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Characterizing injury severity in non-accidental trauma: Does injury severity score miss the mark?

Brown JB, Gestring ML, Leeper CM, Sperry JL, Peitzman AB, Billiar TR, Gaines BA.

J Trauma Acute Care Surg. 2018 Feb 17. doi: 10.1097/TA.0000000000001841. [Epub ahead of print]


Toll Like Receptor 4 Signaling Licenses the Cytosolic Transport of Lipopolysaccharide from Bacterial Outer Membrane Vesicles.

Gu L, Meng R, Tang Y, Zhao K, Liang F, Zhang R, Xue Q, Chen F, Xiao X, Wang H, Wang H, Billiar TR, Lu B.

Shock. 2018 Feb 16. doi: 10.1097/SHK.0000000000001129. [Epub ahead of print]


Diagnosis and Management of Polytraumatized Patients With Severe Extremity Trauma.

McKinley TO, Gaski GE, Vodovotz Y, Corona BT, Billiar TR.

J Orthop Trauma. 2018 Mar;32 Suppl 1:S1-S6. doi: 10.1097/BOT.0000000000001114.


cGAS-mediated autophagy protects the liver from ischemia/reperfusion injury independent of STING.

Lei Z, Deng M, Yi Z, Sun Q, Shapiro RA, Xu H, Li T, Loughran PA, Griepentrog JE, Huang H, Scott MJ, Huang F, Billiar TR.

Am J Physiol Gastrointest Liver Physiol. 2018 Feb 15. doi: 10.1152/ajpgi.00326.2017. [Epub ahead of print]


Over Resuscitation With Plasma is Associated With Sustained Fibrinolysis Shutdown and Death in Pediatric Traumatic Brain Injury.

Leeper CM, Neal MD, Billiar TR, Sperry JL, Gaines BA.

J Trauma Acute Care Surg. 2018 Feb 14. doi: 10.1097/TA.0000000000001836. [Epub ahead of print]


"Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress.

Vodovotz Y, Simmons RL, Gandhi CR, Barclay D, Jefferson BS, Huang C, Namas R, El-Dehaibi F, Mi Q, Billiar TR, Zamora R.

Front Physiol. 2017 Dec 22;8:1104. doi: 10.3389/fphys.2017.01104. eCollection 2017.


Speed isn't everything: Identifying patients who may benefit from helicopter transport despite faster ground transport.

Chen X, Gestring ML, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL, Brown JB.

J Trauma Acute Care Surg. 2017 Dec 14. doi: 10.1097/TA.0000000000001769. [Epub ahead of print]


JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.

Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, Wang P, Ma X, Kroemer G, Bartlett DL, Billiar TR, Lotze M, Zeh H, Kang R, Tang D.

Gastroenterology. 2017 Dec 14. pii: S0016-5085(17)36696-9. doi: 10.1053/j.gastro.2017.12.004. [Epub ahead of print]


Principal component analysis of coagulation assays in severely injured children.

Leeper CM, Neal MD, McKenna C, Billiar T, Gaines BA.

Surgery. 2017 Dec 13. pii: S0039-6060(17)30671-2. doi: 10.1016/j.surg.2017.09.031. [Epub ahead of print]


NO and COX2: Dual targeting for aggressive cancers.

Davila-Gonzalez D, Chang JC, Billiar TR.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13591-13593. doi: 10.1073/pnas.1717440114. Epub 2017 Dec 13. No abstract available.


Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice.

Zettel K, Korff S, Zamora R, Morelli AE, Darwiche S, Loughran PA, Elson G, Shang L, Salgado-Pires S, Scott MJ, Vodovotz Y, Billiar TR.

Front Immunol. 2017 Nov 28;8:1672. doi: 10.3389/fimmu.2017.01672. eCollection 2017.


HMGB1 Controls Liver Cancer Initiation through YAP-dependent Aerobic Glycolysis.

Chen R, Zhu S, Fan XG, Wang H, Lotze MT, Zeh HJ 3rd, Billiar TR, Kang R, Tang D.

Hepatology. 2017 Nov 17. doi: 10.1002/hep.29663. [Epub ahead of print]


Comparing the Air Medical Prehospital Triage Score With Current Practice for Triage of Injured Patients to Helicopter Emergency Medical Services: A Cost-effectiveness Analysis.

Brown JB, Smith KJ, Gestring ML, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL, Weissman JS.

JAMA Surg. 2017 Nov 1. doi: 10.1001/jamasurg.2017.4485. [Epub ahead of print]


Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury.

Yang MQ, Du Q, Goswami J, Varley PR, Chen B, Wang RH, Morelli AE, Stolz DB, Billiar TR, Li J, Geller DA.

Hepatology. 2017 Oct 23. doi: 10.1002/hep.29605. [Epub ahead of print]


ALK is a therapeutic target for lethal sepsis.

Zeng L, Kang R, Zhu S, Wang X, Cao L, Wang H, Billiar TR, Jiang J, Tang D.

Sci Transl Med. 2017 Oct 18;9(412). pii: eaan5689. doi: 10.1126/scitranslmed.aan5689.


Stearoyl Lysophosphatidylcholine Inhibits Endotoxin-Induced Caspase-11 Activation.

Li W, Zhang W, Deng M, Loughran P, Tang Y, Liao H, Zhang X, Liu J, Billiar TR, Lu B.

Shock. 2017 Oct 4. doi: 10.1097/SHK.0000000000001012. [Epub ahead of print]


High-mobility group box 1 protein is involved in the protective effect of Saquinavir on ventilation-induced lung injury in mice.

Wang X, Zhang R, Tong Y, Ding X, Jin S, Zhao X, Zong J, Chen Z, Billiar TR, Li Q.

Acta Biochim Biophys Sin (Shanghai). 2017 Oct 1;49(10):907-915. doi: 10.1093/abbs/gmx085.


Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation.

von Ungern-Sternberg SNI, Vogel S, Walker-Allgaier B, Geue S, Maurer A, Wild AM, Münzer P, Chatterjee M, Heinzmann D, Kremmer E, Borst O, Loughran P, Zernecke A, Neal MD, Billiar TR, Gawaz M, Seizer P.

Thromb Haemost. 2017 Nov;117(11):2063-2078. doi: 10.1160/TH17-01-0067. Epub 2017 Nov 30.


Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria.

Li Z, Jiao Y, Fan EK, Scott MJ, Li Y, Li S, Billiar TR, Wilson MA, Shi X, Fan J.

J Immunol. 2017 Nov 1;199(9):3176-3186. doi: 10.4049/jimmunol.1700140. Epub 2017 Sep 25.


An Enrichment Strategy Yields Seven Novel Single Nucleotide Polymorphisms Associated With Mortality and Altered Th17 Responses Following Blunt Trauma.

Schimunek L, Namas RA, Yin J, Liu D, Barclay D, El-Dehaibi F, Abboud A, Lindberg H, Zamora R, Billiar TR, Vodovotz Y.

Shock. 2018 Mar;49(3):259-268. doi: 10.1097/SHK.0000000000000987.


Cyclic stretch induced IL-33 production through HMGB1/TLR-4 signaling pathway in murine respiratory epithelial cells.

Chang J, Xia Y, Wasserloos K, Deng M, Blose KJ, Vorp DA, Turnquist HR, Billiar TR, Pitt BA, Zhang MZ, Zhang LM.

PLoS One. 2017 Sep 12;12(9):e0184770. doi: 10.1371/journal.pone.0184770. eCollection 2017.


The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity.

Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, Zhong M, Yuan H, Zhang L, Billiar TR, Lotze MT, Zeh HJ 3rd, Kang R, Kroemer G, Tang D.

Cell Rep. 2017 Aug 15;20(7):1692-1704. doi: 10.1016/j.celrep.2017.07.055.


Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.

Jiao Y, Li Z, Loughran PA, Fan EK, Scott MJ, Li Y, Billiar TR, Wilson MA, Shi X, Fan J.

J Leukoc Biol. 2018 Feb;103(2):175-183. doi: 10.1189/jlb.3HI0517-173R. Epub 2017 Dec 28.


The research agenda for trauma critical care.

Asehnoune K, Balogh Z, Citerio G, Cap A, Billiar T, Stocchetti N, Cohen MJ, Pelosi P, Curry N, Gaarder C, Gruen R, Holcomb J, Hunt BJ, Juffermans NP, Maegele M, Midwinter M, Moore FA, O'Dwyer M, Pittet JF, Schöchl H, Schreiber M, Spinella PC, Stanworth S, Winfield R, Brohi K.

Intensive Care Med. 2017 Sep;43(9):1340-1351. doi: 10.1007/s00134-017-4895-9. Epub 2017 Jul 29. Review.


TLR4 Inactivation in Myeloid Cells Accelerates Bone Healing of a Calvarial Defect Model in Mice.

Wang D, Gilbert JR, Taylor GM, Sodhi CP, Hackam DJ, Losee JE, Billiar TR, Cooper GM.

Plast Reconstr Surg. 2017 Aug;140(2):296e-306e. doi: 10.1097/PRS.0000000000003541.


IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.

Xu J, Guardado J, Hoffman R, Xu H, Namas R, Vodovotz Y, Xu L, Ramadan M, Brown J, Turnquist HR, Billiar TR.

PLoS Med. 2017 Jul 25;14(7):e1002365. doi: 10.1371/journal.pmed.1002365. eCollection 2017 Jul.


Inflammasome and autophagy regulation - a two-way street.

Sun Q, Fan J, Billiar TR, Scott MJ.

Mol Med. 2017 Jul 24;23. doi: 10.2119/molmed.2017.00077. [Epub ahead of print]


Time for trauma immunology.

Billiar TR, Vodovotz Y.

PLoS Med. 2017 Jul 11;14(7):e1002342. doi: 10.1371/journal.pmed.1002342. eCollection 2017 Jul.


Sepsis Upregulates CD14 Expression in a MyD88-Dependent and Trif-Independent Pathway.

Chen Z, Shao Z, Mei S, Yan Z, Ding X, Billiar T, Li Q.

Shock. 2018 Jan;49(1):82-89. doi: 10.1097/SHK.0000000000000913.


The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure.

Moore FA, Moore EE, Billiar TR, Vodovotz Y, Banerjee A, Moldawer LL.

J Trauma Acute Care Surg. 2017 Sep;83(3):520-531. doi: 10.1097/TA.0000000000001587.


Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans.

Cao Y, Liu X, Li Y, Lu Y, Zhong H, Jiang W, Chen AF, Billiar TR, Yuan H, Cai J.

Int Urol Nephrol. 2017 Aug;49(8):1409-1417. doi: 10.1007/s11255-017-1626-7. Epub 2017 May 22.


NK1.1+ cells promote sustained tissue injury and inflammation after trauma with hemorrhagic shock.

Chen S, Hoffman RA, Scott M, Manson J, Loughran P, Ramadan M, Demetris AJ, Billiar TR.

J Leukoc Biol. 2017 Jul;102(1):127-134. doi: 10.1189/jlb.3A0716-333R. Epub 2017 May 17.


Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma.

Li Z, Fan EK, Liu J, Scott MJ, Li Y, Li S, Xie W, Billiar TR, Wilson MA, Jiang Y, Wang P, Fan J.

Cell Death Dis. 2017 May 11;8(5):e2775. doi: 10.1038/cddis.2017.187.


Distance matters: Effect of geographic trauma system resource organization on fatal motor vehicle collisions.

Brown JB, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL.

J Trauma Acute Care Surg. 2017 Jul;83(1):111-118. doi: 10.1097/TA.0000000000001508.


Aging-related Atg5 defect impairs neutrophil extracellular traps formation.

Xu F, Zhang C, Zou Z, Fan EKY, Chen L, Li Y, Billiar TR, Wilson MA, Shi X, Fan J.

Immunology. 2017 Aug;151(4):417-432. doi: 10.1111/imm.12740. Epub 2017 May 16.


Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer.

Kang R, Xie Y, Zhang Q, Hou W, Jiang Q, Zhu S, Liu J, Zeng D, Wang H, Bartlett DL, Billiar TR, Zeh HJ 3rd, Lotze MT, Tang D.

Cell Res. 2017 Jul;27(7):916-932. doi: 10.1038/cr.2017.51. Epub 2017 Apr 4.


Enhanced Calvarial Bone Healing in CD11c-TLR4-/- and MyD88-/- Mice.

Wang D, Taylor GM, Gilbert JR, Losee JE, Sodhi CP, Hackam DJ, Billiar TR, Cooper GM.

Plast Reconstr Surg. 2017 Apr;139(4):933e-940e. doi: 10.1097/PRS.0000000000003206.


The value of the injury severity score in pediatric trauma: Time for a new definition of severe injury?

Brown JB, Gestring ML, Leeper CM, Sperry JL, Peitzman AB, Billiar TR, Gaines BA.

J Trauma Acute Care Surg. 2017 Jun;82(6):995-1001. doi: 10.1097/TA.0000000000001440.


TLR4 signaling induces TLR3 up-regulation in alveolar macrophages during acute lung injury.

Ding X, Jin S, Tong Y, Jiang X, Chen Z, Mei S, Zhang L, Billiar TR, Li Q.

Sci Rep. 2017 Feb 15;7:34278. doi: 10.1038/srep34278.


Role of the IL-33-ST2 axis in sepsis.

Xu H, Turnquist HR, Hoffman R, Billiar TR.

Mil Med Res. 2017 Feb 2;4:3. doi: 10.1186/s40779-017-0115-8. eCollection 2017. Review.


RNA Editing, ADAR1, and the Innate Immune Response.

Wang Q, Li X, Qi R, Billiar T.

Genes (Basel). 2017 Jan 18;8(1). pii: E41. doi: 10.3390/genes8010041. Review.


Factors Associated With Nontransfer in Trauma Patients Meeting American College of Surgeons' Criteria for Transfer at Nontertiary Centers.

Zhou Q, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL, Brown JB.

JAMA Surg. 2017 Apr 1;152(4):369-376. doi: 10.1001/jamasurg.2016.4976.


Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.

Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE.

J Neurosci. 2017 Feb 1;37(5):1139-1155. doi: 10.1523/JNEUROSCI.2002-16.2016. Epub 2016 Dec 16.


Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients.

Abdul-Malak O, Vodovotz Y, Zaaqoq A, Guardado J, Almahmoud K, Yin J, Zuckerbraun B, Peitzman AB, Sperry J, Billiar TR, Namas RA.

Mediators Inflamm. 2016;2016:7950374. Epub 2016 Nov 15.


N-tert-butylmethanimine N-oxide is an efficient spin-trapping probe for EPR analysis of glutathione thiyl radical.

Scott MJ, Billiar TR, Stoyanovsky DA.

Sci Rep. 2016 Dec 12;6:38773. doi: 10.1038/srep38773.


External validation of the Air Medical Prehospital Triage score for identifying trauma patients likely to benefit from scene helicopter transport.

Brown JB, Gestring ML, Guyette FX, Rosengart MR, Stassen NA, Forsythe RM, Billiar TR, Peitzman AB, Sperry JL.

J Trauma Acute Care Surg. 2017 Feb;82(2):270-279. doi: 10.1097/TA.0000000000001326.


Surgical rescue: The next pillar of acute care surgery.

Kutcher ME, Sperry JL, Rosengart MR, Mohan D, Hoffman MK, Neal MD, Alarcon LH, Watson GA, Puyana JC, Bauzá GM, Schuchert VD, Fombona A, Zhou T, Zolin SJ, Becher RD, Billiar TR, Forsythe RM, Zuckerbraun BS, Peitzman AB.

J Trauma Acute Care Surg. 2017 Feb;82(2):280-286. doi: 10.1097/TA.0000000000001312.


Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients.

Namas RA, Almahmoud K, Mi Q, Ghuma A, Namas R, Zaaqoq A, Zhu X, Abdul-Malak O, Sperry J, Zamora R, Billiar TR, Vodovotz Y.

J Crit Care. 2016 Dec;36:146-153. doi: 10.1016/j.jcrc.2016.07.002. Epub 2016 Jul 11.


PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation.

Xie M, Yu Y, Kang R, Zhu S, Yang L, Zeng L, Sun X, Yang M, Billiar TR, Wang H, Cao L, Jiang J, Tang D.

Nat Commun. 2016 Oct 25;7:13280. doi: 10.1038/ncomms13280.


Redox-dependent regulation of hepatocyte absent in melanoma 2 inflammasome activation in sterile liver injury in mice.

Sun Q, Loughran P, Shapiro R, Shrivastava IH, Antoine DJ, Li T, Yan Z, Fan J, Billiar TR, Scott MJ.

Hepatology. 2017 Jan;65(1):253-268. doi: 10.1002/hep.28893. Epub 2016 Nov 29.

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