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Items: 1 to 50 of 110

1.

Enhancer dysfunction in leukemia.

Bhagwat AS, Lu B, Vakoc CR.

Blood. 2018 Apr 19;131(16):1795-1804. doi: 10.1182/blood-2017-11-737379. Epub 2018 Feb 9. Review.

PMID:
29439951
2.

A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers.

Wei S, Perera MLW, Sakhtemani R, Bhagwat AS.

PLoS One. 2017 Sep 19;12(9):e0185010. doi: 10.1371/journal.pone.0185010. eCollection 2017.

3.

Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases.

Siriwardena SU, Chen K, Bhagwat AS.

Chem Rev. 2016 Oct 26;116(20):12688-12710. doi: 10.1021/acs.chemrev.6b00296. Epub 2016 Sep 1. Review.

4.

BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements.

Bhagwat AS, Roe JS, Mok BYL, Hohmann AF, Shi J, Vakoc CR.

Cell Rep. 2016 Apr 19;15(3):519-530. doi: 10.1016/j.celrep.2016.03.054. Epub 2016 Apr 7.

5.

APOBEC3A damages the cellular genome during DNA replication.

Green AM, Landry S, Budagyan K, Avgousti DC, Shalhout S, Bhagwat AS, Weitzman MD.

Cell Cycle. 2016;15(7):998-1008. doi: 10.1080/15384101.2016.1152426.

6.

Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli.

Bhagwat AS, Hao W, Townes JP, Lee H, Tang H, Foster PL.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2176-81. doi: 10.1073/pnas.1522325113. Epub 2016 Feb 2.

7.

Targeting Transcription Factors in Cancer.

Bhagwat AS, Vakoc CR.

Trends Cancer. 2015 Sep 1;1(1):53-65.

8.

Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine.

Siriwardena SU, Guruge TA, Bhagwat AS.

J Mol Biol. 2015 Sep 25;427(19):3042-55. doi: 10.1016/j.jmb.2015.08.006. Epub 2015 Aug 14.

9.

The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer.

Wang E, Kawaoka S, Roe JS, Shi J, Hohmann AF, Xu Y, Bhagwat AS, Suzuki Y, Kinney JB, Vakoc CR.

Elife. 2015 Apr 28;4:e06377. doi: 10.7554/eLife.06377.

10.

A versatile new tool to quantify abasic sites in DNA and inhibit base excision repair.

Wei S, Shalhout S, Ahn YH, Bhagwat AS.

DNA Repair (Amst). 2015 Mar;27:9-18. doi: 10.1016/j.dnarep.2014.12.006. Epub 2015 Jan 6.

11.

Transcription-associated mutagenesis.

Jinks-Robertson S, Bhagwat AS.

Annu Rev Genet. 2014;48:341-59. doi: 10.1146/annurev-genet-120213-092015. Epub 2014 Sep 10. Review.

PMID:
25251854
12.

Genomic uracil homeostasis during normal B cell maturation and loss of this balance during B cell cancer development.

Shalhout S, Haddad D, Sosin A, Holland TC, Al-Katib A, Martin A, Bhagwat AS.

Mol Cell Biol. 2014 Nov;34(21):4019-32. doi: 10.1128/MCB.00589-14. Epub 2014 Aug 25.

13.

A new bump in the epigenetic landscape.

Bhagwat AS, Vakoc CR.

Mol Cell. 2014 Mar 20;53(6):857-8. doi: 10.1016/j.molcel.2014.03.001.

14.

The COMBREX project: design, methodology, and initial results.

Anton BP, Chang YC, Brown P, Choi HP, Faller LL, Guleria J, Hu Z, Klitgord N, Levy-Moonshine A, Maksad A, Mazumdar V, McGettrick M, Osmani L, Pokrzywa R, Rachlin J, Swaminathan R, Allen B, Housman G, Monahan C, Rochussen K, Tao K, Bhagwat AS, Brenner SE, Columbus L, de Crécy-Lagard V, Ferguson D, Fomenkov A, Gadda G, Morgan RD, Osterman AL, Rodionov DA, Rodionova IA, Rudd KE, Söll D, Spain J, Xu SY, Bateman A, Blumenthal RM, Bollinger JM, Chang WS, Ferrer M, Friedberg I, Galperin MY, Gobeill J, Haft D, Hunt J, Karp P, Klimke W, Krebs C, Macelis D, Madupu R, Martin MJ, Miller JH, O'Donovan C, Palsson B, Ruch P, Setterdahl A, Sutton G, Tate J, Yakunin A, Tchigvintsev D, Plata G, Hu J, Greiner R, Horn D, Sjölander K, Salzberg SL, Vitkup D, Letovsky S, Segrè D, DeLisi C, Roberts RJ, Steffen M, Kasif S.

PLoS Biol. 2013;11(8):e1001638. doi: 10.1371/journal.pbio.1001638. Epub 2013 Aug 27. No abstract available.

15.

Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent.

Chan K, Sterling JF, Roberts SA, Bhagwat AS, Resnick MA, Gordenin DA.

PLoS Genet. 2012;8(12):e1003149. doi: 10.1371/journal.pgen.1003149. Epub 2012 Dec 13.

16.

Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.

Hashimoto H, Hong S, Bhagwat AS, Zhang X, Cheng X.

Nucleic Acids Res. 2012 Nov 1;40(20):10203-14. doi: 10.1093/nar/gks845. Epub 2012 Sep 8.

17.

Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G.

Wijesinghe P, Bhagwat AS.

Nucleic Acids Res. 2012 Oct;40(18):9206-17. doi: 10.1093/nar/gks685. Epub 2012 Jul 13.

18.

In vivo genome editing restores haemostasis in a mouse model of haemophilia.

Li H, Haurigot V, Doyon Y, Li T, Wong SY, Bhagwat AS, Malani N, Anguela XM, Sharma R, Ivanciu L, Murphy SL, Finn JD, Khazi FR, Zhou S, Paschon DE, Rebar EJ, Bushman FD, Gregory PD, Holmes MC, High KA.

Nature. 2011 Jun 26;475(7355):217-21. doi: 10.1038/nature10177.

19.

Comment on "Deoxyuridine triphosphate incorporation during somatic hypermutation of mouse VkOx genes after immunization with phenyloxazolone".

Bhagwat AS.

J Immunol. 2010 Dec 15;185(12):7130-1; author reply 7131. doi: 10.4049/jimmunol.1090111. No abstract available.

20.

Importance of the tmRNA system for cell survival when transcription is blocked by DNA-protein cross-links.

Kuo HK, Krasich R, Bhagwat AS, Kreuzer KN.

Mol Microbiol. 2010 Nov;78(3):686-700. doi: 10.1111/j.1365-2958.2010.07355.x. Epub 2010 Sep 16.

21.

Determinants of sequence-specificity within human AID and APOBEC3G.

Carpenter MA, Rajagurubandara E, Wijesinghe P, Bhagwat AS.

DNA Repair (Amst). 2010 May 4;9(5):579-87. doi: 10.1016/j.dnarep.2010.02.010. Epub 2010 Mar 24.

22.

Use of Drosophila deoxynucleoside kinase to study mechanism of toxicity and mutagenicity of deoxycytidine analogs in Escherichia coli.

Betham B, Shalhout S, Marquez VE, Bhagwat AS.

DNA Repair (Amst). 2010 Feb 4;9(2):153-60. doi: 10.1016/j.dnarep.2009.11.006. Epub 2009 Dec 11.

23.

Central base pair flipping and discrimination by PspGI.

Szczepanowski RH, Carpenter MA, Czapinska H, Zaremba M, Tamulaitis G, Siksnys V, Bhagwat AS, Bochtler M.

Nucleic Acids Res. 2008 Nov;36(19):6109-17. doi: 10.1093/nar/gkn622. Epub 2008 Oct 1.

24.

Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase.

Canugovi C, Samaranayake M, Bhagwat AS.

FASEB J. 2009 Jan;23(1):34-44. doi: 10.1096/fj.08-115352. Epub 2008 Sep 4.

25.

DNA base flipping by both members of the PspGI restriction-modification system.

Carpenter MA, Bhagwat AS.

Nucleic Acids Res. 2008 Sep;36(16):5417-25. doi: 10.1093/nar/gkn528. Epub 2008 Aug 20.

26.

Transcription increases methylmethane sulfonate-induced mutations in alkB strains of Escherichia coli.

Fix D, Canugovi C, Bhagwat AS.

DNA Repair (Amst). 2008 Aug 2;7(8):1289-97. doi: 10.1016/j.dnarep.2008.04.008. Epub 2008 Jun 2.

27.

Is AID a monomer in solution?

Bhagwat AS, Carpenter MA, Bujnicki JM.

DNA Repair (Amst). 2008 Mar 1;7(3):349-50; author reply 351-2. doi: 10.1016/j.dnarep.2007.10.009. Epub 2008 Jan 9. No abstract available.

PMID:
18187371
28.

Kinetic studies of Escherichia coli AlkB using a new fluorescence-based assay for DNA demethylation.

Roy TW, Bhagwat AS.

Nucleic Acids Res. 2007;35(21):e147. Epub 2007 Nov 14.

29.

Sequence-dependent enhancement of hydrolytic deamination of cytosines in DNA by the restriction enzyme PspGI.

Carpenter M, Divvela P, Pingoud V, Bujnicki J, Bhagwat AS.

Nucleic Acids Res. 2006 Aug 7;34(13):3762-70. Print 2006.

30.

Evaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repair.

Samaranayake M, Bujnicki JM, Carpenter M, Bhagwat AS.

Chem Rev. 2006 Feb;106(2):700-19. Review. No abstract available.

31.
32.

DNA-cytosine deaminases: from antibody maturation to antiviral defense.

Bhagwat AS.

DNA Repair (Amst). 2004 Jan 5;3(1):85-9. Review.

33.

Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB.

Kurowski MA, Bhagwat AS, Papaj G, Bujnicki JM.

BMC Genomics. 2003 Dec 10;4(1):48.

34.
35.

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations.

Sohail A, Klapacz J, Samaranayake M, Ullah A, Bhagwat AS.

Nucleic Acids Res. 2003 Jun 15;31(12):2990-4.

37.

Mismatch uracil glycosylase from Escherichia coli: a general mismatch or a specific DNA glycosylase?

O'Neill RJ, Vorob'eva OV, Shahbakhti H, Zmuda E, Bhagwat AS, Baldwin GS.

J Biol Chem. 2003 Jun 6;278(23):20526-32. Epub 2003 Mar 31.

38.

A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.

Roberts RJ, Belfort M, Bestor T, Bhagwat AS, Bickle TA, Bitinaite J, Blumenthal RM, Degtyarev SKh, Dryden DT, Dybvig K, Firman K, Gromova ES, Gumport RI, Halford SE, Hattman S, Heitman J, Hornby DP, Janulaitis A, Jeltsch A, Josephsen J, Kiss A, Klaenhammer TR, Kobayashi I, Kong H, Krüger DH, Lacks S, Marinus MG, Miyahara M, Morgan RD, Murray NE, Nagaraja V, Piekarowicz A, Pingoud A, Raleigh E, Rao DN, Reich N, Repin VE, Selker EU, Shaw PC, Stein DC, Stoddard BL, Szybalski W, Trautner TA, Van Etten JL, Vitor JM, Wilson GG, Xu SY.

Nucleic Acids Res. 2003 Apr 1;31(7):1805-12.

39.

Limited proteolysis of maize NADP-malic enzyme.

Pinto S, Rao SR, Bhagwat AS.

Indian J Biochem Biophys. 2002 Dec;39(6):382-9.

PMID:
22905395
40.

Mismatch repair in methylated DNA. Structure and activity of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4.

Wu P, Qiu C, Sohail A, Zhang X, Bhagwat AS, Cheng X.

J Biol Chem. 2003 Feb 14;278(7):5285-91. Epub 2002 Nov 26.

41.
42.

Lack of dependance of transcription-induced cytosine deaminations on protein synthesis.

Mokkapati SK, Bhagwat AS.

Mutat Res. 2002 Oct 31;508(1-2):131-6.

PMID:
12379468
43.

Protection of DNA by alpha/beta-type small, acid-soluble proteins from Bacillus subtilis spores against cytosine deamination.

Sohail A, Hayes CS, Divvela P, Setlow P, Bhagwat AS.

Biochemistry. 2002 Sep 24;41(38):11325-30.

PMID:
12234173
45.

Limited proteolysis by trypsin influences activity of maize phosphoenolpyruvate carboxylase.

Maralihalli G, Bhagwat AS.

Indian J Biochem Biophys. 2001 Dec;38(6):361-7.

PMID:
11989665
46.

Inactivation of maize NADP-malic enzyme by Cu2+-ascorbate.

Pinto SE, Rao SR, Bhagwat AS.

Indian J Biochem Biophys. 2002 Feb;39(1):55-9.

PMID:
22896889
47.
49.

Escherichia coli DNA glycosylase Mug: a growth-regulated enzyme required for mutation avoidance in stationary-phase cells.

Mokkapati SK, Fernández de Henestrosa AR, Bhagwat AS.

Mol Microbiol. 2001 Sep;41(5):1101-11.

50.

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