5.

Structure and dynamics of the aliphatic cholesterol side chain in membranes as studied by (2)H NMR spectroscopy and molecular dynamics simulation.

Vogel A, Scheidt HA, Baek DJ, Bittman R, Huster D.

Phys Chem Chem Phys. 2016 Feb 7;18(5):3730-8. doi: 10.1039/c5cp05084g.

PMID:
26762541
6.

"Pulmonary Endothelial Cell Barrier Enhancement by Novel FTY720 Analogs: Methoxy-FTY720, Fluoro-FTY720, and β-Glucuronide-FTY720".

Camp SM, Chiang ET, Sun C, Usatyuk PV, Bittman R, Natarajan V, Garcia JG, Dudek SM.

Chem Phys Lipids. 2016 Jan;194:85-93. doi: 10.1016/j.chemphyslip.2015.10.004. Epub 2015 Oct 29.

PMID:
26496151
7.

Ceramide channel: Structural basis for selective membrane targeting.

Perera MN, Ganesan V, Siskind LJ, Szulc ZM, Bielawska A, Bittman R, Colombini M.

Chem Phys Lipids. 2016 Jan;194:110-116. doi: 10.1016/j.chemphyslip.2015.09.007. Epub 2015 Sep 25.

8.

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways.

Blom T, Li S, Dichlberger A, Bäck N, Kim YA, Loizides-Mangold U, Riezman H, Bittman R, Ikonen E.

Nat Chem Biol. 2015 Oct;11(10):799-806. doi: 10.1038/nchembio.1889. Epub 2015 Aug 17.

PMID:
26280656
9.

Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720.

Camp SM, Chiang ET, Sun C, Usatyuk PV, Bittman R, Natarajan V, Garcia JG, Dudek SM.

Chem Phys Lipids. 2015 Oct;191:16-24. doi: 10.1016/j.chemphyslip.2015.08.004. Epub 2015 Aug 10.

10.

Synthesis and biological activity of alkynoic acids derivatives against mycobacteria.

Vilchèze C, Leung LW, Bittman R, Jacobs WR Jr.

Chem Phys Lipids. 2016 Jan;194:125-38. doi: 10.1016/j.chemphyslip.2015.08.001. Epub 2015 Aug 6.

11.

Synthesis and antiproliferative properties of a new ceramide analog of varacin.

Mahendran A, Ghogare AA, Bittman R, Arthur G, Greer A.

Chem Phys Lipids. 2016 Jan;194:165-70. doi: 10.1016/j.chemphyslip.2015.07.023. Epub 2015 Aug 5.

12.

Synthesis and photochemical properties of PEGylated coumarin-caged ceramides for cell studies.

Kim YA, Day J, Lirette CA, Costain WJ, Johnston LJ, Bittman R.

Chem Phys Lipids. 2016 Jan;194:117-24. doi: 10.1016/j.chemphyslip.2015.07.006. Epub 2015 Jul 19.

13.

Properties of HIV-1 associated cholesterol in addition to raft formation are important for virus infection.

Hawkes D, Jones KL, Smyth RP, Pereira CF, Bittman R, Jaworowski A, Mak J.

Virus Res. 2015 Dec 2;210:18-21. doi: 10.1016/j.virusres.2015.06.023. Epub 2015 Jul 17.

PMID:
26191619
14.

Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis.

Boomkamp SD, Byun HS, Ubhi S, Jiang HR, Pyne S, Bittman R, Pyne NJ.

Chem Phys Lipids. 2016 Jan;194:2-11. doi: 10.1016/j.chemphyslip.2015.07.001. Epub 2015 Jul 14.

PMID:
26187854
15.

Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures.

Schweitzer KS, Chen SX, Law S, Van Demark M, Poirier C, Justice MJ, Hubbard WC, Kim ES, Lai X, Wang M, Kranz WD, Carroll CJ, Ray BD, Bittman R, Goodpaster J, Petrache I.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L175-87. doi: 10.1152/ajplung.00411.2014. Epub 2015 May 15.

16.

Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics.

Woodcock JM, Coolen C, Goodwin KL, Baek DJ, Bittman R, Samuel MS, Pitson SM, Lopez AF.

Oncotarget. 2015 Jun 10;6(16):14522-36.

17.

Junctional complex and focal adhesion rearrangement mediates pulmonary endothelial barrier enhancement by FTY720 S-phosphonate.

Wang L, Bittman R, Garcia JG, Dudek SM.

Microvasc Res. 2015 May;99:102-9. doi: 10.1016/j.mvr.2015.03.007. Epub 2015 Apr 7.

18.

Ceramide-1-phosphate inhibits cigarette smoke-induced airway inflammation.

Baudiß K, Ayata CK, Lazar Z, Cicko S, Beckert J, Meyer A, Zech A, Vieira RP, Bittman R, Gómez-Muñoz A, Merfort I, Idzko M.

Eur Respir J. 2015 Jun;45(6):1669-80. doi: 10.1183/09031936.00080014. Epub 2015 Jan 22.

19.

p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas.

Hendley AM, Provost E, Bailey JM, Wang YJ, Cleveland MH, Blake D, Bittman RW, Roeser JC, Maitra A, Reynolds AB, Leach SD.

Dev Biol. 2015 Mar 1;399(1):41-53. doi: 10.1016/j.ydbio.2014.12.010. Epub 2014 Dec 16.

20.

Phosphatidic acid inhibits ceramide 1-phosphate-stimulated macrophage migration.

Ouro A, Arana L, Rivera IG, Ordoñez M, Gomez-Larrauri A, Presa N, Simón J, Trueba M, Gangoiti P, Bittman R, Gomez-Muñoz A.

Biochem Pharmacol. 2014 Dec 15;92(4):642-50. doi: 10.1016/j.bcp.2014.10.005. Epub 2014 Oct 18.

PMID:
25450673
21.

Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.

Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD.

J Clin Invest. 2014 Dec;124(12):5368-84. doi: 10.1172/JCI74188. Epub 2014 Oct 27.

22.

Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells.

Venkataswamy MM, Ng TW, Kharkwal SS, Carreño LJ, Johnson AJ, Kunnath-Velayudhan S, Liu Z, Bittman R, Jervis PJ, Cox LR, Besra GS, Wen X, Yuan W, Tsuji M, Li X, Ho DD, Chan J, Lee S, Frothingham R, Haynes BF, Panas MW, Gillard GO, Sixsmith JD, Korioth-Schmitz B, Schmitz JE, Larsen MH, Jacobs WR Jr, Porcelli SA.

PLoS One. 2014 Sep 25;9(9):e108383. doi: 10.1371/journal.pone.0108383. eCollection 2014.

23.

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.

Evangelisti C, Evangelisti C, Teti G, Chiarini F, Falconi M, Melchionda F, Pession A, Bertaina A, Locatelli F, McCubrey JA, Beak DJ, Bittman R, Pyne S, Pyne NJ, Martelli AM.

Oncotarget. 2014 Sep 15;5(17):7886-901.

24.

Membrane properties of cholesterol analogs with an unbranched aliphatic side chain.

Meyer T, Baek DJ, Bittman R, Haralampiev I, Müller P, Herrmann A, Huster D, Scheidt HA.

Chem Phys Lipids. 2014 Dec;184:1-6. doi: 10.1016/j.chemphyslip.2014.08.002. Epub 2014 Aug 27.

PMID:
25173446
25.

Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes.

Neuvonen M, Manna M, Mokkila S, Javanainen M, Rog T, Liu Z, Bittman R, Vattulainen I, Ikonen E.

PLoS One. 2014 Aug 26;9(8):e103743. doi: 10.1371/journal.pone.0103743. eCollection 2014.

26.

Synthesis of cholesterol analogues bearing BODIPY fluorophores by Suzuki or Liebeskind-Srogl cross-coupling and evaluation of their potential for visualization of cholesterol pools.

Liu Z, Thacker SG, Fernandez-Castillejo S, Neufeld EB, Remaley AT, Bittman R.

Chembiochem. 2014 Sep 22;15(14):2087-96. doi: 10.1002/cbic.201402042. Epub 2014 Aug 22.

PMID:
25154602
27.

Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver.

Fruhwürth S, Kovacs WJ, Bittman R, Messner S, Röhrl C, Stangl H.

Histochem Cell Biol. 2014 Dec;142(6):645-55. doi: 10.1007/s00418-014-1251-9. Epub 2014 Jul 25.

28.

Inhibition of mTOR down-regulates scavenger receptor, class B, type I (SR-BI) expression, reduces endothelial cell migration and impairs nitric oxide production.

Fruhwürth S, Krieger S, Winter K, Rosner M, Mikula M, Weichhart T, Bittman R, Hengstschläger M, Stangl H.

Biochim Biophys Acta. 2014 Jul;1841(7):944-53. doi: 10.1016/j.bbalip.2014.03.014. Epub 2014 Apr 5.

29.

A fluorescent alkyllysophospholipid analog exhibits selective cytotoxicity against the hormone-insensitive prostate cancer cell line PC3.

Samadder P, Byun HS, Bittman R, Arthur G.

Anticancer Agents Med Chem. 2014 May;14(4):528-38.

PMID:
24628239
30.

Glycosylated antitumor ether lipids: activity and mechanism of action.

Arthur G, Bittman R.

Anticancer Agents Med Chem. 2014 May;14(4):592-606. Review.

PMID:
24628233
32.

A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.

Arora P, Baena A, Yu KO, Saini NK, Kharkwal SS, Goldberg MF, Kunnath-Velayudhan S, Carreño LJ, Venkataswamy MM, Kim J, Lazar-Molnar E, Lauvau G, Chang YT, Liu Z, Bittman R, Al-Shamkhani A, Cox LR, Jervis PJ, Veerapen N, Besra GS, Porcelli SA.

Immunity. 2014 Jan 16;40(1):105-16. doi: 10.1016/j.immuni.2013.12.004. Epub 2014 Jan 9.

34.

Cholesterol's aliphatic side chain modulates membrane properties.

Scheidt HA, Meyer T, Nikolaus J, Baek DJ, Haralampiev I, Thomas L, Bittman R, Müller P, Herrmann A, Huster D.

Angew Chem Int Ed Engl. 2013 Dec 2;52(49):12848-51. doi: 10.1002/anie.201306753. Epub 2013 Nov 25.

35.

High-density lipoprotein endocytosis in endothelial cells.

Fruhwürth S, Pavelka M, Bittman R, Kovacs WJ, Walter KM, Röhrl C, Stangl H.

World J Biol Chem. 2013 Nov 26;4(4):131-40. doi: 10.4331/wjbc.v4.i4.131.

36.

FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury.

Wang L, Sammani S, Moreno-Vinasco L, Letsiou E, Wang T, Camp SM, Bittman R, Garcia JG, Dudek SM.

Crit Care Med. 2014 Mar;42(3):e189-99. doi: 10.1097/CCM.0000000000000097.

37.

Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif.

Fells JI, Lee SC, Norman DD, Tsukahara R, Kirby JR, Nelson S, Seibel W, Papoian R, Patil R, Miller DD, Parrill AL, Pham TC, Baker DL, Bittman R, Tigyi G.

FEBS J. 2014 Feb;281(4):1017-28. doi: 10.1111/febs.12674. Epub 2014 Jan 15.

38.

Membrane orientation and lateral diffusion of BODIPY-cholesterol as a function of probe structure.

Solanko LM, Honigmann A, Midtiby HS, Lund FW, Brewer JR, Dekaris V, Bittman R, Eggeling C, Wüstner D.

Biophys J. 2013 Nov 5;105(9):2082-92. doi: 10.1016/j.bpj.2013.09.031.

39.

LDL cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin-dependent membrane transport route.

Kanerva K, Uronen RL, Blom T, Li S, Bittman R, Lappalainen P, Peränen J, Raposo G, Ikonen E.

Dev Cell. 2013 Nov 11;27(3):249-62. doi: 10.1016/j.devcel.2013.09.016. Epub 2013 Oct 24.

40.

Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors.

Baek DJ, MacRitchie N, Anthony NG, Mackay SP, Pyne S, Pyne NJ, Bittman R.

J Med Chem. 2013 Nov 27;56(22):9310-27. doi: 10.1021/jm401399c. Epub 2013 Nov 14.

41.

Lipid metabolites enhance secretion acting on SNARE microdomains and altering the extent and kinetics of single release events in bovine adrenal chromaffin cells.

García-Martínez V, Villanueva J, Torregrosa-Hetland CJ, Bittman R, Higdon A, Darley-Usmar VM, Davletov B, Gutiérrez LM.

PLoS One. 2013 Sep 20;8(9):e75845. doi: 10.1371/journal.pone.0075845. eCollection 2013.

42.

The role of sphingosine 1-phosphate in inflammation and cancer.

Pyne NJ, Ohotski J, Bittman R, Pyne S.

Adv Biol Regul. 2014 Jan;54:121-9. doi: 10.1016/j.jbior.2013.08.005. Epub 2013 Sep 11. Review.

PMID:
24070975
43.
44.

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells.

Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, Sun C, Saddoughi SA, Bielawski J, Blum W, Klisovic RB, Solt JA, Byrd JC, Volinia S, Cortes J, Huettner CS, Koschmieder S, Holyoake TL, Devine S, Caligiuri MA, Croce CM, Garzon R, Ogretmen B, Arlinghaus RB, Chen CS, Bittman R, Hokland P, Roy DC, Milojkovic D, Apperley J, Goldman JM, Reid A, Mulloy JC, Bhatia R, Marcucci G, Perrotti D.

J Clin Invest. 2013 Oct;123(10):4144-57. doi: 10.1172/JCI68951. Epub 2013 Sep 3.

45.

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies.

Oaks JJ, Santhanam R, Walker CJ, Roof S, Harb JG, Ferenchak G, Eisfeld AK, Van Brocklyn JR, Briesewitz R, Saddoughi SA, Nagata K, Bittman R, Caligiuri MA, Abdel-Wahab O, Levine R, Arlinghaus RB, Quintas-Cardama A, Goldman JM, Apperley J, Reid A, Milojkovic D, Ziolo MT, Marcucci G, Ogretmen B, Neviani P, Perrotti D.

Blood. 2013 Sep 12;122(11):1923-34. doi: 10.1182/blood-2013-03-492181. Epub 2013 Aug 7. Erratum in: Blood. 2014 May 8;123(19):3056.

46.

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.

Pietiäinen V, Vassilev B, Blom T, Wang W, Nelson J, Bittman R, Bäck N, Zelcer N, Ikonen E.

J Cell Sci. 2013 Sep 1;126(Pt 17):3961-71. doi: 10.1242/jcs.128132. Epub 2013 Jun 26.

47.

Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.

Fells JI, Lee SC, Fujiwara Y, Norman DD, Lim KG, Tsukahara R, Liu J, Patil R, Miller DD, Kirby RJ, Nelson S, Seibel W, Papoian R, Parrill AL, Baker DL, Bittman R, Tigyi G.

Mol Pharmacol. 2013 Sep;84(3):415-24. doi: 10.1124/mol.113.087080. Epub 2013 Jun 21.

48.

Lipid Phase Separation and Protein-Ganglioside Clustering in Supported Bilayers Are Induced by Photorelease of Ceramide.

Carter Ramirez DM, Kim YA, Bittman R, Johnston LJ.

Soft Matter. 2013 May 21;9(19):4890-4899.

49.

Organization of fluorescent cholesterol analogs in lipid bilayers - lessons from cyclodextrin extraction.

Milles S, Meyer T, Scheidt HA, Schwarzer R, Thomas L, Marek M, Szente L, Bittman R, Herrmann A, Günther Pomorski T, Huster D, Müller P.

Biochim Biophys Acta. 2013 Aug;1828(8):1822-8. doi: 10.1016/j.bbamem.2013.04.002. Epub 2013 Apr 11.

50.

Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators.

Liu Z, MacRitchie N, Pyne S, Pyne NJ, Bittman R.

Bioorg Med Chem. 2013 May 1;21(9):2503-10. doi: 10.1016/j.bmc.2013.02.042. Epub 2013 Mar 7.

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