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Items: 35


Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.

Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R.

Mol Cell. 2018 Feb 15;69(4):610-621.e5. doi: 10.1016/j.molcel.2018.01.024.


NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.

Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R.

Nature. 2017 Nov 30;551(7682):639-643. doi: 10.1038/nature24637. Epub 2017 Nov 22.


A CRISPR screen identifies a pathway required for paraquat-induced cell death.

Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS.

Nat Chem Biol. 2017 Dec;13(12):1274-1279. doi: 10.1038/nchembio.2499. Epub 2017 Oct 23.


PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.

Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, Vazquez F, Widlund HR, Sabatini DM, Hahn WC.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3434-E3443. doi: 10.1073/pnas.1617922114. Epub 2017 Apr 10.


Amplification of Adipogenic Commitment by VSTM2A.

Secco B, Camiré É, Brière MA, Caron A, Billong A, Gélinas Y, Lemay AM, Tharp KM, Lee PL, Gobeil S, Guimond JV, Patey N, Guertin DA, Stahl A, Haddad É, Marsolais D, Bossé Y, Birsoy K, Laplante M.

Cell Rep. 2017 Jan 3;18(1):93-106. doi: 10.1016/j.celrep.2016.12.015.


Drugging ACAT1 for Cancer Therapy.

Garcia-Bermudez J, Birsoy K.

Mol Cell. 2016 Dec 1;64(5):856-857. doi: 10.1016/j.molcel.2016.11.023.


Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism.

Chen WW, Freinkman E, Wang T, Birsoy K, Sabatini DM.

Cell. 2016 Aug 25;166(5):1324-1337.e11. doi: 10.1016/j.cell.2016.07.040.


Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Nat Chem Biol. 2016 Jul 19;12(8):656. doi: 10.1038/nchembio0816-656. No abstract available.


The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine.

Chidley C, Trauger SA, Birsoy K, O'Shea EK.

Elife. 2016 Jul 12;5. pii: e14601. doi: 10.7554/eLife.14601.


A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. Erratum in: Nat Chem Biol. 2016 Jul 19;12 (8):656.


Identification and characterization of essential genes in the human genome.

Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM.

Science. 2015 Nov 27;350(6264):1096-101. doi: 10.1126/science.aac7041. Epub 2015 Oct 15.


Corrigendum to "Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression"[Mol Metab 4 (2015) 392-405].

Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM.

Mol Metab. 2015 Jun 6;4(8):592. doi: 10.1016/j.molmet.2015.05.004. eCollection 2015 Aug.


An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM.

Cell. 2015 Jul 30;162(3):540-51. doi: 10.1016/j.cell.2015.07.016.


Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression.

Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM.

Mol Metab. 2015 Feb 13;4(5):392-405. doi: 10.1016/j.molmet.2015.02.002. eCollection 2015 May. Erratum in: Mol Metab. 2015 Aug;4(8):592.


SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM.

Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8.


A critical role for mTORC1 in erythropoiesis and anemia.

Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM.

Elife. 2014 Sep 8;3:e01913. doi: 10.7554/eLife.01913.


Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

Chen WW, Birsoy K, Mihaylova MM, Snitkin H, Stasinski I, Yucel B, Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, Sabatini DM.

Cell Rep. 2014 Apr 10;7(1):27-34. doi: 10.1016/j.celrep.2014.02.046. Epub 2014 Mar 27.


Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM.

Nature. 2014 Apr 3;508(7494):108-12. doi: 10.1038/nature13110. Epub 2014 Mar 16.


A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM.

Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14.


The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.

Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T.

Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Erratum in: Sci Signal. 2014 Mar 4;7(315):er2. Lamming, Dudley A [corrected to Lamming, Dudley W].


A comparative perspective on lipid storage in animals.

Birsoy K, Festuccia WT, Laplante M.

J Cell Sci. 2013 Apr 1;126(Pt 7):1541-52. doi: 10.1242/jcs.104992.


MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.

Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM.

Nat Genet. 2013 Jan;45(1):104-8. doi: 10.1038/ng.2471. Epub 2012 Dec 2.


Molecular profiling of activated neurons by phosphorylated ribosome capture.

Knight ZA, Tan K, Birsoy K, Schmidt S, Garrison JL, Wysocki RW, Emiliano A, Ekstrand MI, Friedman JM.

Cell. 2012 Nov 21;151(5):1126-37. doi: 10.1016/j.cell.2012.10.039.


DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.

Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini DM.

Cell Metab. 2012 Aug 8;16(2):202-12. doi: 10.1016/j.cmet.2012.07.008.


Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.

Birsoy K, Sabatini DM, Possemato R.

Nat Med. 2012 Jul 6;18(7):1022-3. doi: 10.1038/nm.2870. No abstract available.


mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, Sabatini DM.

Nature. 2012 Jun 28;486(7404):490-5. doi: 10.1038/nature11163.


Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.

Ceyhan O, Birsoy K, Hoffman CS.

Chem Biol. 2012 Jan 27;19(1):155-63. doi: 10.1016/j.chembiol.2011.12.010.


Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis.

Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS.

Development. 2011 Nov;138(21):4709-19. doi: 10.1242/dev.067710.


Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM.

Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350.


A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism.

Chen W, Zhang X, Birsoy K, Roeder RG.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10196-201. doi: 10.1073/pnas.1005626107. Epub 2010 May 17.


Antidiabetic effects of IGFBP2, a leptin-regulated gene.

Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman JM.

Cell Metab. 2010 Jan;11(1):11-22. doi: 10.1016/j.cmet.2009.11.007. Erratum in: Cell Metab. 2010 Mar 3;11(3):239.


Identification of white adipocyte progenitor cells in vivo.

Rodeheffer MS, Birsoy K, Friedman JM.

Cell. 2008 Oct 17;135(2):240-9. doi: 10.1016/j.cell.2008.09.036. Epub 2008 Oct 2.


Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach.

Birsoy K, Soukas A, Torrens J, Ceccarini G, Montez J, Maffei M, Cohen P, Fayzikhodjaeva G, Viale A, Socci ND, Friedman JM.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12985-90. doi: 10.1073/pnas.0805621105. Epub 2008 Aug 27.


Transcriptional regulation of adipogenesis by KLF4.

Birsoy K, Chen Z, Friedman J.

Cell Metab. 2008 Apr;7(4):339-47. doi: 10.1016/j.cmet.2008.02.001.


SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5.

Boyer-Guittaut M, Birsoy K, Potel C, Elliott G, Jaffray E, Desterro JM, Hay RT, Oelgeschläger T.

J Biol Chem. 2005 Mar 18;280(11):9937-45. Epub 2005 Jan 6.

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